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HMGB1 Inhibitor Effectively Alleviates Psoriasis-Like Lesions and Inflammatory Cytokines in K14-VEGF Transgenic Mice

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International Journal of Dermatology and Venereology 2023年第1期6卷 9-14页

作者： Li-Xin Fu Bin Yin Na Cao Sha Qin Xiao-Yu Lei Tao Chen zai-pei guo Department of Dermatovenereology Chengdu Second People’s HospitalChengduSichuan 610041China Department of Dermatovenereology Chengdu Qingbaijiang Distinct People’s HospitalChengduSichuan 610300China Department of Dermatovenereology West China Hospital of Sichuan UniversityChengduSichuan 610041China

Objective:Anti-high-mobility group box 1(HMGB1)is involved in the pathogenesis of many inflammatory and autoimmune diseases,including *** present study aimed to investigate the therapeutic effects of HMGB1 monoclonal antibody(mAb)in keratin 14(K14)-vascular endothelial growth factor(VEGF)transgenic homozygous ***:Twelve VEGF transgenic mice were randomly divided into two groups of six mice each:the anti-HMGB1 mAb group and the immune complex(IC)mAb *** mice underwent intraperitoneal injection of anti-HMGB1 mAb or IC mAb once every 2 days for a total of three *** the lesions on the ears of the mice and evaluate the severity of the lesions using the baseline and clinical scores on the last day of *** changes in psoriasis-like lesions,cellular infiltration of T cells,dendritic cells,and neutrophils were detected by hematoxylin-eosin staining and *** mRNA expression of the inflammatory cytokines,including interleukin(IL)-6,tumor necrosis factor-α,interferon-γ,and IL-17 in the lesions were assessed by real-time quantitative polymerase chain *** number ofγδT cells in the lesions of two groups were detected by flow *** test was used to compare their ***:The anti-HMGB1 mAb effectively ameliorated the clinical skin *** clinical scores in the anti-HMGB1 mAb group were lower than those in the IC mAb group(6.00±0.52vs.10.83±0.48,P<0.001).Histopathologic changes and improvements in the K14-VEGF transgenic homozygous mice were evident after three *** scores of mice in the anti-HMGB1 mAb group were significantly lower than those in the IC mAb group(3.25±0.71vs.6.95±0.83,P=0.0033).The average epidermal thickness in the anti-HMGB1 mAb group was reduced by about 45%when compared with that in the IC mAb group(32.15±7.08vs.64.69±7.93,P=0.0054).Moreover,anti-HMGB1 mAb also decreased the number of infiltrating CD3+T cells,myeloperoxidase-positive neutrophils,and C

关键词： high-mobility group box 1 inflammatory cytokines K14-VEGF transgenic mouse psoriasis

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Secukinumab demonstrates high efficacy and a favorable safety profile over 52 weeks in Chinese patients with moderate to severe plaque psoriasis

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Chinese Medical Journal 2020年第22期133卷 2665-2673页

作者： Lin Cai Jian-Zhong Zhang Xu Yao Jun Gu Quan-Zhong Liu Min Zheng Shi-Fa Zhang Jin-Hua Xu Cheng-Xin Li Hao Cheng Qing guo Wei-Li Pan Shen-Qiu Li Ruo-Yu Li zai-pei guo Zhi-Qi Song Shan-Shan Li Xiu-Qin Dong Linda Wang Rong Fu Pascaline Regnault Pascal Charef Ratal Mazur Manmath Patekar Department of Dermatology.Peking University People's Hospital Beijing 100044China Institute of Dermatology Chinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100730China Department of Dermatology Changhai HospitalShanghai 200433China Department of Dermatology Tianjin Medical University General HospitalTianjin 300052China Department of Dermatology Second Affiliated Hospital School of MedicineZhejiang UniversityHangzhouZhejiang 311215China Department of Dermatology General Hospital of Northern Theater CommandShenyangLiaoning 110016China Department of Dermatology Huashan HospitalFudan UniversityShanghai 200040China Department of Dermatology and Venereology Chinese People's Liberation Army General HospitalBeijing 100853China Department of Dermatology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouZhejiang 310016China Department of Dermatology Sun Yat-Sen Memorial HospitalGuangzhouGuangdong 510120China Department of Dermatology Zhejiang Provincial People's HospitalZhejiangHangzhouZhejiang 310014China Department of Dermatology Tongji HospitalTongji Medical College of Huazhong University of Science&TechnologyWuhanHubei 430030China Department of Dermatology Peking University First HospitalBeijing 100034China Department of Dermatology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Dermatology First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning 116011China Department of Dermatology The First Hospital of Jilin UniversityChangchunJilin 130021China Department of Dermatology Guangdong General HospitalGuangzhouGuangdong 510080China Beijing Novartis Pharma Co.Ltd. Shanghai 201203China Novartis Pharma AG Basel 6463Switzerland

Background:Psoriasis is a chronic inflammatory skin disease,affecting about 0.6%of the Chinese *** patients are not well controlled by conventional treatments,thus there is need for new treatment *** this study,we assessed the efficacy and safety of secukinumab in Chinese patients with moderate to severe plaque ***:This study was a 52-week,multicentre,randomized,double-blind,placebo-controlled,parallel-group,Phase 3 trial.A sub-population of study participants(≥18 years)of Chinese ethnicity were randomized to receive subcutaneous injections of 300 or 150 mg secukinumab,or *** co-primary endpoints were psoriasis area severity index(PASI)75 and Investigator’s Global Assessment(IGA)0/1 at Week ***:A total of 441 Chinese patients were enrolled in this ***-primary outcomes were achieved;300 and 150 mg secukinumab were superior to placebo as shown in the proportion of patients that achieved PASI 75(97.7%and 87.2%vs.3.7%,respectively;P<0.001),and IGA 0/1(82.3%and 69.7%vs.2.7%;P<0.001)at Week *** efficacy was maintained until Week *** was no increase in overall adverse events with secukinumab relative to placebo throughout the 52-week ***:Secukinumab is highly effective and well tolerated in Chinese patients with moderate to severe plaque psoriasis.

关键词： Chinese Psoriasis IL-17 Dermatology Clinical trial PASI

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Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis

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Chinese Medical Journal 2016年第7期129卷 757-762页

作者： Ping Liu Yan Zhao Zhang-Lei Mu Qian-Jin Lu Qian-Jin L U Li Zhang Xu Yao Min Zheng Yi-Wen Tang Xin-Xiano Lu Xiu-Juan xia You-Kun Lin Yu-Zhen Li Cai-Xia Tu Zhi-Rong Yao Jin-Hua Xu Wei Li Wei Lai Hui-Min Yang Hong-Fu Xie Xiu-Ping Han Zhi-Qiang Xie Xiang Nong zai-pei guo Dan-Qi Deng Tong-Xin Shi Jian-Zhong Zhang Department of Dermatology Peking University People's Hospital Beijing 100044 China Department of Dermatology The Second Xiangya Hospital of Central South University Changsha Hunan 410011 China Department of Dermatology The First Hospital of China Medical University Shenyang Liaoning 110001 China Department of Dermatology Institute of Dermatology Chinese Academy of Medical Sciences Nanjing Jiangsu 210042 China Department of Dermatology The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China Department of Dermatology Tianjin Changzheng Hospital Tianjin 300120 China Department of Dermatology The Affiliated Hospital of Inner Mongolia Medical University Hohhot Inner Mongolia 010050 China Department of Dermatology Yantai Yuhuangding Hospital Yantai Shandong 264000 China Department of Dermatology The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi 530021 China Department of Dermatology The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Dermatology The Second Hospital of Dalian Medical University Dalian Liaoning 116023 China Department of Dermatology Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092 China Department of Dermatology Shanghai Huashan Hospital Shanghai 200040 China Department of Dermatology Xijing Hospital Xi'an Shaanxi 710032 China Department of Dermatology The Third Affiliated Hospital Of Sun Yat-sen University Guangzhou Guangdong 510630 China Department of Dermatology The Second Hospital of Heilongjiang Province Harbin Heilongjiang 150010 China Department of Dermatology Xiangya Hospital of Central South University Changsha Hunan 410008 China Department of Dermatology.Shengjing Hospital of China Medical University Shenyang Liaoning 110004 China Department of Dermatology Peking University Third Hospital Beijing 100191 China Department of Dermatology The First Affili

Background： Atopic dermatitis （AD） is an inflammatory skin disease characterized by chronic recurrent dermatitis with profound itching. Most patients have personal and/or family history of atopic diseases. Several criteria have been proposed for the diagnosis of AD. Although the clinical features of childhood AD have been widely studied, there has been less large-scale study on adult/adolescent AD. The aim of this study was to investigate the clinical features of adult/adolescent patients with chronic symmetrical eczemaJAD and to propose Chinese diagnostic criteria for adult/adolescent AD. Methods： A hospital-based study was performed. Forty-two dermatological centers participated in this study. Adult and adolescent patients （12 years and over） with chronic symmetrical eczema or AD were included in this study. Questionnaires were completed by both patients and-investigators. The valid questionnaires were analyzed using EpiData 3.1 and SPSS 17.0 software. Results： A total of 2662 valid questionnaires were collected （1369 male and 1293 female）. Of all 2662 patients, 2062 （77.5%） patients had the disease after 12 years old, while only 600 （22.5%） patients had the disease before 12 years old, suggesting late-onset eczema/AD is common. Two thousand one hundred and thirty-nine （80.4%） patients had the disease for more than 6 months. One thousand one hundred and forty-four （43.0%） patients had a personal and/or family history of atopic diseases. One thousand five hundred and forty-eight （58.2%） patients had an elevated total serum IgE and/or eosinophilia and/or positive allergen-specific IgE. Based on these clinical and laboratory features, we proposed Chinese criteria for adult/adolescent AD. Of all 2662 patients, 60.3% were satisfied with our criteria, while only 48.2% satisfied with Hanifin Rajka criteria and 32.7% satisfied with Williams criteria, suggesting a good sensitivity of our criteria in adult/adolescent AD patients. Conclusion： Late-onset of eczema or AD is co

关键词： Adolescents and Adults Atopic Dermatitis Clinical Features Diagnostic Criteria Eczema

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Estimation on Magnetic Refrigeration Material (Gd_(1-x)RE_x)_5Si_4 (RE=Dy,Ho)

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Journal of Materials Science & Technology 2006年第6期22卷 839-842页

作者： Wei WU zai FENG Lijun guo School of Materials Science and Engineering Xihua Univiersity Chengdu 610039 China

A systematic （Gd1-xREx）sSi4 （RE=Dy, Ho） alloys are investigated to estimate their magnetocaloric effect. The Curie points of （Gd1-xREx）Si4 alloys can tunable from 266 K to 336 K when RE=Dy, Ho; z=0N0.35 and 0-0.15, respectively, and decrease nearly linearly with increasing x. These alloys keep orthorhombic structures GesSm4 and exhibit second order transition when they experience in a change magnetic field at about Curie points. The weight and voluminal magnetic entropy changes are about 3.5 J/（kg.K） and 23-29 mJ/（cm^3.K） when magnetic field changes 0-2 T. The adiabatic temperatures changes （△Tad） of these alloys at Curie points are larger than 1 K in a field change 0-1.4 T, the curve of ATad is wide as that of Gd. The relative cooling power is about 0.8-0.9 J/cm^3 when field changes 0-2 T, 55% of that of Gd. Comparing with Gds（Si1-xGex）4, these alloys do not contain expensive element Ge, so that their cost are lower than the former. Because they could work at temperature region 260-340 K due to their Curie points can be tuned, which is an advantage comparing with Gd, these alloys are potential magnetic refrigerants working in a magnetic refrigerator with a low magnetic field at room temperatures.

关键词： Magnetocaloric effect Magnetic refrigerators Magnetic entropy changes Adiabatic temperature changes Rare earths

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Blowing up of Solutions to the Cauchy Problem for the Generalized Zakharov System with Combined Power-Type Nonlinearities

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Acta Mathematica Sinica,English Series 2012年第9期28卷 1917-1936页

作者： zai Hui GAN Bo Ling guo Chun Xiao guo College of Mathematics and Software Science Sichuan Normal University Institute of Applied Physics and Computational Mathematics Department of Mathematics China University of Mining and Technology Beijing

This paper deals with blowing up of solutions to the Cauchy problem for a class of general- ized Zakharov system with combined power-type nonlinearities in two and three space dimensions. On the one hand, for co = ＋oo we obtain two finite time blow-up results of solutions to the aforementioned 4 ≤ p 〈 N＋2/N-2 4 system. One is obtained under the condition a ≥ 0 and 1 ＋ 4/N or a 〈 0 and 1 〈 p 〈 1 ＋（N = 2,3）; the other is established under the condition N = 3, 1 〈 p 〈 N=2/N-2 and α（p - 3）〉 0. On the other hand, for co 〈＋∞ and α（p - 3）〉 0, we prove a blow-up result for solutions with negative energy to the Zakharov system under study.

关键词： Generalized Zakharov system blowing up combined power-type nonlinearities Lyapunov function in time

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Temperature fault-tolerant control system of CSTR with coil and jacket heat exchanger based on dual control and fault diagnosis

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Journal of Central South University 2017年第3期24卷 655-664页

作者： WANG zai-ying WANG guo-xin School of Electrical and Control Engineering Xi＇an University of Science and Technology Xi＇an 710054 China

For the characteristics of the continuous stirred-tank reactor(CSTR) with coil and jacket cooling system,a CSTR temperature dual control solution based on the analysis of the CSTR exothermic reaction control characteristic was proposed for an organic material polymerization *** control solution has passive fault-tolerant ability for the jacket cooling water cutting off fault and active fault-tolerant potential for the coil cooling water cutting off fault,and it has good control ability,high saving energy and reducing consumption *** detection and diagnosis and fault-tolerant control strategy are designed for the coil cooling fault to achieve the active fault-tolerant control *** CSTR temperature dual control,process fault detection and diagnosis and active fault-tolerant control were full integrated into the CSTR temperature fault-tolerant control system,which achieve fault tolerance control of CSTR temperature for any severe malfunction of jacket cooling or coil cooling cutting off,and the security for CSTR exothermic reaction is ***,the effectiveness of this system was validated by semi-physical simulation experiment.

关键词： continuous stirred-tank reactor (CSTR) exothermic reaction dual control process fault diagnosis fault-tolerant control

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Identification of leaf rust resistance genes in common wheat varieties from China and foreign countries

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Journal of Integrative Agriculture 2021年第5期20卷 1302-1313页

作者： LIU Yuan Takele Weldu GEBREWAHID ZHANG pei-pei LI zai-feng LIU Da-qun College of Plant Protection Hebei Agricultural UniversityBaoding 071001P.R.China College of Agriculture Aksum UniversityShire-Indaslassie 314Ethiopia

Wheat leaf rust,triggered by Puccinia triticina Eriks(Pt),is among the most important diseases of wheat *** resistant varieties against leaf rust is the most effective,environmentally-friendly and economic way to control the *** the present study,66 wheat varieties form China and foreign countries were tested with 17 Pt races for gene postulation during the seedling stage in the *** the varieties were also planted to identify slow rusting responses to leaf rust at the adult plant stage in Baoding and Zhoukou field trials during the 2016/2017 to 2017/2018 cropping ***,12 closely linked molecular markers to known leaf rust resistance(Lr)genes were used for assessing all the *** results of both gene postulation and molecular marker identification showed that a total of eight Lr genes,Lr1,Lr10,Lr17,Lr20,Lr26,Lr34,Lr37 and Lr46,either singly or in combination were detected in 32 *** Lr genes were not identified in the remaining 34 *** varieties were found to have slow rusting *** resistance sources identified in this study can be used as resources for resistance against leaf rust in wheat breeding programs in China and the respective foreign countries.

关键词： wheat gene postulation molecular marker Lr gene

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Fundamentals of fast reduction of ultrafine iron ore at low temperature

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Journal of University of Science and Technology Beijing 2008年第2期15卷 104-109页

作者： pei Zhao peimin guo State Key Laboratory for Advanced Iron and Steel Processes and Materials China Iron and Steel Research Institute Group Beijing 100081 China

Fundamentals on the fast reduction of ultrafine iron ore at low temperature, including characterization of ultrafine ore, deoxidation thermodynamics of stored-energy *** ore, kinetics of iron ore deoxidation, and deoxidation mechanism, etc., and a new ironmaking process are presented in this article. Ultrafine ore concentrate with a high amount of stored energy can be produced by mechanical milling, and can be deoxidated fast below 700℃ by either the coal-based or gas-based process. This novel process has some advantages over others： high productivity, low energy consumntion, and environmental friendliness.

关键词： ironmaking low temperature fast reduction powder refining thermodynamics kinetics

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Novel Kinetic Method for Expressing the Ability of Antioxidant to Scavenge Radicals

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Chemical Research in Chinese Universities 2013年第5期29卷 947-951页

作者： LI Yan-feng LI pei-ze LIU zai-qun Department of Organic Chemistry College of Chemistry Jilin University Changehun 130012 t~ R. China

A method was developed to treat the result from an antioxidant trapping radicals including 2,2＇-azinobis （3-ethylbenzothiazoline-6-sulfonate） cationic radieal（ABTS＋＇）, 2,2＇-diphenyl-l-picrylhydrazyl radical（DPPH）, and galvinoxyl radical. In the presence of a certain concentration of an antioxidant, the decrease of the concentration of a kind of radicals follows the second order exponential function with the increase of the reaction time（t）, v＆., [radical]=Ae-t/a＋Be rib＋c, the derivation operation of which obtains the differential style, -d[radical]/dt= （A/a）e t/a＋（B/b）e-t/b, revealing the relationship between the reaction rate（r=-d[radical]/dt） and the reaction time（t）. Thus, the reaction rate at the beginning of the reaction@0） can be calculated by assigning t=-0 in the equation of -d[radical]/dt-t. Based on the concept of the reaction rate, r=k[radical][antioxidant], the rate constant（k） can be calculated based on r0 and the initial concentrations of radical and antioxidant, k=-r0/（[radieal]o[antioxidant]0）. The k means the rate of a fresh antioxidant molecule to trap a fresh radical. This method was used to treat the interactions of ABTS＋＇, DPPH, and galvinoxyl radicals with three homoisoflavonoids, four pyrazoles, and three ferrocenyl Schiff bases. It was found that ferrocenyl group is beneficial for antioxidants to reduce ABTS＋＇, and ortho-hydroxyl group is beneficial for antioxidants to donate hydrogen atom in phenolic hydroxyl group to DPPH and galvinoxyl radicals.

关键词： Rate constant Radical-scavenging ability Antioxidant capacity Chemical kinetics

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Activity Model of Fe-Si-B Ternary Metallic Melts

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Journal of Iron and Steel Research International 2011年第6期18卷 16-21页

作者： ZHAO Ding-guo guo pei-min ZHAO pei State Key Laboratory for Advanced Iron and Steel Processes and Materials Central Iron andSteel Research Institute Beijing 100081 China

According to the ion and molecule coexistence theory, the activity model of Fe-Si-B ternary system was es- tablished, and the influence of ratio ：Csi/XZe, boron content and temperature, etc. on the activity of the melt com- pound was investigated. The results show that the FeB activity is high in the liquid iron, when Xsl/XFo is 0. 5 ; the ac- tivity of boron increases with increasing the boron content for different contents of xe and xs, and the activity of boron at the ratio xFo = 0.4 is about one order of magnitude higher than that for the XFo = 0. 8; The activities of the melt compound were also affected by temperature, but the influencing extent was little. The equal activity diagrams of silicon and boron were drawn for the first time according to the model results.

关键词： activity metallic melt ion and molecule coexistence model equal activity diagram

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