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Complete Dorsal Carpo-Metacarpal Spatular Dislocation: A Case Report

Open Journal of Orthopedics 2022年第1期12卷 26-30页

作者： Mwinyanne Narcisse Dabire Sayouba Tinto zakaria abdel aziz zeba Alexandre Korsag Christian Darga Songahir Christophe Da Université Saint Thomas d’Aquin (USTA) Ouagadougou Burkina Faso Orthopaedics-Traumatology Department University Hospital Center Yalgado Ouedraogo Ouagadougou Burkina Faso

Carpo-metacarpal dislocations are rare traumatic injuries resulting from violent trauma;they are mostly observed in young subjects. The spatular form is often accompanied by metacarpal fractures. We report a clinical case of complete dorsal carpo-metacarpal spatular dislocation. This was a 34-year-old patient, admitted for a closed trauma of the right hand, in whom the clinical examination noted edema of the hand. The radiological workup showed a complete dorsal spatular dislocation associated with a fracture of the base of the 2nd metacarpal. The reduction of these lesions in closed focus followed by stabilization by metacarpal broaching associated with an intermetacarpal transverse broach was done under scopic control in emergency. Functional rehabilitation was started in the 3rd week. The broaches were ablated at the 6th week. The functional result at 3 months was satisfying with good muscle strength. Resumption of work was effective at 8 weeks. Carpo-metacarpal dislocations are rare injuries, often unrecognized, especially in polytrauma patients, and have a good functional prognosis if they are managed correctly in an emergency.

关键词： Dislocation Carpo-Metacarpal Spatular Traumatic Hand

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Hepatitis B virus,HBx mutants and their role in hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第30期20卷 10238-10248页

作者： Ashraf Ali Hany abdel-Hafiz Mohd Suhail Amany Al-Mars Mohammad Khalid zakaria Kaneez Fatima Sultan Ahmad Esam Azhar Adeel Chaudhary Ishtiaq Qadri Department of Medical Biotechnology King Fahad Medical Research CenterKing Abdul Aziz UniversityPO Box 80216Jeddah 21589Saudi Arabia Division of Endocrinology Department of Medicine and MetabolismAnschutz Medical CampusUniversity of Colorado DenverAuroraCO 80045United States Department of Biochemistry All India Institute of Medical SciencesNew Delhi 110029India IQ Institute of Infection and Immunity Lahore 54000Pakistan Special Infectious Agents Unit-Biosafety Level 3 King Fahd Medical Research CenterKing Abdul Aziz UniversityJeddah 21589Saudi Arabia Medical Laboratory Technology Department Faculty of Applied Medical SciencesKing Abdul Aziz UniversityJeddah 21589Saudi Arabia

Hepatocellular carcinoma(HCC)is one of the leading causes of death induced by cancer in the modern world and majority of the cases are related to chronic hepatitis B virus(HBV)***-encoded X protein(HBx)is known to play a pivotal role in the pathogenesis of viral induced *** is a multifunctional protein of17 kDa which modulates several cellular processes by direct or indirect interaction with a repertoire of host factors resulting in *** might interfere with several cellular processes such as oxidative stress,DNA repair,signal transduction,transcription,protein degradation,cell cycle progression and apoptosis.A number of reports have indicated that HBx is one of the most common viral ORFs that is often integrated into the host genome and its sequence variants play a crucial role in *** mutational or deletion analysis it was shown that carboxy terminal of HBx has a likely role in protein-protein interactions,transcriptional transactivation,DNA repair,cell,signaling and pathogenesis of *** accumulated evidence thus far suggests that it is difficult to understand the mechanistic nature of HBx associated HCC,and HBx mediated transcriptional transactivation and signaling pathways may be a major *** article addresses the role of HBx in the development of HCC with particular emphasis on HBx mutants and their putative targets.

关键词： Hepatitis B virus Hepatocellular carcinoma Transcr

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