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Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong li Hui-Min Xing Hai-Dong Qian Qiao Gao Sheng-Lan Xu Hua Ma zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： ling-Xiao Yi Hui Ren Woon Genevieve Saw li Zeng Eng king Tan Zhi Dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

Manufacture the conducting polymer with light

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Science China Chemistry 2025年第1期68卷 8-9页

作者： Yang li Tianyu li Yan Ji Baoguang liu College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology) Nanjing University of Posts & Telecommunications

Poly(3,4-ethylenedioxythiophene) (PEDOT), heralded as the “king” of conducting polymers, is esteemed in bioelectronics for its mixed electronic and ionic conductivity, mechanical properties compatible with biological tissues, tunable healing ability and stability in diverse environments [1]. Based on additive manufacturing of three-dimensional structures,PEDOT realizes the implementation in the efficient production of flexible bioelectronics, the construction of intricate electrode-neural implantations, and the development of smart brain-computer-interfaces [2].

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Selection of Fixed Effects in High-dimensional Generalized linear Mixed Models

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Acta Mathematica Sinica,English Series 2023年第6期39卷 995-1021页

作者： Xi Yun ZHANG zai Xing li School of Science China University of Mining&Technology(Beijing)Beijing 100083P.R.China

The selection of fixed effects is studied in high-dimensional generalized linear mixed models(HDGLMMs)without parametric distributional assumptions except for some moment *** iterative-proxy-based penalized quasi-likelihood method(IPPQL)is proposed to select the important fixed effects where an iterative proxy matrix of the covariance matrix of the random effects is constructed and the penalized quasi-likelihood is *** establish the model selection consistency with oracle properties even for dimensionality of non-polynomial(NP)order of sample *** studies show that the proposed procedure works ***,a real data is also analyzed.

关键词： Fixed effects selection HDGLMMs penalized quasi-likelihood proxy covariance matrices theoretical properties

Effects of Micelle on Pyrazoles as Antioxidants in Radical-induced Oxidation of DNA

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Chemical Research in Chinese Universities 2013年第4期29卷 671-677页

作者： li Yan-feng liU zai-qun Department of Organic Chemistry College of Chemistry Jilin University Changchun 130021 P. R. China

Effects of 4-（1,3-diphenyl-1H-pyrazol-5-yl）phenol（APP）,4-（1,5-diphenyl-lH-pyrazol-3-yl）phenol（BPP） and 4-（3,5-diphenyl-1H-pyrazol-1-yl）phenol（CPP） on 2,2＇-azobis-（2-amidinopropane hydrochloride）（AAPH）-induced oxidation of DNA were measured in the presence of various concentrations of Triton X-100,cetyltrimethylammonium bromide（CTAB）,or sodium dodecyl sulfate（SDS） in order to clarify the influence of neutral,cationic and anionic microenvironments on antioxidant capacities of APP,BPP and *** these surfactants can protect DNA against AAPH-induced oxidation,the pyrazoles in the presence of these surfactants functioned as prooxidants when the concentrations of Triton X-100 and CTAB ***,CPP exhibited antioxidant property with the increase of the concentration of *** the contrary,APP,BPP and CPP were antioxidants in the presence of various concentrations of *** added surfactants resulted in the complication of the microenvironments around DNA,pyrazoles and peroxyl radical（ROO＊） derived from *** anionic charge of SDS was beneficial to enhancing the antioxidant effectiveness of these *** can be concluded that the charge property of surfactants markedly influenced the behavior of an antioxidant in AAPH-induced oxidation of DNA.

关键词： Pyrazole Surfactant Oxidation DNA Free radical Microenvironment effect

Influences of the diameter of the balance hole on the flow characteristics in the hub cavity of the centrifugal pump

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Journal of Hydrodynamics 2019年第5期31卷 1060-1068页

作者： Wei Dong Wu-li Chu zai-lun liu College of Water Resources and Architectural Engineering Northwest A&F UniversityYangling 712100China School of Power and Energy Northwestern Polytechnical UniversityXi'an 710129China College of Energy and Power Engineering Lanzhou University of TechnologyLanzhou 730050China

The diameter of the impeller balance hole in a centrifugal pump is closely related to axial ***,to select the appropriate diameter of a balance hole is crucial for balancing the axial force of the centrifugal *** the validation of the CFD method and the grids independence study,the characteristics of flow in the hub cavity have been analyzed in 4 cases with different diameters of balance *** leakage rate of the liquid in the hub cavity of the centrifugal pump is calculated and compared with the test *** to the research,when no balance hole exists,the distribution of liquid velocity in the core area of the hub cavity exhibits axial symmetry,and the circumferential velocity component is approximately 0.4 times of the impeller's rotational *** the balance hole exists,the distribution of liquid velocity in the hub cavity does not exhibit axial symmetry,and the circumferential velocity component is larger than 0.4 times of the impeller's rotational *** radial leakage velocity on the turbulent boundary layer of the pump cover will increase with the increasing diameter of the balance hole.

关键词： Centrifugal pump balance hole hub cavity circumferential velocity component radial velocity component

Cytogenetics and germplasm enrichment in Brassica allopolyploids in China

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Journal of Integrative Agriculture 2017年第12期16卷 2698-2708页

作者： li zai-yun WANG You-ping National Key Laboratory of Crop Genetic Improvement College of Plant Science and TechnologyHuazhong Agricultural University College of Bioscience and Biotechnology Yangzhou University Key Laboratory of Agrobiology of Jiangsu Jiangsu Academy of Agricultural Sciences

This paper reviews research advances in cytogenetics and germplasm innovation in Brassica allopolyploids, particularly oilseed rape（Brassica napus）, in China. Three naturally evolved Brassica allotetraploid species are cytologically stable but tend to preferentially lose several chromosomes from one subgenome when induced by alien chromosome elimination. A-subgenome is extracted from B. napus, and the ancestral Brassica rapa was restituted after the total loss of C-subgenome chromosomes. Genome-wide genetic and epigenetic alterations were observed in both natural and synthetic Brassica allotetraploids. B. napus was subjected to extensive interspecific hybridization with landraces of B. rapa and Brassica juncea, which exhibit abundant phenotype variations, to widen the genetic diversity in breeding and select numerous elite germplasm resources and cultivars; these cultivars include the representative Zhongyou 821, which also parented numerous other varieties. Novel B. napus genotypes were obtained using Brassica trigenomic hybrids and allohexaploids（2 n=54, AABBCC） by combining subgenomes from extant allotetraploids and diploids as bridge. Alien additions, substitutions, and translocations of the B. napus genome were developed by intergeneric/intertribal sexual and somatic hybridizations with several crucifers. Furthermore, mitochondrial DNA recombination promoted the production of novel cytoplasmic male sterile lines.

关键词： Brassica napus germplasm Brassica rapa Brassicajuncea cytogenetics

Facile Synthesis of Porous Zn–Sn–O Nanocubes and Their Electrochemical Performances

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Nano-Micro Letters 2016年第2期8卷 174-181页

作者： Bo li Xiaomin li Jiantao zai Xuefeng Qian School of Chemistry and Chemical Engineering and State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University

Porous Zn–Sn–O nanocubes with a uniform size were synthesized through a facile aqueous solution route combined with subsequent thermal treatment. The chemical composition, morphology, and microstructure of Zn–Sn–O nanocubes, which have significant effects on the lithium storage performances, were easily tuned by adjusting the calcination temperature in preparation processes of ZnSn(OH)6solid nanocubes. Further studies revealed that porous Zn–Sn–O nanocubes prepared at 600 °C exhibited a good rate capability and a high reversible capacity of 700 m Ah g^(-1)at a current density of 200 m Ag^(-1)after 50 cycles, which may be a great potential as anode materials in lithium-ion batteries.

关键词： Zn–Sn–O Nanocubes Porous lithium-ion batteries

Some Properties for the Estimators in linear Mixed Models

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Acta Mathematicae Applicatae Sinica 2013年第1期29卷 105-116页

作者： zai-xing li Yan Cui Wang-li Xu College of Science China University of Mining and Technology (Beijing) School of Statistics Renmin University of China

linear mixed models （LMMs） have become an important statistical method for analyzing cluster or longitudinal data. In most cases, it is assumed that the distributions of the random effects and the errors are normal. This paper removes this restrictions and replace them by the moment conditions. We show that the least square estimators of fixed effects are consistent and asymptotically normal in general LMMs. A closed-form estimator of the covariance matrix for the random effect is constructed and its consistent is shown. Based on this, the consistent estimate for the error variance is also obtained. A simulation study and a real data analysis show that the procedure is effective.

关键词： Moment conditions LMMs Consistency Asymptotical normality