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New low-rank optimization model and algorithms for spectral compressed sensing

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science China Mathematics 2024年第10期67卷 2409-2432页

作者： zai Yang Xunmeng Wu Zongben Xu school of Mathematics and statistics Xi'an Jiaotong University

In this paper, we investigate the recovery of an undamped spectrally sparse signal and its spectral components from a set of regularly spaced samples within the framework of spectral compressed sensing and super-resolution. We show that the existing Hankel-based optimization methods suffer from the fundamental limitation that the prior knowledge of undampedness cannot be exploited. We propose a new low-rank optimization model partially inspired by forward-backward processing for line spectral estimation and show its capability to restrict the spectral poles to the unit circle. We present convex relaxation approaches with the model and show their provable accuracy and robustness to bounded and sparse noise. All our results are generalized from one-dimensional to arbitrary-dimensional spectral compressed sensing. Numerical simulations are provided to corroborate our analysis and show the efficiency of our model and the advantageous performance of our approach in terms of accuracy and resolution compared with the state-of-the-art Hankel and atomic norm methods.

关键词： low-rank double Hankel model doubly enhanced matrix completion line spectral estimation spectral compressed sensing Kronecker's theorem

Identification of carbonate sedimentary facies from well logs with machine learning Author links open overlay panel

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Petroleum Research 2024年第2期9卷 165-175页

作者： Xianmu Hou Peiqing Lian Jiuyu Zhao Yun zai Weiyao Zhu Fuyong Wang school of Civil and Resources Engineering University of Science and Technology BeijingBeijing100083China sinopec Chongqing Fuling shale Gas Exploration and Development Co. Ltd.Chongqing408000China sinopec Petroleum Exploration&Production Research Institute SINOPECBeijing100083China National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China ChinKunlun Digital Technology Co.Ltd. Beijing102206China

sedimentary facies identification is critical for carbonate oil and gas reservoir *** traditional method of sedimentary facies identification not only be affected by the engineer's experience but also takes a long *** carbonate sedimentary facies based on machine learning is the trend of future development and has the advantages of short time consuming and reliable results without engineers'subjective *** many references reported the application of machine learning to identify lithofacies,but identifying sedimentary facies of carbonate reservoirs is much more challenging due to the complex sedimentary environment and tectonic *** paper compares the performance of the carbonate sedimentary facies identification using four different machine learning models,and the optimal machine learning with the highest prediction accuracy is ***,the carbonate sedimentary facies are classified into the lagoon,shallow sea,shoal,fore-shoal,and inter-shoal five tags based on the well ***,five well log curves including spectral gamma ray(sGR),uranium-free gamma ray(CGR),photoelectric absorption cross-section index(PE),true formation resistivity(RT),shallow lateral resistivity(Rs)are used as the input,and the manual identified carbonate sedimentary facies are used as the output of the machine learning *** performance of four different machine learning algorithms,including support vector machine(sVM),deep neural network(DNN),long short-term memory(LsTM)network,and random forest(RF)are *** other two wells are used for model *** research results show that the RF method has the highest accuracy of sedimentary facies prediction,and the average prediction accuracy is 78.81%;the average accuracy of sedimentary facies prediction using sVM is 77.93%.The sedimentary facies predictions using DNN and LsTM are less satisfying compared with RF and sVM,and the average accuracy is 69.94%and 73.05%,respect

关键词： Carbonate sedimentary facies Well logs Machine learning Deep learning

Comparison of Measurements for Enhanced Diffusion Problem in Chemical Reaction systems

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Chinese Journal of Chemistry 2024年第14期42卷 1659-1664页

作者： ah-Young Jee Ziyang Wen Huan Wang Beijing National Laboratory for Molecular sciences College of Chemistry and Molecular EngineeringBeijing Key Laboratory of Polymer Chemistry&Physics of Ministry of EducationPeking UniversityBeijing100871 China

The problem of molecular diffusion in the soup of chemical reactions attracts mounting interest across fields ranging from chemistry to biophysics to material *** reactions involve bond breakup and formation,whose time scale is typically on the orders of fs to ps,while molecular diffusion occurs at time scales ofμs to *** two processes are often considered orthogonal,given the vastly different *** serial results show that the enzyme's diffusion is enhanced in a substrate-dependent manner,which was further extended to small molecule reaction systems,challenging this classical ***,the results from different groups using different techniques do not quantitatively agree,and a general mechanism is yet to be *** summarize experimental studies on diffusion problems and seek to reconcile the interpretation with understanding the limits of measurement tools and the chemical nature of reaction *** molecular diffusion in chemical reactions will provide fresh thoughts in designing chemical systems such as molecular machines that harvest work at the nanoscale in a controllable manner.

关键词： Molecular diffusion Chemical reactions Enzyme reactions Active matter Diffusion measurements single-molecule studies Fluorescence Time-resolved spectroscopy

Combustion characteristics of low-quality lignite for different bed material sphericities in a circulating fluidized bed boiler:A numerical study

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Particuology 2024年第7期90卷 364-382页

作者： Barış Gürel Gülşah Karaca Dolgun Osman İpek Ali Keçebaş Department of Mechanical Engineering Engineering FacultySüleyman Demirel UniversityÇünürIspartaTurkey Department of Energy systems Engineering Technology FacultyMuğla SıtkıKoçman UniversityKötekliMenteşeMuğlaTurkey

This study delves into the combustion behavior of various lignite types within a circulating fluidized bed boiler(CFBB),with a primary focus on the impact of different bed material sphericity ratios(0.5,0.7,and 0.9).Utilizing bed material with a sphericity ratio of 0.9 sourced from theÇan power plant and verified through experimentation,the research reveals several key ***,furnace temperatures tended to rise with higher sphericity ratios,albeit with variations between lignite types,particularly highlighting the complexity of this relationship in the case of GLI-Tunçbilek *** levels in the combustion chamber remained consistent across different sphericity ratios,indicating minimal influence on pressure *** combustion efficiency,especially at the bottom of the boiler,was observed at lower sphericity levels(0.5 and 0.7)forÇan lignite,as reflected in CO_(2) mole *** NO_(x) emissions generally decreased with lower sphericity,the sensitivity to sphericity varied by lignite type,with Ilgın lignite showcasing low NO_(x) but high sO_(2) emissions,underscoring the intricate interplay between lignite properties,sphericity,and ***,this study advances our understanding of CFBB combustion dynamics,offering insights valuable for optimizing performance and emissions control,particularly in lignite-based power.

关键词： Circulating fluidized bed boiler Computational particle fluid dynamics method Particle sphericity ratios NO_(x)and sO_(2)emissions Energy production efficiency

Optimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection

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signal Transduction and Targeted Therapy 2024年第7期9卷 3063-3076页

作者： Wenjing zai Min Yang Kuan Jiang Juan Guan Huijing Wang Kongying Hu Chao Huang Jieliang Chen Wei Fu Changyou Zhan Zhenghong Yuan Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMs) Research Unit of Cure of Chronic Hepatitis B Virus Infection(CAMS)Shanghai Frontiers Science Center of Pathogenic Microbes and InfectionSchool of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghaiP.R.China Department of Pharmacology School of Basic Medical SciencesFudan UniversityShanghaiP.R.China shanghai Engineering Research Center for synthetic Immunology Fudan UniversityShanghaiP.R.China Eye Institute and Department of Ophthamology Eye and ENT HospitalFudan UniversityShanghaiP.R.China Pharmacy Department of Huashan Hospital Fudan UniversityShanghaiP.R.China Institute of Pediatric Translational Medicine Shanghai Institute for Pediatric Congenital Heart DiseaseShanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina shanghai Institute of Infectious Disease and Biosecurity ShanghaiP.R.China

This study aimed to develop a pan-genotypic and multifunctional small interfering RNA(siRNA)against hepatitis B virus(HBV)with an efficient delivery system for treating chronic hepatitis B(CHB),and explore combined RNA interference(RNAi)and immune modulatory modalities for better viral *** synthetic siRNAs targeting consensus motifs distributed across the whole HBV genome were designed and *** lipid nanoparticle(LNP)formulation was optimized by adopting HO-PEG_(2000)-DMG lipid and modifying the molar ratio of traditional polyethylene glycol(PEG)lipid in LNP *** efficacy and safety of this formulation in delivering siHBV(tLNP/siHBV)along with the mouse IL-2(mIL-2)mRNA(tLNP/siHBVIL2)were evaluated in the rAAVHBV1.3 mouse model.A siRNA combination(terms“siHBV”)with a genotypic coverage of 98.55%was selected,chemically modified,and encapsulated within an optimized LNP(tLNP)of high efficacy and security to fabricate a therapeutic formulation for *** results revealed that tLNP/siHBV significantly reduced the expression of viral antigens and DNA(up to 3log_(10)reduction;vs PBs)in dose-and time-dependent manners at single-dose or multi-dose frequencies,with satisfactory safety *** studies showed that tLNP/siHBVIL2 enables additive antigenic and immune control of the virus,via introducing potent HBsAg clearance through RNAi and triggering strong HBV-specific CD4^(+)and CD8^(+)T cell responses by expressed mIL-2 *** adopting tLNP as nucleic acid nanocarriers,the co-delivery of siHBV and mIL-2 mRNA enables synergistic antigenic and immune control of HBV,thus offering a promising translational therapeutic strategy for treating CHB.

关键词： formulation enable offering

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从梅洛——庞蒂身体现象学到中国古代身道

哲学分析 2024年第2期15卷 59-68,197页

作者：张再林西北工业大学马克思主义学院西安交通大学

一种全面的分析告诉我们:梅洛—庞蒂身体现象学乃是当代身体性哲学的集大成者。无独有偶,一种全面深入的研究发现,就其身体性而言,中国哲学与梅洛—庞蒂哲学二者之间存在着一种明显的“家族相似”的关系。这种“家族相似”同时表明,中... 详细信息

一种全面的分析告诉我们:梅洛—庞蒂身体现象学乃是当代身体性哲学的集大成者。无独有偶,一种全面深入的研究发现,就其身体性而言,中国哲学与梅洛—庞蒂哲学二者之间存在着一种明显的“家族相似”的关系。这种“家族相似”同时表明,中国哲学的身体思想与梅洛—庞蒂哲学的身体思想既存在共通之处,又有一定程度的差异。因此,摆在我们面前的任务是,不在二者之间扬此抑彼,而将二者兼容并蓄地有机结合在一起。惟其如此,我们才能使经过现代化洗礼的中国身体性哲学得以真正确立。

关键词：梅洛—庞蒂身体现象学中国古代身道家族相似中国哲学复兴

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近现代中国宙观的嬗变及其当代命运

江苏行政学院学报 2024年第3期 22-31页

作者：张再林西北工业大学马克思主义学院西安710126

如果说中国传统的宇宙观是一种从身体出发的宇宙观,那么,近现代的宇宙观则是一种从思维出发的宇宙观。在科学主义思潮所向披靡的冲击下,中国宇宙观发生了根本而全面的转变。这种转变具体表现为:从处境化空间向抽象空间的转变;从时机化... 详细信息

如果说中国传统的宇宙观是一种从身体出发的宇宙观,那么,近现代的宇宙观则是一种从思维出发的宇宙观。在科学主义思潮所向披靡的冲击下,中国宇宙观发生了根本而全面的转变。这种转变具体表现为:从处境化空间向抽象空间的转变;从时机化时间向线性时间的转变;从变化式运动向摄力运动的转变;从天人合一之物向自在之物的转变。然而,物极必反,随着当代哲学身体现象学强势崛起和对科学主义思潮深入反思,从中又使一种中国式的宇宙观合理性再次得以彰显。这一切告诉我们,一种更为健全宇宙观的建立,不仅要自觉地向自己传统重返,并且这种重返只能是一种经过现代化洗礼的重返,一种历史的否定之否定的重返,一种从事创造性转换的重返。

关键词：中国古代宇宙观中国近现代宇宙观梅洛-庞蒂的宇宙观

高等教育通向农村的时代内涵、本质特征与中国道路

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高等教育研究 2024年第2期45卷 39-46页

作者：刘在洲武汉纺织大学马克思主义学院

新时代赋予“高等教育通向农村”促进农村人口普遍接受高等教育，提高农村人口适应生产力发展和市场竞争的能力，打造农村学习型社会的环境和条件，助力更多受过高等教育的人员服务农村，支撑乡村全面振兴的时代内涵。我国高等教育通向... 详细信息

新时代赋予“高等教育通向农村”促进农村人口普遍接受高等教育，提高农村人口适应生产力发展和市场竞争的能力，打造农村学习型社会的环境和条件，助力更多受过高等教育的人员服务农村，支撑乡村全面振兴的时代内涵。我国高等教育通向农村有着鲜明的政治性、民生性与战略性特征，推进高等教育通向农村应从加强党的领导、对接国家战略、创新运行模式、转变村民观念等方面探索适合本国国情的发展道路。

关键词：高等教育普及化乡村振兴

Detection and clearance in Alzheimer’s disease: leading with illusive chemical, structural and morphological features of the targets

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Neural Regeneration Research 2024年第3期19卷 497-498页

作者： Luís Gales i3s−Instituto de Investigação e Inovação em saúde Rua Alfredo AllenPortoPortugal(Gales L)IBMC−Instituto de Biologia Molecular e CelularUniversidade do PortoRua Alfredo AllenPortoPortugal ICBAs−Instituto de Ciências Biomédicas Abel salazar Rua de Jorge Viterbo FerreiraPortoPortugal

Highly specific interactions between biomolecules,such as antigen-antibody,protein-ligand,or nucleic acid base pair complementary are on the basis of the organization of complex *** same principles may be tentatively used in molecular medicine for diagnosis and therapeutics.A molecule can be designed to selectively bind a protease and thereby inhibit the production of a peptide that forms toxic aggregates in the brain or an antibody may be produced to bind specifically to that peptide for detection or clearance ***,interference in biological systems is not that *** a start there is the inhibition of the physiological role of the protease;moreover,several cleavage fragments may be produced,which may continue to diverge due to putative post-translational modification and self-assembly processes,hiding the toxic target in a“soup”of peptide species varying in size,structure and chemical composition.A perspective of the current status and challenges in targeting peptide species for diagnosis and treatment in the context of Alzheimer’s disease is given.

关键词： Alzheimer diagnosis thereby