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Piper sarmentosum as an antioxidant on oxidative stress in human umbilical vein endothelial cells induced by hydrogen peroxide

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第5期11卷 357-365页

作者： Abdul Hamid HAFIZAH zakaria zaiton Amom ZULKHAIRI Adenan MOHD ILHAM Megat Mohd Nordin NOR ANITA Abdullah Mahdy ZALEHA Department of Physiology Universiti Kebangsaan Malaysia Medical CentreJalan Raja Muda Aziz50300 Kuala LumpurMalaysia Department of Human Anatomy Division of PhysiologyFaculty of Medicine and Health SciencesUniversiti Putra Malaysia Forest Research Institute of Malaysia Department of Obstetrics and Gynecology Universiti Kebangsaan Malaysia Medical Centre

Endothelial cell death due to increased reactive oxygen species(ROS) may contribute to the initial endothelial injury,which promotes atherosclerotic lesion *** sarmentosum(PS),a natural product,has been shown to have an antioxidant property,which is hypothesized to inhibit production of ROS and prevent cell ***,the present study was designed to determine the effects of PS on the hydrogen peroxide(H2O2)-induced oxidative cell damage in cultured human umbilical vein endothelial cells(HUVECs).In this experiment,HUVECs were obtained by collagenase perfusion of the large vein in the umbilical cord and cultured in medium M200 supplemented with low serum growth supplementation(LSGS).HUVECs were treated with various concentrations of H2O2(0-1000 μmol/L) and it was observed that 180 μmol/L H2O2 reduced cell viability by 50% as denoted by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) *** the above concentration as the positive control,the H2O2-induced HUVECs were concomitantly treated with various concentrations(100,150,250 and 300 μg/ml) of three different extracts(aqueous,methanol and hexane) of ***(MDA),superoxide dismutase(SOD),catalase(CAT) and glutathione peroxidase(GPX) levels showed a significant increase(P<0.05) in HUVECs compared to the negative ***,PS extracts showed a protective effect on HUVECs from H2O2-induced cell apoptosis with a significant reduction in MDA,SOD,CAT and GPX levels(P<0.05).Furthermore,PS had exhibited ferric reducing antioxidant power with its high phenolic ***,it was concluded that PS plays a beneficial role in reducing oxidative stress in H2O2-induced HUVECs.

关键词： Piper sarmentosum Human umbilical vein endothelial cells(HUVECs) Malondialdehyde Oxidative stress Antioxidant enzymes

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Prevalence and Factors Associated with Smartphone Addiction among Adolescents–A Nationwide Study in Malaysia

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International Journal of Mental Health Promotion 2023年第2期25卷 237-247页

作者： Kai Wei Lee Siew Mooi Ching Norsiah Ali Chor Yau Ooi Shahnul Kamal Hj Sidek Azlin Amat Yusnita Yatim zaiton Yahaya Nabihah Shamsuddin Idora Ibrahim Fauzia Abdul Majid Fazlin Suhana Othman Nik Suhaila zakaria Artini Abidin Nor Hazlin Talib Dhashani Sivaratnam Department of Pre-Clinical Sciences Faculty of Medicine and Health SciencesUniversiti Tunku Abdul RahmanKajangSelangor43000Malaysia Department of Family Medicine Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSerdang43400Malaysia Klinik Kesihatan Masjid Tanah Ministry of Health MalaysiaMasjid Tanah78300Malaysia Department of Family Medicine Universiti Malaysia SarawakKota Samarahan94300Malaysia Klinik Kesihatan Tanjung Malim Ministry of Health MalaysiaTanjung Malim35900Malaysia Klinik Kesihatan Hiliran Ministry of Health MalaysiaKuala Terengganu20300Malaysia Klinik Kesihatan Bandar Pekan Ministry of Health MalaysiaPekan26600Malaysia Klinik Kesihatan Sandakan Ministry of Health MalaysiaSandakan90000Malaysia Klinik Kesihatan Serting Hilir Ministry of Health MalaysiaBandar Seri Jempol72120Malaysia Klinik Kesihatan Kuala Perlis Ministry of Health MalaysiaKuala Perlis02000Malaysia Klinik Kesihatan Kempas Ministry of Health MalaysiaJohor Bahru81200Malaysia Klinik Kesihatan Kuala Kedah Ministry of Health MalaysiaKuala Kedah06600Malaysia Klinik Kesihatan Bandar Gua Musang Ministry of Health MalaysiaGua Musang18300Malaysia Klinik Kesihatan Kepala Batas Ministry of Health MalaysiaKepala Batas13200Malaysia Klinik Kesihatan Kajang Ministry of Health MalaysiaKajang43000Malaysia Department of Ophthalmology Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSerdang43400Malaysia

Smartphone ownership among adolescents is getting common in this decade especially in Malaysia;Adolescent are strongly devoted to their smartphone and this may lead to smartphone *** have reported that smartphone addiction has become an emerging social and health problem especially among the youth in many countries however there is lack of study among adolescents in *** study aimed to examine the prevalence and factors associated with smartphone addiction among adolescents in *** was a cross-sectional study involving adolescents from 15 primary care clinics throughout the *** were assessed on their smartphone activities using the Malaysian short version of the Smartphone addiction scale(SAS-M-SV).Multiple logistic regression was used to determine the predictors of smartphone addiction among *** study was conducted among 921 adolescents with 49.6%male(n=457).The mean age of adolescents was 16.4±2.4 *** ethnicity distribution were 74.6%Malay,7.3%Chinese,4.7%Indian and 13.4%other *** prevalence of smartphone addiction was 37.1%(342/921);37.4%in male and 36.9%in *** on multiple logistic regression analysis,longer duration of smartphone use per week was associated with higher odds of smartphone addiction among adolescent(odd ratio=1.005%,95%confidence interval=1.000–1.009,p-value=0.039).Smartphone addiction is present in nearly four in ten adolescents in *** who spend longer duration in smartphone usage per week were associated with higher odds of having smartphone *** should be more alert and vigilant about this ***,parents should limit their children from spending too much of time with smartphone in order to prevent their children from getting smartphone addiction.

关键词： Addiction smartphone adolescents Malaysia internet

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