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Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway

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World Journal of Gastroenterology 2024年第20期30卷 2709-2725页

作者： Kai-Di Chen Kui-Ling Wang Chen Chen Yi-Jia Zhu Wen-Wen tang Yu-Ji Wang ze-Peng Chen Lin-Hai He Yu-Gen Chen Wei Zhang Jiangsu Province Hospital of Chinese Medicine The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina The No.1 Clinical Medical College Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Colorectal Surgery Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Jiangsu Province Key Laboratory of Tumor Systems Biology and Chinese Medicine The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Jiangsu Collaborative Innovation Center of Chinese Medicine in Prevention and Treatment of Tumor The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina

BACKGROUND Constipation,a highly prevalent functional gastrointestinal disorder,induces a significant burden on the quality of patients'life and is associated with substantial healthcare ***,identifying efficient therapeutic modalities for constipation is of paramount *** stress is a pivotal contributor to colonic dysmotility and is the underlying pathology responsible for constipation ***,we postulate that hydrogen therapy,an emerging and promising intervention,can serve as a safe and efficacious treatment for *** To determine whether hydrogen-rich water(HRW)alleviates constipation and its potential *** Constipation models were established by orally loperamide to Sprague-Dawley *** freely consumed HRW,and were recorded their 24 h total stool weight,fecal water content,and charcoal propulsion *** samples were subjected to 16S rDNA gene *** non-targeted metabolomic analysis,malondialdehyde,and superoxide dismutase levels were *** tissues were stained with hematoxylin and eosin,Alcian blue-periodic acid-Schiff,reactive oxygen species(ROS)immunofluorescence,and immunohistochemistry for cell growth factor receptor kit(c-kit),PGP 9.5,sirtuin1(SIRT1),nuclear factor-erythroid-2-related factor 2(Nrf2),and heme oxygenase-1(HO-1).Quantitative real-time PCR and western blot analysis were conducted to determine the expression level of SIRT1,Nrf2 and HO-1.A rescue experiment was conducted by intraperitoneally injecting the SIRT1 inhibitor,EX527,into constipated ***460 cells were induced with H2O2 and treated with the metabolites to evaluate ROS and SIRT1 *** HRW alleviated constipation symptoms by improving the total amount of stool over 24 h,fecal water content,charcoal propulsion rate,thickness of the intestinal mucus layer,c-kit expression,and the number of intestinal *** modulated intestinal microbiota imbalance and abnormaliti

关键词： Hydrogen-rich water Constipation Sirtuin1 Oxidative stress Gut microbiota Serum metabolites

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Markovian Quadratic BSDEs with an Unbounded Sub-quadratic Growth

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Chinese Annals of Mathematics,Series B 2024年第3期45卷 441-462页

作者： Jingnan JU Shanjian tang Shanghai Center for Mathematical Sciences Fudan UniversityShanghai 200433China Department of Finance and Control Sciences School of Mathematical SciencesFudan UniversityShanghai 200433China

This paper is devoted to the solvability of Markovian quadratic backward stochastic differential equations(BSDEs for short)with bounded terminal *** generator is allowed to have an unbounded sub-quadratic growth in the second unknown variable *** existence and uniqueness results are given to these *** an application,an existence result is given to a system of coupled forward-backward stochastic differential equations with measurable coefficients.

关键词： Markovian BSDE Quadratic growth Unbounded sub-quadratic term coeficients Coupled FBSDE

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In-phase and out-of-phase spin pumping effects in Py/Ru/Py synthetic antiferromagnetic structures

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CHINESE PHYSICS B 2024年第9期33卷 541-545页

作者： Huang, Zhaocong tang, Xuejian Chen, Qian Jiang, Wei Guo, Qingjie Jalali, Milad Du, jun Zhai, Ya Southeast Univ Sch Phys Key Lab Quantum Mat & Devices Minist Educ Nanjing 211189 Peoples R China Nanjing Univ Natl Lab Solid Microstruct Nanjing 210093 Peoples R China

The spin pumping effect in magnetic heterostructures and multilayers is a highly effective method for the generation and transmission of spin currents. In the increasingly prominent synthetic antiferromagnetic structures, the two ferromagnetic layers demonstrate in-phase and out-of-phase states, corresponding to acoustic and optical precession modes. Within this context, our study explores the spin pumping effect in Py/Ru/Py synthetic antiferromagnetic structures across different modes. The heightened magnetic damping resulting from the spin pumping effect in the in-phase state initially decreases with increasing Py thickness before stabilizing. Conversely, in the out-of-phase state, the amplified damping exceeds that of the in-phase state, suggesting a greater spin relaxation within this configuration, which demonstrates sensitivity to alterations in static exchange interactions. These findings contribute to advancing the application of synthetic antiferromagnetic structures in magnonic devices.

关键词： spin pumping spin transmission synthetic antiferromagnetic structures spin dynamics 72.25.Pn 72.25.Mk 76.50.+g 67.30.hj TRANSMISSION

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Exploring the impact of pericentric inversion of chromosome 9 on fertility in sperm donors

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Asian Journal of Andrology 2024年第3期26卷 302-307页

作者： Qian Liu Wen-jun Zhou zeng-Hui Huang Xiu-Hai Huang Jian Wu Xi-Ren Ji Xue-Feng Luo Yu-Ling tang Rui-jun Wang Li-Qing Fan Chuan Huang Wen-Bing Zhu Institute of Reproductive and Stem Cell Engineering Basic Medicine CollegeCentral South UniversityChangsha 410013China Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive and Genetic Hospital of CITIC-XiangyaChangsha 410005China

Pericentric inversion of chromosome 9(inv[9])is a common chromosomal structural variant,but its impact on clinical outcomesremains *** screening criteria of sperm banks are rarely mentioned to individuals with inv(9).In this study,we evaluatedthe fertility of sperm donors with inv(9)who met eligibility criteria for sperm banks(inv[9]-eligible donors).From March 2004 toMay 2022,chromosomal analysis of 16124 sperm donors at CITIC-Xiangya Human Sperm Bank in Hunan Province(Changsha,China)found that 251(1.6%)had chromosome variations,with inv(9)being the most prevalent at 1.1%.All 169 inv(9)-eligibledonors were contacted to collect fertility outcome data,along with 206 eligible donors without inv(9)as *** addition,semen samples from inv(9)-eligible donors and eligible donors underwent assessments of sperm fluorescence in situ hybridization(FISH),mitochondrial membrane potential,DNA fragmentation index,acrosome integrity,reactive oxygen species(ROS),andsperm *** showed that inv(9)did not significantly increase reproductive risks *** detecting ROSlevel differences,the clinical impact may be *** study provides new data on the inv(9)population that can serveas a valuable reference for decision-making by sperm banks as well as for genetic counseling and clinical guidance for individualscarrying inv(9)variant.

关键词： male fertility pericentric inversion of chromosome 9 sperm bank sperm functional parameters

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A novel cascaded H-bridge photovoltaic inverter with flexible arc suppression function

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Global Energy Interconnection 2024年第4期7卷 513-527页

作者： junyi tang Wei Gao College of Electrical Engineering and Automation Fuzhou UniversityFuzhou 350108P.R.China

This paper presents a novel approach that simultaneously enables photovoltaic(PV)inversion and flexible arc suppression during single-phase grounding *** compensate for ground currents through an arc-elimination function,while outputting a PV direct current(DC)power *** method effectively reduces the residual grounding *** reduce the dependence of the arc-suppression performance on accurate compensation current-injection models,an adaptive fuzzy neural network imitating a sliding mode controller was *** online adaptive adjustment law for network parameters was developed,based on the Lyapunov stability theorem,to improve the robustness of the inverter to fault and connection ***,a new arc-suppression control exit strategy is proposed to allow a zerosequence voltage amplitude to quickly and smoothly track a target value by controlling the nonlinear decrease in current and reducing the regulation *** results showed that the proposed method can effectively achieve fast arc suppression and reduce the fault impact current in single-phase grounding *** to other methods,the proposed method can generate a lower residual grounding current and maintain good arc-suppression performance under different transition resistances and fault locations.

关键词： Photovoltaic inverter Flexible arc suppression Adaptive control Fuzzy neural network Sliding mode control Exit strategy

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Single-cell RNA sequencing in juvenile idiopathic arthritis

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Genes & Diseases 2024年第2期11卷 633-644页

作者： Xiwen Luo Xuemei tang Department of Rheumatology and Immunology Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Chongqing Key Laboratory of Child Infection and Immunity Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China

Juvenile idiopathic arthritis (JIA) is one of the most common chronic inflammatory rheumatic diseases in children,with onset before age 16 and lasting for more than 6 *** is a highly heterogeneous condition with various consequences for health and quality of *** some JIA patients,early detection and intervention remain *** a result,further investigation of the complex and unknown mechanisms underlying JIA is *** in technology now allow us to describe the biological heterogeneity and function of individual cell populations in *** this review,we hope to provide novel ideas and potential targets for the diagnosis and treatment of JIA by summarizing the current findings of single-cell RNA sequencing studies and understanding how the major cell subsets drive JIA pathogenesis.

关键词： Juvenile idiopathic arthritis Macrophage Macrophage activation syndrome Monocyte Single-cell RNA sequencing Synoviocyte T cell

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Supported Recyclable Metal-free Frustrated Lewis Pair Catalyst for Catalytic Hydrogenation of Substituted Pyridines to Piperidines

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Chemical Research in Chinese Universities 2024年第4期40卷 682-689页

作者： MA Shaohua tang Zhiyong CAS Key Laboratory for Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing100190P.R.China University of Chinese Academy of Sciences Beijing100049P.R.China

The construction of heterogeneous frustrated Lewis pairs(FLPs)catalysts is crucial for realizing highly efficient and recyclable pyridines catalytic *** this work,we prepared a recyclable heterogenous FLPs catalyst CMP-BF with conjugated microporous polymer CMP-ethynyl as the support via self-catalyzed 1,1-carboboration reaction with commercial Lewis acid B(C_(6)F_(5))_(3).The as-synthesized CMP-BF demonstrates superior heterogenous catalytic hydrogenation performance(conversion>99%),and considerable stability(84%conversion after three cycles)in recyclable hydrogenation of 2,*** work provides insights into the fabrication and catalytic application of recyclable heterogenous FLP catalysts.

关键词： Pyridine hydrogenation Frustrated Lewis pair Conjugated microporous polymer

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Surface Patterning of Metal Zinc Electrode with an In‑Region Zincophilic Interface for High‑Rate and Long‑Cycle‑Life Zinc Metal Anode

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Nano-Micro Letters 2024年第6期16卷 192-209页

作者： Tian Wang Qiao Xi Kai Yao Yuhang Liu Hao Fu Venkata Siva Kavarthapu jun Kyu Lee Shaocong tang Dina Fattakhova‑Rohlfing Wei Ai Jae Su Yu Department of Electronics and Information Convergence Engineering Institute for Wearable Convergence ElectronicsKyung Hee UniversityYongin‑siGyeonggi‑do 17104Republic of Korea Frontiers Science Center for Flexible Electronics(FSCFE)and Shaanxi Institute of Flexible Electronics(SIFE) Northwestern Polytechnical University(NPU)127 West Youyi RoadXi’an 710072People’s Republic of China Institute of Energy and Climate Research:Materials Synthesis and Processing(IEK‑1) Forschungszentrum Julich GmbH52425 JulichGermany School of Chemical Engineering Sungkyunkwan University2066 Seobu‑RoJangan‑GuSuwon‑siGyeonggi‑doRepublic of Korea

The undesirable dendrite growth induced by non-planar zinc(Zn)deposition and low Coulombic efficiency resulting from severe side reactions have been long-standing challenges for metallic Zn anodes and substantially impede the practical application of rechargeable aqueous Zn metal batteries(ZMBs).Herein,we present a strategy for achieving a high-rate and long-cycle-life Zn metal anode by patterning Zn foil surfaces and endowing a Zn-Indium(Zn-In)interface in the *** accumulation of electrons in the microchannel and the zincophilicity of the Zn-In interface promote preferential heteroepitaxial Zn deposition in the microchannel region and enhance the tolerance of the electrode at high current ***,electron aggregation accelerates the dissolution of non-(002)plane Zn atoms on the array surface,thereby directing the subsequent homoepitaxial Zn deposition on the array ***,the planar dendrite-free Zn deposition and long-term cycling stability are achieved(5,050 h at 10.0 mA cm^(−2) and 27,000 cycles at 20.0 mA cm^(−2)).Furthermore,a Zn/I_(2) full cell assembled by pairing with such an anode can maintain good stability for 3,500 cycles at 5.0 C,demonstrating the application potential of the as-prepared ZnIn anode for high-performance aqueous ZMBs.

关键词： Zn metal anode Surface patterning Directional Zn deposition Aqueous Zn-I_(2)batteries

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Research progress on the effect of pyroptosis on the occurrence,development,invasion and metastasis of colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3410-3427页

作者： Xu Wang Qi-Hang Yin Lin-Lu Wan Ruo-Lan Sun Gang Wang jun-Fei Gu De-Cai tang School of Traditional Chinese Medicine Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Ana and Intestine Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

Pyroptosis is a type of programmed cell death mediated by gasdermines(GSDMs).The N-terminal domain of GSDMs forms pores in the plasma membrane,causing cell membrane rupture and the release of cell contents,leading to an inflammatory response and mediating *** plays an important role in inflammatory diseases and malignant *** the further study of pyroptosis,an increasing number of studies have shown that the pyroptosis pathway can regulate the tumor microenvironment and antitumor immunity of colorectal cancer and is closely related to the occurrence,development,treatment and prognosis of colorectal *** review aimed to explore the molecular mechanism of pyroptosis and the role of pyroptosis in the occurrence,development,treatment and prognosis of colorectal cancer(CRC)and to provide ideas for the clinical diagnosis and treatment of CRC.

关键词： Cell pyroptosis Tumor metastasis Colorectal cancer Clinical diagnosis Review

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High-precision modeling of tide-induced 3-D magnetic field and analysis of geomagnetic satellite orbit requirements

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Science China Earth Sciences 2024年第1期67卷 165-178页

作者： Zhengyong REN Cong YANG Hongbo YAO Xu tang Jingtian tang Keke ZHANG Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring Ministry of Education Central South UniversityChangsha 410083China Hunan Key Laboratory of Nonferrous Resources and Geological Hazards Exploration Changsha 410083China School of Geosciences and Info-Physics Central South UniversityChangsha 410083China State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao 999078China

Ground-based magnetic observatories and geomagnetic satellites can observe the induced magnetic field generated by the motion of seawater containing sodium and chlorine *** the three-dimensional(3-D)spatial distribution of tide-induced magnetic fields(TIMF)is crucial for inverting the electrical conductivity structure of the oceanic *** also serves as an essential basis for designing optimal geomagnetic observatories and satellite ***,existing methods for simulating TIMF suffer from limitations in inaccurately modeling realistic coastlines,heterogeneous land and sea surface properties,and complex deep Earth structures,thereby the interpretational level of TIMF data is *** overcome this issue,we developed a tetrahedral-based finite element method for simulating TIMF,which can efficiently approximate realistic coastlines,heterogeneous land and sea surface properties,and complex deep Earth ***,we derived the boundary value problem for the seawater motion-induced electromagnetic field,which was solved using the vector finite element method based on tetrahedral ***,using the latest ocean depth and seafloor sediment layer models,we constructed a 3-D conductivity model of the Earth,which includes realistic coastlines,heterogeneous land and sea conductivity *** then computed the TIMF using the M_(2)tidal source as an example and validated our method by comparing it with results obtained from spherical harmonic finite element and integral equation ***,utilizing the computed high-precision M_(2),N_(2),and O1 TIMF signals,we marked global observatories capable of observing strong M_(2),N_(2),and O1 TIMF signals and predicted alternative stations suitable for tide signal ***,we calculated TIMF at heights of 450 and 200 km for the Macao Science Satellite 1 and its subsequent *** results indicate that the amplitude of the tidal-induced magnetic field at

关键词： Ocean motional induction Electromagnetic induction Ocean tides Geomagnetic satellite Macao Science Satellite 1

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