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Synthesis and Identification of Some New Tetrazole Derivatives from 4,5-dichloro Imidazole and Study of Their Biological Activity

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Journal of Chemistry and Chemical Engineering 2016年第7期10卷 347-352页

作者： zainab fadhil Shaimaa Adnan Department of chemistry College of Education Univeristy of AI-QadisiyahIraq

A number of tetrazoles derivatives were prepared by series of steps, the first step includes react （4,5-dichloroimidazole） with （4-aminoacetophenone） to form 1-（4-（（4,5-dichloro-lH-imidazol-2yl）diazenyl）ethanone （1）. The second step was （1） reaction with （Amines derivatives） to get Schiff bases （2-7）. The third step was reaction of Shciff base with sodiumazide to form tetrazoles derivatives （8-13）. then study the biological activity for all compounds to word two type of bacteria.

关键词： Azo Schiffbase tetrazole imidazole biological activity.

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The fate of prazosin and levonorgestrel after electrochemical degradation process: Monitoring by-products using LC-TOF/MS

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Journal of Environmental Sciences 2018年第12期30卷 134-146页

作者： Fouad fadhil Al-Qaim zainab Haider Mussa Ali Yuzir Jalifah Latip Mohamed Rozali Othman Malaysia-Japan International Institute of Technology Universiti Teknologi Malaysia Department of Chemistry Faculty of Science for Women University of Babylon School of Chemical Sciences and Food Technology Faculty of Science and Technology Universiti Kebangsaan Malaysia (UKM) Centre for Water Research and Analysis (ALIR) Faculty of Science and Technology Universiti Kebangsaan Malaysia (UKM)

Prazosin（PRZ） and levonorgestrel（LNG） are widely used as an anti-disease drugs due to their biological activity in the human body. The frequent detection of these compounds in water samples requires alternative technologies for the removal of both compounds. After electrochemical degradation of PRZ and LNG, the parent compounds could be completely removed after treatment, but the identification and characterization of by-products are necessary as well. In this study, the effects of NaCl concentration and applied voltage were investigated during the electrochemical degradation process. The results revealed that the increase of NaCl concentration and applied voltage could promote the generation of hypochlorite OCl-and then enhance the degradation of PRZ and LNG. After initial study, 6 V and 0.2 g NaCl were selected for further experiments（96% and 99% removal of PRZ and LNG after 40 min, respectively）. Energy consumption was also evaluated and calculated for PRZ and LNG at 3, 6 and 8 V. Solid phase extraction（SPE） method plays an important role in enhancing the detection limit of by-products. Furthermore, characterization and identification of chlorinated and non-chlorinated by-products were conducted using an accurate liquid chromatography-time of flight/mass spectrometry LC-TOF/MS instrument. The monitoring of products during the electrochemical degradation process was performed at6 V and 0.2 g NaCl in a 50 m L solution. The results indicated that two chlorinated products were formed during the electrochemical process. The toxicity of by-products toward E. coli bacteria was investigated at 37°C and 20 hr incubation time.

关键词： Prazosin Levonorgestrel Electrochemical degradation Solid phase extraction Chlorinated by-products Toxicity

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