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Microsystems & nanoengineering 2024年第2期10卷 91-99页

作者： Zhixian zhu Hui Ren Dan Wu Zhonghua Ni nan Xiang School of Mechanical Engineering and Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical InstrumentsSoutheast University211189NanjingChina School of Mechanical Technology Wuxi Institute of TechnologyNo.1600 Gaolang West Road214129WuxiChina Department of Oncology Jiangyin People’s Hospital214400JiangyinChina

Tumor cell clusters are regarded as critical factors in cancer pathophysiology,and increasing evidence of their higher treatment resistance and metastasis compared to single tumor cells has been ***,existing cell separation methods that are designed for single tumor cells cannot be used to simultaneously purify tumor cell *** address this problem,we demonstrated a microfluidic approach for the high-throughput,continuous-flow ternary separation of single tumor cells,tumor cell clusters,and WBCs from clinical pleural or abdominal effusions by coupling slanted spiral channels and periodic contraction-expansion *** first systematically explored the influence of particle size and flow rate on particle *** separation performance indicated that 94.0%of WBCs were removed and more than 97%of MDA-MB-231 tumor cells were recovered at a high flow rate of 3500µL/***,more than 90%of tumor cell clusters were effectively preserved after ***,we successfully applied our device for the ternary separation of single tumor cells,tumor cell clusters,and WBCs from different malignant effusions collected from patients with metastatic ***,our spiral-contraction-expansion device has potential as a sample pretreatment tool for the cytological diagnosis of malignant effusions.

关键词： separation contraction removed

Effect of dynamic loading orientation on fracture properties of surrounding rocks in twin tunnels

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 393-409页

作者： ze Deng Zheming zhu Lei Zhou Leijun Ma Jianwei Huang Yao Zhang Key Laboratory of Deep Earth and Engineering(Ministry of Education) College of Architecture and EnvironmentSichuan UniversityChengdu610065China Failure Mechanics and Engineering Disaster Prevention Key Laboratory of Sichuan Province College of Architecture and EnvironmentSichuan UniversityChengdu610065China Institute for Disaster Management and Reconstruction Sichuan UniversityChengdu610065China

For expedited transportation,vehicular tunnels are often designed as two adjacent tunnels,which frequently experience dynamic stress waves from various orientations during blasting *** analyze the impact of dynamic loading orientation on the stability of the twin-tunnel,a split Hopkinson pressure bar(SHPB)apparatus was used to conduct a dynamic test on the twin-tunnel *** two tunnels were rotated around the specimen’s center to consider the effect of dynamic loading ***-DYNA software was used for numerical simulation to reveal the failure properties and stress wave propagation law of the twin-tunnel *** findings indicate that,for a twin-tunnel exposed to a dynamic load from different orientations,the crack initiation position appears most often at the tunnel corner,tunnel spandrel,and tunnel *** the impact direction is created by a certain angle(30°,45°,60°,120°,135°,and 150°),the fractures are produced in the middle of the line between the left tunnel corner and the right tunnel *** the impact loading angle(a)is 90°,the tunnel sustains minimal damage,and only tensile fractures form in the surrounding *** orientation of the impact load could change the stress distribution in the twin-tunnel,and major fractures are more likely to form in areas where the tensile stress is concentrated.

关键词： Twin-tunnel Dynamic load Split Hopkinson pressure bar(SHPB) Fracture mode Stress distribution Displacement field distribution

Advanced cervix cancer patient with chemotherapy-induced grade IV myelosuppression achieved complete remission with cadonilimab:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1510-1516页

作者： Rui zhu Tian-ze Chen Meng-Ting Sun Chun-Rong zhu Department of Oncology The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Urology The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND The prognosis for patients with advanced metastatic cervix cancer(MCC)is poor,and this disease continues to pose a considerable therapeutic *** the administration of first-line regimens consisting of cisplatin,paclitaxel,and bevacizumab,survival rates for patients with metastasis remain *** emergence of bispecific antibodies(BsAbs)offers a novel treatment option for patients diagnosed with *** SUMMARY In this report,we present a patient with MCC who was treated with cadonilimab monotherapy at a dose of 6 mg/kg every two weeks after chemotherapy was proven to be *** patient exhibited a sustained complete response for a duration of 6 months,demonstrating an optimistic *** This case illustrates the considerable efficacy of cadonilimab for treating advanced ***,BsAb therapy is a promising strategy for effectively treating patients with advanced MCC and should be considered as an option when patients are intolerant to standard chemotherapy.

关键词： Cadonilimab Complete response Bispecific antibodies Recurrent or metastatic cervical cancer Programmed death protein 1 Cytotoxic T-lymphocyteassociated antigen-4 Case report

Virus-like nanoparticle vaccines for inducing long-lasting immunity against infectious diseases

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National Science Review 2024年第4期11卷 13-15页

作者： Yi-nan Zhang Sarah Auclair Jiang zhu Department of Integrative Structural and Computational Biology The Scripps Research Institute Department of Immunology and Microbiology The Scripps Research Institute

Prophylactic vaccines that can generate long-lasting protective immune responses are needed for many infectious diseases. Efficient vaccination requires vaccine antigens to be retained and presented to B cells in lymp...

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Effect of Cr_(2)O_(3) on properties of CaO-SiO_(2)-Fe_(t)O-MgO system and dissolution behavior of lime

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Journal of Iron and Steel Research(International) 2024年第4期31卷 870-881页

作者： Shan-nan Li Jian-li Li Yue Yu Hang-yu zhu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina

The productivity of the chrome-containing semi-steel converter smelting process is directly affected by the slag-forming speed during the converter preliminary *** effects of Cr_(2)O_(3) content on the physicochemical properties of the CaO-SiO_(2)-Fe_(t)O-MgO system,such as melting temperature,solidification behavior,mineral composition,and lime dissolution rate,were *** results showed that the slag was an amorphous phase at 1500℃.When Cr_(2)O_(3) was added,Ca(Fe,Mg)Si_(2)O_(6) and spinel were formed in the *** the increase in Cr_(2)O_(3) content,the amount of spinel precipitation increased,and the dendritic FegO_(4) crystal gradually changed into the granular(Fe,Mg)(Fe,Cr)2O_(4) *** the Cr_(2)O_(3) content increased from O to 2.91 wt.%,the melting temperature of the slag rose,and the melting range of the slag expanded slightly,but the lime dissolution rate did not *** the Cr_(2)O_(3) content further increased to 9.09 wt.%,the melting temperature continued to rise,the melting range rapidly expanded,and the lime dissolution rate decreased.

关键词： Cr_(2)O_(3) Vanadium-titanium magnetite Converter Slag Lime dissolution

Astronomical Test with CMOS on the 60 cm Telescope at the Xinglong Observatory,NAOC

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Research in Astronomy and Astrophysics 2024年第5期24卷 85-102页

作者： Hai-Yang Mu Zhou Fan Yi-nan zhu Yu Zhang Hong Wu Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101People’s Republic of China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049People’s Republic of China

This work shows details of an evaluation of an observational system comprising a complementary metal-oxidesemiconductor detector, 60 cm telescope and filter complement. The system’s photometric precision and differential photometric precision, and extinction coefficients were assessed through observations of Supersky flat fields, open clusters, standard stars and exoplanets. Photometry was precision achieved at the 0.02 mag level, with differential photometry of 0.004 mag precision. Extinction was found to agree with previous studies conducted at Xinglong Observatory. Ultimately, the results demonstrate this observing system is capable of precision scientific observations with a charge-coupled device across the optical wavelengths.

关键词： atmospheric effects-instrumentation detectors-techniques polarimetric-stars atmospheres-eclipses

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Biological scaffold as potential platforms for stem cells:Current development and applications in wound healing

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World Journal of Stem Cells 2024年第4期16卷 334-352页

作者： Jie-Yu Xiang Lin Kang Zi-Ming Li Song-Lu Tseng Li-Quan Wang Tian-Hao Li zhu-Jun Li Jiu-Zuo Huang nan-ze Yu Xiao Long Department of Plastic and Reconstructive Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Biomedical Engineering Facility Institute of Clinical MedicinePeking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100021China

Wound repair is a complex challenge for both clinical practitioners and *** approaches for wound repair have several *** cell-based therapy has emerged as a novel strategy to address this issue,exhibiting significant potential for enhancing wound healing rates,improving wound quality,and promoting skin ***,the use of stem cells in skin regeneration presents several ***,stem cells and biomaterials have been identified as crucial components of the wound-healing *** therapy involving the development of biocompatible scaffolds,accompanying cells,multiple biological factors,and structures resembling the natural extracellular matrix(ECM)has gained considerable *** scaffolds encompass a range of biomaterials that serve as platforms for seeding stem cells,providing them with an environment conducive to growth,similar to that of the *** scaffolds facilitate the delivery and application of stem cells for tissue regeneration and wound *** article provides a comprehensive review of the current developments and applications of biological scaffolds for stem cells in wound healing,emphasizing their capacity to facilitate stem cell adhesion,proliferation,differentiation,and paracrine ***,we identify the pivotal characteristics of the scaffolds that contribute to enhanced cellular activity.

关键词： Stem-cell-based therapy Biological scaffolds Wound healing Extracellular matrix mimicry Cellular activities enhancement Scaffold characteristics

Review of Electrical and Electronic Architectures for Autonomous Vehicles:Topologies,Networking and Simulators

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Automotive Innovation 2024年第1期7卷 82-101页

作者： Wenwei Wang Kaidi Guo Wanke Cao Hailong zhu Jinrui nan Lei Yu National Engineering Research Center of Electric Vehicles Beijing Institute of Technology(BIT)Beijing 100081China Shenzhen Automotive Research Institute Beijing Institute of Technology(BIT)Shenzhen 518000China State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationBeijing 100876China Purple Mountain Laboratories Nanjing 211111China Beijing Kawen New Energy Vehicle Co. LTDBeijing 102209China

With the rapid development of autonomous vehicles,more and more functions and computing requirements have led to the continuous centralization in the topology of electrical and electronic(E/E)*** certain Tier1 suppliers,such as BOSCH,have previously proposed a serial roadmap for E/E architecture development,implemented since 2015 with significant contributions to the automotive industry,lingering misconceptions and queries persist in actual engineering ***,there are concerns regarding the perspective of zone-oriented E/E architectures,characterized by zonal concentration,as successors to domain-oriented E/E architectures,known for functional *** these misconceptions and queries,this study introduces a novel parallel roadmap for E/E architecture development,concurrently evaluating domain-oriented and zone-oriented ***,the study explores hybrid E/E architectures,amalgamating features from both *** align with the evolution of E/E architectures,networking technologies must adapt *** networking mechanisms pivotal in E/E architecture design are comprehensively ***,the study delves into modeling and verification tools pertinent to E/E architecture *** conclusion,the paper outlines existing challenges and unresolved queries in this domain.

关键词： Autonomous vehicles Electrical and electronic architectures Topology Networking Domain-oriented Zone-oriented

Generation and propagation of 21-day bottom pressure variability driven by wind stress curl in the East China Sea

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Acta Oceanologica Sinica 2020年第7期39卷 91-106页

作者： Hua Zheng Xiao-Hua zhu Hirohiko Nakamura Jae-Hun Park Chanhyung Jeon Ruixiang Zhao Ayako Nishina Chuanzheng Zhang Hanna Na ze-nan zhu Hong-Sik Min State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China School of Oceanography Shanghai Jiao Tong UniversityShanghai 200030China Southern Marine Science and Engineering Guangdong Laboratory(zhuhai) Zhuhai 519082China Faculty of Fisheries Kagoshima UniversityKagoshima 8900056Japan Department of Ocean Sciences Inha UniversityIncheon 22212Korea Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridge 02139USA School of Earth and Environmental Sciences Seoul National UniversitySeoul 08826Korea Ocean Circulation and Climate Research Center Korea Institute of Ocean Science and TechnologyBusan 49111Korea

Between June 2015 and June 2017,two pressure-recording inverted echo sounders(PIESs)and five current and pressure-recording inverted echo sounders(CPIESs)deployed along a section across the Kerama Gap acquired a dataset of ocean bottom pressure records in which there was significant 21-day variability(Pbot21).The Pbot21,which was particularly strong from July-December 2016,was coherent with wind stress curl(WSC)on the continental shelf of the East China Sea(ECS)with a squared coherence of 0.65 for a 3-day time lag.A barotropic ocean model demonstrated the generation,propagation,and dissipation of *** modeled results show that the Pbot21 driven by coastal ocean WSC in the ECS propagated toward the Ryukyu Island Chain(RIC),while deep ocean WSC could not induce such *** the continental shelf,the Pbot21 was generated nearly synchronously with the WSC from the coastline to the southeast but dissipated within a few days due to the effect of bottom *** detection of Pbot21 by the moored array was dependent on the 21-day WSC patterns on the continental *** Pbot21 driven southeast of the Changjiang Estuary by the WSC was detected while the Pbot21generated northeast of the Changjiang Estuary was not.

关键词： pressure-recording inverted echo sounder East China Sea bottom pressure wind stress curl

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MnS–MnO heterogeneous nanocube@N,S-doped carbon as a highly efficient bifunctional water splitting electrocatalyst

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Rare Metals 2024年第5期43卷 1977-1988页

作者： Xue-Qian Wang Xiang-Ying Ma Wang-Zhi Wu Hui-Bing He nan-nan Wang Ren-Ji Zheng Shao-Jian Ma Yan-Qiu zhu Pei-Kang Shen Jin-Liang zhu School of Resources Environment and MaterialsState Key Laboratory of Featured Metal Materials and Life-Cycle Safety for Composite StructuresCollege of Chemistry and Chemical EngineeringGuangxi UniversityNanning 530004China School of Chemistry and Chemical Engineering Guangxi MinzuUniversity Nanning 530006 China School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China

A stable,efficient,and economical bifunctional electrolytic catalyst would be incredibly beneficial for the development of hydrogen production by electrocatalytic water *** this study,we synthesized a novel MnS–MnO heterogeneous nanocube@N,S-doped carbon(MnS–MnO@NSC).MnS–MnO nanocubes possess rich heterogeneous interfaces and plentiful catalytic active sites to promote electrochemical reactions,while the N,S-doped carbon shell possesses excellent conductivity and catalytic properties and protects the ***–MnO@NSC exhibited excellent electrochemical properties as an effective bifunctional electrocatalyst for the hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)in KOH *** the HER,the overpotential was as low as 124 mV at a current density of 10 mA·cm^(-2)while in the OER,it was only 340 mV at 100 mA·cm^(-2)under the same *** addition,a MnS–MnO@NSC||MnS–MnO@NSC electrolyzer exhibited almost comparable activity and higher steadiness than those exhibited by the state-of-the-art Pt/C||RuO_(2)/C system for full water splitting in KOH solution.

关键词： Manganese sulfide Manganese oxide Doped carbon Heterogeneous nanocube Water splitting

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