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Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma yang Qu Jiaxin Ren Yingying Sun Zhen-Ni Guo Yi yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

德钦—中甸—大具断裂晚第四纪活动的地质与地貌表现

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地震研究 2014年第1期37卷 46-52页

作者：常祖峰张艳凤李鉴林臧阳云南省地震局云南昆明650224 云南大学云南昆明650091

根据野外地质、地貌调查结果,重点论述了德钦-中旬-大具断裂的几何展布、运动性质和最新活动时代.该断裂多处断错了晚更新世及全新世地层,具明显的右旋走滑兼正断性质,最新活动时代为晚更新世至全新世,水平滑动速率为1.7 ～2.0 mm/a,垂... 详细信息

根据野外地质、地貌调查结果,重点论述了德钦-中旬-大具断裂的几何展布、运动性质和最新活动时代.该断裂多处断错了晚更新世及全新世地层,具明显的右旋走滑兼正断性质,最新活动时代为晚更新世至全新世,水平滑动速率为1.7 ～2.0 mm/a,垂直滑动速率为0.6～0.7 mm/a.该断裂是川滇菱形块体西北边缘的一条重要的NW向走滑断裂,它与金沙江断裂带一起,共同构成了川滇菱形块体西北边界.

关键词：活动断裂晚第四纪滑动速率德钦—中甸—大具断裂

多西他赛联合卡铂治疗老年晚期非小细胞肺癌临床观察

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中国医药导报 2009年第6期6卷 42-43页

作者：邓俭臧笑阳沈阳市肿瘤医院辽宁沈阳110023

目的:观察多西他赛联合卡铂对老年晚期非小细胞肺癌治疗的疗效和毒性反应。方法:24例老年晚期非小细胞肺癌初治患者予以国产多西他赛、卡铂,静脉滴注。结果:24例患者均可评价疗效,完全缓解(CR)0例,部分缓解(PR)7例,微效(MR)4例,疾病稳定... 详细信息

目的:观察多西他赛联合卡铂对老年晚期非小细胞肺癌治疗的疗效和毒性反应。方法:24例老年晚期非小细胞肺癌初治患者予以国产多西他赛、卡铂,静脉滴注。结果:24例患者均可评价疗效,完全缓解(CR)0例,部分缓解(PR)7例,微效(MR)4例,疾病稳定(SD)9例,疾病进展(PD)4例,总有效率(RR)为46%,一年生存率是39%。主要不良反应是白细胞下降、消化道反应、乏力、脱发。结论:多西他赛联合卡铂是一种对老年晚期非小细胞肺癌有效的治疗方法,毒性反应轻,临床使用安全。

关键词：非小细胞肺癌药物疗法多西他赛卡铂

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基于EMTP的同塔并架多回线路防雷计算

电网与清洁能源 2010年第12期26卷 12-16页

作者：舒海莲杨秀臧海洋上海电力学院电力与自动化工程学院上海200090

通过对110 kV和220 kV单条输电线和同杆并架双回输电线路的防雷性能的仿真和计算,分析研究在多种雷击方式下输电线路的耐雷水平。采用国际通用的电力系统电磁暂态分析的仿真软件Elector-Magnetic Transient Program(EMTP),对雷电侵入波... 详细信息

通过对110 kV和220 kV单条输电线和同杆并架双回输电线路的防雷性能的仿真和计算,分析研究在多种雷击方式下输电线路的耐雷水平。采用国际通用的电力系统电磁暂态分析的仿真软件Elector-Magnetic Transient Program(EMTP),对雷电侵入波在输电线路上所产生的过电压进行分析计算,得出过电压分布和变化的规律,进而从技术上和经济上限制雷电侵入波过电压。

关键词：同杆并架多回输电线绝缘子串 ATP-EMTP 雷击过电压

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HIV-GAG质粒DNA疫苗的纯化工艺

吉林大学学报（理学版） 2013年第4期51卷 720-723页

作者：刘新涛吴丛梅臧阳孙博殷玉和长春工业大学化学与生命科学学院长春130012 吉林大学生命科学学院长春130012

采用中空纤维超滤浓缩、离子交换介质和复合模式凝胶过滤介质纯化获得了HIV-GAG药用级质粒DNA疫苗,并对菌体培养、菌体裂解、粗提分离和柱层析等环节进行研究.实验结果表明,产品基本符合药用级的质粒DNA要求.

关键词： DNA疫苗菌体裂解离子交换介质复合模式凝胶过滤介质

Sex differences in aging and injured brain

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Neural Regeneration Research 2025年第10期20卷 2901-2902页

作者： Jordan N.Williamson Yuan yang University of Illinois Urbana-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA Northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain disorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic

2013年洱源M_S5.5地震烈度分布及震区活动构造背景研究

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中国地震 2014年第4期30卷 560-570页

作者：常祖峰张艳凤周青云虎雄林臧阳云南省地震局昆明市北市区北辰大道650041 云南大学昆明650091

2013年洱源MS5.5地震震区地质构造复杂,发育有NW向和NE向2组活动断裂。据野外调查和探槽揭示,震中附近的维西-乔后断裂为晚第四纪活动断裂,其新近活动时代主要在晚更新世晚期,全新世仍有较明显的活动迹象,运动性质以右旋走滑为主兼有正... 详细信息

2013年洱源MS5.5地震震区地质构造复杂,发育有NW向和NE向2组活动断裂。据野外调查和探槽揭示,震中附近的维西-乔后断裂为晚第四纪活动断裂,其新近活动时代主要在晚更新世晚期,全新世仍有较明显的活动迹象,运动性质以右旋走滑为主兼有正断。此次地震等烈度线呈NNW向的椭圆形展布,极震区达Ⅶ度,长15km,宽10km,面积约279km2。震源机制解显示:该震源断层为正断兼走滑破裂型,与维西-乔后断裂的运动学特征基本吻合;节面Ⅱ为NW向,与维西-乔后断裂走向基本一致。结合地震烈度分布、滑坡崩塌体分布和微震分布特征等分析推断,此次地震的发震构造应为维西-乔后断裂。震区地处滇西北横断山脉腹地,巨大的地形高差,强烈的表层岩石风化,是造成此次地震破坏较重的自然地理条件,而居民房屋多为抗震性能差的土木结构和砖木结构等简易建筑,是造成地震灾害加重的构筑物背景。

关键词： 2013年洱源5.5级地震等烈度线维西-乔后断裂地震烈度发震构造

Synergistic promotion strategy of “dual-site” and “dual-path” to enhance the C–C coupling between CO2 and HCHO driven by photoelectrocatalysis

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Journal of Energy Chemistry 2025年第1期100卷 39-49页

作者： Hongqiang yang Jianfeng Zheng Guoyu Wang Yifei Gao Yatao yang Jia Li Xiaojin Han Yan Cui Zhanggen Huang National Key Laboratory of High Efficiency and Low Carbon Utilization of Coal Institute of Coal Chemistry Chinese Academy of Science University of Chinese Academy of Science Shenyang University of Chemical Technology

Photoelectrocatalytic coupling CO2and volatile organic compounds （VOCs） is a promising green strategy for the synergistic conversion of the two carbon-containing resources to *** catalytic efficiency is always at the mercy of chemical inertness of CO2and the competitive hydrogen evolution of ***,a modified g-C3N4/ZnAl-LDH Z-scheme heterojunction catalyst with dual reaction site was rationally designed and precisely *** Faraday efficiency of ethanol reached 68.67%with a corresponding formation rate of 227.3μmol *** revealed by in-situ characterizations and density functional theory calculations,CO2and HCHO were absorbed at Zn site and N site,***,*CO generated from CO2and HCHO was converted to*CH3O and*CHO on the dual-active-site *** detailed reaction mechanism experiments indicated that C–C coupling only occurred between*CO and*CH3O in electrocatalysis *** from the“*CO+*CH3O”path,another“*CO+*CHO”coupling path was also detected in photoelectrocatalytic *** selectivity of ethanol was significantly enhanced due to the synthesis of dual-site catalyst and the dual-path coupling path between CO2and HCHO simultaneously driven by light and electricity.

关键词： Ethanol

基于快速甩负荷(FCB)的上海500kV电网黑启动RTDS仿真研究

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华东电力 2011年第6期39卷 900-903页

作者：王伟红张旭航杨增辉刘蓓臧海洋上海电力公司上海200122 华东电力试验研究院有限公司上海200437 上海电力学院上海200090

为开展外高桥三厂1 000 MW机组快速甩负荷功能运行后的黑启动仿真计算研究,在RTDS实时数字仿真系统上创建了外高桥三厂8号发变组及相关厂用电系统模型,同时建立10 km 5138线与500 kV顾路站运行系统模型。主要针对外高桥三厂发电机、升... 详细信息

为开展外高桥三厂1 000 MW机组快速甩负荷功能运行后的黑启动仿真计算研究,在RTDS实时数字仿真系统上创建了外高桥三厂8号发变组及相关厂用电系统模型,同时建立10 km 5138线与500 kV顾路站运行系统模型。主要针对外高桥三厂发电机、升压变、厂用变和厂用电系统在"孤岛"小系统运行启动过程进行全面仿真分析研究,并对可能影响的控制保护装置进行校核,为即将开展的黑启动试验提供理论参考依据。

关键词：快速甩负荷黑启动 RTDS 500kV电网 1000MW机组