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Promising Effects of Zerumbone on the Regulation of Tumor-promoting Cytokines Induced by TNF-α-activated Fibroblasts

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Current Medical Science 2020年第6期40卷 1075-1084页

作者： zahra radaei Alireza Zamani Rezvan Najafi Massoud Saidijam Farid Azizi Jalilian Razieh Ezati Ghasem Solgi Razieh Amini Department of Immunology School of MedicineRamadan University of Medical SciencesHamadan 65178Iran Research Center for Molecular Medicine Hamadan University of Medical SciencesHamadan 65178Iran Department of Microbiology School of MedicineHamadan University of Medical SciencesHamadan 65178Iran Institute of Medical Biotechnology National Institute of Genetic Engineering and BiotechnologyTehran 14965Iran

Inflammation plays an important role in the development of several *** cytokines,including tumor necrosis factor-α(TNF-α),are associated with the induction of *** inflammation contributes to the progression of cancer through several mechanisms,including increased cytokine production and activation of transcription factors,such as nuclear factor-κB(NF-κB).Zerumbone(ZER),a component of subtropical ginger(Zingiber zerumbet Smith),seems to have anti-inflammatory,anti-cancer,and antioxidant *** this study,we aimed to explore the protective function and mechanisms of ZER against TNF-α-induced cancer-promoting *** found that the viability of stimulated human fibroblast cell lines was reduced after treatment with ZER(IC50=18µmol/L),compared to un-stimulated fibroblasts(IC50=40µmol/L).Besides,ZER inhibited mRNA expression and protein secretion of transforming growth factor-β(TGF-β),interleukin-33(IL-33),monocyte chemoattractant protein-1(MCP-1),and stromal cell-derived factor 1(SDF-1),which were produced by TNF-α-induced fibroblasts,as measured by quantitative real time-PCR(qRT-PCR)and ELISA *** mRNA expression levels of TGF-β,IL-33,SDF-1,and MCP-1 showed 8,5,2.5,and 4-fold reductions,***,secretion of TGF-β,IL-33,SDF-1,and MCP-1 was reduced to 3.65±0.34 ng/mL,6.3±0.26,1703.6±295.2,and 5.02±0.18 pg/mL,respectively,compared to the untreated *** addition,the conditioned media(CM)of TNF-α-stimulated fibroblasts increased the NF-κB expression in colorectal cancer cell lines(HCT-116 and Sw48),while in the vicinity of ZER,the expression of NF-κB was *** the significant effects of ZER,this component can be used as an appropriate alternative herbal treatment for cancer-related chronic inflammation.

关键词： inflammation zerumbone activated fibroblasts tumor necrosis factor-α(TNF-α) nuclear factor-κB(NF-κB)

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