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顺北区块5号断裂带二叠系优快钻井方案

内蒙古石油化工 2022年第5期48卷 115-120页

作者：辛泽宇中石化华北石油工程有限公司西部分公司新疆巴音郭楞841600

华北西部分公司70191HB钻井队在顺托果勒区块5号断裂带施工的顺北5-7井在二叠系4 577.50~5 137.00m井段钻遇侵入相玄武岩。玄武岩硬度大,研磨性强,可钻性差,稳定性差,易发生掉块,且侵入体交界处的裂缝容易发生井漏是5号断裂带的施工难点... 详细信息

华北西部分公司70191HB钻井队在顺托果勒区块5号断裂带施工的顺北5-7井在二叠系4 577.50~5 137.00m井段钻遇侵入相玄武岩。玄武岩硬度大,研磨性强,可钻性差,稳定性差,易发生掉块,且侵入体交界处的裂缝容易发生井漏是5号断裂带的施工难点[1]。钻至井深4 932.30m时,顶驱频繁憋停,释放扭矩后上提下放活动钻具遇阻,震击器第205次震击,上提至258t(原悬重208t),震击解卡成功。分析卡钻原因为二叠系玄武岩、玄武岩岩屑掉块未及时返出掉落至井底钻头,井队总结经验,制定井下风险评估,结合临井资料,从钻头、钻井液性能、钻井参数三方面入手,总结了渐进式承压堵漏法、牙轮钻头稳压控参法、泥浆性能转优法来应对二叠地层井塌井漏风险,该井二次施工过程中安全钻穿二叠地层,顺利钻达二开完钻井深5 186m,总结出了一套适用于顺北区块5号断裂带二叠地层优快钻井施工方案。

关键词： 5号断裂带侵入体参数优选工具优选泥浆性能转优法

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： xin Yang yu-Wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

赤潮异弯藻抗体的制备及酶联免疫检测方法的建立

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海洋学报 2006年第5期28卷 167-172页

作者：亓海刚米铁柱辛泽毓李荣秀于志刚中国海洋大学生命科学与技术学部山东青岛266003 中国海洋大学环境科学与工程学院山东青岛266003 中国科学院上海生命科学研究院上海200233 上海交通大学生命科学技术学院上海200030 中国海洋大学化学化工学院山东青岛266003

赤潮异弯藻(Heterosigma akashiwo)是一种广泛分布于世界近岸海域的有害针胞藻类(Raphidophyte)，也是我国近海常见的赤潮生物，曾经有多次引发赤潮的报道~([1,2]).在赤潮发生的早期，自然水体中赤潮生物的细胞密度相对较低，且赤潮藻... 详细信息

赤潮异弯藻(Heterosigma akashiwo)是一种广泛分布于世界近岸海域的有害针胞藻类(Raphidophyte)，也是我国近海常见的赤潮生物，曾经有多次引发赤潮的报道~([1,2]).在赤潮发生的早期，自然水体中赤潮生物的细胞密度相对较低，且赤潮藻个体微小，传统的鉴定方法，即海水样品采集后利用光学显微镜直接观察，主要用于藻的定性和分离，当样品量较多时，定量计数过程则烦琐、费时、费力，工作量大．

关键词：赤潮异弯藻抗体效价特异性酶联免疫检测

Vector meson's spin alignments in high energy reactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 5-20页

作者： Jin-Hui Chen Zuo-Tang Liang yu-Gang Ma xin-Li Sheng Qun Wang Key Laboratory of Nuclear Physics and Ion-beam Application (MoE) Institute of Modern PhysicsFudan University Institute of Frontier and Interdisciplinary Science Key Laboratory of Particle Physics and Particle Irradiation (MOE)Shandong University INFN-Firenze Department of Modern Physics University of Science and Technology of China School of Mechanics and Physics Anhui University of Science and Technology

The global spin alignment of vector mesons has been observed by the STAR collaboration at the Relativistic Heavy Ion Collider （RHIC） at Brookhaven National Laboratory （BNL）.It provides a unique opportunity to probe the correlation between the polarized quark and antiquark in the strongly coupled quark-gluon plasma （sQGP） produced in relativistic heavy ion collisions,opening a new window to explore the properties of s *** addition,spin alignments of vector mesons have also been observed in other high-energy particle collisions such as e+e-annihilations at high energies where hadron production is dominated by quark fragmentation *** results obtained are quite different from those obtained in heavy ion collisions where quark coalescence/combination mechanism dominates suggesting strong dependence on hadronization *** comprehensive studies in different hadronization processes are *** this article,we present a brief review of theoretical and experimental advances in the study of vector meson’s spin alignments in a variety of high-energy particle collisions,with emphasis on hadronization mechanisms.

关键词： vector meson spin alignment global polarization relativistic heavy ion collisions fragmentation

播期对不同基因型小麦生育期、产量和品质性状的影响

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生态学杂志 2021年第10期40卷 3135-3146页

作者：白露李乐连延浩王志强辛泽毓林同保任永哲河南农业大学农学院郑州450046 河南粮食作物协同创新中心郑州450046 省部共建小麦玉米作物学国家重点实验室郑州450046

以8个不同基因型小麦为材料,研究了3种播期处理对小麦生育期、产量和品质的影响。结果表明:随着播期推迟,不同品种的生育期均显著缩短,且播种至拔节期的变化最为明显,其次为散粉至成熟期,但不同冬春性小麦品种受播期影响的阶段存在一定... 详细信息

以8个不同基因型小麦为材料,研究了3种播期处理对小麦生育期、产量和品质的影响。结果表明:随着播期推迟,不同品种的生育期均显著缩短,且播种至拔节期的变化最为明显,其次为散粉至成熟期,但不同冬春性小麦品种受播期影响的阶段存在一定差异;在产量方面,早播条件下,不同品种小麦的穗数会增加,其中冬性小麦品种可育小穗数最多,因此适当早播可以提高冬性品种小麦的产量;而晚播能增加弱春性品种小麦可育小穗数;小麦籽粒蛋白质含量随播期推迟变化相对较小,而湿面筋含量则随播期的推迟大致表现出下降的趋势,冬春性相同的小麦品种的籽粒硬度对播期响应基本一致。在两年试验中,小麦的品质性状表现出明显的基因型效应和年际间差异,其原因尚需进一步研究。

关键词：播期小麦生育期产量品质

华北平原夏玉米农田CO_2通量与光合特性及主要环境因素的关系

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华北农学报 2015年第3期30卷 117-122页

作者：王志强王俊哲辛泽毓曲奕威林同保河南农业大学农学院河南粮食作物协同创新中心河南郑州450002

为准确估算夏玉米产量和净生产力,以华北平原典型夏玉米农田为对象,研究了CO2通量(Fc)与玉米光合特性及主要环境因素的关系。结果表明,Fc与群体光合速率(CAP)之间有明显的正相关关系,相关系数达0.910;从日累积量来看,Fc和CAP均在抽雄吐... 详细信息

为准确估算夏玉米产量和净生产力,以华北平原典型夏玉米农田为对象,研究了CO2通量(Fc)与玉米光合特性及主要环境因素的关系。结果表明,Fc与群体光合速率(CAP)之间有明显的正相关关系,相关系数达0.910;从日累积量来看,Fc和CAP均在抽雄吐丝期达到最大;将单叶净光合速率(Pn)与叶面积指数(LAI)的乘积(Pn·LAI)和Fc进行曲线拟合,预测值与实测值的相关系数为0.790,达极显著水平;从主要环境因素对Fc的通径分析来看,水蒸汽分压对Fc的决定系数及其所占比重最大,其次是水汽浓度、Pn·LAI、光合有效辐射、CO2浓度,可见蒸腾作用对Fc的耦合效应十分显著。

关键词：夏玉米 CO2通量光合特性环境因素

Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-yu Zhao Juan-Han yu Yi-Hua Wang Yi-xin Liu Lu Xu Lin Fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

Adsorption and Diffusion of Hydrogen Atom on Low-index Ag Planes

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Chinese Journal of Structural Chemistry 2005年第10期24卷 1217-1223页

作者： ZHANG Jing DIAO Zhao-yu WANG ze-xin Department of Chemistry Shandong Normal University Jinan 250014 China

The 5-parameter Morse potential （5-MP） of the interaction between H atom and Ag surfaces has been constructed. The adsorption and diffusion of H on Ag low-index surfaces are investigated with 5-MP in detail. The characteristics of critical points are obtained. The theoretical results show that H atom can only adsorb at the three-fold site on Ag（111 ）; the quasi-3-fold site and long-bridge site are stable adsorption sites on Ag（110） surface for the H atom, and at low coverage hydrogen predominantly occupies the quasi-3-fold site. This work predicts that the four-fold hollow site is the most stable adsorption state for H atom on Ag（100）. The results of this work are approved by the experimental and theoretical results.

关键词： H-Ag system 5-MP adsorption vibration low-index surfaces

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-xin Qin xin Tan Xiao-Yan Sun Xu-Fang Ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin