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Exosomes:the next-generation therapeutic platform for ischemic stroke

Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing yin Hongyin Ma Yang Qu Jiaxin Ren yingying Sun Zhen-Ni Guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

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Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑Yuan Yu Jing Wu Guang yin Fan‑Zhen Jiao Zhong‑Zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

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A real-time online data acquisition system for Dragon-I linear induction accelerator

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Nuclear Science and Techniques 2017年第3期28卷 85-90页

作者： Jun Wu Xiang Zhou Chen Yuan ze-Jie yin State Key Laboratory of Particle Detection and Electronics and Department of Modern Physics University of Science and Technology of China Hefei 230026 China

An extensible high-speed accelerator data acquisition system(ADAS) for the Dragon-I linear induction accelerator has been developed. It comprises a ⅤⅪ crate, a controller, four data acquisition plug-ins, and a host computer. A digital compensation algorithm is used to compensate for the distortion of high-speed signals arising from longdistance transmission. Compared with the traditional oscilloscope wall, ADAS has significant improvements in system integration, automation, and reliability. It achieves unified management of data acquisition and waveform monitoring and performs excellently with a 107-ps high-accuracy trigger and 32-channel signal monitoring. In this paper, we focus on the system architecture and hardware design of the ADAS,realization of the trigger, and digital compensation algorithm.

关键词： ADAS LINAC Beam position monitor FPGA

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Experimental Study on the Penetration of Diesel and Biodiesel Spray Liquid Emerging from an Equilateral Triangular Orifice under Evaporative Conditions

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Journal of Thermal Science 2022年第5期31卷 1565-1574页

作者： yin Bifeng YE ze JIA Hekun YU Shenghao DENG Weixin School of Automotive and Traffic Engineering Jiangsu UniversityZhenjiang212013China Science and Technology on Scramjet Laboratory Hypervelocity Aerodynamics Institute of CARDMianyang621000China

This paper reports the results of an experimental study on the liquid phase characteristics of the biodiesel and diesel discharged from an equilateral triangular orifice and a circular orifice under different injection conditions by Mie-scattering *** results revealed that the biodiesel liquid penetration length was longer than that of diesel under the same injection *** addition,the increase of the chamber pressure was expected to enhance the interaction between air and fuel,resulting in the acceleration of the liquid phase breakup ***,with increasing chamber temperature,the liquid penetration of biodiesel was reduced less than that of *** was due to the high surface tension and viscosity of biodiesel which inhibited the chamber air entrainment and suppressed the liquid breakup ***,the higher probability of shorter diesel liquid penetration length indicated better air-fuel mixing than that of ***,the triangular orifice liquid length was shorter than that of the circular *** the stabilized liquid cone angle from the circular orifice was larger than that from the triangular orifice,indicating that using an equilateral triangular orifice has the potential to improve the air-fuel mixing process.

关键词： equilateral triangular orifice liquid penetration length biodiesel diesel

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Self-folding mechanics of graphene tearing and peeling from a substrate

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Frontiers of physics 2018年第3期13卷 17-28页

作者： ze-Zhou He yin-Bo Zhu Heng-An Wu CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern Mechanics University of Science and Technology of China Hefei 230027 China

Understanding the underlying mechanism in the tearing and peeling processes of graphene is crucial for the further hierarchical design of origami-like folding and kirigami-like cutting of graphene. How- ever, the complex effects among bending moduli, adhesion, interlayer interaction, and local crystal structure during origami-like folding and kirigami-like cutting remain unclear, resulting in challenges to the practical applications of existing theoretical and experimental findings as well as to potential manipulations of graphene in metamaterials and nanodevices. Toward this end, classical molecular dynamics （MD） simulations are performed with synergetie theoretical analysis to explore the tearing and peeling of self-folded graphene from a substrate driven by external force and by thermal activation. It is found that the elastic energy localized at the small folding ridge plays a significant role in the crack trajectory. Due to the extremely small bending modulus of monolayer graphene, its taper angle when pulled by an external force follows a scaling law distinct from that in case of bilayer graphene. With the increase in the initial width of the folding ridge, the self-folded graphene, motivated by thermal fluctuations, can be self-assembled by spontaneous self-tearing and peeling from a substrate. Simultaneously, the scaling law between the taper angle and adhesive energy is independent of the motivations for thermal activation-induced self-assembly and external force tearing, providing effective insights into the underlying physics for graphene-based origami-like folding and kirigami-like cutting.

关键词： graphene tearing self-assembly elastic energy molecular dynamics simulation

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Geant4 used in medical physics and hadrontherapy technique

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Nuclear Science and Techniques 2006年第5期17卷 276-279页

作者： TANG Shi-Biao yin ze-Jie HUANG Huan CHENG Yan CHENG Fu-Hui MAO feng-Hua Department of Modern Physics University of Science and Technology of China Hefei 230026 China

This article mainly presents the application of Geant4 package (Geant4.7.0, 2005), developed by CERN (the Center of European Research of Nucleus), in medical physics and a novel technique, namely, hadrontherapy. The distribution of energy deposition in a water model by different radiation beams was also given. The results show that the distributions for proton beams are completely different from those for other radiation beams. Charged particles like protons exhibit little scattering when they penetrate the matter and give the highest energy deposition near the end of their range just before they reach the resting state. These characteristics permit very precise control of the shape of the energy distribution inside the patient’s body.

关键词：医学物理学强子治疗技术辐射能分布能量沉积欧洲核物理研究中心

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Generation of Entanglement for Coherent Excitonic States in Coupled Quantum Dots in a Microcavity

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Communications in Theoretical Physics 2008年第9期50卷 661-663页

作者： yin Miao CHENG ze SHEN Lei-Lei Department of Physics Huazhong University of Science and Technology Wuhan 430074 China

We investigate the generation of entanglement of coherent excitonic states in coupled quantum dots placed in a cavity by meaning of the state preparation fidelity [Nature （London） 404 （2002） 256; Phys. Rev. A 65 （2002） 012107; J. Uffink, Phys. Rev. Lett. 88 （2002） 230406.] The effect of the number of excitons and the coherent intensity ｜α｜ of the cavity field on the entanglement is also studied.

关键词： entanglement state preparation fidelity quantum dots

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Analytic Invariant Curves for a Planar Mapping

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Acta Mathematica Sinica,English Series 2008年第4期24卷 623-630页

作者： Wen Rong LI Han ze LIU Li yin Department of Mathematics Binzhou University Binzhou 256600 P. R. China

This paper is concerned with the existence of analytic invariant curves for a planar mapping. By constructing a convergent power series solution of an auxiliary equation, analytic solutions of the original equation are obtained. In this paper, we discuss not only the general case, but also the critical cases as well, in particular, the case where β is a unit root is discussed.

关键词： planar mapping invariant curves analytic solution Majorant series

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Computational study of bubbly jets in stagnant water

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Journal of Hydrodynamics 2019年第5期31卷 1021-1033页

作者： Yan-xu Wang ze-gao yin Wenming Zhang David ZZhu Engineering College Ocean University of ChinaQingdao 266100China Shandong Province Key Laboratory of Ocean Engineering Ocean University of ChinaQingdao 266100China Water Resources Engineer City of EdmontonEdmontonABCanada Department of Civil and Environmental Engineering University of AlbertaEdmontonABCanada

The air-water bubbly jets in a stagnant water are numerically investigated by using a CFD software package with the realizable k-e turbulence *** focus is on the jet evolutionary behaviors in terms of the gas void fraction,the axial water velocity,the turbulent kinetic energy(TKE),the entrainment coefficient,and the momentum and buoyancy fluxes in a wide range of the bubbly jets(with the initial gas volume fractions ranging from 0 to 0.83).The computational results are found generally in good agreement with the experimental results reported in the *** the gas void fraction and the axial water velocity follow the Gaussian distribution in the radial direction as expected,however a double-peak distribution is found for the TKE at some distance away from the *** the increase of the longitudinal distance,their peak values generally are decreased until reaching approximately their terminal *** non-dimensional relations are revealed in both the radial and longitudinal *** potential core and the spreading rates of the bubbly jets are then *** liquid volume flux of the bubbly jets is found to increase almost linearly along the centerline with an entrainment coefficient of *** momentum flux of the bubbly jets increases due to the buoyancy force,and the relative importance of the momentum and buoyancy fluxes is also discussed.

关键词： Bubbly jet gas void fraction axial water velocity turbulent kinetic energy(TKE) flux

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Modeling and analysis of nano-sized GMRs based on Co,NiFe and Ni materials

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Science China(Information Sciences) 2014年第2期57卷 216-229页

作者： yin Cong JIA ze MA WeiChao REN TianLing Institute of Microelectronics Tsinghua National Laboratory for Information Science and TechnologyTsinghua University

Magnetic simulation method is introduced to analyze giant magnetoresistances(GMRs)in nanoscale for nano-sized biosensors.A spin valve model with special gridding corresponding to the exchange interaction length is proposed to study the influence of easy axes,exchange coefcients,pinning fields and feature widths on magnetization reversals and hysteresis characteristics of nano-sized GMRs with diferent pinned layer and free layer materials of Co,NiFe and *** switching field is found to be almost linear with the pinning field and decrease with the absolute exchange coefcients and the feature widths for the nano-sized *** increase rate of each depends on the spin valve *** investigations into variations of the magnetization distribution reveal that the initial magnetization distribution and the magnetization reversal mode depend greatly on easy axes and materials The dependence on easy axes based mainly on the magnetocrystalline anisotropy is illustrated in detail.

关键词： nano-sized spin valve magnetization reversal switching field hysteresis antiferromagnetic coupling

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