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Communications in Theoretical Physics 2020年第11期72卷 121-126页

作者： Ying-Jie chen ze-chen yan Kai-Yue Zhang Feng-Lan Shao School of Physics and Physical Engineering Qufu Normal University273165QufuChina

By a combination method of Lee-Low-Pines unitary transformation method and Pekar-type variational method,the ground state energy(GSE)of the bound polaron is studied in the asymmetrical Gaussian potential quantum well considering the temperature and *** impacts of the temperature and asymmetrical Gaussian potential,electromagnetic field and phonon-electron coupling upon the GSE are *** results show that the GSE of the bound polaron not only oscillates as the temperature changes regardless of the electromagneticfield and asymmetrical Gaussian potential and Coulomb impurity potential(CIP)and electron-phonon coupling but also has different rules with the electromagnetic field and asymmetrical Gaussian potential and CIP and electron-phonon coupling at different temperature zones.

关键词： asymmetrical Gaussian potential quantum well bound polaron temperature ground state energy

Autophagy-targeting modulation to promote peripheral nerve regeneration

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Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： yan chen Hongxia Deng Nannan Zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and Children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

资源错配变迁与工业经济增长——基于1980-2014年中国工业部门的研究

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山西财经大学学报 2017年第7期39卷 59-71页

作者：李欣泽陈言山东大学经济研究院山东济南250100

1978年至今,中国在推进工业化进程的同时,也伴随着工业部门内部资源错配的变迁。首先,本文构建异质性多部门模型测算出了1980-2014年中国工业部门资源错配系数及其资源错配变动趋势。其次,实证分析了2000-2014年中国由工业化中期推进到... 详细信息

1978年至今,中国在推进工业化进程的同时,也伴随着工业部门内部资源错配的变迁。首先,本文构建异质性多部门模型测算出了1980-2014年中国工业部门资源错配系数及其资源错配变动趋势。其次,实证分析了2000-2014年中国由工业化中期推进到后期过程中资源错配阻碍经济增长的动态效应。研究发现:第一,随着工业化进程的不断推进,资源错配所造成的工业部门产出缺口值虽存在局部波动性,但就整体而言呈现下降趋势;第二,在整个工业化进程中,各工业行业劳动要素和资本要素扭曲程度在工业化前期和中期逐渐优化,但由中期推进到后期时却出现恶化趋势;第三,伴随工业化中期向后期推进的过程中,资源错配对工业经济增长的阻碍作用逐渐增强。

关键词：资源错配工业经济增长产出缺口劳动的扭曲系数资本的扭曲系数

Analysis of Micromechanical Properties at the Interface of Pre-wet SBS Modified Asphalt Mixture Based on Molecular Simulation Technology

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 103-113页

作者： chen Wuxing chen Shuang YU yan ZHANG Jiangyi XU Haiyang GUO Wei School of Mines China University of Mining and TechnologyXuzhou 221000China College of Construction Engineering Jilin Uni-versityChangchun 130026China

The pre-wetting of aggregate surface is a means to improve the interface performance of SBS modified asphalt and *** effect of pre-wetting technology on the interaction between SBS modified asphalt and aggregate was analyzed by molecular dynamics *** diffusion coefficient and concentration distribution of SBS modified asphalt on aggregate surface are *** simulation results show that the diffusion coefficient of the aggregate surface of SBS modified asphalt is increased by 47.6%and 70.5%respectively after 110#asphalt and 130#asphalt are *** concentration distribution of SBS modified asphalt on the aggregate surface after pre-wetting is more *** to the results of interface energy calculation,the interface energy of SBS modified bitumen and aggregate can be increased by about 5%after *** to the results of molecular dynamics simulation,the pre-wetting technology can effectively improve the interface workability of SBS modified bitumen and aggregate,so as to improve the interface performance.

关键词： pre-wet oil-stone interface interface interaction interface mechanics molecular dynamics simulation

海南省南部地区Down综合征患儿的细胞遗传学分析:附1例新发现的染色体异常核型

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南方医科大学学报 2010年第11期30卷 2592-2593,2595页

作者：王玉丰林玲陈泽燕海南省第三人民医院检验科海南三亚572000 海南省第三人民医院科教科海南三亚572000 海南省第三人民医院儿科海南三亚572000

目的探讨海南省南部地区唐氏综合征(Down syndrome,DS)患儿染色体核型分布及特点。方法采用常规方法对海南省南部地区132例疑似DS患儿进行外周血染色体核型分析。结果 86例确诊为DS,其中单纯型占93.02%,嵌合型和易位型均占3.49%;91.86%... 详细信息

目的探讨海南省南部地区唐氏综合征(Down syndrome,DS)患儿染色体核型分布及特点。方法采用常规方法对海南省南部地区132例疑似DS患儿进行外周血染色体核型分析。结果 86例确诊为DS,其中单纯型占93.02%,嵌合型和易位型均占3.49%;91.86%的DS患儿由年轻母亲(<35岁)所生,仅8.14%由高龄产妇所生。另外,我们还发现了1例罕见的DS合并5号和8号染色体平衡易位的染色体异常核型。结论海南省南部地区DS患儿核型绝大多数为单纯型。患儿母亲呈现低龄化趋势。

关键词：唐氏综合征染色体核型分析

基于FMEA和FTA的老年人汽车人机界面交互设计研究

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包装工程 2021年第6期42卷 98-105页

作者：李永锋陈则言江苏师范大学徐州221116

目的提升老年人汽车界面满意度,设计适合老年人使用的汽车界面。方法提出基于失效模式与效应分析(FMEA)、故障树分析(FTA)的研究方法,首先成立会议小组进行SHERPA分析,绘制汽车界面层次任务分析图;随后运用FMEA找出汽车界面中的潜在失... 详细信息

目的提升老年人汽车界面满意度,设计适合老年人使用的汽车界面。方法提出基于失效模式与效应分析(FMEA)、故障树分析(FTA)的研究方法,首先成立会议小组进行SHERPA分析,绘制汽车界面层次任务分析图;随后运用FMEA找出汽车界面中的潜在失效模式,计算风险优先数值;接着选取风险优先数值高的失效模式,运用FTA寻找其发生的原因,对其以图形化表示;再对故障树进行定性定量分析,计算故障树的最小切集和失效事件发生概率,找到失效发生的核心因素;最后对失效事件进行改良并对改良后的结果进行验证。结论以老年人汽车界面为例进行研究,该方法可以有效发现老年人操作汽车界面发生错误的原因,不仅可以帮助设计师找到改良的重点,还可以使老年人获得良好的驾驶体验。

关键词：交互设计失效模式与效应分析故障树分析汽车界面老年人

国务院15号文件指引会展业在新常态下改革发展

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乌鲁木齐职业大学学报 2015年第3期24卷 45-51页

作者：陈泽炎中国会展经济研究会北京100710

文章研讨了国务院15号文件的重要意义,论述了我国会展业在新常态下的改革发展,讨论了"互联网+"与会展业的相互关系。这些都是当前我国会展业界比较关注的热点话题。

关键词：国务院15号文件新常态会展业互联网+

Multifunctional Nacre‑Like Nanocomposite Papers for Electromagnetic Interference Shielding via Heterocyclic Aramid/MXene Template‑Assisted In‑Situ Polypyrrole Assembly

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Nano-Micro Letters 2025年第3期17卷 37-54页

作者： Jinhua Xiong Xu Zhao Zonglin Liu He chen Qian yan Huanxin Lian Yunxiang chen Qingyu Peng Xiaodong He National Key Laboratory of Science and Technology On Advanced Composites in Special Environments Center for Composite Materials and StructuresHarbin Institute of TechnologyHarbin 150080People’s Republic of China

Robust, ultra-flexible, and multifunctional MXene-basedelectromagnetic interference (EMI) shielding nanocomposite filmsexhibit enormous potential for applications in artificial intelligence,wireless telecommunication, and portable/wearable electronic *** this work, a nacre-inspired multifunctional heterocyclic aramid(HA)/MXene@polypyrrole (PPy) (HMP) nanocomposite paper withlarge-scale, high strength, super toughness, and excellent tolerance tocomplex conditions is fabricated through the strategy of HA/MXenehydrogel template-assisted in-situ assembly of PPy. Benefiting from the"brick-and-mortar" layered structure and the strong hydrogen-bondinginteractions among MXene, HA, and PPy, the paper exhibits remarkable mechanical performances, including high tensile strength (309.7 MPa),outstanding toughness (57.6 MJ m−3), exceptional foldability, and structural stability against ultrasonication. By using the template effect ofHA/MXene to guide the assembly of conductive polymers, the synthesized paper obtains excellent electronic conductivity. More importantly,the highly continuous conductive path enables the nanocomposite paper to achieve a splendid EMI shielding effectiveness (EMI SE) of 54.1 dBat an ultra-thin thickness (25.4 μm) and a high specific EMI SE of 17,204.7 dB cm2g−1. In addition, the papers also have excellent applicationsin electromagnetic protection, electro-/photothermal de-icing, thermal therapy, and fire safety. These findings broaden the ideas for developinghigh-performance and multifunctional MXene-based films with enormous application potential in EMI shielding and thermal management.

关键词： MXene Remarkable mechanical properties Heterocyclic aramid Electromagnetic interference shielding Polypyrrole Multifunctionality

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu Zhang yanyu Zhang yan zeng Xingxing chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si chen Fang Huang Lijie Mao Zhimin Zhang Han Lin Qixin yan Xiangyu Lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis