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Frontiers of Structural and Civil Engineering 2023年第5期17卷 704-721页

作者： ze mo Jiangrui QIU Hanbin XU Lanlan XU Yuqing HU Key Laboratory of Concrete and Prestressed Concrete Structures of Ministry of Education School of Civil EngineeringSoutheast UniversityNanjing 211189China College of Civil and Transportation Engineering Hohai UniversityNanjing 210024China School of Civil Engineering Jiangsu Open UniversityNanjing 210036China

In this study,the flexural and longitudinal shear performances of two types of precast lightweight steel–ultra-high performance concrete(UHPC)composite beams are investigated,where a cluster UHPC slab(CUS)and a normal UHPC slab(NUS)are connected to a steel beam using headed studs through discontinuous shear pockets and full-length shear pockets,*** show that the longitudinal shear force of the CUS is greater than that of the NUS,whereas the interfacial slip of the former is *** to its better integrity,the CUS exhibits greater flexural stiffness and a higher ultimate bearing capacity than the *** further optimize the design parameters of the CUS,a parametric study is conducted to investigate their effects on the flexural and longitudinal shear *** square shear pocket is shown to be more applicable for the CUS,as the optimal spacing between two shear pockets is 650 ***,a design method for transverse reinforcement is proposed;the transverse reinforcement is used to withstand the splitting force caused by studs in the shear pocket and prevent the UHPC slab from *** to calculation results,the transverse reinforcement can be canceled when the compressive strength of UHPC is 150 MPa and the volume fraction of steel fiber exceeds 2.0%.

关键词： precast steel-UHPC composite beam flexural performance longitudinal shear performance parametric study transverse reinforcement ratio

Extreme-scale parallel computing:bottlenecks and strategies

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Frontiers of Information Technology & Electronic Engineering 2018年第10期19卷 1251-1260页

作者： ze-yao mo CAEP Software Center for High Performance Numerical Simulation Institute of Applied Physics and Computational Mathematics

Extreme-scale numerical simulations seriously demand extreme parallel computing capabilities. To address the challenges of these capabilities toward exascale, we systematically analyze the major bottlenecks of parallel computing research from three perspectives： computational scale, computing efficiency, and programming productivity. For these bottlenecks, we propose a series of urgent key issues and coping strategies. This study will be useful in synchronizing development between the numerical computing capability and supercomputer peak performance.

关键词： Extreme scale Numerical simulation Parallel computing Supercomputers

Hurdles of CAR-T cell-based cancer immunotherapy directed against solid tumors

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Science China(Life Sciences) 2016年第4期59卷 340-348页

作者： Bing-Lan Zhang Di-Yuan Qin ze-Ming mo Yi Li Wei Wei Yong-Sheng Wang Wei Wang Yu-Quan Wei State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center for Biotherapy Department of Emergency West China Hospital Sichuan University

Recent reports on the impressive efficacy of chimeric antigen receptor(CAR)-modified T cells against hematologic malignancies have inspired oncologists to extend these efforts for the treatment of solid tumors. Clinical trials of CAR-T-based cancer immunotherapy for solid tumors showed that the efficacies are not as remarkable as in the case of hematologic malignancies. There are several challenges that researchers must face when treating solid cancers with CAR-T cells, these include choosing an ideal target, promoting efficient trafficking and infiltration, overcoming the immunosuppressive microenvironment, and avoiding associated toxicity. In this review, we discuss the obstacles imposed by solid tumors on CAR-T cell-based immunotherapy and strategies adopted to improve the therapeutic potential of this approach. Continued investigations are necessary to improve therapeutic outcomes and decrease the adverse effects of CAR-T cell therapy in patients with solid malignancies in the future.

关键词： chimeric antigen receptor T cells solid tumors

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多物理数值模拟中一种有效的并行耦合方法

计算机学报 2007年第9期30卷 1559-1566页

作者：陈军莫则尧北京应用物理与计算数学研究所高性能计算中心与计算物理实验室北京100088

在实现多物理并行数值耦合模拟中,需要处理多个物理过程之间网格、并行区域分解的差异.针对该问题,该文基于三维流体力学与激光传播耦合的并行数值模拟,提出了一种实用的并行耦合方法:引入辅助状态将本地插值与通信相分离;构建并行耦合... 详细信息

在实现多物理并行数值耦合模拟中,需要处理多个物理过程之间网格、并行区域分解的差异.针对该问题,该文基于三维流体力学与激光传播耦合的并行数值模拟,提出了一种实用的并行耦合方法:引入辅助状态将本地插值与通信相分离;构建并行耦合图并定义主导属性,以确定过程间传输的最小数据集合;提供并行数据重分配算法来完成通信.并行数值结果表明:该方法是有效的,在64台处理机上使整体程序获得50.07的加速比.

关键词：并行计算多物理模拟并行数据重分配有向图

Electrosynthesis and Characterization of Aminomethyl Functionalized PEDOT with Electrochromic Property

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Chinese Journal of Polymer Science 2015年第11期33卷 1527-1537页

作者： Hui Sun Bao-yang Lu Du-fen Hu 段学民徐景坤 Shi-jie Zhen Kai-xin Zhang Xiao-fei Zhu Li-qi Dong Dai-ze mo School of Pharmacy Jiangxi Science & Technology Normal University

We herein report the electrosynthesis of an aminomethyl functionalized poly（3,4-ethylenedioxythiophene）（PEDOT） derivative, poly（2＇-aminomethyl-3,4-ethylenedioxythiophene）（PEDOT-Me NH2）, in CH2Cl2-Bu4NPF6（0.1 mol·L^-1） system containing 2% boron trifluoride diethyl etherate（BFEE）. The electrochemical behavior, structure characterization, thermal properties and surface morphology of this novel polymer were systematically investigated by cyclic voltammetry（CV）, Fourier-transform infrared spectroscopy（FTIR）, thermogravimetry（TG） and scanning electron microscopy（SEM）, respectively. Electrochemistry results demonstrated that PEDOT-Me NH2 film displayed good redox properties and high electrochemical stability. Besides, PEDOT-Me NH2 films exhibited the electrochromic nature with obvious color changing from purple in the reduced form to blue upon oxidation. By further investigation, kinetic studies revealed that PEDOT-Me NH2 film had decent contrast ratio（41.8%）, favorable coloration efficiency（152.1 cm^2·C^-1）, low switching voltages and moderate response time（2.4 s）. Satisfactory results implied that the obtained PEDOT-Me NH2 film is a promising optoelectronic material and holds promise for electrochromic devices and display applications.

关键词： Conducting polymers Poly(3 4-ethylenedioxythiophene) derivatives Aminomethyl group Electrochemical polymerization Electrochromics

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一维高效动态负载平衡方法:多层均权法

计算机学报 2001年第2期24卷 183-190页

作者：莫则尧北京应用物理与计算数学研究所高性能计算中心北京100088

提出了一个适合同构和异构并行计算环境的高效一维动态负载平衡方法 :多层均权法 ,并成功解决了多物质非定常流体力学 L agrange法并行数值模拟过程中的动态负载不平衡问题 .文中给出了详细的理论分析以及两台并行机上结合某实际物理问... 详细信息

提出了一个适合同构和异构并行计算环境的高效一维动态负载平衡方法 :多层均权法 ,并成功解决了多物质非定常流体力学 L agrange法并行数值模拟过程中的动态负载不平衡问题 .文中给出了详细的理论分析以及两台并行机上结合某实际物理问题组织的并行数值实验 .

关键词：并行数值模拟动态负载平衡多层均权法非定常流体力学

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实用的并行程序性能分析方法

数值计算与计算机应用 2000年第4期21卷 266-275页

作者：莫则尧北京应用物理与计算数学研究所计算物理实验室北京100088

Firstly, with the discusses of main ingredients to exert the peak float performance for currently high performance mirco-processors in detail, this paper analyzed the principal motivations for the speedup of parallel applied codes under the parallel computers consisted of the these micro-processors. Secondly, this paper presented a suite of performance evaluations rules for parallel codes, which can reveal the overall numerical and parallel performance with respect to the serial codes, pose the performance improving strategies, explain exactly the reasons for super-linear Speedup. The numerical experimential results of two realistic applied codes under two parallel computer are also given in this paper.

关键词：并行程序性能分析方法数值计算

Multiple liver metastases of unknown origin:A case report

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 233-238页

作者： Ying-Jin Wang ze-Chuan Liu Jian Wang Yin-mo Yang Department of Hepatobiliary Pancreatic Surgery Peking University First HospitalBeijing 100034China Department of Interventional and Vascular Surgery Peking University First HospitalBeijing 100034China

BACKGROUND The liver is the most common site of digestive system tumor metastasis,but not all liver metastases can be traced back to the primary *** it is unusual,syphilis can impact the liver,manifesting as syphilitic hepatitis with inflammatory nodules,which might be misdiagnosed as *** SUMMARY This case report involves a 46-year-old female who developed right upper abdominal pain and intermittent low fever that persisted for more than three *** definitive diagnosis of a tumor had been made in the past decades,but signs of multiple liver metastases were recognized after a computed tomo-graphy scan without evidence of primary *** positive serological tests for syphilis and a biopsy of the liver nodules,a diagnosis of hepatic syphilis was made and confirmed with follow-up nodule reduction after anti-syphilis *** Clinicians must be aware of the possibility that syphilis can cause hepatic inflam-matory masses,especially when liver metastasis is suspected without evidence of primary lesions.A definitive diagnosis should be established in conjunction with a review of the patient’s medical history for accurate therapeutic intervention.

关键词： Syphilitic hepatitis Liver nodules Liver metastasis Treponema pallidum Case report

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有向图并行计算中的多目标剖分算法

计算机学报 2005年第12期28卷 2045-2051页

作者：金光浩莫则尧中国工程物理研究院研究生部北京100088 北京应用物理与计算数学研究所高性能计算中心北京100088

在以离散网格为基础的某些数值模拟中,网格间的数据依赖关系可以抽象为有向图.如何剖分这些有向图成多个子图,将各子图对应的数值模拟任务映射到不同的处理机,是该类数值模拟并行计算的基础.剖分算法中,需要综合考虑连通性、并行度、负... 详细信息

在以离散网格为基础的某些数值模拟中,网格间的数据依赖关系可以抽象为有向图.如何剖分这些有向图成多个子图,将各子图对应的数值模拟任务映射到不同的处理机,是该类数值模拟并行计算的基础.剖分算法中,需要综合考虑连通性、并行度、负载平衡、通信开销四个目标.文章在传统有向图剖分算法的基础上,提出了一个权衡这四个目标的有向图多目标剖分区域分解算法.应用于二维非结构网格上的柱对称中子输运并行计算中,通量扫描并行算法在该区域剖分算法上获得的并行效率比原来的无向图区域剖分算法高50%以上.

关键词：有向图图剖分并行计算

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有向图并行计算中一种新的结点调度算法

计算机学报 2009年第11期32卷 2178-2186页

作者：张爱清莫则尧北京应用物理与计算数学研究所高性能计算中心北京100094

在基于有向图的并行计算中,给定图剖分后,如何设计结点调度方案使得并行执行时间最短,是典型的NP完全问题.针对此问题,文中提出一种新的基于顺逆交替迭代技术的启发式调度算法,并给出该算法的并行实现.严格的理论推导证明,新算法在一定... 详细信息

在基于有向图的并行计算中,给定图剖分后,如何设计结点调度方案使得并行执行时间最短,是典型的NP完全问题.针对此问题,文中提出一种新的基于顺逆交替迭代技术的启发式调度算法,并给出该算法的并行实现.严格的理论推导证明,新算法在一定的假设条件下,从任何初始调度方案出发,均可以单调收敛.在数百个处理器上的并行数值实验表明,与常用的调度算法相比,新算法可在付出很少的开销代价下显著提高整体并行效率.

关键词：有向图并行计算结点调度算法顺逆交替迭代技术