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Promotion and Mechanism of Acupotomy on Chondrocyte Autophagy in Knee Osteoarthritis Rabbits

Chinese Journal of Integrative Medicine 2024年第9期30卷 809-817页

作者： LU Man MENG De-hong she ze-yu WU Xian XIA Shuai YANG Kai-ning LIU Cun-bin LI Tao YANG Yong-hui The First Affiliated Hospital of Anhui University of Chinese Medicine Hefei230031China The Second Affiliated Hospital of Anhui University of Chinese Medicine Hefei230038China Department of Acupotomy Rehabilitation Anhui Provincial Hospital of Integrated Traditional Chinese and Western MedicineHefei230031China

Objective:To explore the effect of acupotomy intervention on autophagy of chondrocytes in rabbits with knee osteoarthritis(KOA),and to determine the possible mechanisms of acupotomy to alleviate cartilage ***:The modified Videman method was used to construct a KOA rabbit *** modeling,40 rabbits were randomly divided into 4 groups by a random number table:control;KOA(model);KOA+acupotomy(acupotomy),and KOA+sham acupotomy(sham),10 in each *** a 3-week treatment course,the knee joint activity was determined by the modified Lequesne MG ***-eosin staining staining was used to examine the morphological changes of *** of chondrocytes was observed by transmission electron *** surface morphology of cartilage tissue was observed by scanning electron *** mRNA and protein levels of AMP kinase/mammalian target of rapamycin/Unc-51(AMPK/mTOR/ULK1)signal pathway key proteins,autophagy-related factor Beclin-1 and microtubule-associated protein 1A/1B light chain 3(LC3)in rabbit knee cartilage were assessed by real-time fluorescence quantitative polymerase chain reaction and Western blot,***:The modified Lequesne MG score of acupotomy group was significantly lower than that of model group(P<0.05).Pathological results showed that chondrocyte autophagy decreased and cartilage surface was rough in the model group,which recovered after acupotomy *** mRNA expressions of AMPK,ULK1,Beclin-1 and the protein levels of p-AMPK,p-ULK1,Beclin-1,and LC3Ⅱ/LC3Ⅰwere decreased in the model group,while the mRNA and protein expressions of mTOR were increased(P<0.01).However,acupotomy treatment reversed these abnormal changes(P<0.05).Conclusions:Acupotomy could effectively up-regulate the expressions of AMPK,ULK1 and Beclin1,reduce the expression of mTOR,promote autophagy,and alleviate joint *** is a promising complementary and alternative therapy for KOA.

关键词： acupotomy knee asteoarthritis autophagy AMPK/mTOR/ULK1 signaling pathway rabbit

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Nickel-catalyzed cross-electrophile C–Ge coupling of benzyl pivalates and chlorogermanes

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Science China Chemistry 2023年第12期66卷 3562-3566页

作者： Ming-Xiang You Pei-Feng Su ze-Hui she Xing-Zhong Shu State Key Laboratory of Applied Organic Chemistry(SKLAOC) College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China

The C–Ge cross-coupling offers a promising approach for the precise synthesis of organogermanes. However, the current methods are primarily effective in the germylation of organo(pseudo)halides. This work demonstrates the possibility of transferring low-cost and easily available ester groups into organogermanes through the cleavage of stable C–O bonds. Primary,secondary, and even tertiary benzylic pivalates were coupled well with chlorogermanes. The reactions proceed under mild conditions. The scalability of this reaction and derivatization of the formed benzylgermanes are demonstrated.

关键词： nickel cross-coupling reductive coupling germanium germylation

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Source apportionment of heavy metals in soils around a coal gangue heap with the APCS-MLR and PMF receptor models in Chongqing,southwest China

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Journal of Mountain Science 2023年第4期20卷 1061-1073页

作者： MA Jie sheN Zhi-jie WANG sheng-lan DENG Li SUN Jing LIU Ping she ze-lei Chongqing Ecological and Environmental Monitoring Center Chongqing401147China Key Laboratory of Organic Pollutants in Environmental Chemical Behavior and Ecological Toxicology of Chongqing Chongqing401147China College of Resources and Environment Southwest UniversityChongqing400715China Chongqing University of Arts and Sciences Chongqing402160China

This study studied the characteristics and source apportionment of heavy metal pollution in the agricultural soil surrounding a gangue coal heap in Chongqing,China by using absolute principal component scores-multiple linear regression(APCSMLR)model and positive matrix factorization(PMF)*** applicability of the models was compared in the assessment of source *** results showed that the average contents of Cd,Hg,As,Pb,Cr,Cu,Ni,and Zn in the surface soil were 0.46,0.14,9.66,31.2,127,95.6,76.0,and 158 mg/kg,*** with the spatial distribution and correlation analyses,the results of source apportionment were consistent for both the APCSMLR and PMF ***,Hg,As,and Pb were mainly affected by the gangue heap accumulation,with respective contributions of 74.6%,79.4%,69.1%,and 67.2%based on the APCS-MLR model and respective contributions of 69.7%,60.7%,57.4%,and 41.9%based on the PMF *** and Zn were mainly affected by industrial and agricultural activities,while Cr and Cu were mainly affected by natural *** results of the source apportionment were approximately consistent between the APCS-MLR and PMF *** combined application of the two receptor models can make the results of source apportionment more comprehensive,accurate,and reliable.

关键词： Coal gangue heap Heavy metals Agricultural soil Source apportionment

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Application of labeled radioimmunoimaging tracing in detecting pulmonary embolism in rabbits after bone cement perfusion and relevant treatment effects

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Chinese Medical Journal 2011年第23期124卷 4029-4033页

作者： QI Xiang-bei ZHANG Ying-ze PAN Jin-she MA Li-jie WANG Jian-zhao WANG Lin Department of Emergency Orthopaedics Third Hospital Hebei Medical University Shijiazhuang Hebei 050051 China

Background During the process of bone cement joint replacement, some patients show a series of complications, such as a sudden drop in blood pressure or dyspnea. The cause of the complication is considered to be due to emboli caused by the femur prosthesis insertion. The purpose of the present study was to detect the pulmonary embolism in rabbits after bone cement perfusion by radioimmunoimaging, and to explore its protective measures. Methods Forty rabbits, 2.5-3.0 kg weight, were randomly assigned to four groups, with ten rabbits in each group. Group I （no intervention）： Bone cement perfusion was done after medullary cavity reaming and pressurizing. Group II （epinephrine hydrochlorideintervention）： The medullary cavity was rinsed with a 1：10000 normal saline-diluted epinephrine hydrochloride solution followed by bone cement perfusion after medullary cavity reaming and pressurizing. Group III （fibrin sealant intervention）： The medullary cavity was precoated with fibrin sealant followed by bone cement perfusion after medullary cavity reaming and pressurizing. Group IV （blank control group）： The medullary cavity was not perfused with bone cement after reaming. In each group, the rabbits underwent femoral head resection and medullary cavity reaming. Before bone cement perfusion, 2 ml of developing tracer was injected through the ear vein. Radionuclide imaging was performed at 60, 120, and 180 minutes after bone cement perfusion, and the pulmonary radioactivity in vivo was measured. The rabbits were immediately sacrificed, and the pulmonary tissue was removed and its radioactivity was measured in vitro. Pulmonary tissue was then fixed and the pulmonary embolism and the associated pathological changes were observed. Results The pulmonary radioactivity in vivo was measured at 60, 120, and 180 minutes after bone cement perfusion. The radioactivities of the four groups were 11.67±2.16, 14.59±2.92 and 18.43±4.83 in group I; 8.37±3.05, 10.35±2.24 and 11.48±2.96 in group Ⅱ; 3

关键词： radioimmunoimaging tracer bone cement thrombosis pathology

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高强塑积汽车钢板的显微组织与力学性能

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塑性工程学报 2021年第11期28卷 181-188页

作者：张丽凤王社则田博彤山西交通职业技术学院车辆工程系山西太原030031 太原理工大学材料科学与工程学院山西太原030024

采用扫描电镜、透射电镜和拉伸试验机等手段研究了Nb和C含量对传统淬火-回火(Q-T)态和新型淬火-分配-回火(Q-P-T)态汽车钢板拉伸性能和显微组织的影响。结果表明,Q-T态试样中未见明显奥氏体衍射峰存在,而Q-P-T态试样中可见衍射峰强度不... 详细信息

采用扫描电镜、透射电镜和拉伸试验机等手段研究了Nb和C含量对传统淬火-回火(Q-T)态和新型淬火-分配-回火(Q-P-T)态汽车钢板拉伸性能和显微组织的影响。结果表明,Q-T态试样中未见明显奥氏体衍射峰存在,而Q-P-T态试样中可见衍射峰强度不等的奥氏体衍射峰;含Nb钢板的组织为回火马氏体+残余奥氏体+碳化物,且Q-P-T态钢板中残余奥氏体含量相对较多;Nb元素的添加有助于提高Q-P-T和Q-T态汽车钢板的强度,而对塑性影响较小,适宜的Nb添加量为0.03%;Q-P-T工艺有助于同时提高含0.4%C+0.03%Nb汽车钢板的强度和塑性,此时汽车钢板具有最高的强塑积(32008 MPa·%),这主要与钢板中含有起协调变形能力的薄膜状残余奥氏体以及起第二相强化作用的含Nb碳化物有关。

关键词：淬火-配分-回火残余奥氏体强塑积

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基于蒙特卡罗模拟的煤矸山周边农用地土壤重金属健康风险评估

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环境科学 2023年第10期44卷 5666-5678页

作者：马杰佘泽蕾王胜蓝邓力刘萍孙静重庆市生态环境监测中心重庆401147 农村生态与土壤监测技术研究中心重庆401147 重庆文理学院重庆402160

以重庆市煤矸山周边农用地土壤为研究对象,运用内梅罗指数、地累积指数和潜在生态风险指数分析土壤重金属污染水平,并采用蒙特卡罗模拟的健康风险模型,探析研究区土壤重金属对人体的健康风险.结果表明,研究区土壤Cd、Hg、As、Pb、Cr、Cu... 详细信息

以重庆市煤矸山周边农用地土壤为研究对象,运用内梅罗指数、地累积指数和潜在生态风险指数分析土壤重金属污染水平,并采用蒙特卡罗模拟的健康风险模型,探析研究区土壤重金属对人体的健康风险.结果表明,研究区土壤Cd、Hg、As、Pb、Cr、Cu、Ni和Zn含量均值超重庆市土壤背景值,地累积指数(Igeo)表现为:Cd>Hg>Cu>As>Ni>Zn>Cr>Pb;内梅罗指数表明土壤以轻污染(1Cu>Ni>Cr>Zn>As>Pb>Hg;潜在生态风险指数表明土壤以中等生态风险(150≤RIHg>As>Cu>Ni>Pb>Cr>Zn.土壤健康风险表明,儿童和成人非致癌健康风险可忽略,但存在可耐受致癌健康风险,综合致癌风险指数(TCR)均值分别为1.04E-5和3.94E-6,主要致癌因子为As和Cd.敏感性分析表明非致癌健康风险土壤颗粒摄入速率(Ringest)敏感性最高,其次是As含量,致癌健康风险土壤颗粒摄入速率As含量敏感性最高,其次是土壤颗粒摄入速率(Ringest).整体上儿童非致癌和致癌健康风险高于成人.

关键词：煤矸山土壤重金属蒙特卡罗健康风险评估

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Searching for^(76)Ge neutrinoless double beta decay with the CDEX-1B experiment

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Chinese Physics C 2024年第10期48卷 11-22页

作者： Bing-Tao Zhang Jun-Zheng Wang Li-Tao Yang Qian Yue Ke-Jun Kang Yuan-Jing Li Hai-Peng An C.Greeshma Jian-Ping Chang Yun-Huan Chen Jian-Ping Cheng Wen-Han Dai Zhi Deng Chang-Hao Fang Xin-Ping Geng Hui Gong Qiu-Ju Guo Xu-Yuan Guo Li He sheng-Ming He Jin-Wei Hu Han-Xiong Huang Tu-Chen Huang Hai-Tao Jia Xi Jiang S.Karmakar Hao-Bin Li Jian-Min Li Jin Li Qian-Yun Li Ren-Ming-Jie Li Xue-Qian Li Yu-Lan Li Yi-Fan Liang Bin Liao Fong-Kay Lin Shin-Ted Lin Jia-Xuan Liu Shu-Kui Liu Yan-Dong Liu Yu Liu Yuan-Yuan Liu Zhong-Zhi Liu Hao Ma Yu-Cai Mao Qi-Yuan Nie Jin-Hua Ning Hui Pan Ning-Chun Qi Jie Ren Xi-Chao Ruan ze she Manoj Kumar Singh Tian-Xi Sun Chang-Jian Tang Wei-You Tang Yang Tian Guang-Fu Wang Li Wang Qing Wang Yu-Feng Wang Yun-Xiang Wang Henry-Tsz-King Wong Shi-Yong Wu Yu-Cheng Wu Hao-Yang Xing Rui Xu Yin Xu Tao Xue Yu-Lu Yan Nan Yi Chun-Xu Yu Hai-Jun Yu Jian-Feng Yue Ming zeng Zhi zeng Feng-Shou Zhang Lei Zhang Zhen-Hua Zhang Zhen-Yu Zhang Kang-Kang Zhao Ming-Gang Zhao Ji-Fang Zhou Zu-Ying Zhou Jing-Jun Zhou Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084 Department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875 College of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and Technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 Department of Physics Banaras Hindu UniversityVaranasi 221005 Department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1B,1.008 kg)in the China Jinping Underground Laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1989–2089 keV for this work)with a factor of 23.A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1/2)^(0ν)>1.0×10^(23)yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:<3.2–7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

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重庆市煤矸山周边农产品镉健康风险评价及土壤环境基准值推导

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环境科学 2023年第9期44卷 5264-5274页

作者：马杰佘泽蕾王胜蓝邓力孙静刘萍徐敏重庆市生态环境监测中心重庆401147 农村生态与土壤监测技术研究中心重庆401147 重庆文理学院重庆402160

以重庆市煤矸山周边农用地土壤和农产品(玉米和水稻)为研究对象,测定土壤和农产品(玉米和水稻)中Cd含量,评估摄入农产品(玉米和水稻)对人体的潜在健康风险,并基于物种敏感性分布法(SSD)推导土壤环境基准值.结果表明,重庆煤矸山周边旱地... 详细信息

以重庆市煤矸山周边农用地土壤和农产品(玉米和水稻)为研究对象,测定土壤和农产品(玉米和水稻)中Cd含量,评估摄入农产品(玉米和水稻)对人体的潜在健康风险,并基于物种敏感性分布法(SSD)推导土壤环境基准值.结果表明,重庆煤矸山周边旱地土壤Cd含量超风险筛选值的点位占55.8%,水田土壤Cd含量超风险筛选值的点位占31.6%,土壤Cd以较高生态危害和高生态危害为主,分别占47.4%和36.8%.玉米Cd含量超标点位占4.4%,水稻Cd含量均未超标.健康风险评价表明因食用玉米和水稻摄入Cd的非致癌健康风险可忽略,食用玉米摄入Cd存在可耐受致癌健康风险,食用水稻摄入Cd存在不可耐受致癌健康风险,且玉米和水稻Cd含量敏感度最高.SSD推导出煤矸山周边旱地土壤在pH≤5.5、 5.57.5时Cd的环境基准值分别为0.491、 0.382、 0.376和0.588 mg·kg^(-1),水田土壤Cd的环境基准值为0.807 mg·kg^(-1).水田土壤和旱地土壤pH≤7.5时,现行土壤标准(GB 15618-2018)相对偏严;旱地土壤pH>7.5时,现行土壤标准(GB 15618-2018)相对偏宽松.应加强煤矸山周边土壤Cd污染防治和农产品安全利用研究,并对土壤Cd环境基准值进行适当调整.

关键词：煤矸山土壤镉(Cd) 物种敏感性分布(SSD) 玉米水稻

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正弦波形壁面紊流临界分离流动特性的数值研究

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水电能源科学 2024年第5期42卷 84-87页

作者：余泽江黄社华武汉大学水利水电学院湖北武汉430072

波形壁面对波纹管内流动的影响十分显著,其中流动分离对波纹管的流动阻力和传热特性有重要和本质的影响。针对波形比对产生流动分离的影响问题,采用SSTκ-ω紊流模型对不同波形比的正弦型波纹管内流动进行数值模拟,描述了波纹管流的流... 详细信息

波形壁面对波纹管内流动的影响十分显著,其中流动分离对波纹管的流动阻力和传热特性有重要和本质的影响。针对波形比对产生流动分离的影响问题,采用SSTκ-ω紊流模型对不同波形比的正弦型波纹管内流动进行数值模拟,描述了波纹管流的流动特性,分析了波纹管波形比和雷诺数对流动分离的影响。结果表明,在不同波形比的波纹管流中均存在一个流动分离的临界雷诺数,当雷诺数小于临界雷诺数时,波纹管内不会发生流动分离现象;最后拟合得到流动分离临界雷诺数关于波形比的分布公式。研究结果可在一定程度上为波形壁面的工业设计提供参考。

关键词：流动分离波纹管 SSTκ-ω紊流模型数值计算

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粉煤灰基P型沸石吸附水中Cu^(2+)和Cd^(2+)

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中国环境科学 2024年第6期44卷 3132-3141页

作者：孙昊勇汪泽华姚亦扬吴代赦南昌大学资源与环境学院江西南昌330031 萍乡学院材料与化学工程学院江西萍乡337000

以粉煤灰(FA)为原料经水热反应合成了P型沸石(Z-P).采用X射线荧光光谱仪、X射线衍射仪、场发射环境扫描电子显微镜、比表面孔径分析仪、傅里叶变换红外光谱仪和X射线光电子能谱对Z-P进行表征,并研究了其对Cu^(2+)和Cd^(2+)的吸附性能.... 详细信息

以粉煤灰(FA)为原料经水热反应合成了P型沸石(Z-P).采用X射线荧光光谱仪、X射线衍射仪、场发射环境扫描电子显微镜、比表面孔径分析仪、傅里叶变换红外光谱仪和X射线光电子能谱对Z-P进行表征,并研究了其对Cu^(2+)和Cd^(2+)的吸附性能.结果表明,Z-P的BET比表面积和孔隙体积分别为38.46m^(2)/g和0.2180cm^(3)/g,均高于FA的1.273m^(2)/g和0.0120cm^(3)/***、Z-P对Cu^(2+)和Cd^(2+)的吸附更符合拟二级动力学模型和Langmuir等温线模型.Z-P对Cu^(2+)和Cd^(2+)的最大吸附量分别为157.48,131.57mg/g,远高于于FA的30.88,25.47mg/g.Z-P对Cd^(2+)的循环再生吸附效果好,但对Cu^(2+)的循环再生吸附效果较差.离子强度对Z-P吸附Cu^(2+)和Cd^(2+)分别起促进和抑制作用.表明Z-P可以作为有效且廉价的Cu^(2+)、Cd^(2+)吸附剂,为FA的资源化利用和含Cu^(2+)、Cd^(2+)重金属离子废水吸附剂的开发提供了一种方法.

关键词：粉煤灰 P型沸石吸附 Cu^(2+) Cd^(2+)

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