检索结果-南通市图书馆

Chinese Journal of Polymer Science 2022年第2期40卷 157-165页

作者： Wei Hu Ya-Wei Su Yi-Kun Jiang Wen-Di Fan Song-Yue Cheng zai-zai tong Chao Cen Guo-Hua Jiang College of Materials Science and Engineering and Institute of Smart Biomedical Materials Zhejiang Sci-Tech UniversityHangzhou 310018China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Near-infrared light(NIR)triggered transdermal drug delivery systems are of great interest due to their on-demand drug release,which enable to enhance drug treatment efficiency as well as reduce side ***,a NIR-triggered microneedle(MN)patch array has been fabricated through depositing the photothermal conversion agent and anti-diabetic drug-loaded polymer vesicles with upper critical solution temperature(UCST)into dissolvable polymer *** UCST-type polymer has a clearing point temperature of 41℃ and the drug-loaded polymer vesicles present excellent NIR-triggered and temperature responsive drug release behavior in vitro due to the disassociation of polymer vesicles upon NIR *** applying MNs to diabetic rats,significant hypoglycemic effect is achieved upon interval NIR irradiation and the blood glucose concentration can decrease to normal state for several hours,which enables to achieve the goal of on-demand drug *** work suggests that the NIR-triggered MN drug release device has a potential application in the treatment of diabetes,especially for those requiring an active drug release manner.

关键词： Diabetes Upper critical solution temperature Near-infrared light On-demand drug release Polymeric vesicles

Optimization of polyacrylonitrile-cysteine resin synthesis and its selective removal of Cu(Ⅱ) in aqueous solutions

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2017年第2期28卷 319-323页

作者： Yang Chang Chen Shen Pin-Yi Li Lei Fang zai-zai tong Min Min Chun-Hua Xiong Department of Applied Chemistry Zhejiang Congshang University Hangzhou 310012 China Department of Food Science and Human Nutrition University of Florida Bldg 475 Newell Drive FL 32611 USA Zhejiang Provincial Key Laboratory of Fiber Materials and Manufacturing Technology Hangzhou 310018 China Department of Materials Engineering Zhejiang Sci-Tech University Hangzhou 310018 China

Polyacrylonitrile beads（PAN） cysteine（CS） was synthesized from polyacrylonitrile beads（PAN） and cysteine（CS）.The content of the functional group and the percentage conversion of the functional group of PAN-CS prepared under the optimum condition using response surface methodology（RSM） for the first attempt were 3.22 mmol/g and 35.78%.The structure was characterized by ET-IR and elemental *** adsorption properties of the resin for Cu（Ⅱ） were investigated by batch and column *** adsorption results suggested that PAN-CS had higher adsorption capability for Cu（Ⅱ）than other metal ions and maximum saturated adsorption capacity was 184.7 mg/*** resin and its metal complexes were studied by ***,the resin can be eluted easily using 1 mol/L ***-CS can provide a potential application for selective removal of copper from waste solution.

关键词： Chelating resin Cysteine RSM Adsorption Cu(Ⅱ)

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 587-597页

作者： tong Li Hui-Min Xing Hai-Dong Qian Qiao Gao Sheng-Lan Xu Hua Ma zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

Optimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第7期9卷 3063-3076页

作者： Wenjing zai Min Yang Kuan Jiang Juan Guan Huijing Wang Kongying Hu Chao Huang Jieliang Chen Wei Fu Changyou Zhan Zhenghong Yuan Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) Research Unit of Cure of Chronic Hepatitis B Virus Infection(CAMS)Shanghai Frontiers Science Center of Pathogenic Microbes and InfectionSchool of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghaiP.R.China Department of Pharmacology School of Basic Medical SciencesFudan UniversityShanghaiP.R.China Shanghai Engineering Research Center for Synthetic Immunology Fudan UniversityShanghaiP.R.China Eye Institute and Department of Ophthamology Eye and ENT HospitalFudan UniversityShanghaiP.R.China Pharmacy Department of Huashan Hospital Fudan UniversityShanghaiP.R.China Institute of Pediatric Translational Medicine Shanghai Institute for Pediatric Congenital Heart DiseaseShanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Institute of Infectious Disease and Biosecurity ShanghaiP.R.China

This study aimed to develop a pan-genotypic and multifunctional small interfering RNA(siRNA)against hepatitis B virus(HBV)with an efficient delivery system for treating chronic hepatitis B(CHB),and explore combined RNA interference(RNAi)and immune modulatory modalities for better viral *** synthetic siRNAs targeting consensus motifs distributed across the whole HBV genome were designed and *** lipid nanoparticle(LNP)formulation was optimized by adopting HO-PEG_(2000)-DMG lipid and modifying the molar ratio of traditional polyethylene glycol(PEG)lipid in LNP *** efficacy and safety of this formulation in delivering siHBV(tLNP/siHBV)along with the mouse IL-2(mIL-2)mRNA(tLNP/siHBVIL2)were evaluated in the rAAVHBV1.3 mouse model.A siRNA combination(terms“siHBV”)with a genotypic coverage of 98.55%was selected,chemically modified,and encapsulated within an optimized LNP(tLNP)of high efficacy and security to fabricate a therapeutic formulation for *** results revealed that tLNP/siHBV significantly reduced the expression of viral antigens and DNA(up to 3log_(10)reduction;vs PBS)in dose-and time-dependent manners at single-dose or multi-dose frequencies,with satisfactory safety *** studies showed that tLNP/siHBVIL2 enables additive antigenic and immune control of the virus,via introducing potent HBsAg clearance through RNAi and triggering strong HBV-specific CD4^(+)and CD8^(+)T cell responses by expressed mIL-2 *** adopting tLNP as nucleic acid nanocarriers,the co-delivery of siHBV and mIL-2 mRNA enables synergistic antigenic and immune control of HBV,thus offering a promising translational therapeutic strategy for treating CHB.

关键词： formulation enable offering

Insights into the history and tendency of glycosylation and digestive system tumor:A bibliometric-based visual analysis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第3期16卷 1059-1075页

作者： Jie Jiang zai Luo Ren-Chao Zhang Yue-Ling Wang Jun Zhang Ming-Yu Duan Zheng-Jun Qiu Chen Huang Department of Gastrointestinal Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Jiangnan University Wuxi School of Medicine Wuxi 214122Jiangsu ProvinceChina Department of Education Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

BACKGROUND Glycosylation,a commonly occurring post-translational modification,is highly expressed in several tumors,specifically in those of the digestive system,and plays a role in various cellular pathophysiological *** the importance and detection methods of glycosylation in digestive system tumors have garnered increasing attention in recent years,bibliometric analysis of this field remains *** present study aims to identify the developmental trends and research hotspots of glycosylation in digestive system *** To find and identify the developmental trends and research hotspots of glycosylation in digestive system *** We obtained relevant literature from the Web of Science Core Collection and employed VOSviewer 1.6.19 and CiteSpace(version 6.1.R6)to perform bibliometric *** A total of 2042 documents spanning from 1978 to the present were analyzed,with the research process divided into three phases:the period of obscurity(1978-1990),continuous development period(1991-2006),and the rapid outbreak period(2007-2023).These documents were authored by researchers from 66 countries or regions,with the United States and China leading in terms of publication *** Celso A had the highest number of publications,while Pinho SS was the most cited ***-occurrence analysis revealed the most popular keywords in this field are glycosylation,expression,cancer,colorectal cancer,and pancreatic ***,the Journal of Proteome Research was the most prolific journal in terms of publications,while the Journal of Biological Chemistry had the most *** The bibliometric analysis shows current research focus is primarily on basic research in this ***,future research should aim to utilize glycosylation as a target for treating tumor patients.

关键词： Glycosylation Cancer Digestive system Bibliometric analysis CiteSpace VOS viewer

Effectiveness of onsite and online education in enhancing knowledge and use of human immunodeficiency virus pre-and postexposure prophylaxis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第22期12卷 5042-5050页

作者： Ying Shao Mei Zhang Li-Jun Sun Hong-Wei Zhang An Liu Xi Wang Ruo-Lei Xin Jian-Wei Li Jiang-Zhu Ye Yue Gao Zhang-Li Wang zai-Cun Li tong Zhang Clinic of Center for Infection Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Department of Infectious Diseases and Medical Immunology Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Chinese Association of STD and AIDS Prevention and Control Beijing 100050China Institute of STD/AIDS Prevention and Control Beijing Center for Disease Prevention and ControlBeijing 100013China

BACKGROUND Enhancing awareness and use of pre-exposure prophylaxis(PrEP)and postexposure prophylaxis(PEP)is vital to curb human immunodeficiency virus(HIV)***-risk behaviors prevalent among sexually transmitted infection clinic outpatients underscore the need for increased PrEP/PEP education in this *** To investigate the effects of both onsite and online health education on the knowledge of,and willingness to use,PrEP and PEP among individuals receiving PEP *** Participants were drawn from a cohort study on PEP service intervention at an STD/AIDS outpatient clinic in designated HIV/AIDS hospitals in Beijing,conducted from January 1 to June 30,*** education was provided both onsite and online during *** assessing knowledge of,and willingness to use,PrEP/PEP were administered at baseline and again at 24 wk *** A total of 112 participants were enrolled in the study;105 completed the follow-up at week *** percentage of participants with adequate knowledge of,and willingness to use,PrEP significantly increased from 65.2%and 69.6%at baseline to 83.8%and 82.9%at the end of the intervention(both P<0.05).Similarly,those with adequate knowledge of,and willingness to use,PEP increased from 74.1%and 77.7%at baseline to 92.4%and 89.5%at week 24(P<0.05).Being between 31 years and 40 years of age,having a postgraduate degree or higher,and reporting a monthly expenditure of RMB 5000 or more were found to be significantly associated with knowledge of PrEP and PEP(both P<0.05).CONCLUSION The findings show that both onsite and online health education significantly improved the knowledge of,and increased willingness to use,PrEP and PEP in individuals utilizing PEP services.

关键词： Human immunodeficiency virus Pre-exposure prophylaxis Post-exposure prophylaxis Health education Intervention

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

尼帕病毒的研究进展

中国口岸科学技术 2024年第3期6卷 36-42页

作者：马思杰龙再浩胡群童淑梅宁波国际旅行卫生保健中心(宁波海关口岸门诊部) 宁波315012

尼帕病毒(Nipah virus,NiV)是一种由蝙蝠传播的人畜共患病病毒,于1999年在马来西亚首次被发现,此后在南亚和东南亚地区引发了数次疫情,造成了严重的经济损失和人员伤亡。尼帕病毒具有高度传染性,可通过受感染的动物或人在人群中传播,引... 详细信息

尼帕病毒(Nipah virus,NiV)是一种由蝙蝠传播的人畜共患病病毒,于1999年在马来西亚首次被发现,此后在南亚和东南亚地区引发了数次疫情,造成了严重的经济损失和人员伤亡。尼帕病毒具有高度传染性,可通过受感染的动物或人在人群中传播,引起严重的神经系统和呼吸系统疾病,病死率高。本文就尼帕病毒的病毒特性、流行病学、临床症状、实验室检测、预防控制等内容进行阐述,为国境口岸尼帕病毒的疫情防控提供参考。

关键词：尼帕病毒流行病学实验室检测

在线全文

学校读者我要写书评

暂无评论

紫楠天然群落优势物种生态位与种间联结性

林业科学研究 2024年第3期37卷 61-67页

作者：陆云峰杨安娜王豪刘伟张俊红楼炉焕童再康浙江农林大学省部共建亚热带森林培育国家重点实验室浙江杭州311300 宁波市农业技术推广总站浙江宁波315012 丽水市森林资源保护管理总站浙江丽水323000

[目的]探究紫楠天然群落优势物种种间关系和群落稳定性。[方法]基于野外样地调查,从物种组成、重要值、生态位宽度、生态位重叠指数、方差比率法和χ^(2)检验等方面研究紫楠群落乔木层、灌木层各优势物种的生态位特征和种间联结性。[结... 详细信息

[目的]探究紫楠天然群落优势物种种间关系和群落稳定性。[方法]基于野外样地调查,从物种组成、重要值、生态位宽度、生态位重叠指数、方差比率法和χ^(2)检验等方面研究紫楠群落乔木层、灌木层各优势物种的生态位特征和种间联结性。[结果]紫楠在调查群落中的重要值最大,且其Levins指数生态位宽度和Shannon指数生态位宽度均最大,说明在群落中资源利用程度较高,竞争优势强;紫楠群落乔木层优势物种间总体呈不显著正联结(VR=1.247,χ^(2)_(0.95)(12)>W>χ^(2)_(0.05)(12)),而灌木层总体呈不显著负联结(VR=0.674,χ^(2)_(0.95)(36)>W>χ^(2)_(0.05)(36)),说明乔木层稳定性较高,且高于灌木层;χ^(2)检验结果显示乔木层、灌木层优势物种间正联结种对数均多于负联结,正负联结比分别为1.8∶1和1.5∶1,且绝大部分种对联结性均不显著,表明紫楠群落大多数优势物种间的生态特征较一致。[结论]紫楠群落总体稳定性较好,但仍可进行适当的人工抚育,促进紫楠种群自然更新。

关键词：紫楠天然群落优势物种生态位种间联结性

维普期刊数据库博看期刊

The roles of microRNAs in spinal cord ischemia-reperfusion injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第12期17卷 2593-2599页

作者： Feng-Shou Chen Xiang-Yi tong Bo Fang Dan Wang Xiao-Qian Li zai-Li Zhang Department of Anesthesiology the First Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

Spinal cord ischemia/reperfusion injury is a devastating medical disorder with poor prognosis that is associated with several pathophysiological ***,multiple stimuli can trigger SCII,so the underlying mechanism of this pathology has not yet been fully ***(miRNAs)are a class of non-coding RNAs that mediate a variety of nervous system diseases and regulate numerous physiological functions,including apoptosis,autophagy,inflammation,and blood-spinal cord barrier *** expression profiles are known to be altered after spinal cord ischemia/reperfusion ***,gaining a better understanding of the significant roles that miRNAs play in spinal cord ischemia/reperfusion injury could help develop potential preventive and therapeutic strategies for spinal cord ischemia/reperfusion *** review summarizes the current state of our knowledge about the relationship between miRNAs and spinal cord ischemia/reperfusion injury,as well as potential miRNAs that could be targeted to treat spinal cord ischemia/reperfusion injury.

关键词： apoptosis autophagy blood-spinal cord barrier inflammation microRNAs pathophysiology review spinal cord ischemia-reperfusion injury

在线全文

学校读者我要写书评

暂无评论

元素化学教学内容与模式的重构策略

化学教育（中英文） 2024年第4期45卷 34-41页

作者：张卫宰建陶马荔陈虹锦郭洪燃魏霄上海交通大学化学化工学院上海交通大学教学发展中心化学化工学院分中心上海200240

无机化学课程是高校化学及其近源专业一门重要的专业核心课程,教学内容中元素及其化合物的性质及应用部分知识点分散、信息量大,学生难以将化学反应原理等与具体的化合物性质、递变规律相结合,易产生畏难情绪,课堂教学效率低。本研究聚... 详细信息

无机化学课程是高校化学及其近源专业一门重要的专业核心课程,教学内容中元素及其化合物的性质及应用部分知识点分散、信息量大,学生难以将化学反应原理等与具体的化合物性质、递变规律相结合,易产生畏难情绪,课堂教学效率低。本研究聚焦元素化学课程内容与教学模式的重构,通过梳理教学内容和有效的教学设计,以点带面,高效组织课堂教学,打破传统课堂对于课时数的依赖,同时帮助学生构建系统、完整的元素化学知识体系;通过TBL教学法的引入,建立“以学为中心”的理念和思路,强化学生自主学习的能力和效率,增强学生对相关理论知识的分析、理解、运用等综合能力,推动学生的价值增值。

关键词：元素化学内容重构模式重构 TBL