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LED可靠性寿命模型及应用

中国照明电器 2024年第3期 22-26,43页

作者：汤赞任艳艳龚伟斌张嘉显吴晶深圳市瑞丰光电子股份有限公司广东深圳518132

发光二极管(LED)被广泛用于室内照明,路灯,广告显示,装饰照明和监视器背光等领域。与传统光源相比,LED光源因其高效率,环保效益,高可靠性和长寿命而吸引了人们的兴趣。对于LED研发人员来说,使用记录故障数据的传统破坏性寿命测试来估计... 详细信息

发光二极管(LED)被广泛用于室内照明,路灯,广告显示,装饰照明和监视器背光等领域。与传统光源相比,LED光源因其高效率,环保效益,高可靠性和长寿命而吸引了人们的兴趣。对于LED研发人员来说,使用记录故障数据的传统破坏性寿命测试来估计LED的寿命是非常消耗时间以及浪费测试资源的。因此,通过进行短期和具有成本效益的高温老化测试,并结合LED寿命模型来进行推算其应用环境下的使用寿命是有必要的。本文介绍了几种常见的LED寿命推算模型,并以威布尔分布作为寿命模型,结合高温老化实验数据计算了在实际应用环境下的LED寿命。

关键词： LED使用寿命可靠性高温老化 LED寿命模型 LED测试

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可调谐超快激光贝塞尔光束加工方法研究

红外与激光工程 2024年第8期53卷 56-64页

作者：全宏升马威峰唐赞张宗全金昌骏邱丽荣徐可米赵维谦北京理工大学光电学院“复杂环境智能感测技术”工信部重点实验室北京100081

为了实现高效率和加工精度可灵活调节的超快激光微器件加工,提出了一种基于可调谐贝塞尔光束的超快激光加工方法。该方法通过调节可对初级贝塞尔光束压缩的双远心光学系统压缩比,实现了超快激光贝塞尔光束的中心主瓣半径和最大无衍射传... 详细信息

为了实现高效率和加工精度可灵活调节的超快激光微器件加工,提出了一种基于可调谐贝塞尔光束的超快激光加工方法。该方法通过调节可对初级贝塞尔光束压缩的双远心光学系统压缩比,实现了超快激光贝塞尔光束的中心主瓣半径和最大无衍射传输距离的灵活调节,其中不同压缩比的双远心光学系统通过闭环反馈控制的高分辨位移音圈致动器控制实现。理论分析和实验测试证实,在锥透镜(底角2°)和双远心光学系统(f_(1)=250 mm,f_(2)=36、18、9 mm)配合下,超快激光贝塞尔光束的中心主瓣半径和最大无衍射传输距离分别为3.73μm和5.28 mm,1.86μm和1.32 mm,0.93μm和0.33 mm。同时,设计了一套贝塞尔光束检测系统,可以实现对上述设计的可调谐贝塞尔光束的精确测量。最后对厚度为1 mm的熔融石英样品进行了打孔实验,实验结果表明熔融石英上的表面微孔直径与设计的贝塞尔光束的中心主瓣直径相符。该研究内容为实现高精密高效超快激光加工提供了一种新方法,具备工程化价值。

关键词：超快激光加工贝塞尔光束双远心光学系统音圈致动器

Neiguan(PC6) acupoint stimulation for preventing chemotherapy-induced nausea and vomiting: a cost-effective supplement in guideline-inconsistent chemotherapy-induced nausea and vomiting prophylaxis subgroup

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Journal of Traditional Chinese Medicine 2024年第3期44卷 581-585页

作者： YU Wenxi tang Lina LI Hongtao WANG Yonggang SHEN zan Department of Oncology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

OBJECTIVE: To assess the efficacy and safety of Neiguan(PC6) acupoint acustimulation in preventing chemotherapy-induced nausea and vomiting(CINV),especially for patients with guideline-inconsistent CINV prophylaxis(GICP) due to personal reasons METHODS: From January 2021 to December 2021, 373 patients suffered from solid malignancy were recruited according to the inclusion criteria. Complete response(no emesis and no rescue medication use) rate during the overall phase(0-120 h of each chemo-cycle) was the primary assessment of CINV control. The Functional Living Index-Emesis(FLIE) questionnaire was investigated among these patients as a secondary 'quality of life' objective to assess the impact of CINV on patients' daily life by recording score of nausea and vomiting. RESULTS: With acustimulation of Neiguan(PC6) acupuncture point through a portable, noninvasive and user-friendly device, in terms of complete response rate and scores in nausea/vomiting by FLIE questionnaire, patients achieve a better outcome in highly emetogenic chemotherapy(HEC) induced CINV, especially GICP subgroup. Meanwhile, analysis also demonstrated this tendency existed in other patients with HEC/GCCP(guideline consistent CINV prophylaxis) and moderate emetogenic chemotherapy, although the difference was not significant. CONCLUSION: Considering advantages of Neiguan(PC6) acustimulation such as noninvasive, covered by medical insurance and few side effects, we believe it would be an ideal auxiliary tool in CINV control, especially in patients who receive highly emetogenic chemoprotocol and are reluctant to GCCP for economic reasons.

关键词： acupuncture acustimulation chemotherapy-induced nausea and vomiting tumor

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Expression levels of CXCR4 and VEGF correlate with blood-borne metastatic progression and outcome in patients with osteosarcoma

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The Chinese-German Journal of Clinical Oncology 2009年第5期8卷 292-295页

作者： Feng Lin Shuier Zheng zan Shen Lina tang Ping Chen Yuanjue Sun Hui Zhao Yang Yao Department of Oncology Affiliated People＇s 6th Hospital Shanghai Jiaotong University Shanghai 200233 China

Objective:We determine whether chemokine receptor CXCR4 and vascular endothelial growth factor(VEGF) expression related to the metastasis and survival outcome of patients with ***:Tissue microarray(TMA) was used to detect the expression of CXCR4 and VEGF in 56 osteosarcoma patient ***-year follow-up was performed to observe the metastatic behavior and overall survival of osteosarcoma ***:There was a significant correlation between the expression levels of CXCR4 and VEGF in 56 osteosarcoma patient samples(P = 0.002).Univariate analysis revealed the expression of CXCR4 and VEGF was not associated with age, gender and the level of ALP but associated with clinical ***:These data raises the possibility that VEGF could regulate the levels of CXCR4 to promote the migration of tumor cells to target ***4 and VEGF expression are highly correlated with metastatic progression in patients with osteosarcoma and their immunohistochemical expression have predictive value for the metastatic development.

关键词： osteosarcoma CXCR4 VEGF blood metastasis

A Study on Integrated Model of Decision Support Systems

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Systems Science and Systems Engineering 2002年第3期11卷 328-332页

作者： MO zan, FENG Shan, tang ChaoInstitute of Systems Engineering, Huazhong University of Science and Technology, Wuhan 430074, China Institute of Systems Engineering Huazhong University of Science and Technology Wuhan 430074 China

This paper discusses two kinds of systems integrated models available to DSS: Multi-Agent-Based Model and Application-Framework-Oriented Model. Both of them are application-oriented integration so it is possible to combine them at the level of application. Based on this theory, this paper presents a new model, MAAFUM, which combines two models and applies them synthetically in DSS.

关键词： DSS Model systems integration Multi-Agent-Based Model Application-Framework-Oriented Model MAAFUM

YTE-17 inhibits colonic carcinogenesis by resetting antitumor immune response via Wnt5a/JNK mediated metabolic signaling

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Journal of Pharmaceutical Analysis 2024年第4期14卷 525-541页

作者： Hua Sui Wanli Deng Qiong Chai Bing Han Yuli Zhang Zhenzhen Wei zan Li Ting Wang Jiling Feng Man Yuan Qingfeng tang Hongxi Xu Medical Experiment Center Jiading Branch of Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai201803China Translational Medicine Research Center for Cancer Prevention and Treatment Shanghai General Hospital Jiading Branch-School of Pharmacy of Shanghai University of Traditional Chinese Medicine Joint LaboratoryShanghai201803China Department of Medical Oncology Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai200062China School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghai201203China The Second Clinical Medical College of Henan University of Traditional Chinese Medicine Zhengzhou450000China Shanghai University of Traditional Chinese Medicine Shanghai201203China Precision Research Center for Refractory Diseases Institute for Clinical ResearchShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai201620China

The density and composition of lymphocytes infiltrating colon tumors serve as predictive factors for the clinical outcome of colon *** previous studies highlighted the potent anti-cancer properties of the principal compounds found in Garcinia yunnanensis(YTE-17),attributing these effects to the regu-lation of multiple signaling ***,knowledge regarding the mechanism and effect of YTE-17 in the prevention of colorectal cancer is *** this study,we conducted isobaric tags for relative and absolute quantification(iTRAQ)analysis on intestinal epithelial cells(IECs)exposed YTE-17,both in vitro and in vivo,revealing a significant inhibition of the Wnt family member 5a(Wnt5a)/c-Jun N-terminal kinase(JNK)signaling ***,we elucidated the influence and mechanism of YTE-17 on the tumor microenvironment(TME),specifically focusing on macrophage-mediated T helper 17(Th17)cell induction in a colitis-associated cancer(CAC)model with Wnt5a ***,we performed the single-cell RNA sequencing(scRNA-seq)on the colonic tissue from the Wnt5a-deleted CAC model to characterize the composition,lineage,and functional status of immune mesenchymal cells during different stages of colorectal cancer(CRC)***,our findings demon-strate a significant reduction in M2 macrophage polarization and Th17 cell phenotype upon treatment with YTE-17,leading to the restoration of regulatory T(Treg)/Th17 cell balance in azoxymethane(AOM)/dextran sodium sulfate(DSS)***,we also confirmed that YTE-17 effectively inhibited the glycolysis of Th17 cells in both direct and indirect co-culture systems with M2 ***,our study shed light on potential mechanisms linking the non-canonical Wnt5a/JNK signaling pathway and well-established canonical b-catenin oncogenic pathway in ***,we proposed that Wnt5a/JNK signaling activity in IECs promotes the development of cancer stem cells with b-catenin activity within

关键词： Tumor microenvironment Intestinal epithelial cells Treg/Th17 cells Metabolism Wnt5a/JNK signaling Tumorigenesis

基于包络延拓和本征波匹配的时变DoS攻击频谱检测

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计算机科学 2015年第4期42卷 127-131页

作者：唐赞玉刘宏吉首大学信息科学与工程学院吉首416000 湖南师范大学数学与计算机学院长沙410081

DoS攻击信号具有非平稳时变特性,湮没在色噪声背景的复杂网络环境中,对之难以有效检测。传统方法中采用基于非平稳时变信号处理的Hough变换单谱脉冲响应检测算法,由于二次型时频分布的边缘效应会引起较大包络衰减,检测性能不好。因此提... 详细信息

DoS攻击信号具有非平稳时变特性,湮没在色噪声背景的复杂网络环境中,对之难以有效检测。传统方法中采用基于非平稳时变信号处理的Hough变换单谱脉冲响应检测算法,由于二次型时频分布的边缘效应会引起较大包络衰减,检测性能不好。因此提出一种基于包络延拓和本征波匹配的时变DoS攻击信号频谱检测算法来对DoS攻击检测信号进行双曲调频分解,构建信号数学演化模型,得到信号包络和本征波特征提取结果。采用双线性Hough变换法分析频谱特征畸变,进行瞬时频率估计,得到信号的单谱脉冲响幅频响应,在包络时频特征空间优化搜索路径实现包络延拓,基于最小均方误差准则设计本征波匹配滤波器,控制DoS频谱偏移,实现信号频谱检测。仿真结果表明,本算法能在强色噪声背景干扰下提高检测性能,检测概率高于传统算法,且能准确估计参量信息,提高对DoS攻击信号的主动防御能力。

关键词：包络延拓本征波匹配 DoS攻击信号检测网络安全

多阶段大规模网络攻击下的网络安全态势评估方法研究

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计算机科学 2018年第1期45卷 245-248页

作者：唐赞玉刘宏吉首大学信息科学与工程学院湖南吉首416000 湖南师范大学数学与计算机学院长沙410081

针对传统的网络安全态势评估方法一直存在评估偏差较大的问题,为了准确分析网络安全状况,提出一种新的多阶段大规模网络攻击下的网络安全态势评估方法。首先根据多阶段大规模网络攻击下的网络安全多数据源的特点,建立基于信息融合的多... 详细信息

针对传统的网络安全态势评估方法一直存在评估偏差较大的问题,为了准确分析网络安全状况,提出一种新的多阶段大规模网络攻击下的网络安全态势评估方法。首先根据多阶段大规模网络攻击下的网络安全多数据源的特点,建立基于信息融合的多阶段大规模网络攻击下的网络安全态势评估模型;然后对大规模网络攻击阶段进行识别,计算网络攻击成功的概率和网络攻击阶段的实现概率;最后利用CVSS中的3个评价指标对网络安全态势进行评估。实例分析证明,所提方法更加符合实际应用,评估结果准确且有效。

关键词：多阶段大规模网络攻击网络安全态势评估方法

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气体测量仪表综合检测校验装置

现代工业经济和信息化 2015年第11期5卷 50-52页

作者：唐瓒中煤科工集团重庆研究院有限公司瓦斯灾害监控与应急技术国家重点实验室重庆400037

气体测量仪表综合检测校验装置,主要用于对氧气、一氧化碳、甲烷传感器的检定,氧气、一氧化碳、甲烷报警仪的检定。文章中的气体测量仪表综合检测校验装置是结合了电脑控制自动化与实际操作人员的经验反馈而研制的。

关键词：模块气体仪表