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Early and delayed castrations confer a similar survival advantage in TRAMP mice

Asian Journal of Andrology 2009年第3期11卷 291-297页

作者： zai-xian zhang qing-quan xu xiao-bo huang ji-chuan zhu xiao-feng wang Department of Urology Peking University People＇s Hospital Beijing 100044 China

The most appropriate time to introduce androgen deprivation therapy for prostate cancer remains controversial. Our aim was to evaluate the effects of early versus delayed surgical castration on prostate cancer progression and survival in the transgenic adenocarcinoma of the mouse prostate （TRAMP） model. TRAMP mice were randomly divided into three groups： the early castration group （on which castration was performed at the age of 4 weeks）, the delayed castration group （on which castration was performed when abdominal tumours could be palpated）, and the sham-castrated group. Mice were monitored daily throughout their lives until cancer-related death or the develop- ment of an obviously moribund appearance, at which time the individual mouse was killed. Androgen receptor expression in prostate tumours was also evaluated. The results shows that the average lifespan in early castration, delayed castration and sham-castrated groups were 54.1 weeks, 59.9 weeks and 39.1 weeks, respectively. both early castration and delayed castration conferred a statistically significant survival advantage when compared with the sham-castrated group （P 〈 0.001）. However, the difference in lifespan between the early castration group and the delayed castration group was not statistically significant （P = 0.85）. The increase in lifespan in the TRAMP mice that received either early or delayed castration correlated with lower G/B value （genitourinary tract weight/body weight） at death than the sham-castrated mice. In conclusion, early and delayed castrations in TRAMP mice pro- longed survival to a similar extent. This finding may provide a guide for clinical practice in prostate cancer therapy.

关键词： castration prostate cancer survival TRAMP

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Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in China:A national multicenter survey of 35,566 individuals

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 113-120页

作者： Meng-Fan Liu Rui-Xia Ma xian-Bao Cao Hua zhang Shui-Hong Zhou Wei-Hong jiang Yan jiang jing-Wu Sun Qin-Tai Yang xue-Zhong Li Ya-Nan Sun Li Shi Min wang Xi-Cheng Song Fu-quan Chen xiao-Shu zhang Hong-quan Wei Shao-qing Yu Dong-Dong zhu Luo Ba Zhi-Wei Cao xu-Ping xiao Xin Wei Zhi-Hong Lin feng-Hong Chen Chun-Guang Shan Guang-Ke wang jing Ye Shen-Hong Qu Chang-qing Zhao Zhen-Lin wang Hua-Bin Li feng Liu xiao-bo Cui Sheng-Nan Ye Zheng Liu Yu xu xiao Cai Wei huang Ru-Xin zhang Yu-Lin Zhao Guo-Dong Yu Guang-Gang Shi Mei-Ping Lu Yang Shen Yu-Tong Zhao jia-Hong Pei Shao-Bing Xie Long-Gang Yu Ye-Hai Liu Shao-Wei Gu Yu-Cheng Yang Lei Cheng jian-feng liu Graduate School of Beijing University of Chinese Medicine BeijingChina Department of Otorhinolaryngology Head and Neck Surgery China-Japan Friendship HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First People's Hospital of YinchuanYinchuanChina Department of Otorhinolaryngology The First People's Hospital of Yunnan ProvinceKunmingChina Department of Otorhinolaryngology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Xiangya Hospital Central South UniversityChangshaChina Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of USTCHefeiChina Department of Otorhinolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Qilu Hospital of Shandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Otolaryngology The Second Hospital of Shandong UniversityShandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery Peking University People's HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery Yantai Yuhuangding HospitalQingdao UniversityYantaiChina Department of Otorhinolaryngology Head and Neck Surgery Xijing HospitalThe Fourth Military Medical UniversityXi'anChina Gansu Provincial Center for Disease Control and Prevention LanzhouChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of China Medical UniversityShenyangChina Department of Otorhinolaryngology Head and Neck Surgery Tongji Hospit

Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in ***:This study was conducted by 45 tertiary Grade-A hospitals in *** and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,*** collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory ***:Complete questionnaires were obtained from 35,566 *** overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste *** received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such *** infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the *** median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 *** overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying ***:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in *** and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.

关键词： epidemiologic studies incidence olfactory disorders prognosis SARS-CoV-2 taste disorders

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The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-Li Luo Yong-Heng Zhao Gang Zhao Li-Cai Deng xiao-Wei Liu Yi-Peng jing Gang wang Hao-Tong zhang jian-Rong Shi xiang-Qun Cui Yao-quan Chu Guo-Ping Li Zhong-Rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-huang Cao Jeffrey L.Carlin Hai-Yuan Chen jian-Jun Chen Kun-Xin Chen Li Chen xue-Lei Chen xiao-Yan Chen Ying Chen Norbert Christlieb jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei feng jian-Ning Fu Peng Gao xue-Fei Gong bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han bo-Liang He jin-Liang Hou Yong-Hui Hou Wen Hou Hong-zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei jia Fang-Hua jiang xiang jiang Zhi-bo jiang Ge jin xiao Kong xu Kong Ya-Juan Lei Ai-Hua Li Chang-Hua Li Guang-Wei Li Hai-Ning Li jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li Yan Li Yin-Bi Li Ye-Ping Li Yuan Liang Chien-Cheng Lin Chao Liu Gen-Rong Liu Guan-Qun Liu Zhi-Gang Liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg ji-Jun Ni Zhao-xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-Ming Shi jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang qing-Sheng Tao Yuan Tian Dan wang Da-Qi wang feng-Fei wang Guo-Min wang Hai wang Hong-Chi wang jian wang jia-Ning wang jian-Ling wang jian-Ping wang Jun-xian wang Lei wang Meng-Xin wang Shou-Guan wang Shu-qing wang Xia wang Ya-Nan wang You wang Yue-Fei wang You-Fen wang Peng Wei Ming-Zhi Wei Hong Wu Ke-Fei Wu xue-Bing Wu Yu-Zhong Wu xiao-Zheng Xing Ling-Zhe xu Xin-Qi xu Yan xu Tai-Sheng Yan De-Hua Yang Hai-feng Yang Hui-Qin Yang Ming Yang Zheng-Qiu Yao Yong Yu Hui Yuan Hai-bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng zhang Hua-Wei zhang jian-Nan zhang Li-Pin zhang Wei zhang Yong zhang Yan-Xia zhang Zheng-Chao zhang Ming Zhao Fang Zhou xu Zhou jie zhu Yong-Tian zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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前列腺脓肿2例报告及近10年国内文献复习

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中华男科学杂志 2007年第10期13卷 903-905页

作者：许清泉黄晓波王晓峰朱积川刘乾文张在先马凯北京大学人民医院泌尿外科北京100044

目的:结合2例前列腺脓肿病例及文献复习,评估我国前列腺脓肿的新特点。方法:报告2例前列腺脓肿病例,以前列腺脓肿作为关键词或篇名检索中国期刊全文数据库及万方数据数字化期刊全文数据库1997～2006年的资料,进行荟萃分析。结果:2病例... 详细信息

目的:结合2例前列腺脓肿病例及文献复习,评估我国前列腺脓肿的新特点。方法:报告2例前列腺脓肿病例,以前列腺脓肿作为关键词或篇名检索中国期刊全文数据库及万方数据数字化期刊全文数据库1997～2006年的资料,进行荟萃分析。结果:2病例既往均无糖尿病史但均有血糖升高,1例发病前曾行下尿路器械检查。2例均表现为显著排便困难,会阴疼痛伴有高热,外周血白细胞均不高,尿常规检查无感染表现。病例1通过MRI确诊,脓肿破溃至尿道经用抗生素痊愈;病例2通过经直肠B超及CT确诊,经直肠B超穿刺引流后治愈。荟萃分析结果表明,糖尿病、留置尿管或尿道器械操作是前列腺脓肿的主要致病因素,致病菌主要是金黄色葡萄球菌和大肠埃希菌,临床表现主要是膀胱刺激症状、排尿困难及会阴疼痛,多数患者经B超确诊,需行穿刺引流或开放手术引流。结论:现阶段前列腺脓肿表现不典型、可疑病例应及时行经直肠B超或CT检查确诊,B超引导下脓肿穿刺引流简便有效。

关键词：前列腺脓肿诊断治疗

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抗肿瘤药物处方审核专家共识——乳腺癌

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中国药学杂志 2020年第11期55卷 961-967页

作者：杨珺于波黄红兵翟青李焕杜琼刘澍戴媛媛贺飞樊英王晨董梅刘江刘玉国徐珽黄萍张文周蒋刚曹俊岭王丽霞戴助孙言才姜明燕吕永宁卢晓阳刘茂柏梁宁生宋燕青李朋梅刘广宣郝志英姚敦武李桂茹孔树佳谢瑞祥王建华魏青贾乐川李玫孟珺曹舫陈寒杰鄢丹白在先李国辉赫捷国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院北京100021 复旦大学附属肿瘤医院上海200032 中山大学肿瘤防治中心广州510060 天津医科大学肿瘤医院天津300060 哈尔滨医科大学附属肿瘤医院哈尔滨150081 河北医科大学第四医院石家庄050000 山东省肿瘤医院济南250117 四川大学华西医院成都610041 浙江省肿瘤医院杭州310022 河南省肿瘤医院郑州450008 四川省肿瘤医院成都610047 北京中医药大学东方医院北京100078 中国中医科学院广安门医院北京100053 湖北省肿瘤医院武汉430079 安徽省肿瘤医院合肥230031 中国医科大学附属第一医院沈阳110001 华中科技大学同济医学院附属协和医院武汉430022 浙江大学附属第一医院杭州310003 福建医科大学附属协和医院福州350001 广西医科大学附属肿瘤医院南宁530021 吉林大学第一医院长春130021 中日友好医院北京100029 辽宁省肿瘤医院沈阳110042 山西省肿瘤医院太原030013 湖南省肿瘤医院长沙410013 大连医科大学附属第二医院辽宁大连116023 云南省肿瘤医院昆明650000 福建省肿瘤医院福州350014 新疆医科大学第一附属医院乌鲁木齐830011 江苏省肿瘤医院南京210009 宁夏医科大学总医院肿瘤医院银川750004 吉林省肿瘤医院长春130000 国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院深圳医院广东深圳518116 陕西省肿瘤医院西安710061 青海省人民医院西宁810007 首都医科大学附属北京世纪坛医院北京100038 内蒙古自治区肿瘤医院呼和浩特010020 上海交通大学医学院附属同仁医院上海200336

乳腺癌是我国女性人群中发病率和死亡率最高的恶性肿瘤,年新发病例约27.89万例,占女性全部恶性肿瘤发病的16.51%,位居女性恶性肿瘤发病的首位[1]。和很多恶性肿瘤一样,乳腺癌的治疗采取多学科综合治疗与个体化治疗相结合的模式,根据患... 详细信息

乳腺癌是我国女性人群中发病率和死亡率最高的恶性肿瘤,年新发病例约27.89万例,占女性全部恶性肿瘤发病的16.51%,位居女性恶性肿瘤发病的首位[1]。和很多恶性肿瘤一样,乳腺癌的治疗采取多学科综合治疗与个体化治疗相结合的模式,根据患者的身体状况、肿瘤的病理组织学类型和分子分型、侵及范围和发展趋向,采取手术、放疗、化疗、内分泌治疗和分子靶向治疗等手段。

关键词：抗肿瘤处方共识乳腺癌

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