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藏药三果汤散对高原红细胞增多症模型大鼠氧化应激损伤的作用机制研究

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中华中医药学刊 2018年第10期36卷 2401-2406,I0018页

作者：罗强杨文娟张艺更藏加李宁聂佳成都中医药大学民族医药学院

目的：观察藏药三果汤散对高原红细胞增多症模型大鼠抗氧化等指标表达的影响,探究三果汤散干预高原红细胞增多症模型大鼠的氧化应激作用机制。方法：雄性SD大鼠48只,每组8只,随机分为平原组,高原模型组,阳性对照组,三果汤高、中、低剂... 详细信息

目的：观察藏药三果汤散对高原红细胞增多症模型大鼠抗氧化等指标表达的影响,探究三果汤散干预高原红细胞增多症模型大鼠的氧化应激作用机制。方法：雄性SD大鼠48只,每组8只,随机分为平原组,高原模型组,阳性对照组,三果汤高、中、低剂量组。将模型组和给药组置于5000米高原环境模拟舱内,40 d后测定大鼠血常规、血流变、SOD、MDA、EPO、ROS、HIF-1α等指标,探究三果汤散干预高原红细胞增多症大鼠氧化应激的作用机制。结果：与高原模型组相比,三果汤高剂量组和中剂量组的RBC、HGB和HCT显著降低,血液黏稠度也有显著改善,三果汤散高剂量组大鼠脑组织HIF-1α蛋白含量降低。与平原对照组相比,高原模型组大鼠血清SOD活性显著降低,MDA含量显著升高,脑组织HIF-1α蛋白含量显著升高,EPO浓度显著升高,EPO mRNA表达明显升高（P 〈0. 05）。结论：三果汤散具有明显的抗缺氧作用,能降低耗氧量、清除氧自由基、降低脂质过氧化反应、抑制缺氧造成的血流变改变、改善机体的能量代谢,这可能是其治疗高原红细胞增多症模型大鼠氧化应激损伤的作用机制。

关键词：藏药三果汤散高原红细胞增多症抗缺氧作用机制

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藏医药经典著作《晶珠本草》的学术特色探析

世界科学技术-中医药现代化 2014年第1期16卷 112-115页

作者：俞佳张艺聂佳张丹降拥四郎更藏加成都中医药大学民族医药学院成都 611137 青海大学藏医学院西宁 810001

藏医药古籍文献是藏医临床与学术研究的重要基础,在藏医药特色与优势的继承和发展中发挥着不可估量的作用。《晶珠本草》是藏药学方面迄今为止最重要的经典著作,其内容详实、藏医药特色浓厚、高原特点突出,临床实用性强。本文从药物分... 详细信息

藏医药古籍文献是藏医临床与学术研究的重要基础,在藏医药特色与优势的继承和发展中发挥着不可估量的作用。《晶珠本草》是藏药学方面迄今为止最重要的经典著作,其内容详实、藏医药特色浓厚、高原特点突出,临床实用性强。本文从药物分类、加工炮制方法、文献价值,以及藏药与中药的药性理论比较等方面,对《晶珠本草》的学术价值和学术特色进行分析,为推动藏医药古籍文献发掘整理,更好地发挥对藏医药科研、医疗及应用开发的参考借鉴作用。

关键词：《晶珠本草》藏医药经典著作学术特色

Quantum purification for coherent states and its application

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 37-50页

作者： Lei Wang geng Chai Zhengwen Cao Xinlei Chen Kexin Liang Jinye Peng Laboratory of Quantum Information and Technology School of Information Science and TechnologyNorthwest UniversityXi'an 710127China

The inevitable decoherence of quantum states leaks information to the environments and reduces the practical performance of quantum-information *** purification of coherent states provides an easy-to-implement approach to decouple from the environments utilizing the correlation of several ***,repeated transmission of quantum states reduces the randomness of the collectivity and generates security *** this paper,we propose a modified purification scheme and apply it to the continuous-variable quantum secure direct communication(CV-QSDC)protocol based on coherent *** designed purification scheme improves the security capacity of communication systems through the effective suppression of excess noises,accompanied by the maintenance of source-side *** conduct a proof-of-principle experiment of the purification scheme in the CV-QSDC *** appearance of transmitted quantum states in phase space and two-dimensional Gaussian distributions have high goodness of fit at two *** security capability of this system is improved by 43.6%as the excess noise is reduced to 0.58 times the original noise by purification.

关键词： quantum purification coherent state quantum secure direct communication

黄水病经典方通过“代谢-免疫-中枢神经系统”网络改善阿尔茨海默病认知障碍的研究进展

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中草药 2024年第19期55卷 6789-6796页

作者：何黎黎更藏加田生乾胡明慧徐亚韩宇欣顾健西南民族大学药学院

由于人口老年化的进展，阿尔茨海默病（Alzheimer's disease,AD）的发病率呈上升趋势，认知障碍是其主要症状，但其发病机制尚不明确。最新的研究证实，AD的发病与代谢紊乱及免疫应激有密切联系，是一种涉及“代谢-免疫-中枢神经系统”... 详细信息

由于人口老年化的进展，阿尔茨海默病（Alzheimer's disease,AD）的发病率呈上升趋势，认知障碍是其主要症状，但其发病机制尚不明确。最新的研究证实，AD的发病与代谢紊乱及免疫应激有密切联系，是一种涉及“代谢-免疫-中枢神经系统”网络的全身系统性疾病。骨髓来源的先天免疫细胞巨噬细胞处于代谢-免疫-中枢神经系统的交叉点。藏医“整体观”对于全身系统性疾病的多靶点调控治疗更具优势。藏医理论中，黄水病的产生与饮食摄入及代谢紊乱关系密切，这与现代医学中糖尿病-免疫系统疾病相关联的发病机制吻合，因此黄水病经典治疗方在AD所致的认知障碍治疗中有潜在的应用价值。通过对AD“代谢-免疫-中枢神经系统”发病机制、藏医中黄水病理论的关系，及经典黄水病治疗方在临床实践及实验研究中对认知障碍、神经系统保护方面的疗效及机制研究进行综述，为该类药物防治认知障碍的特色作用机制阐释与新药二次开发提供理论参考与科学依据。

关键词：认知障碍免疫代谢中枢神经系统藏医药黄水病阿尔茨海默病巨噬细胞五根散如意珍宝丸

基于藏医宏观信息的高原红细胞增多症藏医证型分类的研究思路初探

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辽宁中医杂志 2017年第9期44卷 1801-1805页

作者：更藏加尕藏措吉先才让万玛太张艺成都中医药大学四川成都611137 青海大学藏医学院青海西宁810016 青海省藏医院青海西宁810007

高原红细胞增多症(HAPC)是由于高原低氧引起的红细胞过度代偿性增生的慢性高原病,藏医称为"查培病"。该病严重影响到高原居住人群的健康。在前期国家自然科学基金(30973957)研究的基础上,证实藏医临床防治HAPC确有疗效,发现HAPC藏医治... 详细信息

高原红细胞增多症(HAPC)是由于高原低氧引起的红细胞过度代偿性增生的慢性高原病,藏医称为"查培病"。该病严重影响到高原居住人群的健康。在前期国家自然科学基金(30973957)研究的基础上,证实藏医临床防治HAPC确有疗效,发现HAPC藏医治疗前后代谢谱有差异,但HAPC不同藏医证型的生物学基础尚不明确,文章提出"依据藏医诊断-生化检测-生物标志等多维信息的相关性分析,能揭示HAPC藏医隆型、血型的生物学基础"的假说,拟结合HAPC国际诊断标准,用藏医三诊(望、触、问)方法,收集100例青藏高原地区HAPC有效病例的头痛、头晕等临床体征,全自动生化分析红细胞数、血红蛋白、红细胞压积等指标,LC-MS等代谢组学方法分析血、尿样本,结合主成分分析等数学处理方法,发现HAPC藏医证型相关的特征性生物标志,以探索HAPC藏医隆型、血型的证型生物学的科学内涵,为其临床辨证客观化提供科学依据。

关键词：宏观信息 HAPC 证型分类研究思路

Explaining the better generalization of label distribution learning for classification

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Science China(Information Sciences) 2025年

作者： Jing WANG Xin geng School of Computer Science and Engineering Southeast University Key Laboratory of New Generation Artificial Intelligence Technology and Its Interdisciplinary Applications(Southeast University) Ministry of Education

Label distribution learning (LDL) has shown advantages over traditional single-label learning (SLL) in many realworld applications, but its superiority has not been theoretically understood. In this paper, we attempt to explain why LDL generalizes better than SLL. Label distribution has rich supervision information such that an LDL method can still choose the sub-optimal label from label distribution even if it neglects the optimal one. In comparison, an SLL method has no information to choose from when it fails to predict the optimal label. The better generalization of LDL can be credited to the rich information of label distribution. We further establish the label distribution margin theory to prove this explanation; inspired by the theory,we put forward a novel LDL approach called LDL-LDML. In the experiments, the LDL baselines outperform the SLL ones, and LDL-LDML achieves competitive performance against existing LDL methods, which support our explanation and theories in this paper.

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Edge-aware Feature Aggregation Network for Polyp Segmentation

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Machine Intelligence Research 2025年第1期22卷 101-116页

作者： Tao Zhou Yizhe Zhang geng Chen Yi Zhou Ye Wu Deng-Ping Fan PCA Lab Key Laboratory of Intelligent Perception and Systems for High-dimensional Information of Ministry of EducationSchool of Computer Science and EngineeringNanjing University of Science and TechnologyNanjing210094China School of Computer Science and Engineering Northwestern Polytechnical University(NPU)Xi’an710129China School of Computer Science and Engineering Southeast UniversityNanjing211189China Computer Vision Lab ETH ZürichZürich8092Switzerland

Precise polyp segmentation is vital for the early diagnosis and prevention of colorectal cancer(CRC)in clinical ***,due to scale variation and blurry polyp boundaries,it is still a challenging task to achieve satisfactory segmentation performance with different scales and *** this study,we present a novel edge-aware feature aggregation network(EFA-Net)for polyp segmentation,which can fully make use of cross-level and multi-scale features to enhance the performance of polyp ***,we first present an edge-aware guidance module(EGM)to combine the low-level features with the high-level features to learn an edge-enhanced feature,which is incorporated into each decoder unit using a layer-by-layer ***,a scale-aware convolution module(SCM)is proposed to learn scale-aware features by using dilated convolutions with different ratios,in order to effectively deal with scale ***,a cross-level fusion module(CFM)is proposed to effectively integrate the cross-level features,which can exploit the local and global contextual ***,the outputs of CFMs are adaptively weighted by using the learned edge-aware feature,which are then used to produce multiple side-out segmentation *** results on five widely adopted colonoscopy datasets show that our EFA-Net outperforms state-of-the-art polyp segmentation methods in terms of generalization and *** implementation code and segmentation maps will be publicly at https://***/taozh2017/EFANet.

关键词： Colorectal cancer polyp segmentation edge-aware guidance module scale-aware convolution module cross-level fusion module

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均匀设计法优化藏药多血康提取工艺

中国药房 2017年第10期28卷 1361-1364页

作者：吕秀梅王静赵可惠张静赖先荣范刚张艺更藏加成都中医药大学民族医药学院成都611137

目的:优化多血康的提取工艺。方法:以红景天苷、没食子酸含量及出膏率的综合评分为指标,采用U6(63)均匀设计法优化多血康提取工艺中的料液比、乙醇体积分数及提取时间,再优化提取次数,并进行验证试验。结果:最优提取工艺为采用50%乙醇,... 详细信息

目的:优化多血康的提取工艺。方法:以红景天苷、没食子酸含量及出膏率的综合评分为指标,采用U6(63)均匀设计法优化多血康提取工艺中的料液比、乙醇体积分数及提取时间,再优化提取次数,并进行验证试验。结果:最优提取工艺为采用50%乙醇,料液比1∶14,浸泡1.5 h,回流提取1 h并重复2次;3次试验平均出膏率为50.18%,红景天苷和没食子酸含量分别为1.82、16.54 mg/g(RSD≤0.84%,n=3)。结论:优化的多血康提取工艺合理、简单、可行。

关键词：藏药多血康均匀设计法红景天苷没食子酸含量提取工艺优化

Impact of aerosol-radiation interaction and heterogeneous chemistry on the winter decreasing PM_(2.5)and increasing O_(3)in Eastern China 2014–2020

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Journal of Environmental Sciences 2025年第5期151卷 469-483页

作者： Yasong Li Tijian Wang Qin’geng Wang Mengmeng Li Yawei Qu Hao Wu Min Xie School of the Environment Nanjing UniversityNanjing 210023China School of Atmospheric Sciences Nanjing UniversityNanjing 210023China College of Intelligent Science and Control Engineering Jinling Institute of TechnologyNanjing 211169China Key Laboratory of Transportation Meteorology of China Meteorological Administration Nanjing Joint Institute for Atmospheric SciencesNanjing 210041China School of Environment Nanjing Normal UniversityNanjing 210023China

In the context of the prevalent winter air quality issues in China marked by declining PM_(2.5)and rising O_(3),this study employed amodified WRF-Chem model to examine the aerosol radiation interaction(ARI),heterogeneous chemistry(AHC),and their combined impact(ALL)on the variations in O_(3)and PM_(2.5)during the 2014–2020 in eastern *** analysis confirmed that ARI curtailed O_(3)while elevating PM_(2.5).AHC reduced O_(3)through heterogeneous absorption of NOx and hydroxideswhile notably fostering fine-grained sulfate,resulting in a PM_(2.5)*** reductions mitigated the inhibitory impact of ARI on meteorological fields and photolysis *** reduction individually without aerosol feedback led to a 5.43 ppb O_(3)increase and a 22.89μg/m^(3)PM_(2.5)*** and AHC amplified the emission-reduction-induced(ERI)O_(3)rise by 1.83 and 0.31 ppb,*** response of ARI to emission diminution brought about a modest PM_(2.5)increase of 0.31μg/m^(3).Conversely,AHC,acting as the primary contributor,caused a noteworthy PM_(2.5)decrease of 4.60μg/m^(3).As efforts concentrate on reducing PM_(2.5),the promotion of ARI on PM_(2.5)counterbalanced the efficacy of emission reduction and the AHC-induced strengthening of PM_(2.5)*** ALL magnified the ERI O_(3)increase by 38.9%and PM_(2.5)decrease by 18.7%.Sensitivity experiments with different degrees of emission reduction demonstrated a consistent linear relationship between the ALL-induced enhancement of O_(3)increase and PM_(2.5)decrease to the ERI PM_(2.5)*** investigation revealed the complex connection between emissions and aerosol feedback in influencing air quality.

关键词： Aerosol-radiation interaction Heterogeneous chemistry O_(3)increase PM_(2.5)decrease Emission reduction