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COVID-19 vaccination produces exercise-responsive SARS-CoV-2 specific T-cells regardless of infection history

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Journal of Sport and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.Smith Tiffany M.zúñiga Forrest L.Baker Helena Batatinha Charles R.Pedlar Shane C.Burgess Michael P.Gustafson Emmanuel Katsanis Richard J.Simpson School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and Health University College LondonLondon WC1E 7HUUK Department of Animal and Comparative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona Cancer Center The University of ArizonaTucsonAZ 85719USA Laboratory Medicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of Medicine The University of ArizonaTucsonAZ 85724USA Department of Pathology The University of ArizonaTucsonAZ 85724USA

Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(COVID-19).We sought to determine if COVID-19 vaccination would elicit exercise-responsive SARS-CoV-2 T-cells and transiently alter nAb ***:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a COVID-19 *** major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-CoV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TCR)-βsequencing,and SARS-CoV-2 nAb ***:COVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced mobilization of CD4+and CD8+naive T-cells,as well as CD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-CoV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SARS-CoV-2 specific T-cells to blood in an intensity-dependent *** groups mobilized T-cells that reacted to spike protein;however,only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid *** increased significantly during exercise only in the hybrid immunity ***:These data indicate that acute exercise mobilizes SARS-CoV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral COVID-19 Exercise immunology SARS-CoV-2 T-Cells Vaccine

Comparison of Semi-Parametric Shared Frailty Models for Bees’Survival

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Journal of Data Analysis and Information Processing 2024年第2期12卷 267-288页

作者： Patience Isiaho Daisy Salifu Samuel Mwalili Henri E. z. Tonnang Department of Statistics and Actuarial Sciences Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya Data Management Modelling and Geo-Information Unit International Centre of Insect Physiology and Ecology (ICIPE) Nairobi Kenya

Survival analysis is a fundamental tool in medical science for time-to-event data. However, its application to colony organisms like bees poses challenges due to their social nature. Traditional survival models may not accurately capture the interdependence among individuals within a colony. Frailty models, accounting for shared risks within groups, offer a promising alternative. This study evaluates the performance of semi-parametric shared frailty models (gamma, inverse normal, and positive stable-in comparison to the traditional Cox model using bees’ survival data). We examined the effect of misspecification of the frailty distribution on regression and heterogeneity parameters using simulation and concluded that the heterogeneity parameter was more sensitive to misspecification of the frailty distribution and choice of initial parameters (cluster size and true heterogeneity parameter) compared to the regression parameter. From the data, parameter estimates for covariates were close for the four models but slightly higher for the Cox model. The shared gamma frailty model provided a better fit to the data in comparison with the other models. Therefore, when focusing on regression parameters, the gamma frailty model is recommended. This research underscores the importance of tailored survival methodologies for accurately analyzing time-to-event data in social organisms.

关键词： Correlated Failure Times Frailty Survival Analysis Unobserved Heterogeneity

Rare-Element Pegmatites Rocks Rich and Li of the Aïr Massif of the Tchirozerine: Mineralogy and Chemical Composition Agadez Region-Northem Niger

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Open Journal of Applied Sciences 2024年第1期14卷 171-181页

作者： Ntoumbé Mama Hamza Bassara Amaya Adama Awona Paul zéphyrin Nomenjanahary Limbisoa Department of Mines Geology School of Geology and Mining Engineering University of Ngaoundere Meiganga Cameroon Department of Geology Faculty of Sciences and Technic University of Abdou Moumouni Niger Department of Geomatic and Geology Mapping School of Geology and Mining Engineering University of Ngaoundere Meiganga Cameroon National Advance School of Engineering of Yaounde Yaounde Cameroon School of Thematic Doctoral Faculty of Sciences University of Antsiranana Antsiranana Madagascar

The lithium potential in the Aïr massif is represented by mineral index of spodumene pegmatites and, lepidolite pegmatites. The mineral deposits of lithium occur in cluster or veins that cut the host rock or are located near the contact between the greenstone belt and granitic massif. The evidence of lithium is in the form of clusters or disseminated and stockwerk. Mineralogical characteristics show similarities between the Air Massif pegmatites and indicate the same homogenous source during the magma-generation process. The pegmatite rocks attracted the attention due to their wide exposure and composition, well appearance, and economically hosting of significant rare earth metals such as Sn and W. The mineralogical and petrographical investigations on the eight pegmatites rocks samples observed have a relative similarity, while a little difference in the shapes attributed to the ratio in the pegmatite rocks of the minerals. The occurrence of the kink band indicates the influence of the tectonic processes which affected the Aïr massif after the emplacement of late magmatic or post-magmatic pegmatites by injection into fractured rocks in the upper part of the crust. The Air Massif pegmatite has higher concentrations Li and of all trace elements except Hf and occasionally zr, Ti, Sn and Mg of for the economic exploration.

关键词： Pegmatite Lithium Rare Elements Hydrothermal Processes Aïr Massif

Modelling the Survival of Western Honey Bee Apis mellifera and the African Stingless Bee Meliponula ferruginea Using Semiparametric Marginal Proportional Hazards Mixture Cure Model

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Journal of Data Analysis and Information Processing 2024年第1期12卷 24-39页

Classical survival analysis assumes all subjects will experience the event of interest, but in some cases, a portion of the population may never encounter the event. These survival methods further assume independent survival times, which is not valid for honey bees, which live in nests. The study introduces a semi-parametric marginal proportional hazards mixture cure (PHMC) model with exchangeable correlation structure, using generalized estimating equations for survival data analysis. The model was tested on clustered right-censored bees survival data with a cured fraction, where two bee species were subjected to different entomopathogens to test the effect of the entomopathogens on the survival of the bee species. The Expectation-Solution algorithm is used to estimate the parameters. The study notes a weak positive association between cure statuses (ρ1=0.0007) and survival times for uncured bees (ρ2=0.0890), emphasizing their importance. The odds of being uncured for A. mellifera is higher than the odds for species M. ferruginea. The bee species, A. mellifera are more susceptible to entomopathogens icipe 7, icipe 20, and icipe 69. The Cox-Snell residuals show that the proposed semiparametric PH model generally fits the data well as compared to model that assume independent correlation structure. Thus, the semi parametric marginal proportional hazards mixture cure is parsimonious model for correlated bees survival data.

关键词： Mixture Cure Models Clustered Survival Data Correlation Structure Cox-Snell Residuals EM Algorithm Expectation-Solution Algorithm

High Dimension Multivariate Data Analysis for Small Group Samples of Chemical Volatile Profiles of African Nightshade Species

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Journal of Data Analysis and Information Processing 2024年第2期12卷 210-231页

作者： Lorna Chepkemoi Daisy Salifu Lucy Kananu Murungi Henri E. z. Tonnang International Centre of Insect Physiology and Ecology (ICIPE) Nairobi Kenya Department of Horticulture and Food Security Jomo Kenyatta University of Agriculture and Technology (JKUAT) Nairobi Kenya

Quantitative headspace analysis of volatiles emitted by plants or any other living organisms in chemical ecology studies generates large multidimensional data that require extensive mining and refining to extract useful information. More often the number of variables and the quantified volatile compounds exceed the number of observations or samples and hence many traditional statistical analysis methods become inefficient. Here, we employed machine learning algorithm, random forest (RF) in combination with distance-based procedure, similarity percentage (SIMPER) as preprocessing steps to reduce the data dimensionality in the chemical profiles of volatiles from three African nightshade plant species before subjecting the data to non-metric multidimensional scaling (NMDS). In addition, non-parametric methods namely permutational multivariate analysis of variance (PERMANOVA) and analysis of similarities (ANOSIM) were applied to test hypothesis of differences among the African nightshade species based on the volatiles profiles and ascertain the patterns revealed by NMDS plots. Our results revealed that there were significant differences among the African nightshade species when the data’s dimension was reduced using RF variable importance and SIMPER, as also supported by NMDS plots that showed S. scabrum being separated from S. villosum and S. sarrachoides based on the reduced data variables. The novelty of our work is on the merits of using data reduction techniques to successfully reveal differences in groups which could have otherwise not been the case if the analysis were performed on the entire original data matrix characterized by small samples. The R code used in the analysis has been shared herein for interested researchers to customise it for their own data of similar nature.

关键词： Random Forest Similarity Percentage PERMANOVA ANOSIM Non-Metric Multi-Dimensional Scaling

STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He Y.L.He z.B.He z.X.Heng B.L.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia z.K.Jia H.B.Jiang J.Jiang S.z.Jiang J.B.Jiao z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.Li C.Li D.Y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li Y.Li Y.Y.Li z.J.Li H.Liang J.H.Liang Y.T.Liang G.R.Liao L.z.Liao Y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu z.Q.Liu z.Y.Liu z.W.Liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

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一支莫扎特音乐的奥秘

中学生博览 2024年第22期 16-17页

作者： z姑娘不详

沃尔夫冈·阿玛多伊斯·莫扎特(Wolfgang Amadeus Mozart),幼年时便被誉为“音乐神童”,他一生创作了754部作品,重塑并定义了古典音乐。莫扎特出生于音乐世家,听说,我们普通人听完他的音乐也会变得聪明。那一首首外行人听着也觉得恰到... 详细信息

沃尔夫冈·阿玛多伊斯·莫扎特(Wolfgang Amadeus Mozart),幼年时便被誉为“音乐神童”,他一生创作了754部作品,重塑并定义了古典音乐。莫扎特出生于音乐世家,听说,我们普通人听完他的音乐也会变得聪明。那一首首外行人听着也觉得恰到好处的乐曲里,到底有着怎样的魔力?

关键词：莫扎特音乐音乐神童音乐世家古典音乐沃尔夫冈外行人普通人

Characteristics of the imaging diagnosis of alveolar echinococcosis

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2748-2754页

作者： Sonay Aydin Baris Irgul Kemal Bugra Memis Volkan Kızılgoz Mecit Kantarci Department of Radiology Erzincan Binali Yıldırım UniversityFaculty of MedicineErzincan 24100Türkiye Department of Radiology Erzurum Ataturk UniversityErzurum 25000Türkiye

Alveolar echinococcosis(AE)primarily manifests in the liver and exhibits charac-teristics resembling those of slow-growing malignant *** Echino-coccus multilocularis infection can be *** infiltrating the vascular systems,biliary tracts,and the hilum of the liver,it might lead to various *** to its ability to infiltrate neighbouring tissues or metastasize to distant organs,AE can often be mistaken for *** present a concise overview of the epi-demiological and pathophysiological characteristics of AE,as well as the clinical manifestations of the *** article primarily examines the imaging charac-teristics of AE using various imaging techniques such as ultrasonography,com-puted tomography(CT),magnetic resonance imaging,diffusion-weighted ima-ging,and virtual non-enhanced dual-energy *** additionally examined the contribution of radiography in the diagnosis,treatment,and monitoring of the condition.

关键词： Alveolar echinococcosis Echinococcus multilocularis Virtual non-enhanced dual-energy computed tomography Percutaneous cyst drainage Cyst infection Interven-tional radiology

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是骤雨不是星河

中学生博览 2024年第7期 52-53页

作者： z姑娘不详

我承认,我一直是被家庭保护的女孩子,但我也有自己走入社会的方式,没必要跟不属于自己的事物死磕。1/和朋友们聊起课余兼职经历,大家都有这样的感触:是不是每个人都有一段在餐厅当服务员的日子?虽然我会去,纯属意外。我们寝室是四人间,... 详细信息

我承认,我一直是被家庭保护的女孩子,但我也有自己走入社会的方式,没必要跟不属于自己的事物死磕。1/和朋友们聊起课余兼职经历,大家都有这样的感触:是不是每个人都有一段在餐厅当服务员的日子?虽然我会去,纯属意外。我们寝室是四人间,从来只有“一台戏”的秘诀,在于大部分时间我们是两两同行。我和上铺花花一个写杂志一个写网文,每天夜里抱着电脑“噼里啪啦”,这时阿薄就戴上耳塞,用呼噜声配合我们“演奏交响乐”。

关键词：呼噜声课余兼职经历服务员交响乐