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Expression level of interferon-stimulated genes PKR,OAS1,MX1,and ISG15 in peripheral blood mononuclear cells of COVID-19 patients:A retrospective study

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Journal of Acute Disease 2024年第3期13卷 111-115页

作者： Elham jafari Maskouni Samaneh Abbasi Elham Mousavi zahra Najafimemar Ali Mohammad Arabzadeh Mehrdad Farrokhnia Saeedeh Ebrahimi Department of Medical Microbiology(Bacteriology&Virology) Afzalipour Faculty of MedicineKerman University of Medical SciencesKermanIran Abadan University of Medical Sciences AbadanIran Infectious Diseases Research Center Golestan University of Medical SciencesGorganIran Department of Internal Medicine Afzalipour School of MedicineKerman University of Medical SciencesKermanIran

Objective:To explore expression level of interferon-stimulated genes PKR,OAS1,MX1,and ISG15 in peripheral blood mononuclear cells of COVID-19 ***:In this study,changes in the expression of four interferon-stimulated genes(ISGs),including PKR,OAS1,MX1,and ISG15,in peripheral blood mononuclear cells of 45 COVID-19 patients with different severities were evaluated by real-time PCR ***:OAS1,MX1,PKR,and ISG15 were differently expressed in COVID-19 patients with different *** results showed that the expression of OAS1,MX1,PKR,and ISG15 genes was significantly(P=0.001)lower in severe ***:Weak and defective IFN response and subsequent disruption of ISGs may be associated with COVID-19 severity.

关键词： COVID-19 SARS-CoV-2 Interferon ISGs Severe COVID-19 Risk factors Interferon signaling

Direct production of hydrogen peroxide over bimetallic CoPd catalysts:Investigation of the effect of Co addition and calcination temperature

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Green Energy & Environment 2023年第1期8卷 246-257页

作者： Hamidreza Nazeri Alireza Najafi chermahini zahra Mohammadbagheri Mirko Prato Department of Chemistry Isfahan University of Technology84154-83111IsfahanIran Materials Characterization Facility Istituto Italiano di TecnologiaVia Morego 3016163GenovaItaly

A series of CoPd/KIT-6 bimetallic catalysts with various Co:Pd molar ratios at different calcination temperatures were prepared and used for the direct synthesis of H_(2)O_(2) from H_(2) and O_(2).These catalysts were characterized by nitrogen adsorption-desorption,low and wide-angle X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),transmission electron microscopy(TEM),scanning electron microscopy(SEM),elemental mapping and energy-dispersive X-ray(EDX)*** was found that the particle size,electronic interactions,morphology,and textural properties of these catalysts as well as their catalytic activity in the reaction of H_(2) with O_(2) were affected by Co addition and different calcination ***,the results showed that while the H_(2)O_(2) selectivity depends on Pd^(2+) species,the H_(2) conversion is related to Pd0 active *** these catalysts,CoPd/KIT-6 calcined at 350℃(CoPd/KIT-350 catalyst)showed the best catalytic activity with 50%of H_(2)O_(2) selectivity and 51%conversion of H_(2).

关键词： Direct synthesis of hydrogen peroxide Co/Pd catalysts Selectivity The oxidation state of Pd Reusability

A drought resistance index to select drought resistant plant species based on leaf water potential measurements

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Journal of Arid Land 2019年第4期11卷 623-635页

作者： SayedJamaleddin KHAJEDDIN SayedHamid MATINKHAH zahra jafari Department of Natural Resources Isfahan University of Technology

The water deficit in arid and semi-arid regions is the primary limiting factor for the development of urban greenery and forestation. In addition, planting the species that consume low levels of water is useful in arid and semi-arid regions that have poor water management measures. Leaf water potential(Ψ) is a physiological parameter that can be used to identify drought resistance in various species. Indeed, Ψ is one of the most important properties of a plant that can be measured using a pressure chamber. Drought avoiding or drought resistant species have a lower Ψ than plants that use normal or high levels of water. To determine drought resistance of species that are suitable for afforestation in arid urban regions, we evaluated twenty woody species in the Isfahan City, central Iran. The experimental design was random split-split plots with five replications. The species were planted outdoor in plastic pots and then subjected to treatments that consisted of two soil types and five drip irrigation regimes. To evaluate the resistance of each species to drought, we used the Ψ and the number of survived plants to obtain the drought resistance index(DRI). Then, cluster analysis, dendrogram, and similarity index were used to group the species using DRI. Result indicates that the evaluated species were classified into five groups:(1) high water consuming species(DRI>–60 MPa);(2) above normal water consuming species(–60 MPa≥DRI>–90 MPa);(3) normal water consuming species(–90 MPa≥DRI>–120 MPa);(4) semi-drought resistant species(–120 MPa≥DRI>–150 MPa);and(5) drought resistant species(DRI≤–150 MPa). According to the DRI, Salix babylonica L., Populus alba L., and P. nigra L. are high water consuming species, Platanus orientalis L. and Albizia julibrissin Benth are normal water consuming species, and Quercus infectoria Oliv. and Olea europaea L. can be considered as drought resistant species.

关键词： drought resistant species drought resistance index forestation leaf water potential water deficit

Wettability alteration analysis of smart water/novel functionalized nanocomposites for enhanced oil recovery

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Petroleum Science 2020年第5期17卷 1318-1328页

作者： Sara Habibi Arezou jafari zahra F.akhroueian Chemical Engineering Faculty Tarbiat Modares UniversityTehranIran School of Chemical Engineering College of EngineeringInstitute of Petroleum EngineeringUniversity of TehranTehranIran

Smart water flooding,as a popular method to change the wettability of carbonate rocks,is one of the interesting and challenging issues in reservoir *** addition,the recent studies show that nanoparticles have a great potential for application in EOR ***,little research has been conducted on the use of smart water with nanoparticles in enhanced oil *** this study,stability,contact angle and IFT measurements and multi-step core flooding tests were designed to investigate the effect of the ionic composition of smart water containing SO4^2- and Ca^2+ ions in the presence of nanofluid on EOR *** amine/organosiloxane@Al2O3/SiO2(AOAS) nanocomposite previously synthesized using co-precipitation-hydrothermal method has been used ***,for the first time the application of this nanocomposite along with smart water has been studied in this *** show that by increasing the concentrations of calcium and sulfate ions in smart water,oil recovery is improved by 9% and 10%,respectively,compared to *** addition,the use of smart water and nanofluids simultaneously is very effective on increasing oil ***,the best performance was observed in smart water containing two times of sulfate ions concentration(SW2 S) with nanofluids,showing increased efficiency of about 7.5%.

关键词： Smart water Nanofluid Wettability alteration Contact angle Stability Enhanced oil recovery

Evaluation of the efficiency of irrigation methods on the growth and survival of tree seedlings in an arid climate

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Journal of Arid Land 2020年第3期12卷 495-507页

作者： zahra jafari SayedHamid MATINKHAH Mohammad R MOSADDEGHI Mostafa TARKESH Department of Natural Resources Isfahan University of TechnologyIsfahan ***Iran Department of Soil Science Department of AgricultureIsfahan University of TechnologyIsfahan ***Iran

Scarce and scattered precipitation in arid regions is detrimental for newly planted *** is essential to provide required water storage for seedlings in restoration projects in the first year of their *** subsurface irrigation can be much more effective than the surface irrigation because of the regulation of water availability and reduction in water *** studied the effect of surface and subsurface irrigation methods on the growth and survival of four common tree species including heaven tree(Ailanthus altissima(Mill.)Swingle),China berry(Melia azedarach L.),white mulberry(Morus alba L.),and black locust(Robinia pseudoacacia L.)by installing underground clay reservoirs with different permeabilities in Isfahan City,*** amounts of animal manure and wheat straw were mixed with clay fraction and cooked in a pottery kiln at 900°C to produce reservoirs with different *** experimental treatments consisting of irrigation and tree species were considered with a factorial arrangement in a completely randomized design with three replications in 2016 and *** water potential of seedlings,which is indirectly related to drought resistance,was measured by a portable pressure *** results showed that saplings height,basal diameter,number of leaves,chlorophyll content and stomatal conductance were significantly(P0.05)affected by the irrigation methods and different permeabilities of clay *** clay reservoirs with low and medium permeabilities constantly provide better conditions for plant growth,and water with lower pressure and longer time intervals to the plant roots as compared with the reservoirs with high *** of variance of the data showed that year and interaction between year and permeability of reservoir had si

关键词： subsurface irrigation clay reservoirs permeability restoration arid area

Prevention and treatment of constipation in children from the perspective of Iranian traditional medicine

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Journal of Integrative Medicine 2016年第6期14卷 429-435页

作者： Monireh Sadat Motaharifard zahra jafari Maryam Sadat Paknejad Laleh Oveidzadeh Mehrdad Karimi School of Traditional Medicine Tehran University of Medical Sciences Department of Traditional Medicine Faculty of Iranian Traditional MedicineShahid Sadoughi University of Medical Sciences

Constipation is one of the most common complaints of children and a common cause of referrals to pediatricians. Numerous reasons for this disease have been mentioned in the Iranian traditional medicine （ITM）. It is believed that this disorder is mostly due to the lack of consideration of the six essential principles （Setteh-ye-Zarurieah）, which are necessary to maintain health and prevent disease. In this descriptive study we collected and classified the concepts related to the topic by reviewing reliable ITM text books. Scientific databases were also searched for the most commonly used herbs in the treatment of constipation. The results showed that, from the perspective of ITM, the first step in treating constipation in children is making lifestyle changes. This includes giving appropriate training in the six essential principles, and making modification in existing habits where necessary. In the next steps, using some herbal remedies for topical or oral administration is recommended. On the other hand, a few clinical trials have been done concerning the effects of herbal medicines on pediatric constipation. Therefore, ITM＇s preventive and curative strategies can provide an efficient and cost-effective way to address constipation in children. This study can serve as a preface to performing clinical studies in this field.

关键词： children constipation Iranian traditional medicine six essential principles

Immune checkpoints in targetedi-mmunotherapy of pancreatic cancer:New hope for clinical development

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Acta Pharmaceutica Sinica B 2021年第5期11卷 1083-1097页

作者： Seyed Hossein Kiaie Mohammad Javad Sanaei Masoud Heshmati zahra Asadzadeh Iman Azimi Saleh Hadidi Reza jafari Behzad Baradaran Immunology Research Center Tabriz University of Medical SciencesTabriz ***Iran Nano Drug Delivery Research Center Kermanshah University of Medical SciencesKermanshah ***Iran Cellular and Molecular Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekord ***Iran School of Pharmacy and Pharmacology College of Health and MedicineUniversity of TasmaniaHobart 7001TasmaniaAustralia Clinical Biochemistry Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekord ***Iran Solid Tumor Research Center Cellular and Molecular Medicine InstituteUrmia University of Medical SciencesUrmia ***Iran Department of Immunology and Genetics School of MedicineUrmia University of Medical SciencesUrmia ***Iran

Immunotherapy has been recently considered as a promising alternative for cancer ***,targeting of immune checkpoint(ICP)strategies have shown significant success in human ***,despite remarkable success of cancer immunotherapy in pancreatic cancer(PCa),many of the developed immunotherapy methods show poor therapeutic outcomes in PCa with no or few effective treatment options thus *** this process,immunosuppression in the tumor microenvironment(TME)is found to be the main obstacle to the effectiveness of antitumor immune response induced by an immunotherapy *** this paper,the latest findings on the ICPs,which mediate immunosuppression in the TME have been *** addition,different approaches for targeting ICPs in the TME of PCa have been *** review has also synopsized the cutting-edge advances in the latest studies to clinical applications of ICP-targeted therapy in PCa.

关键词： Immune checkpoint Pancreatic cancer Tumor microenvironment Immunotherapy Clinical development

Investigation of wax precipitation in crude oil:Experimental and modeling

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Petroleum 2015年第3期1卷 223-230页

作者： Taraneh jafari Behbahani Ali Akbar Miran Beigi zahra Taheri Bahram Ghanbari Research Institute of Petroleum Industry(RIPI) P.O.Box 14665-1998TehranIran

In this work,a series of experiments were carried to investigation of rheological behavior of crude oil using waxy crude oil sample in the absence/presence of flow improver such as ethylene-vinyl acetate *** rheological data covered the temperature range of 5e30*** results indicated that the performance of flow improver was dependent on its molecular *** of small quantities of flow improver,can improve viscosity and pour point of crude ***,an Artificial Neural Network(ANN)model using Multi-Layer Perceptron(MLP)topology has been developed to account wax appearance temperature and the amount of precipitated wax and the model was verified using experimental data given in this work and reported in the *** order to compare the performance of the proposed model based on Artificial Neural Network,the wax precipitation experimental data at different temperatures were predicted using solid solution model and multi-solid phase *** results showed that the developed model based on Artificial Neural Network can predict more accurately the wax precipitation experimental data in comparison to the previous models such as solid solution and multi-solid phase model with AADs less than 0.5%.Furthermore,the number of parameters required for the Artificial Neural Network(ANN)model is less than the studied thermodynamic models.

关键词： Wax precipitation Artificial neural network Solid solution model Multi-solid phase model

Excess mortality in Northeast Iran caused by COVID-19:Neglect of offset community transformations of health

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Asian Pacific Journal of Tropical Medicine 2023年第6期16卷 261-267页

作者： Nayereh Esmaeilzadeh Seyed Javad Hoseini Majid jafari Nejad-Bajestani Mohammadtaghi Shakeri zahra Izadi Mood Hamidreza Hoseinzadeh Mohammad Hasan Derakhshan Dooghaee Department of Epidemiology School of HealthMashhad University of Medical SciencesMashhadIran Department of Medical Biotechnology and Nanotechnology Faculty of MedicineMashhad University of Medical SciencesMashhadIran Department of Persian Medicine School of Persian and Complementary MedicineMashhad University of Medical SciencesMashhadIran Department of Biostatistics School of HealthMashhad University of Medical SciencesMashhadIran Health Deputy Mashhad University of Medical SciencesMashhadIran

Objective:To make evidence-based decisions based on broad mortality trends for Razavi Khorasan province,***:In order to determine the baseline number of deaths,we used univariate time series analyses for monthly data from the monthly vital statistics reports(From April 2015 to March 2022).For excess mortalities,these baselines were subtracted from reported deaths with a 95%prediction *** compare time and causes,a P-score was ***:From March 2020 to March 2022,there were 61949 registered deaths,and the estimated deaths with a 95%confidence interval(CI)were 43246.16(35718.28,50774.05).So,in 2020-2021 and 2021-2022,the death counts were 35.15%and 51.33%higher than projected.A total of 18666 cardiovascular diseases were reported and a total of 15704.46(12006.95,19401.96)was *** P-score for this duration was 14.49%and 23.23%higher than *** and parasitic diseases plus COVID-19 were 16633 and estimated to be 1044.87(456.77,1632.96).A total of 4420 diseases of the respiratory system were reported,and 4564.94 deaths were predicted(2277.43,6852.43).In the first year of the pandemic,the P-score dropped to-35.28%and in the second year,it jumped sharply to 22.38%.Conclusions:Excess mortality,along with cause-specific mortality,can be helpful for monitoring trends and developing public health policies at the local,national,and international levels.

关键词： Mortality COVID-19 Health Systems Plans Prediction Cardiovascular deaths