检索结果-南通市图书馆

维普期刊数据库

Antimicrobial resistance crisis:could artificial intelligence be the solution?

在线全文

学校读者我要写书评

暂无评论

Military Medical Research 2025年第1期12卷 72-95页

作者： guang-Yu Liu Dan Yu Mei-Mei Fan Xu Zhang ze-Yu Jin Christoph Tang Xiao-Fen Liu Department of Immunology and Pathogen Biology School of Basic Medical SciencesHangzhou Normal UniversityKey Laboratory of Aging and Cancer Biology of Zhejiang ProvinceKey Laboratory of Inflammation and Immunoregulation of HangzhouHangzhou Normal UniversityHangzhou 311121China National Key Discipline of Pediatrics Key Laboratory of Major Diseases in Children Ministry of Education Laboratory of DermatologyBeijing Pediatric Research InstituteBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Robert and Arlene Kogod Center on Aging Mayo ClinicRochesterMN 55905USA Department of Biochemistry and Molecular Biology Mayo ClinicRochesterMN 55905USA Department of Molecular and Human Genetics Baylor College of MedicineHoustonTX 77030USA Sir William Dunn School of Pathology University of OxfordOxford OX13REUK Institute of Antibiotics Huashan HospitalFudan UniversityKey Laboratory of Clinical Pharmacology of AntibioticsNational Health Commission of the People’s Republic of ChinaNational Clinical Research Centre for Aging and MedicineHuashan HospitalFudan UniversityShanghai 200040China

Antimicrobial resistance is a global public health threat,and the World Health Organization(WHO)has announced a priority list of the most threatening pathogens against which novel antibiotics need to be *** discovery and introduction of novel antibiotics are time-consuming and *** to WHO’s report of antibacterial agents in clinical development,only 18 novel antibiotics have been approved since ***,novel antibiotics are critically *** intelligence(AI)has been rapidly applied to drug development since its recent technical breakthrough and has dramatically improved the efficiency of the discovery of novel ***,we first summarized recently marketed novel antibiotics,and antibiotic candidates in clinical *** addition,we systematically reviewed the involvement of AI in antibacterial drug development and utilization,including small molecules,antimicrobial peptides,phage therapy,essential oils,as well as resistance mechanism prediction,and antibiotic stewardship.

关键词： Antibiotic Artificial intelligence(AI) Clinical development Machine learning(ML) Antimicrobial peptide Phage therapy Antibiotic stewardship

维普期刊数据库

Giant phonon anomaly in topological nodal-line semimetals

在线全文

学校读者我要写书评

暂无评论

Fundamental Research 2025年第1期5卷 145-150页

作者： zhou, Zizhen Yang, Xiaolong Wang, Honghui Han, guang Lu, Xu Wang, Guoyu Wang, Rui zhou, Xiaoyuan Center of Quantum Materials and Devices College of Physics Chongqing University Chongqing 401331 China College of Materials Science and Engineering Chongqing University Chongqing 400044 China

The band topology has been revealed to bring a wide array of novel electronic transport phenomena, but its interaction with phonon properties remains largely unexplored. Here we propose that continuous topological singularities with variable Fermi wave vectors can lead to giant effects on phonon transport in nodal-line semimetals. Using first-principles calculations, we show that such an exotic feature is present in a well-known topological semimetal ZrSiSe, in which the unique nodal-line can guarantee considerable momentum-continuous phonons to satisfy the stringent condition of Kohn anomaly and thereby dramatically strengthen the electron-phonon coupling. Moreover, the momentum-continuous anomaly phonons with eight arms of vertical Fermi surface drive intense phonon-electron scattering that is even comparable with intrinsic phonon-phonon scattering, giving rise to a reduction of ∼45% on room temperature lattice thermal conductivity. Our findings not only uncover giant phonon anomaly in topological nodal-line semimetals but also provide guidance for exploring the vital influence of electronic band topology on thermal transport bridged by the electron-phonon coupling. © 2023

关键词： Electron-phonon coupling First-principles Kohn anomaly Nodal-line semimetal Phonon transport

Effect of rolling schedules on ridging resistance of ultra-thin ferritic stainless steel foil

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2025年第1期32卷 198-214页

作者： Jing-wei Zhao Qing-zhong Xie Li-nan Ma Cun-long zhou Zheng-yi Jiang Xi Liao Xiao-guang Ma College of Mechanical and Vehicle Engineering Taiyuan University of TechnologyTaiyuan030024ShanxiChina Engineering Research Center of Advanced Metal Composites Forming Technology and Equipment Ministry of EducationTaiyuan030024ShanxiChina National Key Laboratory of Metal Forming Technology and Heavy Equipment Ministry of Science and TechnologyTaiyuan030024ShanxiChina School of Mechanical Engineering Taiyuan University of Science and TechnologyTaiyuan 030024ShanxiChina School of Mechanical MaterialsBiomedical and Mechatronic EngineeringUniversity of WollongongWollongongNSW2522Australia Shanxi Taigang Stainless Steel Precision Strip Co. Ltd.Taiyuan 030006ShanxiChina

The effect of rolling schedules on the ridging resistance of ultra-thin ferritic stainless steel(FSS)430 foil was evaluated by studying the microstructure and *** results show that specimens processed with three-pass cold rolling under the reductions of 40%,40%and 31%,respectively,exhibit improved ridging resistance owing to the microstructural refinement and the texture structure optimization.A nearly 40%reduction of ridging height can be achieved using the proposed rolling schedule compared to the other two rolling *** addition,the effect of annealing temperature after cold rolling on the ridging resistance of FSS 430 foil is also found to be crucial,and an optimal annealing temperature of 900℃ is obtained for FSS 430 foil with high ridging ***,the improvement in the ridging resistance of FSS 430 foil can be attributed to the reduction in the fraction of{001}and{114}components by optimization of the rolling and annealing processes.

关键词： Ferritic stainless steel foil Ridging Cold rolling Annealing Microstructure Texture

Comparison of the effect of ranibizumab in retinal vein occlusion and macular edema with different optical coherence tomographic patterns

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2025年第2期18卷 275-282页

作者： Yue Xu Yue-Cong Yin ze-Yu Song Xiao-Yu zhou Jia-Ju Zhang Juan Liang Department of Ophthalmology the Fourth Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

AIM:To explore the morphological and functional parameters to evaluate the effectiveness of intravitreal injections of ranibizumab(IVR)in treating macular edema(ME)secondary to retinal vein occlusion(RVO).METHODS:This retrospective study involved 65 RVO patients(65 eyes)who received IVR and were followedup for more than *** was categorized into cystoid macular edema(CME),diffuse retinal thickening(DRT),and serous retinal detachment(SRD)according to optical coherence tomography(OCT)*** comparison of best corrected visual acuity(BCVA;logMAR)and central macular thickness(CMT)among different follow-up points and those among 3 groups were performed by Kruskal-Wallis *** correlation between BCVA and baseline parameters during treatment was analyzed using Spearman correlation ***:BCVA tended to improve in all groups,with marked improvement in CME and DRT *** showed the greatest reduction after 1wk,and remained stable over the following *** patients had the worst BCVA and the highest CMT at baseline,but the differences became smaller after IVR *** in SRD group was significantly better than in CME and DRT groups 3mo after *** patients of CME and SRD groups transitioned to a normal pattern at 3mo *** patients were most likely to transform into the other morphological groups,while SRD patients showed minimal *** at baseline was identified as the most important prognostic indicator in all 3 ***,DRT patients with a longer clinical course,higher CMT and central retinal vein occlusion(CRVO)tend to exhibit worse BCVA after *** addition,CRVO patients are more likely to have worse BCVA at 2 and 3mo follow-up compared with branch retinal vein occlusion(BRVO)patients in CME *** patients with higher baseline CMT were prone to experiencing worse BCVA after ***:The effectiveness of IVR is strongly correlated with baseline BCVA in all 3 *** parameters inc

关键词： retinal vein occlusion optical coherence tomography serous retinal detachment cystoid macular edema diffuse retinal thickening

Preparations of Mytilus edulis protein hydrolysate-iron complexes and their ameliorative effects on mice with iron deficiency anemia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2025年

作者： guang Li Xuening Yu Shuling zhou Xiaoyang Liu Fawen Yin Deyang Li Baocai Xu Dayong zhou School of Food and Biological Engineering， Hefei University of Technology SKL of Marine Food Processing & Safety Control， National Engineering Research Center of Seafood， Collaborative Innovation Center of Seafood Deep Processing， Liaoning Province Key Laboratory for Marine Food Science and Technology， School of Food Science and Technology， Dalian Polytechnic University

Iron is a fundamental trace element essential for the immune system， and current research on iron supplements is increasingly focusing on food-derived peptides capable of binding iron ions. The objectives of this study were to characterize the iron-chelating peptide (MEPH) derived from Mytilus edulis and to investigate the effects of MEPH-Fe complexes on mice with iron deficiency-induced anemia (IDA). MEPH and iron(II) sulfate heptahydrate successfully formed MEPH-Fe complexes under conditions of 4.5 mg/mL concentration， 45 ℃ temperature， and 60 minutes of incubation， utilizing both carboxyl and amino binding sites. Compared to MEPH alone， the MEPH-Fe complexes exhibited fluorescence quenching， ultraviolet shifts， reduced X-ray diffraction peak intensities， stabilization during in vitro digestion， microstructural changes， increased particle size， and decreased absolute values of zeta potential. In the IDA mouse model， the MEPH-Fe complexes were able to restore body weight， hematological indices， organ coefficients， iron content in organs， and antioxidant capacity to normal levels. Additionally， they demonstrated beneficial effects on IDA-induced colonic inflammation by normalizing tumor necrosis factor-alpha (TNF-α) and interleukin-10 (IL-10) levels. The results indicated that MEPH-Fe complexes had more positive effects on IDA mice compared to ferrous sulfate. In conclusion， this study provides valuable insights into the potential of MEPH-Fe complexes as iron supplements.

关键词：

Traditional Chinese medicine in the treatment of Helicobacter pylorirelated gastritis:The mechanisms of signalling pathway regulations

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第3期31卷 11-28页

作者： Pei-Pei Zhang Liang Li Hao-Yu Qu guang-Yu Chen Meng-zhou Xie Yan-Kun Chen School of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Hunan Engineering Technology Research Center for Medicinal and Functional Food Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine Heart and Lung Syndrome Differentiation and Medicated Diet and Dietotherapy Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina School of Informatics Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Precision Medicine Research and Development Center Zhuhai Institute of Advanced TechnologyChinese Academy of SciencesZhuhai 519000Guangdong ProvinceChina

Helicobacter pylori-associated gastritis(HPAG)is a common condition of the gastrointestinal ***,extensive and long-term antibiotic use has resulted in numerous adverse effects,including increased resistance,gastrointestinal dysfunction,and increased recurrence *** these concerns develop,traditional Chinese medicine(TCM)may have *** is based on the concept of completeness and aims to eliminate pathogens and strengthen the *** has the potential to prevent this condition while also boosting the rate of Helicobacter pylori *** review elaborates on the mechanism of TCM treatment for HPAG based on cellular signalling pathways,which reflects the flexibility of TCM in treating diseases and the advantages of multi-level,multipathway,and multi-target treatments for HPAG.

关键词： Helicobacter pylori Helicobacter pylori-associated gastritis Traditional Chinese medicine Signalling pathway Eliminate pathogens Strengthen the body

miR-2940-1 is involved in the circadian regulation of oviposition in Aedes albopictus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2025年第1期32卷 69-79页

作者： Xiaolin Xiao Ling Kong Zhensheng Xie Hongkai Liu Lijun Cai Siyu Zhao Jiayong zhou Shuang Liu Jing Wu Yiming Wu Peilin Wu Anthony A.James Xiao-guang Chen Department of Pathogen Biology Institute of Tropical MedicineSchool of Public HealthSouthern Medical UniversityGuangzhouChina Department of Microbiology&Molecular Genetics University of CaliforniaIrvineCAUSA Department of Molecular Biology&Biochemistry University of CaliforniaIrvineCAUSA

The vast majority of all global species have circadian rhythm cycles that allow them to adapt to natural *** regular rhythms are regulated by core clock genes and recent studies have also implicated roles for microRNAs in this *** is an important circadian behavior in the reproductive cycle of insect vectors of diseases,and little is known about the rhythm or its regulation in *** albopictus is a diurnal mosquito that transmits arboviruses and is the major cause of outbreaks of dengue fever in *** analyzed the oviposition rhythm patterns of *** under different light/dark conditions and show that the mosquitoes have an oviposition peak between zeitgeber time 9(ZT 9)and ZT ***,the antagomir-mediated knockdown of expression of the microRNA miR-2940-1 affected the oviposition rhythm of *** data support the conclusion that miR-2940-1 is involved in the regulation of oviposition rhythm in *** and provide a foundation for using oviposition rhythms as a new target for vector mosquito control.

关键词： Aedes albopictus miR-2940-l oviposition rhythm regulation

Accelerating homogenization kinetics and enhancing hot-workability of as-cast nickel-based superalloy via prior hot-deformation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2025年第1期32卷 215-226页

作者： Jia-jun Chen Yang zhou Hao-ran Han Xian-guang Zhang Goro Miyamoto Ping-mei Tang Dong-ping Xiao Jian-hui Fu Peng Shi Yi-wu Pei Jian Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Chengdu Advanced Metal Materials Industrial Technology Institute Co. Ltd.Chengdu 610300SichuanChina Institute for Materials Research Tohoku UniversitySendai 980-8577Aoba-KuJapan

Enhancing homogenization efficiency and hot-workability is the key issue for wrought superalloys in the industry.A novel approach for simultaneous accelerating the homogenization kinetics and improving hot-workability via a simple way of prior hot-deformation was proposed,which was not widely accepted for wrought *** homogenization efficiency is increased by 40%-70%via performing 10%-20%prior *** theoretical and experimental analyses revealed that the increment in homogenization efficiency is mainly attributed to the decrease in interdendritic-segregation spacing,and thus the necessary diffusion distance,rather than that of *** addition,dynamic and static recrystallizations occurred during the prior hot-deformation and diffusion-annealing processes,and the grains were significantly refined even after the ***,the size of the precipitates was refined as *** enhanced the hot-workability of the homogenized ingot for the subsequent cogging process.

关键词： Nickel-based superalloy Homogenization kinetics Prior hot-deformation Grain size Hot workability

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

既有上部结构向下增建地下结构抗震性能研究

振动与冲击 2025年第2期44卷 245-253页

作者：邬泽卢广庄海洋唐柏赞中铁工程设计咨询集团有限公司北京100055 南京工业大学岩土工程研究所南京210009 华东交通大学土木建筑学院南昌330013

基于深圳北站广场向下增建城际铁路地下车站结构的实际工程背景,场地土中地下车站附带上部已建结构的地震反应特征、相互作用机理及其破坏机制成为结构抗震性能评价的关键问题。鉴于此,采用整体动力时程分析方法建立了土-地下结构-上部... 详细信息

基于深圳北站广场向下增建城际铁路地下车站结构的实际工程背景,场地土中地下车站附带上部已建结构的地震反应特征、相互作用机理及其破坏机制成为结构抗震性能评价的关键问题。鉴于此,采用整体动力时程分析方法建立了土-地下结构-上部结构静、动力耦合非线性动力相互作用的三维精细化数值模型,系统地研究了地下车站附带上部结构、单建地下车站结构、单建地上结构的地震响应规律及其损伤演变过程。结果表明:相比单建地下车站结构,由于受上部结构影响,增建地下车站结构的水平侧向力及其层间位移角均显著增大,且顶、底板地震损伤面积及程度明显加剧;相比单建地上结构,由于受地下车站结构影响,增建地下车站结构的上部结构的变形协调性显著降低,其地震损伤较单建地上结构严重,尤其在中柱与二层楼板连接处。研究成果可为既有上部结构向下增层拓建的科学设计、防震减灾提供支撑和借鉴。

关键词：土-地下结构-上部结构动力相互作用增建地下结构抗震性能地震损伤时程分析法

维普期刊数据库