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Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin zeng Le Wang Wenwu Zhang Gang li Xing Cheng Peiqiang Su Yong Wan Xiang li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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Effect of Bi/Si Ratio of BiBSi Glass on Its Structure, Properties and Laser Sealing Shear Strength for Vacuum Glazing

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 13-24页

作者： liU Wei JIAO Jinxu LUO Dusha ZHOU Junjie SHI lifen WANG Weiwei li Changqing WANG Peng XIONG Dehua li Hong State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China Silica-Based Materials Laboratory of Anhui Province CNBM Research Institute for Advanced Glass Materials Group Co.LtdBengbu 233018China State Key Laboratory of Advanced Technology for Float Glass CNBM Research Institute for Advanced Glass Materials Group Co.LtdBengbu 233018China

The low-melting glass of Bi2O_(3)-B2O_(3)-SiO_(2)(BiBSi)system was used for the first time for laser sealing of vacuum *** the condition of constant boron content,how the structure and properties vary with Bi/Si ratio in low-melting glass was *** addition,the relationships between laser power,low-melting glass solder with different Bi/Si ratios and laser sealing shear strength were *** results show that a decrease in the Bi/Si ratio can cause a contraction of the glass network of the low-melting glass,leading to an increase of its characteristic temperature and a decrease of its coefficient of thermal *** laser sealing,the copper ions in the low-melting glass play an endothermic role.A change in the Bi/Si ratio will affect the valence state transition of the copper ions in the low-melting *** absorbance of the low-melting glass does not follow the expected correlation with the Bi/Si ratio,but shows a linear correlation with the content of divalent copper *** greater the concentration of divalent copper ions,the greater the absorbance of the low-melting glass,and the lower the laser power required for laser *** shear strength of the low melting glass solder after laser sealing was tested,and it was found that the maximum shear strength of Z1 glass sample was the highest up to 2.67 MPa.

关键词： Bi2O_(3)-B2O_(3)-SiO_(2)(BiBSi) Bi/Si ratio low-melting glass laser sealing vacuum glazing

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Epigenetic regulation of the inflammatory response in stroke

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Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingyi liang Fei Yang Zixiao li Qian li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment

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Bulging Performance and Quality Control of Aluminum Alloy Tailor-welded Overlapping Sheets Based on Interface Friction

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 258-264页

作者： GAO Tiejun GAO Bowen li Weijie ZHANG Jiabin College of Aerospace Engineering Shenyang Aerospace UniversityShenyang 110136China Shenyang Aerospace Xinguang Group Co.L td. Shenyang 110043China

In order to solve the problem of poor formability caused by different materials and properties in the process of tailor-welded sheets forming,a forming method was proposed to change the stress state of tailor-welded sheets by covering the tailor-welded sheets with better plastic properties overlapping *** the same time,the interface friction effect between the overlapping and tailor-welded sheets was utilized to control the stress magnitude and further improve the formability and quality of the tailor-welded *** this work,the bulging process of the tailor-welded overlapping sheets was taken as the research *** alloy tailor-welded overlapping sheets bulging specimens were studied by a combination of finite element analysis and experimental *** results show that the appropriate use of interface friction between tailor-welded and overlapping sheets can improve the formability of tailor-welded sheets and control the flow of weld seam to improve the forming *** increasing the interface friction coefficient on the side of tailor-welded sheets with higher strength and decreasing that on the side of tailor-welded sheets with lower strength,the deformation of the tailor-welded sheets are more uniform,the offset of the weld seam is minimal,the limit bulging height is maximal,and the forming quality is optimal.

关键词： tailor-welded sheets overlapping sheet bulging interface friction weld seam stress

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Preliminary efficacy of CyberKnife radiosurgery for locally advanced pancreatic cancer

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Chinese Journal of Cancer 2010年第9期29卷 802-809页

作者： ze-Tian Shen Xin-Hu Wu bing li Lei Wang Xi-Xu Zhu Department of Radiation Oncology Nanjing General Hospital of Nanjing Military Command Nanjing Jiangsu 210002 P. R. China

Background and Objective:CybeKnife is a newly developed technology in the field of stereotactic radiosurgery/radiotherapy (SRS/SRT).Compared with conventional SRS/SRT, there are many advantages for CyberKnife in terms of treating tumors that move with respiration, being real-time image-guidance, frameless, high accurateness, and so ***, it has been used to treat different types of malignant carcinoma including intracranial and caudomedial *** study was designed to evaluate the short-term efficacy and toxicity of the CyberKnife radiotherapy for locally advanced pancreatic ***:A total of 20 patients with locally advanced (stage II-III) pancreatic cancer treated with CyberKnife were recruited between April 2009 and December *** 20 patients, 13 were with cancer located at the pancreatic head and 7 were located at the pancreatic body and *** planning target volume (PTV) was defined as gross tumor volume (GTV) plus 2-3 mm, and more than 95% PTV should be covered by 75% isodose *** median of PTV was 47 cm3 (26-64 cm3).The median total prescription dose was 40 Gy (32-55 Gy) at 3-6 *** treatment delivery, X-Sight Spine Tracking System was used in 5 patients to track movement of the *** 15 patients were implanted fiducials in the tumors to track movement of the tumor and patient breathing ***:The median follow-up time was 7 months (3-11 months).All patients had finished the treatment and 19 were alive by the last *** fatigue was the most common *** by CT scan, 6 were complete response, 9 were partial response, 3 were stable disease, and 1 was progression; 1 was *** were 6 patients with grade I granulocytopenia, 7 with grade I nausea, and 5 with grade II ***:The CyberKnife radiosurgery for the locally advanced pancreatic cancer shows a high rate of local control and minimal ***-term follow-up is necessary to evaluate the survival and late

关键词：胰腺癌晚期电脑疗效放射治疗恶性肿瘤跟踪系统呼吸方式

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A PAIR OF COUPliNG METRICS FOR SOFTWARE NETWORKS

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Journal of Systems Science & Complexity 2011年第1期24卷 51-60页

作者： Huan li bing li Center of Modern Educational Technology Shanghai University of Political Science and Law Shanghai 201701 China State Key Laboratory of Software Engineering Wuhan University Wuhan 430072 China

Complex networks are everywhere. A typical example is software network. How to measure and control coupling interactions of software components is a largely explored research problem in software network. In terms of graph theory and linear algebra, this paper investigates a pair of coupling metrics to evaluate coupling interactions between the classes of object-oriented systems. These metrics differ from the majority of existing metrics in three aspects： Taking into account the strength that one class depends on other ones, reflecting indirect coupling, and distinguishing various coupling interaction. An empirical comparison of the novel measures with one of the most widely used coupling metrics is described. Specifically, an experiment about the relationships of this pair metrics is conducted. The result shows that software complexity derived from coupling interaction could not be accurately reflected by one dimension of coupling metric for negative correlation.

关键词： Complex network coupling metric software network software system

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Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

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Neural Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang Zhang Henrik Biverstål Nicolas GBazan Shuai Tan Nailin li Makiko Ohshima Marianne Schultzberg Xiaofei li Department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden Department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

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Genus two correlation functions in CFTs with TT deformation

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Science China(Physics,Mechanics & Astronomy) 2023年第5期66卷 106-119页

作者： Song He Yun-ze li Center for Theoretical Physics and College of Physics Jilin UniversityChangchun 130012China Max Planck Institute for Gravitational Physics(Albert Einstein Institute) Am Mühlenberg 114476 GolmGermany

Since the definition of TT deformation in the curved Riemann surface is obstructive in the literature,we propose a way to do the deformation in the genus two Riemann surfaces by sewing *** construct the correlation functions of conformal field theories(CFTs)on genus two Riemann surfaces with the TT deformation in terms of the perturbative CFT *** to sewing construction to form higher genus Riemann surfaces from lower genus ones and conformal symmetry,we systematically obtain the first-order TT correction to the genus two correlation functions in the TT deformed CFTs,e.g.,partition function and one/higher-point correlation functions.

关键词： conformal field theory gauge/gravity duality TT deformation higher genus correlation function

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Electrochemical reduction and electrocrystallization process of B(Ⅲ) in the liF-NaF-KF-KBF_4 molten salt

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Rare Metals 2007年第1期26卷 74-78,96页

作者： li Jun li bing School of Materials Engimeting Shanghai University of Engineering Science Shanghai 201600 China School of Resource and Environment Engineering East China University of Science and Technology Shanghai 200237 China

The mechanisms of the electrochemical reduction and nucleation process of B（Ⅲ） on the platinum electrode in the liF-NaF-KF-KBF4 molten salt at 700℃ were first investigated using cyclic voltammetry and chronoamperometry techniques. It was found that the electrochemical reduction of B（Ⅲ） occurs in single-step charge transfer： B（Ⅲ）＋ 3e → B, and the cathode process is reversible. The electrocrystallization process of B（Ⅲ） is instantaneous.

关键词： electrochemical reduction boron coatings molten salt

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Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua li Xiao-Jiang li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

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