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Regulation role of miR-204 on SIRT1/VEGF in metabolic memory induced by high glucose in human retinal pigment epithelial cells

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1232-1237页

作者： Qiao-Ling Lai Ting xie wei-Dong Zheng Yan Huang Department of Ophthalmology Renmin Hospital of Wuhan UniversityWuhan 460060Hubei ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350004Fujian ProvinceChina Department of Ophthalmology&Optometry Fujian Medical UniversityFuzhou 350004Fujian ProvinceChina

AIM:To examine the regulatory role of microRNA-204(miR-204)on silent information regulator 1(SIRT1)and vascular endothelial growth factor(VEGF)under highglucose-induced metabolic memory in human retinal pigment epithelial(hRPE)***:Cells were cultured with either normal(5 mmol/L)or high D-glucose(25 mmol/L)concentrations for 8d to establish control and high-glucose groups,*** induce metabolic memory,cells were cultured with 25 mmol/L D-glucose for 4d followed by culture with 5 mmol/L D-glucose for *** addition,exposed in 25 mmol/L D-glucose for 4d and then transfected with 100 nmol/L miR-204 control,miR-204 inhibitor or miR-204 mimic in 5 mmol/L D-glucose for *** reverse transcription-polymerase chain reaction(RT-qPCR)was used to detect miR-204 mRNA ***1 and VEGF protein levels were assessed by immunohistochemical and Western *** cytometry was used to investigate apoptosis ***:It was found that high glucose promoted miR-204 and VEGF expression,and inhibited SIRT1 activity,even after the return to normal glucose culture *** of miR-204 promoted apoptosis inhibiting SIRT1 and increasing VEGF ***,downregulation of miR-204 produced the opposite ***:The study identifies that miR-204 is the upstream target of SIRT1and VEGF,and that miR-204 can protect hRPE cells from the damage caused by metabolic memory through increasing SIRT1 and inhibiting VEGF expression.

关键词： human retinal pigment epithelial metabolic memory microRNA-204 silent information regulator 1 vascular endothelial growth factor high-glucose

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Regularly Tuning Quantum Interference in Single-Molecule Junctions through Systematic Substitution of Side Groups with Varied Electron Effects

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Chinese Journal of Chemistry 2024年第11期42卷 1217-1222页

作者： Xianjing xie Yirong Zhang Junrui Zhang Xingyuan Cui wei Liu Xunshan Liu Key Laboratory of Surface&Interface Science of Polymer Materials of Zhejiang Province School of Chemistry and Chemical EngineeringZhejiang Sci-Tech University928 Second StreetHangzhouZhejiang310018 China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunJilin130022 China School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjingJiangsu210094 China

Investigating the quantum interference effect in single molecules is essential to comprehensively understand the underlying mechanism of single-molecule charge *** this study,we employed the mother molecule m-OPE and introduced a series of side groups with various electronic effects at the 2-position of the central phenyl ring,creating four daughter m-OPE *** single molecular conductivities of these molecule wires were measured using the scanning tunneling microscope breaking junction *** findings demonstrate that the substitutions regularly modulate the destructive quantum interference occurring within the m-OPE *** combining optical and electrochemical investigations,along with density functional theory computations,we discover that the conductivity of the molecules corresponds to the electron-donating/withdrawing ability of the ***,by adjusting the electron structures of the molecular backbone,we can systematically tailor the destructive quantum interference in the m-OPE molecules.

关键词： Quantum interference Single-molecule junctions Electron effect substituents Charge transport Molecular devices

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Interplay between the atomic structures and superconductivity of two-monolayer Pb films

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 90-98页

作者： Kun xie ze Huang Pengju Li Yumin Xia Desheng Cai Yitong Gu Yuzhou Liu Fangliang Cai Runxiao Zhang Haohao Shi Ping Cui Shengyong Qin International Center for Quantum Design of Functional Materials(ICQD) University of Science and Technology of ChinaHefei 230026China CAS Key Laboratory of Strongly Coupled Quantum Matter Physics Department of PhysicsUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China

Superconductors with reduced dimensionality have been widely explored for their exotic superconducting ***,at the two-dimensional limit,two-monolayer Pb films with two types of structures provide an ideal platform to unveil the underlying superconducting mechanism[Science 324,1314(2009)].Here,by combining scanning tunneling microscopy(STM)with the first-principle calculations,we successfully identify that these two types have different atomic lattice structures with varying stacking phases,which further enables us to calculate the phonon spectrum and electron phonon coupling strength of each *** theoretical calculations are in good agreement with tunneling spectroscopy measurements of the superconducting transition temperatures(T_(c)),which established a correlation between atomic structures and ***,it was observed that the higher T_(c)of these two types also possess higher out-of-plane upper critical magnetic fields(Hc2).These findings will provide important new insights into two-dimensional superconductivity at the atomic level.

关键词： 2 ML Pb films superconductivity atomic structure scanning tunneling microscopy first-principle calculations

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Regulating CRISPR/Cas9 Using Streptavidin-Biotin Interactions

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Chinese Journal of Chemistry 2024年第12期42卷 1387-1393页

作者： wei Shen wei Xiong Qianqian Qi Xingyu Liu Zhongpao xie Yuanyuan Zhang Jinxuan Hou Tian Tian Xiang Zhou College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei 430072China Department of Thyroid&Breast Surgery Zhongnan Hospitalof Wuhan University Wuhan Hubei43001Chin

Comprehensive Summary Currently,CRISPR/Cas9 technology has found widespread applications across various ***,the utility of CRISPR/Cas9 is encumbered by issues pertaining to its reliability and safety,primarily stemming from the uncontrolled activity of the ***,the design and development of CRISPR/Cas9 systems with controllable activity is of paramount ***,characterized by its small molecular weight,and streptavidin,distinguished by its substantial spatial steric hindrance,can be harnessed as an ideal OFF switch(termed a"bioactivity brake")due to their interaction *** this work,we present a strategy that employs the streptavidin-biotin interaction as a"brake system"for CRISPR/Cas9,effectively allowing for the shutdown of the enzymatic activity of CRISPR/Cas9.

关键词： Streptavidin-biotin CRISPR/Cas9 CRISPR-OFF Guide RNA 2'-OH acylation Gene technology DNA cleavage

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JW-1-283 inhibits melanoma tumor growth via stabilization of the p53 pathway

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Genes & Diseases 2024年第3期11卷 18-21页

作者： Yang xie Ruida Hou Kelli LHartman Jianxiong Jiang Zhongzhi Wu wei Li Drug Discovery Center College of PharmacyUniversity of Tennessee Health Science CenterMemphisTN38163USA

Melanoma is a lethal skin malignancy and the fifth most diagnosed cancer in the United States.1 Currently,for unresectable melanoma,the recommended treatment options include checkpoint inhibitor immunotherapy targeting programmed cell death 1(PD-1),and inhibitors targeting the mitogen-activated protein kinase(MAPK)***,the response rate may vary among the patients,and therefore demanding the development of novel treatment *** suppressor TP53has been suggested as one of the critical regulators mediating the aggressiveness and progression of melanoma.

关键词： melanoma suppressor death

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Investigating the effect of volatility on the hygroscopicities of acetate nanoparticle aerosols by surface plasmon resonance microscopy

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Journal of Environmental Sciences 2024年第4期138卷 167-178页

作者： Bo Yang Zhibo xie Jianguo Liu Huaqiao Gui Jiaoshi Zhang Xiuli wei zetao Fan Douguo Zhang Key Laboratory of Environmental Optics and Technology Anhui Institute of Optics and Fine MechanicsHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China CAS Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Advanced Laser Technology Laboratory of Anhui Province Department of Optics and Optical EngineeringUniversity of Science and Technology of ChinaHefei 230026China

Under high relative humidity(RH)conditions,the release of volatile components(such as acetate)has a significant impact on the aerosol *** this work,one surface plasmon resonance microscopy(SPRM)measurement system was introduced to determine the hygroscopic growth factors(GFs)of three acetate aerosols separately or mixed with glucose at different *** Ca(CH_(3)COO)_(2) or Mg(CH_(3)COO)_(2) aerosols,the hygroscopic growth trend of each time was lower than that of the previous time in three cyclic humidification from 70% RH to 90% RH,which may be due to the volatility of acetic acid leading to the formation of insoluble hydroxide(Ca(OH)_(2) or Mg(OH)_(2))under high RH *** the third calculated GF(using the Zdanovskii-Stokes-Robinson method)for Ca(CH_(3)COO)_(2) or Mg(CH_(3)COO)_(2) in bicomponent aerosols with 1:1 mass ratio were 3.20% or 5.33% lower than that of the first calculated GF at 90% *** calculated results also showed that the hygroscopicity change of bicomponent aerosol was negatively correlated with glucose content,especially when the mass ratio of Mg(CH_(3)COO)_(2) to glucose was 1:2,the GF at 90% RH only decreased by4.67% after three cyclic *** coupled plasma atomic emission spectrum(ICP-AES)based measurements also indicated that the changes of Mg^(2+)concentration in bicomponent was lower than that of the *** results of this study reveal thatduring the efflorescence transitions of atmospheric nanoparticles,the organic acids diffusion rate may be inhibited by the coating effect of neutral organic components,and the particles aging cycle will be prolonged.

关键词： Hygroscopic growth Volatility Acetate aerosols Nanoparticle aerosol Surface plasmon resonance

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Flowering-time regulation by the circadian clock:From Arabidopsis to crops

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The Crop Journal 2024年第1期12卷 17-27页

作者： Mingkang Yang Wenjie Lin Yarou Xu Biyu xie Baiyin Yu Liang Chen wei Huang State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life SciencesSouth China Agricultural UniversityGuangzhou 510642GuangdongChina Henry Fok School of Biology&Agriculture Shaoguan UniversityShaoguan 512005GuangdongChina Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms South China Agricultural UniversityGuangzhou 510642GuangdongChina Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510642GuangdongChina Guangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region Shaoguan UniversityShaoguan 512005GuangdongChina

Precise timing of flowering in plants is critical for their growth and reproductive *** factor controlling flowering time is the cycle of light and darkness within a day,known as the *** are classified into long-day,short-day,and day-neutral plants based on light requirements for floral *** the molecular mechanisms that govern this differentiation remain incompletely understood,studies have consistently shown that the circadian clock plays a central role in regulating photoperiod response across diverse plant ***,there is a scarcity of reviews describing the regulatory network linking the circadian clock with photoperiodic *** review summarizes that regulatory network,focusing on the distinct roles of clock genes in long-day and short-day *** also discuss the strategies of clock gene mutations contributing to geographic variation in longday and short-day crops.

关键词： Circadian clock Photoperiod Short-day plants Long-day plants

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Graph convolutional network combined with random walks and graph attention network for node classification

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The Journal of China Universities of Posts and Telecommunications 2024年第3期31卷 1-14页

作者： Chen Yong xie Xiaozhu Weng wei College of Computer and Information Engineering Xiamen University of TechnologyXiamen 361024China Fujian Key Laboratory of Pattern Recognition and Image Understanding Xiamen University of TechnologyXiamen 361024China

Graph conjoint attention(CAT)network is one of the best graph convolutional networks(GCNs)frameworks,which uses a weighting mechanism to identify important neighbor ***,this weighting mechanism is learned based on static information,which means it is susceptible to noisy nodes and edges,resulting in significant *** this paper,a method is proposed to obtain context dynamically based on random walk,which allows the context-based weighting mechanism to better avoid noise ***,the proposed context-based weighting mechanism is combined with the node content-based weighting mechanism of the graph attention(GAT)network to form a model based on a mixed weighting *** model is named as the context-based and content-based graph convolutional network(CCGCN).CCGCN can better discover important neighbors,eliminate noise edges,and learn node embedding by message *** show that CCGCN achieves state-of-the-art performance on node classification tasks in multiple datasets.

关键词： graph neural network(GNN) graph convolutional network(GCN) semi-supervised classification graph analysis

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Progress in the diagnosis and treatment of graft fibrosis after liver transplantation

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Portal Hypertension & Cirrhosis 2024年第1期3卷 22-30页

作者： Youwei Zhao Lijun Wang Man xie wei Rao Department of Gastroenterology Medical College of Qingdao UniversityQingdaoShandongChina Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdaoShandongChina Division of Hepatology Liver Disease CenterThe Affiliated Hospital of Qingdao UniversityQingdaoShandongChina Department of Organ Transplantation Center The Affiliated Hospital of Qingdao UniversityQingdaoShandongChina

Liver transplantation(LT)is considered one of the best treatments for patients with end-stage liver ***,some patients with no significant clinical manifestations or abnormal laboratory tests still experience graft fibrosis during postoperative follow-up,which is often recognized by graft *** fibrosis can lead to graft dysfunction,thereby reducing the survival time of the recipient and even requiring ***,noninvasive methods are widely applied in the assessment of hepatic and allograft *** both noninvasive diagnostic models based on laboratory examination indicators and elastography technology that can quantify liver stiffness have some value in the evaluation of fibrosis,the diagnostic accuracy and characteristics of these various methods vary and cannot replace liver biopsy *** recent years,some liver-protective drugs and proprietary Chinese traditional medicines have been proven to delay or reverse chronic liver ***,their efficacy and safety for LT recipients need to be further *** article reviews the diagnosis and treatment of graft fibrosis after LT to provide a reference for improving the overall survival rate of LT recipients.

关键词： diagnosis fibrosis liver transplantation therapeutics

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Poly(heptazine imide)nanocrystal for hydrogen peroxide evolution in the dark by accumulating photo-generated electrons

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Nano Research 2024年第9期17卷 8036-8044页

作者： Song Kou Shu Lian Xiaodong xie wei Ren Yu Jin Jiahui Bao Honghui Ou Guidong Yang XJTU-Oxford International Joint Laboratory for Catalysis School of Chemical Engineering and TechnologyXi’an Jiaotong UniversityXi’an 710049China Fujian-Taiwan-Hongkong-Macao Science and Technology Cooperation Base of Intelligent Pharmaceutics Institute of OceanographyCollege of Materials and Chemical EngineeringMinjiang UniversityFuzhou 350108China School of Food and Bioengineering Fujian Polytechnic Normal UniversityFuqing 350300China

Organic conjugated polymers have received extensive attention due to their unique electronic ***,there have been relatively few reports on the dark photocatalytic reactions utilizing organic conjugated ***,we report the successful synthesis of an organic conjugated polymer based on poly(heptazine imide)nanocrystals(CNNCs)for H_(2)O_(2)evolution and biomedical applications using a simple salt molten method and sonication-centrifugation *** results show that these colloid CNNCs have the characteristics of photogenerated electrons accumulation and realize dark photocatalysis with high reducibility under visible light ***,these accumulating photogenerated electrons can reduce O_(2)in darkness to produce H_(2)O_(2).In addition,cytotoxicity tests were conducted and it was found that H_(2)O_(2)produced under dark conditions could oxidize L-arginine(L-Arg)to NO,which effectively killed tumors in the *** work provides an important strategy to construct organic conjugated semiconductor nanocrystals and applying them to future energy and biomedical fields.

关键词： poly(heptazine imide) photocatalysis photogenerated electrons hydrogen peroxide evolution cancer treatment

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