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Minimally invasive thalamic hematoma drainage can improve the six-month outcome of thalamic hemorrhage

Journal of Geriatric Cardiology 2017年第4期14卷 266-273页

作者： Wen-Ming liU Xue-Guang zhang ze-li zhang Gang li Qi-Bing HUANG Department of Emergency Surgery Qilu Hospital of Shandong University and Brain Science Research Institute of Shandong University Jinan ShandongChina Department of Neurosurgery Liaocheng People's Hospital Liaocheng Shandong China Department of Neurosurgery Qilu Hospital of Shandong University and Brain Science Research Institute of Shandong University Jinan Shandong China

Objective To explore predictors of the 6-month clinical outcome ofthalamic hemorrhage, and evaluate if minimally invasive thalamic hematoma drainage （THD） could improve its prognosis. Methods A total of 54 patients with spontaneous thalamic hemorrhage were evaluated retrospectively. Clinical data, including demographics, stroke risk factors, neuroimaging variables, Glasgow Coma Score （GCS） on admission, surgical strategy, and outcome, were collected. Clinical outcome was assessed using a modified Rankin Scale, six months after onset. Univariate analysis and multivariate logistic regression analysis were performed to determine predictors of a poor outcome. Results Conservative treatnaent was performed for five patients （9.3%）, external ventricular drainage （EVD） for 20 patients （37.0%）, THD for four patients （7.4%）, and EVD combined with THD for 25 patients （46.3%）. At six months after onset, 21 （38.9%） patients achieved a favorable outcome, while 33 （61.1%） had a poor outcome. In the univariate analysis, predictors of poor 6-month outcome were lower GCS on admis- sion （P = 0.001）, larger hematoma volume （P 〈 0.001）, midline shift （P = 0.035）, acute hydrocephalus （P = 0.039）, and no THD （P = 0.037）. The independent predictors of poor outcome, according to the multivariate logistic regression analysis, were no THD and larger hematoma volume. Conclusions Minimally invasive THD, which removes most of the hematoma within a few days, with limited damage to perihematomal brain tissue, improved the 6-month outcome of thalamic hemorrhage. Thus, THD can be widely applied to treat patients with thalamic hemorrhage.

关键词： Hematoma volume Minimally invasive Outcome Predictor Thalamic hematoma drainage Thalamic hemorrhage

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Preparation of silver nanoparticles through the reduction of straw-extracted lignin and its antibacterial hydrogel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 504-514页

作者： Lou zhang Shuo li Fu Tang Jingkai zhang Yuetong Kang Hean zhang lidong li State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial ***,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water *** this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing *** analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag *** surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their *** the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite *** inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag *** prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.

关键词： silver nanoparticles hydrogel straw extraction antibacterial

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Network pharmacological approach to explore the mechanisms of lianhua Qingwen capsule in coronavirus disease 2019

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Precision Medicine Research 2020年第2期2卷 67-77页

作者： Wen-li You Jin-E Wan Hai-Rui Gao Peng-lin liu li-ze zhang Dan-Dan Wang Gang Zhao Department of Traditional Chinese Medicine the Affiliated Hospital of Qingdao UniversityQingdao 266000China Department of Hyperbaric Oxygen the Affiliated Hospital of Qingdao University Qingdao 266000China

Background:This study aimed to explore the molecular mechanisms of the active compounds of lianhua Qingwen capsule in the treatment of coronavirus disease 2019 by using systemic pharmacology ***:In this study,network pharmacology methodology was applied,including active chemical component screening,target gene prediction,herbal-compound and compound-target gene network construction,gene enrichment analysis,pathway enrichment analysis and network ***:Network analysis showed that 3 bioactive ingredients(quercetin,kaempferol,AC1liUG4)were screened as pivotal ingredients.30 target genes were identified as the anti-coronavirus disease 2019 of lianhua Qingwen *** the targets,tumor necrosis factor,JUN(transcription factor AP-1),interleukin 6,vascular endothelial growth factor A,interleukin 1B,interleukin 2,mitogen-activated protein kinases 1 were regulated by various compounds and screened as the core genes of protein-protein interaction *** signaling pathways screened by Kyoto Encyclopedia of Genes and Genomes pathway enrichment(Pling pathways such as interleukin 17 signaling pathway,NF-κB signaling pathway,tumor necrosis factor signaling pathway and C-type lectin receptor signaling ***:The bioactive compounds in lianhua Qingwen capsule may have a therapeutic effect on coronavirus disease 2019 by inhibiting cytokine storms by regulating multiple inflammatory signaling pathways.

关键词： COVID-19 lianhua Qingwen capsule Network pharmacology Cytokine storm

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Synthesis of N-aryl-N'-(5-aryloxymethyl-1,3,4-thiadiazol-2-yl)-ureas Under Microwave Irradiation

Synthesis of N-aryl-N'-(5-aryloxymethyl-1,3,4-thiadiazol-2-y...

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甘肃省化学会第二十七届年会暨第九届甘肃省中学化学教学经验交流会

作者： Chai Lan-Qin~*,zhang Yu-li,Cui Kai,Wang Zai-rui,zhang Yong-ze,zhang li-wen (School of Chemical and Biological Engineering,Lanzhou Jiaotong University,730070)

The rapid heating effect of microwave irradiation has caught the attention of synthetic chemists in the recent times due to the remarkable reduction of reaction *** is an efficient method because of its virtue of rapid heating capability,high yield and simple *** superiority of these virtues goes beyond of traditional heating *** derivatives are widely used as medicines and agrochemicals because of their anticonvulsive,herbicidal,

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Depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 335-345页

作者： Feng zhang Chenyang zhang linlin Wu Wei Sun Hongliang zhang Jianhua Chen Yong Pei Songjiang li Engineering Research Center of Ministry of Education for Carbon Emission Reduction in Metal Resource Exploitation and Utilization Hunan International Joint Research Center for Efficient and Clean Utilization of Critical Metal Mineral ResourcesSchool of Minerals Processing and BioengineeringCentral South UniversityChangsha 410083China State Key Laboratory of Mineral Processing Beijing General Research Institute of Mining&MetallurgyBeijing 100160China Hunan Provincial Key Laboratory of Micro&Nano Materials Interfaces Science College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China School of Resources Environment and MaterialsGuangxi UniversityNanning 530004China Department of Chemistry Xiangtan UniversityXiangtan 411105China China Railway Resource Group Co.Ltd Beijing 102300China

The depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite still lacked in-depth ***,the depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite was further systematically investigated with experiments and density functional theory(DFT)*** X-ray photoelectric spectroscopy(XPS)results,DFT calculation results,and frontier molecular orbital analysis indicated that sulfite ions were difficult to be adsorbed on sphalerite surface,suggesting that sulfite ions achieved depression effects on sphalerite through other non-adsorption ***,the oxygen content in the surface of sphalerite treated with sulfite ions in creased,which enhanced the hydrophilicity of the sphalerite and further increased the difference in hydrophilicity between sphalerite and ***,sulfite ions were chelated with lead ions to form PbSO_(3)in *** hydrophilic PbSO_(3)was more easily adsorbed on sphalerite than *** interaction between sulfite ions and lead ions could effectively inhibit the activation of *** addition the UV spectrum showed that after adding sulfite ions,the peak of perxanthate in the sphalerite treated xanthate solution was significantly stronger than that in the galena with xanthate solution,indicating that xanthate interacted more readily with sulfite ions and oxygen mo lecules within the sphalerite system,leading to the formation of ***,sulfite ions hardly depressed the flotation of ga lena and could promote the flotation of galena to some *** study deepened the understanding of the depression mechanism o sulfite ions on sphalerite and Pb^(2+)activated sphalerite.

关键词： sphalerite galena sulfite ion density functional theory depression mechanism

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过氧化氢增强紫外-臭氧降解偏二甲肼

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含能材料 2016年第12期24卷 1168-1172页

作者：徐泽龙张立清赵冰王莹吴翼中国酒泉卫星发射中心甘肃酒泉732750

建立了氧化偏二甲肼(UDMH)废水的H_2O_2-UV-O_3氧化体系。以偏二甲肼和化学需氧量(COD)的去除率为检测指标,用正交实验确定了反应的主要影响因素和最佳工艺组合。比较了O_3、UV-O_3、UV-H_2O_2、H_2O_2-UV-O_3四种反应体系的降解情况。... 详细信息

建立了氧化偏二甲肼(UDMH)废水的H_2O_2-UV-O_3氧化体系。以偏二甲肼和化学需氧量(COD)的去除率为检测指标,用正交实验确定了反应的主要影响因素和最佳工艺组合。比较了O_3、UV-O_3、UV-H_2O_2、H_2O_2-UV-O_3四种反应体系的降解情况。初步探讨了中间产物的变化规律。结果表明:在pH=9.0,鼓气处理24 h,臭氧投加速率19.6 mg·(L·min)-1,过氧化氢与偏二甲肼的物质的量之比为5∶1,紫外线类型VUV+UV-C,反应时间1.5h的条件下,偏二甲肼废水(质量分数1%)中偏二甲肼去除率和COD去除率可分别达到99.99%和99.30%。

关键词：偏二甲肼(UDMH) 臭氧紫外线过氧化氢

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Microstructural evolution during the progressive transformation-induced plasticity effect in a Fe-0.1C-5Mnmedium manganese steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 369-379页

作者： Mei zhang Wenhao li Yangfei Chen Yang Jiang Xiaofei Guo Han Dong School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile ***-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation *** findings were discussed with the local strain measurements via digital image *** results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of *** small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier *** volume fraction of RA gradually decreased from 26.8%to 8.2%prior to *** the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.

关键词： medium-Mn steel retained austenite progressive transformation-induced plasticity effect local strain fracture initiation

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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-li Kang Yi Jiang Hua-Wei zhang Xiao-Mei Song Yu-ze li Wen-li Huang Dong-Dong zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi zhang Zhongwu liu Michael Chopp Michael Millman Yanfeng li Pasquale Cepparulo Amy Kemper Chao li li zhang Zheng Gang zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

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Multiphase reaction spinning of high-temperature resistant weavable SiO_(2)-Kevlar hybrid aerogel fibers

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Nano Research 2025年第1期18卷 424-433页

作者： Yunna Chen Wenlu zhang Qingyang li Wenbin li Chong He School of Textile Science and Engineering Wuhan Textile UniversityWuhan 430200China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200China

Advanced aerogel fibers possess numerousadvantages amalgamating the attributes of aerogels and fibermaterials, rendering them invaluable in the realm of thermalmanagement and regulation. However, the achievement ofrobust mechanical properties and increased temperaturestability is still a major challenge for the majority of aerogelfibers. Herein, SiO_(2)-Kevlar hybrid aerogel fibers with bioniccore-shell structure were prepared by reaction spinning andweaved into fabric. Kevlar nanowires dispersion is pumpedinto a bath comprising a self-synthesized silica sol, whichfacilitates the hybridization of biphasic aerogels through thegel reaction. Precise control over the diameter (200-800 μm)and structure of the wet gel fibers was achieved throughmeticulous adjustment of the spinning solution composition and spinning parameters. Subsequent freeze-drying processfacilitates the formation of a core-shell hybrid structure, in which the SiO_(2) aerogel layer effectively encapsulate the Kevlaraerogel core fiber. Taking full advantage of the mechanical properties of the Kevlar core fiber, the resulting SiO_(2)-Kevlaraerogel fibers exhibit commendable weaving characteristics (51.8 MPa). Furthermore, SiO_(2)-Kevlar aerogel fabrics exhibitenhanced thermal insulation characteristics with a thermal conductivity of 0.037 W/(m·K). As a result of the presence ofexternal SiO_(2) aerogel layer, the overall temperature resistance performance of the SiO_(2)-Kevlar fabric reach up to 700 ℃.

关键词： aerogel fibers SiO_(2)aerogel Kevlar aerogel reaction spinning thermal protective performance

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