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Resolving the developmental mechanisms of cardiac microthrombosis of SARS-CoV-2 based on single-cell transcriptome analysis

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Science China Life Sciences 2025年第1期 103-115页

作者： Xizi Luo Nan Zhang Yuntao Liu Beibei Du Xuan Wang Tianxu Zhao Bingqiang Liu Shishun Zhao Jiazhang qiu Guoqing Wang State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Basic MedicineJilin University State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Veterinary MedicineJilin University College of Mathematics Jilin University Bioinformatic Lab School of MathematicsShandong University Department of Cardiology China-Japan Union HospitalJilin University

The coronavirus disease 2019（COVID-19） outbreak caused by the severe acute respiratory syndrome coronavirus-2（SARS-CoV-2） developed into a global health emergency. Systemic microthrombus caused by SARS-CoV-2 infection is a common complication in patients with COVID-19. Cardiac microthrombosis as a complication of SARS-CoV-2 infection is the primary cause of cardiac injury and death in patietns with severe COVID-19. In this study, we performed single-cell sequencing analysis of the right ventricular free wall tissue from healthy donors,patients who died during the hypercoagulable period of characteristic coagulation abnormality（CAC）, and patients who died during the fibrinolytic period of CAC. We collected 61,187 cells enriched in 24 immune cell subsets and 13 cardiac-resident cell subsets. We found that in the course of SARS-CoV-2 infected heart microthrombus, MYO1EhighRASGEF1Bhighmonocyte-derived macrophages promoted hyperactivation of the immune system and initiated the extrinsic coagulation pathway by activating chemokines CCL3, CCL5. This series of events is the main cause of cardiac microthrombi following SARS-CoV-2 infection. In a SARS-CoV-2 infected heart microthrombus, excessive immune activation is accompanied by an increase in cellular iron content, which in turn promotes oxidative stress and intensifies intercellular competition. This induces cells to alter their metabolic environment, resulting in increased sugar uptake via the glycosaminoglycan synthesis pathway. In addition, high levels of reactive oxygen species generated by elevated iron levels promote increased endogenous malondialdehyde synthesis in a subpopulation of cardiac endothelial cells. This exacerbates endothelial cell dysfunction and exacerbates the coagulopathy process.

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A novel testability model for health management of heading attitude system

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Chinese Journal of Aeronautics 2013年第1期26卷 201-208页

作者： Liu Guanjun yang Shuming qiu Jing yang Peng Laboratory of Science and Technology on Integrated Logistics Support College of Mechatronics Engineering and Automation National University of Defense Technology

Prognostics and health management （PHM） is very important to guarantee the reliability and safety of aerospace systems, and sensing and test are the precondition of PHM. Integrating design for testability into early design stage of system early design stage is deemed as a fundamental way to improve PHM performance, and testability model is the base of testability analysis and design. This paper discusses a hierarchical model-based approach to testability modeling and analysis for heading attitude system health management. Quantified directed graph, of which the nodes represent components and tests and the directed edges represent fault propagation paths, is used to describe fault-test dependency, and quantitative testability information is assigned to nodes and directed edges. The fault dependencies between nodes can be obtained by functional fault analysis methodology that captures the physical architecture and material flows such as energy, heat, data, and so on. By incorporating physics of failure models into component, the dynamic process of a failing or degrading component can be projected onto system behavior, i.e., system symptoms. Then, the analysis of extended failure modes, mechanisms and effects is utilized to construct fault evolution-test dependency. Using this integrated model, the designers and system analysts can assess the test suite＇s fault detectability, fault isolability and fault predictability. And heading attitude system application results show that the proposed model can support testability analysis and design for PHM very well.

关键词： Fault evolution Functional fault analysis Physics of failure model Prognostics and health management Quantified directed graph Testability analysis

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Halide ion-induced formation of single crystalline mesoporous PtPd bimetallic nanoparticles with hollow interiors for electrochemical methanol and ethanol oxidation reaction

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Nano Research 2017年第3期10卷 1064-1077页

作者： Pengtao qiu Shaomin Lian Guang yang Shengchun yang School of Science Key Laboratory of Shaanxi for Advanced Materials and Mesoscopic Physics State Key Laboratory for Mechanical Behavior of Materials Xi'an 2iaotong University Xi'an 710049 China Electronic Materials Research Laboratory Key Laboratory of the Ministry of Education & International Center for Dielectric Research Xi' an Jiaotong University Xi'an 710049 China Collaborative Innovation Center of Suzhou Nano Science and Technology Suzhou Academy of Xi'an Jiaotong University Suzhou 215000 China

We demonstrate a facile hydrothermal one-pot synthesis method for producing single crystalline mesoporous PtPd bimetallic nanoparticles with a hollow interior and porous surface structure in the presence of Br- and F ions. The formation process analysis indicated that the coexistence of Br- and I- ions is responsible for the formation of the novel bimetallic nanoparticles. The changes in the reduction potential of Pt and Pd metal ions achieved by the coordination with different halide ions resulted in the formation of hollow interiors as a galvanic reaction between Pd2~ and Pt4. ions occurred. In addition, the size of the mesoporous PtPd nanoparticles can be well controlled by slightly changing the amount of I- ions used. The electrochemical tests indicated that the as- synthesized single crystalline mesoporous PtPd hollow nanoparticles exhibited enhanced catalytic properties toward methanol and ethanol oxidation reactions as compared with the commercial Pt black and Pt/C materials.

关键词： noble metalmesoporous single crystal hollow interior electrocatalysis

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Mast fruiting in a hawkmoth- pollinated orchid Habenaria glaucifolia: an 8-year survey

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Journal of Plant Ecology 2015年第2期8卷 136-141页

作者： Ying-ze Xiong Chang-qiu Liu Shuang-Quan Huang School of Life Sciences Central China Normal University152 Luoyu AvenueHongshan DistrictWuhan 430079China Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of Sciences132 Lanhei RoadKunming 650204China

Aims The hypothesis of predator satiation has been proposed to explain mast fruiting in various flowering *** considers that the simultaneous production of large numbers of seeds by a plant population reduces the risk of seed predation for each *** produce huge numbers of seeds per fruit and rarely experience seed *** remains unclear which factors may affect fluctuating fruit production in orchids,which generally suffer a widespread pol-len *** explore the temporal pattern of fruiting and poten-tial factors related to fluctuation in fruit production,we investigated reproductive success of a long-spurred orchid(Habenaria glaucifo-lia)in an alpine meadow with thousands of individuals over 8 *** To estimate reproductive success,pollinator observation was con-ducted by day and at night,and pollinia removal and receipt were recorded in the field population for 8 *** examine whether fruit set and seed set are pollen limited,we conducted supple-mentary pollination experiments and compared fruit set,seed set and pollinia movement of open-pollinated flowers from 2011 to *** measured lengths of spurs and pollinator probos-cises,and nectar volume and concentration,to identify potential *** Findings Hawkmoths were seen to be effective pollinators for ***-folia in 3 years,whereas in the remaining 5 years no pollinators were observed,and consequently pollinia were rarely *** pollinia movements were observed in 2012,2013 and 2014(pollinia removal:48,59 and 85%;pollinia receipt 51,70 and 80%),and correspondingly fruit set was significantly higher in 2012 and 2013(59 and 46%)than in 2011(25%).it was fruit set,rather than seed set,that was pollen limited in this orchid in the 3 years,in that supplementary pollination increased fruit set but did not increase seed set per fruit compared to *** species of hawkmoths had proboscis lengths that matched the spur length of ***

关键词： Habenaria glaucifolia mast fruiting orchidaceae pollinator scarcity pollen limitation pollinia movement ‘sit and wait’strategy

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Optimization of dynamic sequential test strategy for equipment health management

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Journal of Systems Engineering and Electronics 2012年第1期23卷 71-77页

作者： Shuming yang Jing qiu Guanjun Liu Peng yang Laboratory of Science and Technology on Integrated Logistics Support College of Mechatronics Engineering and Automation National University of Defense Technology Changsha 410073 P. R. China

Testing is the premise and foundation of realizing equipment health management （EHM）. To address the problem that the static periodic test strategy may cause deficient test or excessive test, a dynamic sequential test strategy （DSTS） for EHM is presented. Considering the situation that equipment health state is not completely observable in reality, a DSTS optimization method based on partially observable semi-Markov decision pro- cess （POSMDP） is proposed. Firstly, an equipment health state degradation model is constructed by Markov process, and the control limit maintenance policy is also introduced. Secondly, POSMDP is formulated in great detail. And then, POSMDP is converted to completely observable belief semi-Markov decision process （BSMDP） through belief state. The optimal equation and the corresponding optimal DSTS, which minimize the long-run ex- pected average cost per unit time, are obtained with BSMDP. The results of application in complex equipment show that the proposed DSTS is feasible and effective.

关键词： equipment health management (EHM) dynamic sequential test strategy (DSTS) partially observable semi-Markov decision process (POSMDP) optimal equation.

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Shear Model of Metal Melt Flowing on Vibration Wall and Effect of Shear Stress on Solidification Microstructure

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Acta Metallurgica Sinica(English Letters) 2018年第6期31卷 650-658页

作者： Ren-Guo Guan Xiang Wang Ying-qiu Shang Di Tie Run-ze Chao School of Materials Science and Engineering Northwestern Polytechnical University Xi'an 710072 China School of Materials Science and Engineering Northeastern University Shenyang 110819 China Luoyang Ship Material Research Institute Luoyang 471000China

In this work,the shear model of metal melt flowing on vibration surface is established,and coupling effects of vibration and shear on the distribution of shear stress in melt and melt solidification microstructure are *** results show that the transition of melt from laminar flow to turbulent flow occurs earlier with increasing vibration frequency and vibration *** the laminar flow melt,shear stress in melt decreases with increasing vertical length,but it decreases firstly and then stabilizes with increasing flow *** the turbulent flow melt,shear stress decreases firstly and then stabilizes with increasing vertical length,but it increases with increasing flow *** the increase in vibration frequency and amplitude,shear stress along flow direction in laminar flow melt increases,while shear stresses along both flow direction and vertical direction in turbulent flow melt *** stress in melt decreases with increasing length along vertical *** the increase in flow length,shear stress decreases firstly and then stabilizes in laminar flow melt,while it increases in turbulent flow *** the increase in vibration frequency and amplitude,shear stress increases in laminar flow melt,while it stabilizes in turbulent flow *** on theoretical calculation,the maximum shear stress in melt during vibration shear flow is always much lower than the yield strength of a-Al grain,so the shear stress induced by vibration shear flow cannot break columnar crystal,which agrees with the experiment ***,the model can explain the shear constitutive relation of melt flow on vibration surface relatively well.

关键词： Solidification Flow near surface Shear Vibration Columnar crystal

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Sensor Optimization Selection Model Based on Testability Constraint

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Chinese Journal of Aeronautics 2012年第2期25卷 262-268页

作者： yang Shuming qiu Jing LIU Guanjun Laboratory of Science and Technology on Integrated Logistics Support College of Mechatronics Engineering and AutomationNational University of Defense TechnologyChangsha 410073China

Sensor selection and optimization is one of the important parts in design for testability. To address the problems that the traditional sensor optimization selection model does not take the requirements of prognostics and health management especially fault prognostics for testability into account and does not consider the impacts of sensor actual attributes on fault detectability, a novel sensor optimization selection model is proposed. Firstly, a universal architecture for sensor selection and optimization is provided. Secondly, a new testability index named fault predictable rate is defined to describe fault prognostics requirements for testability. Thirdly, a sensor selection and optimization model for prognostics and health management is constructed, which takes sensor cost as objective function and the defined testability indexes as constraint conditions. Due to NP-hard property of the model, a generic algorithm is designed to obtain the optimal solution. At last, a case study is presented to demonstrate the sensor selection approach for a stable tracking servo platform. The application results and comparison analysis show the proposed model and algorithm are effective and feasible. This approach can be used to select sensors for prognostics and health management of any system.

关键词： prognostics and health management design for testability fault predictable rate sensor selection and optimization generic algorithm

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Determination of an Unknown Time-dependent Heat Source from A Nonlocal Measurement by Finite Difference Method

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Acta Mathematicae Applicatae Sinica 2020年第1期36卷 151-165页

作者： ze-wen WANG Zhou-sheng RUAN He-lu HUANG Shu-fang qiu School of Science East China University of TechnologyNanchang 330013China Institute of Science and Engineering Computing East China University of TechnologyNanchang 330013China

In this paper,we consider an inverse time-dependent source problem of heat conduction ***,the ill-posedness and conditional stability of this inverse source problem is ***,a finite difference inversion method is proposed for reconstructing the time-dependent source from a nonlocal *** existence and uniqueness of the finite difference inverse solutions are rigorously analyzed,and the convergence is *** with the mollification method,the proposed finite difference inversion method can obtain more stable reconstructions from the nonlocal data with ***,numerical examples are given to illustrate the efficiency and convergence of the proposed finite difference inversion method.

关键词： inverse source problem ill-posed problem finite difference heat equation mollification

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Thermally Conductive,Healable Glass Fiber Cloth Reinforced Polymer Composite based onβ-Hydroxyester Bonds Crosslinked Epoxy with Improved Heat Resistance

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Chinese Journal of Polymer Science 2024年第5期42卷 643-654,I0009页

作者： Fang Chen Xiao-Yan Pang ze-Ping Zhang Min-Zhi Rong Ming-qiu Zhang Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education GD HPPC LabIGCMESchool of ChemistrySun Yat-sen UniversityGuangzhou510275China Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Jieyang515200China

To simultaneously endow thermal conductivity,high glass transition temperature(Tg)and healing capability to glass fiber/epoxy(GFREP)composite,dynamic crosslinked epoxy resin bearing reversibleβ-hydroxyl ester bonds was reinforced with boron nitride nanosheets modified glass fiber cloth(GFC@BNNSs).The in-plane heat conduction paths were constructed by electrostatic self-assembly of polyacrylic acid treated GFC and polyethyleneimine decorated ***,the GFC@BNNSs were impregnated with the mixture of lower concentration(3-glycidyloxypropyl)trimethoxysilane grafted BN micron sheets,3,4-epoxycyclohexylmethyl 3,4-epoxycyclohexanecarboxylate and hexahydro-4-methylphthalic anhydride,which accounted for establishing the through-plane heat transport pathways and avoiding serious deterioration of mechanical *** resultant GFREP composite containing less boron nitride particles(17.6 wt%)exhibited superior in-plane(3.29 W·m^(-1)·K^(-1))and through-plane(1.16 W·m^(-1)·K^(-1))thermal conductivities,as well as high Tg of 204℃(Tg of the unfilled epoxy=177℃).The reversible transesterification reaction enabled closure of interlaminar cracks within the composite,achieving decent healing efficiencies estimated by means of tensile strength(71.2%),electrical breakdown strength(83.6%)and thermal conductivity(69.1%).The present work overcame the disadvantages of conventional thermally conductive composites,and provided an efficient approach to prolong the life span of thermally conductive GFREP laminate for high-temperature resistant integrated circuit application.

关键词： Thermally conductive composites Boron nitride High-temperature resistance β-Hydroxyl ester bond Healing

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Combination of structural reliability and interval analysis

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Acta Mechanica Sinica 2008年第1期24卷 61-67页

作者： Zhiping qiu Di yang Isaac Elishakoff Institute of Solid Mechanics Beihang University Beijing 100083 China Department of Mechanical Engineering Florida Atlantic UniversityBoca Raton FL 33431-0991 USA

In engineering applications, probabilistic reliability theory appears to be presently the most important method, however, in many cases precise probabilistic reliability theory cannot be considered as adequate and credible model of the real state of actual affairs. In this paper, we developed a hybrid of probabilistic and non-probabilistic reliability theory, which describes the structural uncertain parameters as interval variables when statistical data are found insufficient. By using the interval analysis, a new method for calculating the interval of the structural reliability as well as the reliability index is introduced in this paper, and the traditional probabilistic theory is incorporated with the interval analysis. Moreover, the new method preserves the useful part of the traditional probabilistic reliability theory, but removes the restriction of its strict requirement on data acquisition. Example is presented to demonstrate the feasibility and validity of the proposed theory.

关键词： Non-probabilistic Reliability Interval analysis Parameter estimation

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