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Effect of tankyrase 1 on autophagy in the corpus cavernosum smooth muscle cells from ageing rats with erectile dysfunction and its potential mechanism

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Asian Journal of Andrology 2010年第5期12卷 744-752页

作者： Jian Zhang Xiao-Jun Wu De-Xiang Zhuo Tao Liu Wei-Ren Li ze-bin mao Zhong-Cheng Xin Andrology Center First Hospital Peking University Beijing 100009 China Institute of Urinary Surgery Southwest Hospital Third Military Medical University Chongqing 400038 China The Department of Biochemistry and Molecular Biology Health Science Center Peking University Beijing 100191 China

This study compared tankyrase 1 expression and autophagy quantity between erectile dysfunction （ED） and non-ED rats＇ corpus cavernosum smooth muscle cells （CSMCs）. This study aslo explored the effect and possible mechanism of tankyrase 1 on autophagy and cell proliferation in ageing ED rats＇ CSMCs. The intracavernous pres- sure and mean systemic arterial pressure were measured to investigate erectile function so that eight 24-month-old ED and eight 8-month-old male Wistar rats were choosed respectively. The rat CSMCs were isolated and cultured by enzyme digestion, in which tankyrase 1 expression and autophagy quantity were compared. Tankyrase 1 over-expression was induced with plasmid transfection by Lipofectamine^TM. The effect of tankyrase 1 overexpression on proliferation, autophagy and mTOR pathway in 24-month-old ED rats＇ CSMCs was measured by the cell growth curve in MTT assay, cell cycle analysis in flow cytometry （FCM）, key protein expression in Western blot, autophagy quantity in transmission electron microscopy, monodansylcadaverine staining and GFP-LC3 fluorescence. The primary CSMCs were confirmed by immunofluorescence, and the purity was 99.1% in FCM. Compared with that of 8-month-old rats, tankyrase 1 expression and autophagy quantity significantly decreased in 24-month-old ED rats＇ primary CSMCs （P 〈 0.01）. Tankyrase 1 overexpression significantly increased the growth rate （P 〈 0.05） and increased the S phase of cell cycle （P 〈 0.01）. The autophagosome quantity was remarkably increased （P 〈 0.01）, LC3-Ⅰ/Ⅱ and Beclin 1 were upregulated （P 〈 0.01 and P 〈 0.05）, and p-p70S6K （Thr389） was downregulated in 24-month-old ED rat CSMCs （P 〈 0.05）. In conclusion, Tankyrase 1 and autophagy decrease in the CSMCs from aging rats with ED, and tankyrase 1 may have a positive effect on proliferation by enhancing autophagy and regulating the mTOR signalling pathway.

关键词： ageing autophagy corpora cavernosum corpus cavemosum smooth muscle cells erectile dysfunction senile tankyrase

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Characterization of a novel positive transcription regulatory element that differentially regulates the IGFBP-3 gene in senescent cells

Characterization of a novel positive transcription regulator...

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第七届全国老年医学学术会议暨海内外华人老年医学学术会议

作者： Xiao Feng Lv Xiao Gang Jiang Jun Hai Bai Ylun Biao Lu ze bin mao

IGFBP-3 is a well. documented growth inhibitor and proapoptotic factor. The evidences have demonstrated that IGFBP. 3 mRNA and its protein are over expressed by senescent human diplOid fibroblasts. However, the mechanism responsible for the up—regulation of its expression still is unclear. In this report a novel transcriptional regulatory element was identified in the 5’-untranslated region. Of the IGFBP-3 gene. We show that this element differentially activity IGFBP-3 expression in senescent ver-

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Wave effect of gravitational waves intersected with a microlens field Ⅱ:An adaptive hierarchical tree algorithm and population study

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 241-254页

作者： Xikai Shan Guoliang Li Xuechun Chen Wen Zhao bin Hu Shude mao Department of Astronomy Tsinghua University Purple Mountain Observatory Chinese Academy of Sciences Institute for Frontier in Astronomy and Astrophysics Beijing Normal University School of Physics and Astronomy Beijing Normal University School of Astronomy and Space Science University of Science and Technology of China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of Astronomy University of Science and Technology of ChinaChinese Academy of Sciences

The gravitational lensing wave effect generated by a microlensing field embedded in a lens galaxy is an inevitable phenomenon in strong lensed gravitational waves （SLGWs）.This effect presents both challenges and opportunities for the detection and application of ***,investigating this wave effect requires computing a complete diffraction integral over each microlens in the *** is extremely time-consuming due to the large number of microlenses （10～3-10～6）.Therefore,simply adding all the microlenses is ***,the complexity of the time delay surface makes the lens plane resolution a crucial factor in controlling numerical *** this paper,we propose a trapezoid approximation-based adaptive hierarchical tree algorithm to meet the challenges of calculation speed and *** find that this algorithm accelerates the calculation by four orders of magnitude compared to the simple adding method and is one order of magnitude faster than the fixed hierarchical tree algorithm proposed for electromagnetic *** importantly,our algorithm ensures controllable numerical errors,increasing confidence in the *** with our previous work （***.66,239511,2023）,this paper addresses all numerical issues,including integral convergence,precision,and computational time1).Finally,we conducted a population study on the microlensing wave effect of SLGWs using this algorithm and found that the microlensing wave effect cannot be ignored,especially for Type II SLGWs （from saddle position of the time delay surface） due to their intrinsic geometric structures and their typical intersection with a denser microlensing ***,more than 33%（11%） of SLGWs have a mismatch larger than 1%（3%） compared to the unlensed ***,we found that the mismatch between signal pairs in a doubly imaged GW is generally larger than 10-3,and 61%（25%） of signal pairs have a mismatch larger than 1%（3%）.Therefo

关键词： gravitational lensing diffractional integral algorithm gravitational wave

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CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-Cui mao Hui-Lin Jiang Bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface

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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu Jia Rui mao Xiang Cao Yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

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Review of precipitation strengthening in ultrahigh-strength martensitic steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 256-269页

作者： Zhihao Tian Chunlei Shang Chaolei Zhang Xiaoye Zhou Honghui Wu Shuize Wang Guilin Wu Junheng Gao Jiaming Zhu Xinping mao Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China Institute of Steel Sustainable Technology Liaoning Academy of MaterialsShenyang 110004China Department of Materials Science and Engineering Shenzhen MSU-BIT UniversityShenzhen 518172China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China School of Civil Engineering Shandong UniversityJinan 250061China

Martensite is an important microstructure in ultrahigh-strength steels,and enhancing the strength of martensitic steels often involves the introduction of precipitated phases within the martensitic *** considerable research efforts devoted to this area,a systematic summary of these advancements is *** review focuses on the precipitates prevalent in ultrahigh-strength martensitic steel,primarily carbides(e.g.,MC,M_(2)C,and M_(3)C)and intermetallic compounds(e.g.,Ni Al,Ni_(3)X,and Fe_(2)Mo).The precipitation-strengthening effect of these precipitates on ultrahigh-strength martensitic steel is discussed from the aspects of heat treatment processes,microstructure of precipitate-strengthened martensite matrix,and mechanical ***,a perspective on the development of precipitation-strengthened martensitic steel is presented to contribute to the advancement of ultrahigh-strength martensitic *** review highlights significant findings,ongoing challenges,and opportunities in the development of ultrahigh-strength martensitic steel.

关键词： ultrahigh-strength martensitic steel precipitation strengthening mechanical property carbide intermetallic compound

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A novel HfNbTaTiV high-entropy alloy of superior mechanical properties designed on the principle of maximum lattice distortion

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Journal of Materials Science & Technology 2021年第20期79卷 109-117页

作者： Zibing An Shengcheng mao Yinong Liu Li Wang Hao Zhou bin Gan ze Zhang Xiaodong Han Beijing Key Lab of Microstructure and Property of Advanced Materials Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing100124China Department of Mechanical Engineering The University of Western AustraliaPerthWA6009Australia Nano and Heterogeneous Structural Materials Center School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing210094China Beijing Key Laboratory of Advanced High Temperature Materials Central Iron and Steel Research InstituteBeijing100081China State Key Laboratory of Silicon Materials Department of Materials Science and EngineeringZhejiang UniversityHangzhou310058China

This paper reports a synergistic design of high-performance BCC high-entropy alloy based on the combined consideration of the principles of intrinsic ductility of elements,maximum atomic size difference for solid solution strengthening and the valence electron concentration criterion for *** single-phase BCC HfNbTaTiV alloy thus designed exhibited a high compressive yield strength of 1350 MPa and a high compressive ductility of>45%at the room *** represents a 50%increase in yield strength relative to a HfNbTaTiZr *** is attributed to the maximized solid solution strengthening effect caused by lattice distortion,which is estimated to be 1094 *** alloy was also able to retain 53%of its yield strength and 77%of its ductility at 700℃.These properties are superior to those of most refractory BCC high-entropy alloys reported in the literature.

关键词： High-entropy alloy Solid solution strengthening Strengthening mechanism Mechanical properties

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Fault Estimation and Accommodation for Networked Control Systems with Transfer Delay

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自动化学报 2007年第7期33卷 738-743页

作者： mao ze-Hui JIANG bin College of Automation Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 P. R. China

在这份报纸，差错评价和差错的一个方法为有转移延期和进程噪音的联网的控制系统(NCS ) 的容忍的控制被介绍。首先，联网的控制系统作为有转移的分离时间的系统推迟的 multiple-input-multiple-output (MIMO ) 被建模，处理噪音，并且... 详细信息

在这份报纸，差错评价和差错的一个方法为有转移延期和进程噪音的联网的控制系统(NCS ) 的容忍的控制被介绍。首先，联网的控制系统作为有转移的分离时间的系统推迟的 multiple-input-multiple-output (MIMO ) 被建模，处理噪音，并且为无常建模。在这个模型下面并且在一些条件下面，一个差错评价方法被建议估计系统差错。根据差错评价和滑动模式控制理论的信息，一个差错容忍的控制器被设计恢复系统性能。最后，模拟结果被用来验证方法的效率。

关键词：网络控制系统迟滞转移容错估计容错控制不确定性模型滑动模型控制

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Aerodynamic Interactions Between Wing and Body of a Model Insect in Forward Flight and Maneuvers

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Journal of Bionic Engineering 2013年第1期10卷 19-27页

作者： bin Liang mao Sun Ministry-of-Education Key Laboratory of Fluid Mechanics Beihang University Beoing 100191 P. R. China

The aerodynamic interactions between the body and the wings of a model insect in forward flight and maneuvers are studied using the method of numerically solving the Navier-Stokes equations over moving overset grids. Three cases are con- sidered, including a complete insect, wing pair only and body only. By comparing the results of these cases, the interaction effect between the body and the wing pair can be identified. The changes in the force and moment coefficients of the wing pair due to the presence of the body are less than 4.5% of the mean vertical force coefficient of the model insect; the changes in the aero- dynamic force coefficients of the body due to the presence of the wings are less than 5.0% of the mean vertical force coefficient of the model insect. The results of this paper indicate that in studying the aerodynamics and flight dynamics of a flapping insect in forward flight or maneuver, separately computing （or measuring） the aerodynamic forces and moments on the wing paig and on the body could be a good approximation.

关键词： insect wing-body aerodynamic interaction forward flight maneuvers Navier-Stokes simulation

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Aerodynamic Interactions Between Contralateral Wings and Between Wings and Body of a Model Insect at Hovering and Small Speed Motions

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Chinese Journal of Aeronautics 2011年第4期24卷 396-409页

作者： LIANG bin SUN mao Ministry-of-Education Key Laboratory of Fluid Mechanics Beihang University Beijing 100191 China

In this paper, we study the aerodynamic interactions between the contralateral wings and between the body and wings of a model insect, when the insect is hovering and has various translational and rotational motions, using the method numerically solving the Navier-Stokes equations over moving overset grids. The aerodynamic interactional effects are identified by compar-ing the results of a complete model insect, the corresponding wing pair, single wing and body without the wings. Horizontal, vertical and lateral translations and roll, pitch and yaw rotations at small speeds are considered. The results indicate that for the motions considered, both the interaction between the contralateral wings and the interaction between the body and wings are weak. The changes in the forces and moments of a wing due to the contralateral wing interaction, of the wings due to the pres-ence of the body, and of the body due to the presence of the wings are generally less than 4.5%. Results show that aerodynamic forces of wings and body can be measured or computed separately in the analysis of flight stability and control of hovering in-sects.

关键词： insect aerodynamics Navier-Stokes simulation wing/wing interaction wing/body interaction

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