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Cryptic diversity and rampant hybridization in annual gentians on the Qinghai-Tibet Plateau revealed by population genomic analysis

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Plant Diversity 2024年第2期46卷 194-205页

作者： peng-Cheng Fu Qiao-Qiao Guo Di Chang Qing-Bo gao Shan-Shan Sun School of Life Science Luoyang Normal UniversityLuoyang 471934PR China Key Laboratory of Adaptation and Evolution of Plateau Biota Northwest Institute of Plateau BiologyChinese Academy of SciencesXining 810001PR China

Understanding the evolutionary and ecological processes involved in population differentiation and speciation provides critical insights into biodiversity formation. In this study, we employed 29,865 single nucleotide polymorphisms(SNPs) and complete plastomes to examine genomic divergence and hybridization in Gentiana aristata, which is endemic to the Qinghai-Tibet Plateau(QTP) region. Genetic clustering revealed that G. aristata is characterized by geographic genetic structures with five clusters(West, East, Central, South and North). The West cluster has a specific morphological character(i.e., blue corolla) and higher values of FSTcompared to the remaining clusters, likely the result of the geological barrier formed by the Yangtze River. The West cluster diverged from the other clusters in the Early Pliocene;these remaining clusters diverged from one another in the Early Quaternary. Phylogenetic reconstructions based on SNPs and plastid data revealed substantial cyto-nuclear conflicts. Genetic clustering and D-statistics demonstrated rampant hybridization between the Central and North clusters,along the Bayankala Mountains, which form the geological barrier between the Central and North clusters. Species distribution modeling demonstrated the range of G. aristata expanded since the Last Interglacial period. Our findings provide genetic and morphological evidence of cryptic diversity in G. aristata, and identified rampant hybridization between genetic clusters along a geological *** findings suggest that geological barriers and climatic fluctuations have an important role in triggering diversification as well as hybridization, indicating that cryptic diversity and hybridization are essential factors in biodiversity formation within the QTP region.

关键词： Gentiana aristata Hybrid zone Qinghai-Tibet Plateau Plastome Nuclear SNPs

The role of intestinal flora on tumorigenesis,progression,and the efficacy of PD-1/PD-L1 antibodies in colorectal cancer

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Cancer Biology & Medicine 2024年第1期21卷 65-82页

作者： Sen Wang Benling Xu Yangyang Zhang Guangyu Chen peng Zhao Quanli gao Long Yuan Department of Gastrointestinal Surgery Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003China Department of Immunotherapy Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003China

Intestinal flora affects the maturation of the host immune system,serves as a biomarker and efficacy predictor in the immunotherapy of several cancers,and has an important role in the development of colorectal cancer(CRC).Anti-PD-1/PD-L1 antibodies have shown satisfactory results in MSI-H/d MMR CRC but performed poorly in patients with MSS/p MMR *** recent years an increasing number of studies have shown that intestinal flora has an important impact on anti-PD-1/PD-L1 antibody efficacy in CRC *** and clinical evidence have suggested that anti-PD-1/PD-L1 antibody efficacy can be improved by altering the composition of the intestinal flora in ***,we summarize the studies related to the influence of intestinal flora on anti-PD-1/PD-L1 antibody efficacy in CRC and discuss the potential underlying mechanism(s).We have focused on the impact of the intestinal flora on the efficacy and safety of anti-PD-1/PD-L1 antibodies in CRC and how to better utilize the intestinal flora as an adjuvant to improve the efficacy of anti-PD-1/PD-L1 *** addition,we have provided a basis for the potential of the intestinal flora as a new treatment modality and indicator for determining patient prognosis.

关键词： Intestinal flora anti-PD-1/PD-L1 therapy colorectal cancer immune checkpoint inhibitor CD8~+T cell

Integrated application of synthetic community reduces consumption of herbicide in field Phalaris minor control

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Soil Ecology Letters 2024年第2期6卷 125-136页

作者： Amina Hadayat Zahir Ahmad Zahir peng Cai Chun-Hui gao National Key Laboratory of Agricultural Microbiology College of Resources and EnvironmentHuazhong Agricultural UniversityWuhan430070China Soil Microbiology and Biochemistry Laboratory Institute of Soil and Environmental SciencesUniversity of AgricultureFaisalabadPakistan

Herbicide-based weeds control impacts wheat crops as *** of Pseudomonas strains reduce the need for high-dose herbicides.100%Axial provides less weed control compared to 75%Axial with C4 *** 75%with C4 SynCom promotes... 详细信息

关键词： weed control synthetic microbial communities Phalaris minor wheat growth promotion synergistic effect

Dynamic shielding of bacterial outer membrane vesicles for safe and efficient chemo-immunotherapy against tumors

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Nano Research 2024年第2期17卷 836-847页

作者： Shuping Li Xin Li Jiaqi Meng Weier Bao Shuang Wang peng Ye Xiao-Dong gao Wei Wei Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of Education School of BiotechnologyJiangnan UniversityWuxi 214122China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Bacterial outer membrane vesicles(OMVs)are potent immunostimulants of regulating the tumor microenvironment(TME)for immunotherapy,and can be used to deliver ***,the severe systemic inflammatory response triggered by OMVs upon intravenous(i.v.)injection has limited their ***,we developed a safe and effective strategy by conjugating doxorubicin-loaded serum albumin(SA-DOX,AD)onto the surface of OMVs using a matrix metalloproteinase(MMP)-cleavable peptide linker(cL).This approach enabled the dynamic shielding of OMVs to reduce the systemic side effects while simultaneously enhancing the anti-tumor effects through ***,the resulting OMV-cL-AD formulation exhibited significantly enhanced accumulation at the tumor site after ***,facilitated by the SA decoration on the OMVs ***,the shield on the OMV-cL-AD was cleaved by the over-expressed MMP in the TME,leading to the release of both OMVs and *** process provided OMV-induced immunotherapy and DOX-induced chemotherapy,resulting in synergistic tumor *** conclusion,our work demonstrated the potential of OMV-cL-AD as an effective immunochemotherapy strategy that can prolong the survival time of mice without inducing side effects.

关键词： outer membrane vesicles doxorubicin tumor microenvironment immunotherapy chemotherapy

Mechanical reliable,NIR light-induced rapid self-healing hydrogel electrolyte towards flexible zinc-ion hybrid supercapacitors with low-temperature adaptability and long service life

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Journal of Energy Chemistry 2024年第5期92卷 63-73页

作者： Tengjia gao Na Li Yang Yang Jing Li peng Ji Yunlong Zhou Jianxiong Xu School of Materials and Advanced Manufacturing Hunan Key Laboratory of Electrochemical Green Metallurgy TechnologyHunan University of TechnologyZhuzhou 412007HunanChina School of Life Sciences and Chemistry Hunan Key Laboratory of Biomedical Nanomaterials and DevicesHunan University of TechnologyZhuzhou 412007HunanChina

Hydrogel electrolytes hold great potential in flexible zinc ion supercapacitors(ZICs)due to their high conductivity,good safety,and ***,freezing of electrolytes at low temperature(subzero)leads to drastic reduction in ionic conductivity and mechanical properties that deteriorates the performance of flexible ***,the mechanical fracture during arbitrary deformations significantly prunes out the lifespan of the flexible ***,a Zn^(2+)and Li^(+)co-doped,polypyrrole-dopamine decorated Sb_(2)S_(3)incorporated,and polyvinyl alcohol/poly(N-(2-hydroxyethyl)acrylamide)double-network hydrogel electrolyte is constructed with favorable mechanical reliability,anti-freezing,and self-healing *** addition,it delivers ultra-high ionic conductivity of 8.6 and 3.7 S m^(-1)at 20 and−30°C,respectively,and displays excellent mechanical properties to withstand tensile stress of 1.85 MPa with tensile elongation of 760%,together with fracture energy of 5.14 MJ m^(-3).Notably,the fractured hydrogel electrolyte can recover itself after only 90 s of infrared illumination,while regaining 83%of its tensile strain and almost 100%of its ionic conductivity during−30–60°***,ZICs coupled with this hydrogel electrolyte not only show a wide voltage window(up to 2 V),but also provide high energy density of 230 Wh kg^(-1)at power density of 500 W kg^(-1)with a capacity retention of 86.7%after 20,000 cycles under 20°***,the ZICs are able to retain excellent capacity even under various mechanical deformation at−30°*** contribution will open up new insights into design of advanced wearable flexible electronics with environmental adaptability and long-life span.

关键词： Flexible zinc ion supercapacitor Hydrogel electrolyte Self-healing Anti-freezing

Copper naphthalocyanine-based hole-transport material for highperformance and thermally stable perovskite solar cells

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Science China Chemistry 2024年第8期67卷 2701-2709页

作者： Yue Qiang Huaiman Cao Yuzhen Pan Yi Chi Liangyu Zhao Yingguo Yang Hai-Bei Li Yan gao Licheng Sun ze Yu State Key Laboratory of Fine Chemicals Frontier Science Center for Smart MaterialsDalian University of Technology(DUT).Dalian 116024China School of Chemistry Dalian University of Technology(DUT)Dalian 116024China School of Microelectronics Fudan UniversityShanghai 200433China Shanghai Synchrotron Radiation Facility(SSRF) Zhangjiang LabShanghai Advanced Research InstituteShanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China School of Ocean Shandong UniversityWeihai 264209China Center of Artificial Photosynthesis for Solar Fuels and Department of Chemistry School of ScienceWestlake UniversityHangzhou 310024China Department of Chemistry School of Engineering Sciences in ChemistryBiotechnology and HealthKTH Royal Institute of Technology Stockholm 10044Sweden

Metal phthalocyanines(MPcs) have gained considerable research attention as hole-transport materials(HTMs) in perovskite solar cells(PSCs) because of their superb stability. However, the photovoltaic performance of MPc-based HTMs in PSCs is still lagging behind their small molecule and polymeric counterparts, largely due to their relatively low hole mobility. Here, we report for the first time the application of a copper naphthalocyanine derivative(namely t Bu-Cu Nc) as a hole-transport material(HTM)in perovskite solar cells(PSCs), and systematically study its optoelectronic and photovoltaic property compared with its Cu Pc analog(t Bu-Cu Pc). Combined experiments disclose that the extension of π-conjugation from Pc to Nc core leads to not only an enhanced hole-carrier mobility associated with a stronger intermolecular interaction, but also an elevated glass transition temperature(T_g) of 252 °C. The resultant PSCs employing t Bu-Cu Nc deliver an excellent power conversion efficiency of 24.03%, which is the record efficiency reported for metal complex-based HTMs in PSCs. More importantly, the encapsulated t Bu-Cu Nc-based devices also show dramatically improved thermal stability than the devices using the well-known SpiroOMe TAD, with a T_(80)lifetime for more than 1,000 h under damp-heat stress. This study unfolds a new avenue for developing efficient and stable HTMs in PSCs.

关键词： hole-transport materials perovskite solar cells copper naphthalocyanine extendedπ-conjugation thermal stability

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Interactive effect of thermal aging and proton irradiation on microstructural evolution and hardening ofδ-ferrite in 308L stainless steel weld metal

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Journal of Materials Science & Technology 2024年第3期170卷 140-155页

作者： Xiaodong gao Xiaodong Lin Tao Guo Lining Xu Yaolei Han Baolong Jiang Xingyuan Mei Qunjia peng Lijie Qiao Beijing Advanced Innovation Center for Materials Genome Engineering Institute of Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China Institute of Materials Shanghai UniversityShanghai 200072China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Suzhou Nuclear Power Research Institute Suzhou 215004China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

In the harsh service environment of high temperature and intense neutron irradiation in water-cooled nuclear reactors,the austenitic stainless steel weld overlay cladding on the inner surface of the reactor pressure vessel suffers from thermal aging and irradiation damage simultaneously,which can induce microstructural evolution and hardening of the *** it is quite difficult to achieve this simul-taneous process out of the pile,two kinds of combined experiments,i.e.,post-irradiation thermal aging and post-aging irradiation were performed on 308 L stainless steel weld metals in this *** interactive effect of thermal aging and proton irradiation on microstructural evolution and hardening ofδ-ferrite in 308 L weld metal was investigated by combining atom probe tomography,transmission elec-tron microscopy and nanoindentation *** results revealed that thermal aging could eliminate the dislocation loops induced by irradiation and affect the phase transition process by accelerating spinodal decomposition and G-phase precipitation,thus enhancing hardening of irradiatedδ-*** the effect of irradiation on the microstructure and hardening of thermally agedδ-ferrite,however,intensive collision cascades can intensify G-phase precipitation and dislocation loop formation but decrease spinodal decomposition,leading to a limited effect on hardening of thermally agedδ-***,the interaction of thermal aging and irradiation can promote G-phase ***,the interaction can causeδ-ferrite hardening,which is mainly influenced by spinodal decomposition,followed by G-phase and dislocation loops,where spinodal decomposition and G-phase cause hardening by inducing strain fields.

关键词： Austenitic stainless steel weld metals Thermal aging Proton irradiation Interaction Microstructural evolution Hardening

Characteristics of Rock Mechanics Response and Energy Evolution Regime of Deep Reservoirs in the Bozhong Sag,Bohai Bay Basin

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Energy Engineering 2024年第9期121卷 2505-2524页

作者： Suogui Shang Kechao gao QingbinWang Xinghua Zhang pengli Zhou Jianhua Li peng Chu Tianjin Branch of CNOOC Limited Tianjin300459China Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and Green EnergyShenzhen UniversityShenzhen518060China College of Civil and Transportation Engineering Shenzhen Key Laboratory of Deep Engineering Sciences and Green EnergyShenzhen UniversityShenzhen518060China

Hydraulic fracturing is a mature and effectivemethod for deep oil and gas production,which provides a foundation for deep oil and gas *** of the key aspects of implementing hydraulic fracturing technology lies in understanding mechanics response characteristics of rocks in deep reservoirs under complex stress *** this work,based on outcrop core samples,high-stress triaxial compression tests were designed to simulate the rock mechanics behavior of deep reservoirs in Bozhong ***,this study analyzes the deformation and damage law for rock under different stress ***,with a particular focus on combining energy dissipation theory to further understand damage law for deep *** experimental results show that regardless of stress conditions,the process of deformation/failure of deep-seated reservoirs goes through five stages:Fracture compaction,newfracture formation,stable fracture expansion,unstable fracture expansion,and post-peak residual *** different stress conditions,the energy change laws of specimens are *** energy dissipation process of rocks corresponds closely to the trend of deformation-failure curve,then displays distinctive stage ***,in stage of rock fracture compaction,the input energy curve is approximately coincident with the elastic strain energy curve,while the dissipation energy curve remains near *** the increase of strain,the growth rate of elastic strain energy increases gradually,but with the deformation entering the crack propagation stage,the growth rate of elastic strain energy slows down and the dissipation energy increases ***,in the post-peak stage,rock fracture releases a lot of energy,which leads to the sharp decline of elastic strain energy *** addition,the introduction of damage variable D quantifies the analysis of the extent of failure for *** the process of increasing strain,rock damage exhibits nonlinear

关键词： Deep rock mechanics triaxial compression energy dissipation damage variable

Industry-Oriented Detection Method of PCBA Defects Using Semantic Segmentation Models

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1438-1446页

作者： Yang Li Xiao Wang Zhifan He ze Wang Ke Cheng Sanchuan Ding Yijing Fan Xiaotao Li Yawen Niu Shanpeng Xiao Zhenqi Hao Bin gao Huaqiang Wu Department of Internet of Things Technology and Application China Mobile Research InstituteBeijing 100053China Beijing Advanced Innovation Center for Integrated Circuits the School of Integrated CircuitTsinghua UniversityBeijing 100084China SigmaStar Technology Limited Xiamen 361199China IEEE

Automated optical inspection(AOI)is a significant process in printed circuit board assembly(PCBA)production lines which aims to detect tiny defects in *** AOI equipment has several deficiencies including low throughput,large computation cost,high latency,and poor flexibility,which limits the efficiency of online PCBA *** this paper,a novel PCBA defect detection method based on a lightweight deep convolution neural network is *** this method,the semantic segmentation model is combined with a rule-based defect recognition algorithm to build up a defect detection *** improve the performance of the model,extensive real PCBA images are collected from production lines as *** optimization methods have been applied in the model according to production demand and enable integration in lightweight computing *** results show that the production line using our method realizes a throughput more than three times higher than traditional *** method can be integrated into a lightweight inference system and pro-mote the flexibility of *** proposed method builds up a general paradigm and excellent example for model design and optimization oriented towards industrial requirements.

关键词： Automated optical inspection(AOI) deep learning defect detection printed circuit board assembly(PCBA) semantic segmentation.