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复合改性大豆分离蛋白乳液冻融稳定性研究

粮食与油脂 2024年第6期37卷 49-54页

作者：李少康武琼琼袁雪春藏小丹牡丹江医学院黑龙江牡丹江157000

以大豆分离蛋白为原料,利用超声波协同木瓜蛋白酶对大豆分离蛋白进行改性,并利用高速均质机将改性后的产物制备成O/W型乳状液。以乳化活性指数为指标,在单因素试验基础上通过正交试验确定最佳改性条件。结果表明:最佳改性条件为料液比为... 详细信息

以大豆分离蛋白为原料,利用超声波协同木瓜蛋白酶对大豆分离蛋白进行改性,并利用高速均质机将改性后的产物制备成O/W型乳状液。以乳化活性指数为指标,在单因素试验基础上通过正交试验确定最佳改性条件。结果表明:最佳改性条件为料液比为7∶100(g/mL)、酶添加量6000 U/g(以大豆分离蛋白质量计)、水解时间1.5 h。在此条件下得到的改性大豆分离蛋白与木瓜蛋白酶改性大豆分离蛋白相比,乳化性提高了4.567%,经过3次冻融循环后,其乳状液分层系数和出油率明显下降。

关键词：大豆分离蛋白木瓜蛋白酶超声波技术乳化性冻融稳定性

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槲皮素-山奈酚共递送体系的构建及表征

粮食与油脂 2024年第10期37卷 113-118页

作者：武琼琼梁雯菁李少康王宇浩藏小丹牡丹江医学院公共卫生学院黑龙江牡丹江157011

采用反溶剂沉淀法制备了可溶性大豆多糖(SSPS)稳定的玉米醇溶蛋白(zein)纳米粒子,以此作为稳定的递送体系用于递送活性物质槲皮素(QCT)和山奈酚(KAE)。结果表明:当zein与SSPS质量比为1∶1时,在pH 4时制备了粒径最小(195.7 nm)的zein/SSP... 详细信息

采用反溶剂沉淀法制备了可溶性大豆多糖(SSPS)稳定的玉米醇溶蛋白(zein)纳米粒子,以此作为稳定的递送体系用于递送活性物质槲皮素(QCT)和山奈酚(KAE)。结果表明:当zein与SSPS质量比为1∶1时,在pH 4时制备了粒径最小(195.7 nm)的zein/SSPS纳米颗粒。同时验证了zein/SSPS纳米颗粒在pH 1~5和40℃下加热稳定性较好。在壁芯质量比60∶1时,QCT和KAE的包埋率达到最大,分别为50%和76%。抗氧化试验表明,负载活性物质的纳米颗粒对DPPH和ABTS自由基的清除率分别为86.35%和81.95%。zein/SSPS纳米粒子可作为递送载体应用于食品领域。

关键词：槲皮素山奈酚玉米醇溶蛋白共递送抗氧化活性

The F5 gene predicts poor prognosis of patients with gastric cancer by promoting cell migration identified using a weighted gene co-expression network analysis

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BIOCELL 2021年第4期45卷 911-921页

作者： MENGYI TANG BOWEN YANG CHUANG ZHANG CHAOXU ZHANG dan zang LIBAO GONG YUNPENG LIU ZHI LI XIUJUAN QU Department of Medical Oncology The First Hospital of China Medical UniversityShenyangChina Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province The First Hospital of China Medical UniversityShenyangChina Liaoning Province Clinical Research Center for Cancer ShenyangChina Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors Ministry of EducationShenyangChina

Distal gastric cancer(DGC)is a subgroup of gastric cancer(GC),which has different molecular characteristics from proximal gastric cancer(PGC).These differences result in different overall survival(OS)rates;however,data pertaining to the survival rate in PGC or DGC are *** suggests that the location of GC is not the unique cause of the different survival rates,while the molecular characteristics might be more important factors determining the prognosis of ***,the aim of this study was to discover key prognostic factors in DGC using bioinformatic methods and to explore the potential molecular *** Cancer Genome Atlas(TCGA)public database was employed to screen data relating to DGC,and we conducted a weighted gene co-expression network analysis(WGCNA)on DGC patient samples to establish co-expression ***-weight genes(hub genes)in a dominant color module were *** vitro experiments and gene set enrichment analyses(GSEA)were carried out to elucidate the potential molecular *** this study,139 DGC samples were enrolled to perform a co-expression *** to the correlation between gene modules and clinical characteristics,the royal blue module related to stage M of DGC was screened,and a survival analysis was conducted to show that highcoagulation-factor V(F5)expression was related to the short OS of patients with *** vitro experiments confirmed that F5 could promote the migration of GC *** suggested that F5 might have affected the prognosis of GC by modulating the activities of the Wnt and/or the TGF-βsignaling *** results indicated that high F5 expression predicts poor prognosis of patients with DGC,and it functions probably by promoting cell migration through the Wnt and/or the TGF-βsignaling pathways.

关键词： Distal gastric cancer WGCNA F5 Cell migration Poor prognosis

Penumbra-targeted CircOGDH siRNA-loaded nanoparticles alleviate neuronal apoptosis in focal brain ischaemia

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Stroke & Vascular Neurology 2024年第2期9卷 134-144,I0396-I0413页

作者： Yanfang Liu Tianyuan Zhang Xing Zou Zhongwen Yuan Yufeng Li Jiankun zang Niu He Lizhen He Anding Xu dan Lu Department of Neurology and Stroke Center Jinan University First Affiliated HospitalGuangzhouGuangdongChina Department of Clinical Neuroscience Institute The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdongChina Key Lab of Guangzhou Basic and Translational Research of Pan-vascular Diseases The First Affiliated Hospital of Jinan UniversityGuangzhouChina

Background Nanoparticles(NPs)are a class of substances that can be loaded with therapeutic agents delivered to specific *** our earlier research,we identified a neuron-derived circular RNA(circRNA),circular oxoglutarate dehydrogenase(CircOGDH),as a promising therapeutic target for acute ischaemic *** study dedicated to explore a prospective preliminary strategy of CircOGDH-based NP delivered to the ischaemic penumbra region in middle cerebral artery occlusion/reperfusion(MCAO/R)*** Immunofluorescence in primary cortex neurons and in vivo fluorescence imaging revealed endocytosis of Poly(lactide-co-glycolide)(PLGA)poly amidoamine(PAMAM)@CircOGDH small interfering RNA(siRNA)*** blotting analysis and CCK8 assay were performed to evaluate the apoptotic level in ischaemic neurons treated with PLGA–PAMAM@CircOGDH siRNA *** reverse transcription PCR experiments,mice behaviour test,T2 MRI analysis,Nissl and TdT-mediated dUTP nick end labeling(TUNEL)co-staining were performed to evaluate the apoptosis level of ischaemic penumbra neurons in MCAO/R *** evaluation of NPs in MCAO/R mice was detected by blood routine examination,liver and kidney function examination and HE *** PLGA–PAMAM@CircOGDH siRNA NPs were successfully *** of PLGA–PAMAM@CircOGDH siRNA NPs in ischaemic neurons alleviated neuronal apoptotic level in vitro and in ***,mice behaviour test showed that the neurological defects of MCAO/R mice were significantly alleviated after the tail injection of PLGA–PAMAM@CircOGDH siRNA NPs,and no toxic effects were *** In conclusion,our results suggest that PLGA–PAMAM@CircOGDH siRNA NPs can be delivered to the ischaemic penumbra region and alleviate neuron apoptosis in MCAO/R mice and in ischaemic neurons;therefore,our study provides a desirable approach for using circRNA-based NPs for the treatment of ischaemic stroke.

关键词： OGD routine loaded

Robust Transfer of Optical Frequency over 500km Fiber Link with Instability of 10^(−21)

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Chinese Physics Letters 2024年第8期41卷 22-27页

作者： Qian Zhou Xiang Zhang Qi zang Mengfan Wu dan Wang Jie Liu Ruifang Dong Tao Liu Shougang Zhang National Time Service Center Chinese Academy of SciencesXi’an 710600China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Time and Frequency Standards Chinese Academy of SciencesXi’an 710600China Hefei National Laboratory Hefei 230088China

Our primary objective is to mitigate the adverse effects of temperature fluctuations on the optical frequency transmission system by reducing the length of the *** optimization,the phase-temperature coefficient of the optical system is reduced to approximately 1.35 fs/*** applying a sophisticated temperature control to the remained“out-of-loop”optics fiber,the noise floor of the system has been effectively lowered to 10−21 *** on this performance-enhanced transfer system,we demonstrate coherent transmission of optical frequency through 500-km spooled fiber *** being actively compensated,the transfer instability of 4.5×10^(−16) at the averaging time of 1 s and 5.6×10^(−21) at 10000 s is *** frequency uncertainty of received light at remote site relative to that of the origin light at local site is achieved to be 1.15×10^(−19).This enhanced system configuration is particularly well suited for future long-distance frequency transmission and comparison of the most advanced optical clock signals.

关键词： fiber interferometer system

LPPR4 promotes peritoneal metastasis via SP1/integrinα/FAK signaling in gastric cancer

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LPPR4 promotes peritoneal metastasis via SP1/integrinα/FAK ...

城市土地资源生产率提高的实现路径及上海实证

2019年中国肿瘤标志物学术大会暨第十三届肿瘤标志物青年科学家论坛

作者： zang,dan Zhang,Chuang Li,Ce Fan,Yibo Liu,Yunpeng Qu,Xiujuan the First Hospital of China Medical University

Purpose:Gastric cancer(GC) is one of the most common malignant tumors with a high incidence and mortality *** peritoneum is a primary metastatic organ of advanced gastric cancer,often leading to massive ascites or intestinal ***,few reliable diagnostic or prognostic biomarkers can be used for peritoneal metastasis of GC in clinical *** this study,

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同济大学学报（社会科学版） 2010年第4期21卷 118-124页

作者：臧漫丹许琨同济大学经济与管理学院上海200092

针对城市快速发展背后隐藏的忽视生态安全和城市低密度扩张的问题,本文以提高城市竞争力为目标,提出在满足城市生态规模极限的前提下,通过提高城市土地资源生产率,实现城市的可持续发展。通过基于循环经济理论的城市土地循环流程的分析... 详细信息

针对城市快速发展背后隐藏的忽视生态安全和城市低密度扩张的问题,本文以提高城市竞争力为目标,提出在满足城市生态规模极限的前提下,通过提高城市土地资源生产率,实现城市的可持续发展。通过基于循环经济理论的城市土地循环流程的分析,提出提高城市建设用地使用和流转效率来提高城市土地资源生产率的思路和方法。最后实证分析了上海市案例。

关键词：土地资源生产率城市竞争力循环经济上海

Non-Deterministic Liveness-Enforcing Supervisor Tolerant to Sensor-Reading Modification Attacks

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 240-248页

作者： dan You Shouguang Wang IEEE the School of Information and Electronic Engineering Sussex Artificial Intelligence InstituteZhejiang Gongshang UniversityHangzhou 310018China

In this paper, we study the supervisory control problem of discrete event systems assuming that cyber-attacks might occur. In particular, we focus on the problem of liveness enforcement and consider a sensor-reading modification attack(SM-attack) that may disguise the occurrence of an event as that of another event by intruding sensor communication channels. To solve the problem, we introduce non-deterministic supervisors in the paper, which associate to every observed sequence a set of possible control actions offline and choose a control action from the set randomly online to control the system. Specifically, given a bounded Petri net(PN) as the reference formalism and an SMattack, an algorithm that synthesizes a liveness-enforcing nondeterministic supervisor tolerant to the SM-attack is proposed for the first time.

关键词： Cyber-attacks cyber-physical system(CPS) liveness non-deterministic supervisors Petri net(PN)

On the Factors Influencing the High Stretch-Flangeability of a Low-Density 1180 MPa Fe-Mn-Al-C-Nbδ-QP Steel

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Acta Metallurgica Sinica(English Letters) 2024年第8期37卷 1291-1300页

作者： dan‑dan Cui Peng Chen Peng‑Fei Wang Xiao‑Wu Li Department of Materials Physics and Chemistry School of Materials Science and Engineeringand Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education)Northeastern UniversityShenyang 110819China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China

Low-densityδ-quenching and partitioning(δ-QP)steels with excellent strength and ductility have been recently ***,there are still rare reports on the formability of δ-QP steels,which are critical for satisfying the manufacture of structural parts during the application in automotive *** the present work,an 1180 MPa Fe–Mn–Al–C–Nbδ-QP steel with a high ductility was adopted for the stretch–flangeability ***δ-QP steel was developed by separated quenching and partitioning processes.A good hole expansion ratio(HER)of 34.9±0.9%was obtained in the quenched steel,but it has been further increased to 52.2%by the tempering *** improved stretch–flangeability was attributed to the enhanced austenite stability and deformation *** the one hand,the stability of austenite was increased by carbon partitioning during tempering,which reduced crack possibility via the suppression of the fresh martensite *** the other hand,the tempering treatment released the internal stress caused by martensitic transformation and reduced the difference in strength among different phases,resulting in an increase in the resistance to crack initiation and propagation.

关键词： Hole expansion ratio Low-densityδ-quenching and partitioning(δ-QP)steel Stretch-flangeability Austenite stability Deformation uniformity