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Antitumor efficacy of multi-target in situ vaccinations with CpG oligodeoxynucleotides,anti-OX40,anti-PD1 antibodies,and aptamers

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The Journal of Biomedical Research 2023年第3期37卷 194-212页

作者： Anastasia s.Proskurina Vera s.Ruzanova Genrikh s.Ritter Yaroslav R.Efremov zakhar s.mustafin sergey A.Lashin Ekaterina A.Burakova Alesya A.Fokina Timofei s.Zatsepin Dmitry A.stetsenko Olga Y.Leplina Alexandr A.Ostanin Elena R.Chernykh sergey s.Bogachev Institute of Cytology and Genetics Siberian Branch of the Russian Academy of SciencesNovosibirsk 630090Russia Department of Natural sciences Novosibirsk State UniversityNovosibirsk 630090Russia Department of Physics Novosibirsk State UniversityNovosibirsk 630090Russia Department of Chemistry Moscow State UniversityMoscow 119991Russia Research Institute of Fundamental and Clinical Immunology Novosibirsk630099Russia

To overcome immune tolerance to cancer,the immune system needs to be exposed to a multi-target action ***,we investigated the activating effect of CpG oligodeoxynucleotides(ODNs),mesyl phosphoramidate CpG ODNs,anti-OX40 antibodies,and OX40 RNA aptamers on major populations of immunocompetent cells ex *** analysis of the antitumor effects of in situ vaccination with CpG ODNs and anti-OX40 antibodies,as well as several other combinations,such as mesyl phosphoramidate CpG ODNs and OX40 RNA aptamers,was *** against programmed death 1(PD1)checkpoint inhibitors or their corresponding PD1 DNA aptamers were also added to vaccination regimens for analytical *** scenarios were considered:a weakly immunogenic Krebs-2 carcinoma grafted in CBA mice;a moderately immunogenic Lewis carcinoma grafted in C57Black/6 mice;and an immunogenic A20 B cell lymphoma or an Ehrlich carcinoma grafted in BALB/c *** anti-PD1 antibodies(CpG+αOX40+αPD1)to in situ vaccinations boosts the antitumor *** to be used instead of antibodies,aptamers also possess antitumor activity,although this effect was less *** strongest effect across all the tumors was observed in highly immunogenic A20 B cell lymphoma and Ehrlich carcinoma.

关键词： immunogenicity Krebs-2 carcinoma Lewis carcinoma Ehrlich carcinoma A20 B cell lymphoma mesyl phosphoramidate

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structure,magnetic and adsorption properties of novel FePt/h-BN heteromaterials

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Nano Research 2023年第1期16卷 1473-1481页

作者： Anton s.Konopatsky Vladislava V.Kalinina Alena s.savchenko Denis.V.Leybo Ekaterina V.sukhanova Viktor s.Baidyshev zakhar I.Popov Andrey V.Bondarev Josef Polčák Dmitry V.shtansky National University of science and Technology(MIsIs) Leninskiy prospect 4Moscow119049Russia Emanuel Institute of Biochemical Physics RAs Kosygina 4Moscow119334Russia Katanov Khakas state University 90 Lenin pr.655017 AbakanRussia Plekhanov Russian University of Economics 36 Stremyanny per.Moscow 117997Russia Department of Control Engineering Faculty of Electrical EngineeringCzech Technical University in PragueTechnicka 2Prague 16627Czech Republic CEITEC-Central European Institute of Technology Brno University of TechnologyPurkyňova 123Brno 61200 BrnoCzech Republic

Nanomaterials with high specific surface area and high absorption capacity are attracting increased interest aimed at imparting the desired magnetic *** work is devoted to the study of the effect of heat treatment in a hydrogen atmosphere on the microstructure,adsorption and magnetic properties of heterogeneous FePt/h-BN *** via the polyol process,FePt nanoparticles(NPs)had a sizestributed over the surface of hexagonal boron nitride(h-BN)*** temperature-activated fcc→fct phase transformation in ultrafine FePt NPs has been well *** NPs act as active centers dissociating H2 molecules and transfer adsorbed hydrogen atoms to the *** functional theory(DFT)calculations also indicate that the h-BN substrate can absorb hydrogen adsorbed on the FePt *** hydrogen circulation in the FePt/h-BN system promoted the fcc→fct phase transformation and allowed to control the magnetic ***/h-BN nanomaterials also exhibited a high adsorption capacity with respect to various organic dyes.

关键词： FePt/h-BN nanomaterials polyol synthesis phase transformations magnetic properties adsorption

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磷掺杂剂和石墨烯包覆层对NiCo_(2)s_(4)电催化剂析氢活性和耐久性的协同影响

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science China Materials 2023年第10期66卷 3875-3886页

作者：陈杰毛梁徐家琛顾修全 zakhar I.Popov 赵宇龙凌意瀚隋艳伟应鹏展蔡晓燕张俊英 school of Materials science and Physics China University of Mining and TechnologyXuzhou 221116China Emanuel Institute of Biochemical Physics RAs 1193344 Kosigin st.MoscowRussian Federation school of Physics Beihang UniversityBeijing 100191China

探索具有优异导电性和稳定性的非贵金属电催化剂对氢经济至关重要.本研究将杂原子掺杂和石墨烯包覆相结合,以控制NiCo_(2)s_(4)(NCs)蛋黄壳微球的电子性能,并抵抗酸性介质中H_(2)O和O_(2)的腐蚀.密度泛函理论(DFT)模拟结合综合表征和实... 详细信息

探索具有优异导电性和稳定性的非贵金属电催化剂对氢经济至关重要.本研究将杂原子掺杂和石墨烯包覆相结合,以控制NiCo_(2)s_(4)(NCs)蛋黄壳微球的电子性能,并抵抗酸性介质中H_(2)O和O_(2)的腐蚀.密度泛函理论(DFT)模拟结合综合表征和实验首次揭示了在NCs中引入P杂原子不仅加速了电子从体相向表面的转移动力学,而且降低了掺杂P原子附近活性s位上的析氢反应势垒.利用DFT计算的穿透能垒预测了rGO覆盖层在P掺杂NCs(P-NCs)表面对质子的渗透性和对H_(2)O和O_(2)分子的抵抗性等重要功能,并用X射线光电子能谱对新催化剂和回收催化剂进行了验证.利用P掺杂剂和rGO覆盖层分别辅助电荷传递和质子传递,通过二者的协同作用获得了催化活性和耐久性之间的平衡.因此,优化后的P-NCs/rGO在70 mV的低过电位下实现了10 mA cm^(-2)的电流密度,并具有令人满意的80小时耐用性.本工作阐明了石墨烯覆盖硫化物催化剂可通过调控电子结构和质子/分子穿透提高电催化性能.

关键词： electrocatalysis elemental doping proton penetration hydrogen evolution corrosion resistance

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