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Systematic review of amyloid-beta clearance proteins from the brain to the periphery:implications for Alzheimer's disease diagnosis and therapeutic targets

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Neural Regeneration Research 2025年第12期20卷 3574-3590页

作者： Letian Huang Mingyue liu ze li Bing li Jiahe Wang Ke Zhang Department of Oncology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Developmental Cell Biology Key Laboratory of Cell BiologyMinistry of Public HealthChina Medical UniversityShenyangLiaoning ProvinceChina Department of Family Medicine Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

Amyloid-beta clearance plays a key role in the pathogenesis of Alzheimer's disease.H oweve r,the variation in functional proteins involved in amyloid-beta clearance and their correlation with amyloid-beta levels remain unclea *** this study,we conducted meta-analyses and a systematic review using studies from the PubMed,Embase,Web of Science,and Cochrane library databases,including journal articles published from inception to J une 30,*** inclusion criteria included studies comparing the levels of functional proteins associated with amyloid-beta clearance in the blood,cere b rospinal fluid,and brain of healthy controls,patients with mild cognitive impairment,and patients with Alzheimer's ***,we analyzed the correlation between these functional proteins and amyloid-beta levels in patients with Alzheimer's *** methodological quality of the studies was assessed via the Newcastle-Ottawa *** to heterogeneity,we utilized either a fixed-effect or random-effect model to assess the 95%confidence interval(CI)of the standard mean difference(SMD)among healthy controls,patients with mild cognitive impairment,and patients with Alzheimer's *** findings revealed significant alterations in the levels of insulin-degrading enzymes,neprilysin,matrix metalloproteinase-9,cathepsin D,receptor for advanced glycation end products,and P-glycoprotein in the brains of patients with Alzheimer's disease,patients with mild cognitive impairment,and healthy *** cerebrospinal fluid,the levels of triggering receptor expressed on myeloid cells 2 and ubiquitin C-terminal hydrolase L1 are altered,whereas the levels of TREM2,CD40,CD40L,CD14,CD22,cathepsin D,cystatin C,andα2 M in peripheral blood ***,TREM2 and cathepsin D showed changes in both brain(SMD=0.31,95%CI:0.16-0.47,P<0.001,I^(2)=78.4%;SMD=1.24,95%CI:0.01-2.48,P=0.048,I^(2)=90.1%)and peripheral blood(SMD=1.01,95%CI:0.35-1.66,P=0.003,I^(2)=96.5%;SMD=7.55,95%CI:3.92-11.18,P<0.001,I^(

关键词： Alzheimer’s disease amyloid-β blood‒brain barrier cerebrospinal fluid diagnostic biomarker meta-analysis mild cognitive impairment peripheral blood systematic review therapeutic targets

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Skeletal muscle-specific Bambi deletion induces hypertrophy and oxidative switching coupling with adipocyte thermogenesis against metabolic disorders

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Science China life Sciences 2025年

作者： Xiangping Yao Xudong Mai Ye Tian Yifan liu Guanghui Jin ze li Shujie Chen Xiaoshuang Dai liujing Huang Zijing Fan Guihua Pan Xiaohan Pan Xiangmin li Michael C Yu Jia Sun Jingxing Ou Hong Chen liwei Xie College of life and Health Sciences Guangdong Industry Polytechnic Department of Endocrinology and Metabolism Zhujiang Hospital Southern Medical University State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application Guangdong Open Laboratory of Applied MicrobiologyInstitute of Microbiology Guangdong Academy of Sciences Institute of Aging Research Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics School of Medical Technology Guangdong Medical University Department of Hepatic Surgery and liver transplantation Center of the Third Affiliated Hospital Organ Transplantation Institute Sun Yat-sen University Organ Transplantation Research Center of Guangdong ProvinceGuangdong province engineering laboratory for transplantation medicine Guangdong Provincial Key Laboratory of Liver Disease Research School of Public Health Xinxiang Medical University BGI Institute of Applied Agriculture BGI-Shenzhen Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Department of Biological Sciences State University of New York at Buffalo Department of Internal Medicine Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan) Guangdong Medical University

Skeletal muscle plays a significant role in both local and systemic energy metabolism. The current investigation aims to explore the role of the Bambi gene in skeletal muscle, focusing on its implications for muscle hypertrophy and systemic metabolism. We hypothesize that skeletal muscle-specific deletion of Bambi induces muscle hypertrophy, improves metabolic performance, and activates thermogenic adipocytes via the reprogramming of progenitor of i WAT, offering potential therapeutic strategies for metabolic syndromes. Leveraging the Chromatin immunoprecipitation(ChIP)-seq and bioinformatics analysis, Bambi gene is shown to be a direct target of HIF2α, which is further confirmed by ChIP-qPCR and promoter luciferase assay. Skeletal muscle-specific Bambi deletion led to significant muscle hypertrophy and improved metabolic parameters, even under high-fat diet conditions. This deletion induced metabolic reprogramming of stromal vascular fractions(SVFs) into thermogenic adipocytes, contributing to systemic metabolic improvements, potentially through the secretory ***, mice with skeletal muscle-specific Bambi deletion demonstrate resistance to high-fat diet-induced metabolic disorders, highlighting a potential therapeutic pathway for metabolic syndrome management. Thus, skeletal muscle-specific deletion of Bambi triggers muscle growth, enhances metabolic performance, and activates thermogenic adipocytes. These findings suggest Bambi as a novel therapeutic target for metabolic syndromes, providing new insights into the interaction between muscle hypertrophy and systemic metabolic improvement. The study underscores the potential of manipulating muscle physiology to regulate whole-body metabolism, offering a novel perspective on treating metabolic disorders.

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多失效模式的时变体系可靠度分析

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山西建筑 2025年第5期51卷 18-24页

作者：李泽北京工业大学城市建设学部北京100124

多失效模式下的系统可靠度计算一直是结构可靠度分析的重点和难点。利用等价极值事件原理,并结合MPHI2方法和Guass-Legendre积分来计算时变体系的失效概率,提出了一种基于高阶矩法的时变系统可靠度分析方法。在此基础上,分别采用串联、... 详细信息

多失效模式下的系统可靠度计算一直是结构可靠度分析的重点和难点。利用等价极值事件原理,并结合MPHI2方法和Guass-Legendre积分来计算时变体系的失效概率,提出了一种基于高阶矩法的时变系统可靠度分析方法。在此基础上,分别采用串联、并联、混联体系三个算例进行方法验证,结果表明:所提方法与MCS计算得到的体系可靠度指标,二者累积失效概率曲线较为吻合,证明了该方法在计算系统时变可靠度的准确性。

关键词：多失效模式等价极值事件时变体系可靠度高阶矩法 MPHI2方法

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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-li Kang Yi Jiang Hua-Wei Zhang Xiao-Mei Song Yu-ze li Wen-li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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RCEP背景下中国生产性服务贸易竞争力分析

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中国商论 2025年第1期34卷 110-114页

作者：李泽哈尔滨师范大学黑龙江哈尔滨150500

当今世界正面临百年未有之大变局,RCEP对于增强各国对多边贸易体系的信心、促进经济复苏、实现互利共赢具有重要意义。本文基于2018-2022年中国与RCEP其他部分成员国的生产性服务贸易进出口数据进行生产性服务贸易竞争力分析。研究表明... 详细信息

当今世界正面临百年未有之大变局,RCEP对于增强各国对多边贸易体系的信心、促进经济复苏、实现互利共赢具有重要意义。本文基于2018-2022年中国与RCEP其他部分成员国的生产性服务贸易进出口数据进行生产性服务贸易竞争力分析。研究表明,相较RCEP其他部分成员国,中国的生产性服务市场最大,出口增速快,生产性服务贸易综合竞争力较强,运输服务业的出口市场占有率高,在电信计算机服务业与商品相关服务业具有竞争优势,在知识产权服务、金融服务和保险服务行业竞争力较弱。基于此,我国应积极推进供给侧改革,优化生产性服务贸易进出口结构,深化与RCEP其他成员国间生产性服务贸易合作,并以数字经济赋能制造业与服务业深度融合,从而稳固并加强中国的生产性服务贸易竞争优势,实现高质量发展的经济新常态,仅供参考。

关键词： RCEP 生产性服务贸易国际竞争力服务业多边贸易

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GIS局部放电光信号检测技术及光学图像诊断方法

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电工技术学报 2025年第1期40卷 253-263页

作者：李泽钱勇刘伟臧奕茗盛戈皞江秀臣上海交通大学电气工程系上海200240 国网上海市电力公司电力科学研究院上海200437 六氟化硫气体特性分析与净化处理技术国网公司重点实验室、国网安徽省电力有限公司电力科学研究院合肥230022

光测法是一种有效的局部放电检测技术。为研究典型局部放电的光学特征和光学图像诊断方法,首先搭建气体绝缘局部放电光电联合检测实验平台,实现光信号和电信号的同步采集;然后分别采用导光柱法和荧光光纤法对SF_(6)气体中典型放电光信... 详细信息

光测法是一种有效的局部放电检测技术。为研究典型局部放电的光学特征和光学图像诊断方法,首先搭建气体绝缘局部放电光电联合检测实验平台,实现光信号和电信号的同步采集;然后分别采用导光柱法和荧光光纤法对SF_(6)气体中典型放电光信号进行实验测量和统计分析,对比研究两种光学检测方法的放电特征参数,包括起始放电电压、相位分布、脉冲幅值和数量等;最后,利用导光柱采集的典型局部放电信号,提出一种基于金字塔梯度直方图(PHOG)特征的局部放电光学图像故障诊断方法。结果显示该模型诊断准确率达90.4%,验证了基于导光柱的局部放电光学检测与诊断的可靠性。

关键词：光学局部放电导光柱金字塔梯度直方图天牛须搜索算法支持向量机

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Asymptotic stability of solitons to 1D nonlinear Schrodinger equations in subcritical case

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Frontiers of Mathematics in China 2020年第5期15卷 923-957页

作者： ze li School of Mathematics and Statistics Ningbo UniversityNingbo 315211China

We prove the asymptotic stability of solitary waves to 1D nonlinear Schrodinger equations in the subcritical case with symmetry and spectrum *** of the main ideas is to use the vector fields method developed by ***,***,and ***[*** ***.,2013,6:957-980]to overcome the weak decay with respect to t of the linearized equation caused by the one dimension setting and the weak nonlinearity caused by the subcritical growth of the nonlinearity ***,we apply the polynomial growth of the high Sobolev norms of solutions to 1D Schrodinger equations obtained by ***[Duke Math.J.,1997,86(1):109-142]to control the high moments of the solutions emerging from the vector fields method.

关键词： Nonlinear Schrodinger equation(NLS) solitons weak nonlinearity asymptotic stability

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结合可视化特征提取的格列齐特缓释片释药行为研究

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药学学报 2025年第1期60卷 225-231页

作者：陈思宇李泽亚黎萍赵欣庆龚涛邓黎张志荣四川大学华西药学院靶向药物与释药系统教育部重点实验室四川成都610041 成都市药品检验研究院四川省药品监督管理局化学药品质量研究及控制重点实验室四川成都610046

口服固体制剂需经过崩解和溶出等过程释放药物才可被机体吸收利用。本文采用可视化技术对国内15家格列齐特缓释片的体外静态释药过程进行连续化表征,并结合传统的体外释放度试验,测定格列齐特缓释片在pH 7.4磷酸盐缓冲液介质中的释放曲... 详细信息

口服固体制剂需经过崩解和溶出等过程释放药物才可被机体吸收利用。本文采用可视化技术对国内15家格列齐特缓释片的体外静态释药过程进行连续化表征,并结合传统的体外释放度试验,测定格列齐特缓释片在pH 7.4磷酸盐缓冲液介质中的释放曲线,采用相似因子(f_(2))法评价释放曲线的相似性并根据多种数学模型对释药曲线进行拟合分析。研究结果表明,14家企业生产的格列齐特缓释片为亲水凝胶骨架片,对比仿制制剂与参比制剂,11家企业的仿制制剂与参比制剂的释放曲线相似(f_(2)>50)。其中与参比制剂可视化特征相似的仿制制剂其释放曲线相似。本研究为格列齐特缓释片的体外一致性评价提供了一种全新的思路和方法,旨在更准确、全面地评估仿制制剂的体外释药行为。

关键词：格列齐特缓释片亲水凝胶骨架片可视化方法体外释放度模型拟合

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Cubic Diophantine Inequalities

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Acta Mathematica Sinica,English Series 2001年第1期17卷 153-160页

作者： Hong ze li Department of Mathematics Shandong University

Let λ1, λ2,...,λ7 be real numbers satisfying λi≥1. In this paper, we prove there are integers x1,...,x7 such that the inequalities |λ1x13+λ2x23+...+λ7x73|i|xi]3 （λ1λ2…λ7）89814) hold simultaneously.

关键词： Diophantine inequality Cubic equation Non-trivial solution

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Genus two correlation functions in CFTs with TT deformation

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Science China(Physics,Mechanics & Astronomy) 2023年第5期66卷 106-119页

作者： Song He Yun-ze li Center for Theoretical Physics and College of Physics Jilin UniversityChangchun 130012China Max Planck Institute for Gravitational Physics(Albert Einstein Institute) Am Mühlenberg 114476 GolmGermany

Since the definition of TT deformation in the curved Riemann surface is obstructive in the literature,we propose a way to do the deformation in the genus two Riemann surfaces by sewing *** construct the correlation functions of conformal field theories(CFTs)on genus two Riemann surfaces with the TT deformation in terms of the perturbative CFT *** to sewing construction to form higher genus Riemann surfaces from lower genus ones and conformal symmetry,we systematically obtain the first-order TT correction to the genus two correlation functions in the TT deformed CFTs,e.g.,partition function and one/higher-point correlation functions.

关键词： conformal field theory gauge/gravity duality TT deformation higher genus correlation function

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