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Phytosomal curcumin alleviates collagen-induced arthritis by downregulating Th17 and upregulating Treg cell responses in rats

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Asian Pacific Journal of Tropical Biomedicine 2022年第11期12卷 466-474页

作者： Mahnaz Ramezani Nahid Zainodini Reza Nosratabadi Yaser Yousefpoor zahra taghipour Mitra Abbasifard Mohammad Reza Rahmani Immunology of Infectious Diseases Research Center Research Institute of Basic Medical SciencesRafsanjan University of Medical SciencesRafsanjanIran Department of Medical Immunology Afzalipour Faculty of MedicineKerman University of Medical SciencesKermanIran Gastroenterology and Hepathology Research Center Institute of Basic and Clinical Physiology SciencesKerman University of Medical SciencesKermanIran Department of Medical Biotechnology School of Paramedical SciencesTorbat Heydariyeh University of Medical SciencesTorbat HeydariyehIran Khalil Abad Health Center Mashhad University of Medical SciencesMashhadIran Department of Anatomy School of MedicineRafsanjan University of Medical SciencesRafsanjanIran Department of Internal Medicine Ali-Ibn Abi-Talib HospitalSchool of MedicineRafsanjan University of Medical SciencesRafsanjanIran Physiology-Pharmacology Research Center Research Institute of Basic Medical SciencesRafsanjan University of Medical SciencesRafsanjanIran Department of Physiology and Pharmacology School of MedicineRafsanjan University of Medical SciencesRafsanjanIran

Objective:To explore the effects of a nano-formulation of curcumin(phytosomal curcumin)on the clinical and pathological symptoms of collagen-induced arthritis(CIA)in ***:Forty male Wistar rats were immunized with an emulsion containing bovine typeⅡcollagen and incomplete Freund's adjuvant and then administered phytosomal curcumin *** symptoms and histological analysis of the synovial tissues were *** effect of phytosomal curcumin on Th17 and Treg parameters was also ***:Phytosomal curcumin reduced the clinical severity and paw swelling in CIA-induced rats,which was accompanied by a reduction in the number of inflammatory cell infiltration in the synovial ***,treatment with phytosomal curcumin significantly inhibited CIA-associated mediators as well as increased the anti-inflammatory mediators in comparison to the control ***:Phytosomal curcumin could improve CIA autoimmune responses and can be considered a potential candidate for the treatment of rheumatoid arthritis.

关键词： Phytosomal curcumin Rheumatoid arthritis Collagen Th17 Treg Anti-inflammation Curcuma longa

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Evaluation of Serum Vitamin D Concentration and Blood Eosinophil and Basophil Counts in Patients With Vitiligo:A Cross-sectional Study From Rafsanjan and Zarand,Iran

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International Journal of Dermatology and Venereology 2023年第3期6卷 136-140页

作者： Razieh Taghizadeh Ghavamabadi Reihaneh Pishgooie Shadi Behfar Mohammad Mohsen Taghavi Abdolreza Babaee zahra taghipour Department of Anatomy School of MedicineRafsanjan University of Medical SciencesRafsanjanKerman ***Iran Physiology-Pharmacology Research Center Rafsanjan University of Medical SciencesRafsanjanKerman ***Iran Department of Internal Medicine Rafsanjan University of Medical SciencesRafsanjanKerman ***Iran Department of Dermatology Rafsanjan University of Medical SciencesRafsanjanKerman ***Iran

Objective:Vitiligo is a chronic autoimmune depigmenting skin *** this disease,the destruction of functional melanocytes can lead to reduced or absent pigmentation of the *** D deficiency has been reported in some autoimmune *** association of eosinophils and basophils with autoimmune diseases has also been recently *** present study was performed to evaluate the serum vitamin D concentration and blood eosinophil and basophil counts in patients with ***:Data from 30 patients aged 20 to 40 years with vitiligo and 30 healthy people were *** samples were obtained to evaluate the serum vitamin D concentration,and eosinophil and basophil *** serum vitamin D concentration was measured by enzyme-linked immunosorbent *** t-test was used to compare the quantitative variables between the ***:This descriptive cross-sectional study involved 30 patients with *** average serum vitamin D concentration was significantly lower in the case group than in the control group(P=0.01).Furthermore,the mean serum vitamin D concentration was significantly lower in women than in men(P=0.03).The average eosinophil and basophil counts were not significantly different between the case and control ***:The results of this study showed that the serum vitamin D concentration is low in patients with ***,whether this reduction is a factor in the promotion of vitiligo or occurs after the onset of vitiligo remains *** studies on the serum vitamin D concentration in patients with vitiligo are needed to clarity this issue and develop effective treatments.

关键词： autoimmunity pigmentation disorders vitiligo 1,25-dihydroxyvitamin D3

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Anxiety, Depression and Coronary Artery Disease among Patients Undergoing Angiography in Ghaem Hospital, Mashhad, Iran

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Health 2014年第11期6卷 1108-1115页

作者： Mohammad Tajfard Majid Ghayour-Mobarhan Hamid Reza Rahimi Mohsen Mouhebati Habibollah Esmaeily Gordon A. A. Ferns Latiffah A. Latiff Farzaneh Tajfiroozeh Nagmeh Mokhber Ramin Nazeminezhad Homa Falsoleyman Ali taghipour Ahmad Fazli Abdul Aziz Rosliza A. Manaf zahra Saghiri Parichehr Hanachi Brighton & Sussex Medical School Falmer Brighton UK Cardiovascular Research Center School of Medicine Mashhad University of Medical Sciences Mashhad Iran Departemet of Psychiatry School of Medicine Mashhad University of Medical Sciences Mashhad Iran Department of Biology-Biochemistry Faculty of Science Payame Noor University of Mashhad Mashhad Iran Department of Cardiology School of Medicine Mashhad University of Medical Sciences Mashhad Iran Department of Community Health Faculty of Medicine and Health Sciences Universiti Putra Malaysia Serdang Selangor Malaysia Department of Medicine Faculty of Medicine and Health Sciences University Putra Malaysia Serdang Selangor Malaysia Faculty of Science Biology Department Biochemistry Unit Alzahra University Tehran Iran Health Sciences Research Center Department of Biostatistics School of Health Mashhad University of Medical Sciences Mashhad Iran Health Sciences Research Center Department of Health and management School of Health Mashhad University of Medical Sciences Mashhad Iran Student Research Committee Department of Modern Sciences & Technologies School of Medicine Mashhad University of Medical Sciences Mashhad Iran

The prevalence of coronary artery disease (CAD) is increasing in Iran. Patients with depression who have a myocardial infarction are more likely to die and patients who have depressive symptoms during hospitalization may have increased cardiovascular events. This study aimed to determine the relationship between anxiety, depression and coronary artery disease among patients undergoing angiography in Ghaem Hospital, Mashhad. This was a case-control study conducted between September 2011 and August 2012 among patients undergoing coronary angiography in Ghaem Hospital, Mashhad, Iran. There were 486 cases that were found to have one or more coronary stenoses, with a stenosis of equal or more than 50% of the diameter of at least one major coronary artery. The other patient group consisted of the patients in whom the coronary artery stenosis was less than 50% in diameter which was classified as angiography negative, and a control group that consisted of 440 healthy adults aged 18 years old and above who were selected among people who attended for routine medical checkup and medical examination of employment. The dependent variables were Beck Anxiety and Depression Inventory scores and the independent factors were coronary artery disease, and socioeconomic profiles. Validated and reliability-tested questionnaires were used for data collection. The mean age of patients was 55.75 ± 10.64 years and in the healthy group was 55.83 ± 8.55 years;there was no significant difference in age between subject groups (p = 0.897) nor a significant difference in the gender frequency distribution of subjects (p = 0.610). There was a significant difference in anxiety score between the Angio positive and Angio negative patients and healthy control subjects

关键词： Coronary Artery Disease Anxiety Depression Angiography

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