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Fast and slow inhibition in the visual thalamus is influenced by allocating GABAA receptors with different gamma subunit identity to selective synapses

Fast and slow inhibition in the visual thalamus is influence...

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中国生理学会第24届全国会员代表大会暨生理学学术大会

作者：叶智文 Xiao Yu Catriona M Houston zahra Aboukhalil William Foster Nicholas P Franks William Wisden Stephen G Brickley Imperial College London/Sleep anaesthesia and pain London SW7 2AZ

Cell-type specific differences in the kinetics of inhibitory postsynaptic conductances（IPSCs）impact upon network dynamics throughout the *** attention has been focused on how GABAA receptor alpha and beta subunit diversity can influence IPSC kinetics,but little is known about the influence of different gamma *** have examined whether GABAA receptor gamma subunit heterogeneity influences IPSC properties in the *** gamma2 subunit gene was deleted from GABAA receptors selectively in the dorsal lateral geniculate nucleus（d LGN）and whole-cell recording was then combined with imaging to enable a functional and morphological classification of relay neuron *** removal of the gamma2 subunit from the d LGN reduced the overall s IPSC frequency across all relay cells and produced an absence of IPSCs in a subset of Y-type relay *** remaining slower IPSCs associated with X-type relay neurons were both insensitive to diazepam and zinc indicating the absence of the gamma2 *** these slower IPSCs were potentiated by beta-carbolines,we propose these IPSCs involve gamma1 subunit-containing GABAA receptor ***,gamma subunit heterogeneity appears to influence the kinetics of GABAA receptor-mediated synaptic transmission in the visual thalamus in a cell-type and synapse-selective *** suggest that d LGN GABAergic interneurons generate the slower IPSCs following activation of gamma1 subunit-containing GABAA receptors within X-type relay *** reticular GABAergic input that generates the faster IPSCs involves activation of gamma2 subunit-containing GABAA receptors that dominate Y-type relay neurons.

关键词： thalamus vision synapse GABAA receptors inhibition

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Insulin producing cells established using non-integrated lentiviral vector harboring PdX1 gene

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World Journal of Stem Cells 2013年第4期5卷 217-228页

作者： zahra Niki Boroujeni Ahmad Aleyasin department of Medical Biotechnology National Institute of Genetic Engineering and Biotechnology

AIM: To investigate reprogramming of human adipose tissue derived stem cells into insulin producing cells using non-integrated lentivirus harboring PdX1 ***: In this study, human adipose tissue derived stem cells(hAdSCs) were obtained from abdominal adipose tissues by liposuction, selected by plastic adhesion, and characterized by flow cytometric *** AdSCs were differentiated into adipocytes and osteocytes using differentiating medium to confirm their multipotency. Non-integrated lentiviruses harboring PdX1(Non-integrated LV-PdX1) were constructed using specific plasmids(pLV-HELP, pMd2G, LV-105-PdX1-1).Then, hAdSCs were transduced with non-integrated LVPdX1. After transduction, AdSCsPdX1+were cultured in high glucose dMEM medium supplement by B27, nicotinamide and βFGF for 21 d. Expressions of PdX1 andinsulin were detected at protein level by immunofluorescence analysis. Expressions of PdX1, neurogenin3(Ngn3), glucagon, glucose transporter2(Glut2) and somatostatin as specific marker genes were investigated at mRNA level by quantitative RT-PCR. Insulin secretion of hAdSCsPdX1+in the high-glucose medium was detected by electrochemiluminescence test. Human AdSCsPdX1+were implanted into hyperglycemic ***: Human AdSCs exhibited their fibroblast-like morphology and made colonies after 7-10 d of *** of hAdSCs identified by FACS analysis showed that hAdSCs were positive for mesenchymal cell markers and negative for hematopoietic cell markers that guaranteed the lack of hematopoietic contamination. In vitro differentiation of hAdSCs into osteocytes and adipocytes were detected by Alizarin red and Oil red O staining and confirmed their multilineage differentiation ability. Transduced hAdSCs+PdX1became round and clusters in the differentiation medium. The appropriate expression of PdX1 and insulin proteins was confirmed using immunocytochemistry *** expressions of PdX1, Ngn3, glucagon, Glut2and somatostatin were d

关键词： diabetes mellitus Human adipose tissue derived stem cells Non-integrated lentiviruses PdX1 Insulin producing cells

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Genomic,transcriptomic,and metabolomic analysis of Oldenlandia corymbosa reveals the biosynthesis and mode of action of anti-cancer metabolites

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Journal of Integrative Plant Biology 2023年第6期65卷 1442-1466页

作者： Irene Julca daniela Mutwil-Anderwald Vaishnervi Manoj zahra Khan Soak Kuan Lai Lay K.Yang Ing T.Beh Jerzy dziekan Yoon P.Lim Shen K.Lim Yee W.Low Yuen I.Lam Seth Tjia Yuguang Mu Qiao W.Tan Przemyslaw Nuc Le M.Choo Gillian Khew Loo Shining Antony Kam James P.Tam Zbynek Bozdech Maximilian Schmidt Bjoern Usadel Yoganathan Kanagasundaram Saleh Alseekh Alisdair Fernie Hoi Y.Li Marek Mutwil School of Biological Sciences Nanyang Technological UniversitySingapore 639798Singapore Shared Analytics Singapore Institute of Food and Biotechnology Innovation(SIFBI)Agency for ScienceTechnology and Research(A*STAR)Singapore 138671Singapore department of Biochemistry National University of SingaporeSingapore 117596Singapore Singapore Botanic Gardens Singapore 259569Singapore department of Gene Expression Faculty of BiologyInstitute of Molecular Biology and BiotechnologyAdam Mickiewicz UniversityPoznan 61-614Poland IBG-4 Bioinformatics Forschungszentrum JülichJülich 52428Germany Max-Planck-Institut für Molekulare Pflanzenphysiologie Potsdam-Golm 14476Germany Center of Plant Systems Biology and Biotechnology Plovdiv 4000Bulgaria

Plants accumulate a vast array of secondary metabolites,which constitute a natural resource for *** corymbosa belongs to the Rubiaceae family,and has been used in traditional medicine to treat different diseases,including ***,the active metabolites of the plant,their biosynthetic pathway and mode of action in cancer are *** fill these gaps,we exposed this plant to eight different stress conditions and combined different omics data capturing gene expression,metabolic profiles,and anti-cancer *** results show that *** extracts are active against breast cancer cell lines and that ursolic acid is responsible for this ***,we assembled a high-quality genome and uncovered two genes involved in the biosynthesis of ursolic ***,we also revealed that ursolic acid causes mitotic catastrophe in cancer cells and identified three high-confidence protein binding targets by Cellular Thermal Shift Assay(CETSA)and reverse ***,these results constitute a valuable resource to further characterize the biosynthesis of active metabolites in the Oldenlandia group,while the mode of action of ursolic acid will allow us to further develop this valuable compound.

关键词： genome medicinal metabolomics mode of action transcriptome

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Mobilizing Crop Biodiversity

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Molecular Plant 2020年第10期13卷 1341-1344页

作者： Susan McCouch zahra Katy Navabi Michael Abberton Noelle L.Anglin Rosa Lia Barbieri Michael Baum Kirstin Bett Helen Booker Gerald L.Brown Glenn J.Bryan Luigi Cattivelli david Charest Kellye Eversole Marcelo Freitas Kioumars Ghamkhar dario Grattipaglia Robert Henry Maria Cleria Valadares Inglis Tofazzal Islam Zakaria Kehel Paul J.Kersey Graham J.King Stephen Kresovich Emily Marden Sean Mayes Marie Noelle Ndjiondjiop Henry T.Nguyen Samuel Rezende Paiva Roberto Papa Peter W.B.Phillips Awais Rasheed Christopher Richards Mathieu Flouard Maria Jose Amstalden Sampaio Uwe Scholz Paul d.Shaw Brad Sherman S.Evan Staton Nils Stein Jan Svensson Mark Tester Jose Francisco Montenegro Valls Rajeev Varshney Stephen Visscher Eric von Wettberg Robbie Waugh Peter Wenzl Loren H.Rieseberg Plant Breeding and Genetics School of Integrated Plant SciencesCornell UniversityIthacaNY14853USA divSeek Global Institute for Food Security110 Gymnasium PlaceUniversity of SaskatchewanSaskatoonSKS7N 0W9Canada lnternational Institute of Tropical Agriculture(IITA) PMB 5320Oyo RdIbadanNigeria International Potato Center(CIP)1895 Avenida La Molina Lima Peru 12Lima 15023Peru Embrapa Genetic Resources and Biotechnology Parque Estacjao BiologicaFinal Av W5 NorteCaixa Postal 0237270770-917-Brasilia DFBrazil International Center for Agricultural Research in the dry Areas(I CAR dA) Station Exp.INRA-Quich.Rue Hafiane Cherkaoui.Agdal.Rabat-Instituts10111RabatMorocco department of Plant Sciences University of Saskatchewan51 Campus Dr.SaskatoonSK S7N 5A8Canada department of Plant Agriculture University of GuelphRm 316Crop Science Bldg50 Stone Rd EGuelphON N1G 2W1Canada Genome Prairie 111 Research DriveSuite 101SaskatoonSKS7N 3R2Canada The James Hutt on Institute Errol RoadInvergowrieDundeeDD25DAUK CREA Research Centre for Genomics and Bioinformaticsvia San Protaso 302Fiorenzuola d'Arda29017Italy Genome British Columbia 400-575 West 8th AvenueVancouverBCV5Z 0C4Canada International Wheat Genome Sequencing Consortium 2841 NE Marywood CtLee's SummitMO.64086USA Forage Science Grasslands Research CentreAgResearchPalmerston North4410New Zealand Queensla nd Alliance for Agriculture and Food Inn ovation University of QueenslandBrisbaneQLD 4072Australia Institute of Biotechnology and Genetic Engineering(IBGE) Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh Southern Cross University PO Box 157LismoreNSW 2480Australia Royal Botanic Gardens KewRichmondSurreyTW93AEUK Feed the Future Innovation Lab for Crop Improvement 431 Weill HallCornell UniversityIthacaNY14853USA department of Botany and Biodiversity Research Centre University of British ColumbiaVancouverBC V6R 2A5Canada Crops For the Future(UK)CIC 76-80 Baddow Road ChelmsfordEs

Over the past 70 years,the world has witnessed extraordinary growth in crop productivity,enabled by a suite of technological advances,including higher yielding crop varieties,improved farm management,synthetic agrochemicals,and agricultural *** this"Green Revolution"intensified crop production,and is credited with reducing famine and malnutrition,its benefits were accompanied by several undesirable collateral effects(Pingali,2012).These include a narrowing of agricultural biodiversity,stemming from increased monoculture and greater reliance on a smaller number of crops and crop varieties for the majority of our *** reduction in diversity has created vulnerabilities to pest and disease epidemics,climate variation,and ultimately to human health(Harlan,1972).

关键词： intensified crops agricultural

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中国秃疮花属和海罂粟属的细胞学研究（英文）

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植物分类与资源学报 2015年第6期37卷 721-726页

作者：向春雷董洪进胡国雄纳迪亚.扎赫拉船本常男中国科学院东亚植物多样性与生物地理学重点实验室昆明650201 国家林业局昆明勘察设计院昆明650216 伊斯兰堡真纳大学生物技术系巴基斯坦伊斯兰堡45320 昭和药科大学药学基础教育与研究中心生物研究所

报道了秃疮花属3种,即苣叶秃疮花、秃疮花和宽果秃疮花共11个居群及其姐妹类群海罂粟属1种(海罂粟)一个居群的染色体数目。研究结果表明,秃疮花属全部三种的染色体数目均为2n=12;海罂粟的染色体数目为2n=10,并且是该属中新发现的最小数目。

关键词：秃疮花属海罂粟属罂粟科染色体数目

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瘤胃保护胆碱和莫能菌素对围产期奶牛生产和代谢的影响

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中国畜牧兽医 2007年第8期34卷 19-19页

作者： L.C.zahra 王吉峰

过渡期奶牛日粮中添加胆碱和莫能菌素的作用分别在于促进脂肪代谢和能量平衡。本试验旨在研究瘤胃保护胆碱(RPC)和莫能菌素缓释胶囊(CRC)对过渡期奶牛代谢、干物质进食量、产奶量和肝功能的影响。产犊前3周,182头经产荷斯坦奶牛随意分... 详细信息

过渡期奶牛日粮中添加胆碱和莫能菌素的作用分别在于促进脂肪代谢和能量平衡。本试验旨在研究瘤胃保护胆碱(RPC)和莫能菌素缓释胶囊(CRC)对过渡期奶牛代谢、干物质进食量、产奶量和肝功能的影响。产犊前3周,182头经产荷斯坦奶牛随意分为以下试验组:莫能菌素缓释胶囊(CRC)组;添加56 g/d RPC至产奶28 d组;CRC+RPC组;二者均不添加(对照)组。在试验开始、产犊前1周、产犊后第1周或第2周分别采集血样。每个处理组随机选择经产母牛在产前24 h和产后3周进行肝脏切片检查。记录60d的产奶量。RPC和CRC对测定结果无交互作用。结果表明,RPC组在泌乳期60 d产奶提高1.2 kg/d,这是由于产前3周体况评分≥4,产奶量提高了4.4 kg/d。从产前3周到产后4周,RPC组奶牛采食量提高1.1 kg dM/d,添加莫能菌素显著提高围产期奶牛血清中葡萄糖和尿素的浓度,降低β-羟基丁酸的浓度和天(门)冬氨酸脱氨基酶,提高了泌乳期3周内的肝糖原水平。CRC的代谢作用与前人研究一致,对肝的影响有所不同。本研究中未阐明RPC提高产奶量的机制,有待于进一步研究。

关键词：胆碱莫能菌素过渡期奶牛代谢

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《动荡时代下的国际创业》评述

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管理学季刊 2019年第1期4卷 16-19,98页

作者： Garry d. Bruton 钟莹(翻译) 朱沆(审校) 美国得州基督教大学Neeley商学院 Strategic Entrepreneurship Journal Journal of Management Studies Academy of Management Perspective 不详

本文是对zahra教授论文《动荡时代下的国际创业》的评论。zahra教授的文章提出了很多学者可以关注并作为研究生涯基础的重大问题。这篇评论关注其中的两个:①在国际化过程中建立对微观基础或个人创业者更多的理解;②从中国本土理论的角... 详细信息

本文是对zahra教授论文《动荡时代下的国际创业》的评论。zahra教授的文章提出了很多学者可以关注并作为研究生涯基础的重大问题。这篇评论关注其中的两个:①在国际化过程中建立对微观基础或个人创业者更多的理解;②从中国本土理论的角度进行国际创业的情境化。具体而言,这篇评论鼓励在国际创业的微观基础中关注一系列更宽的问题,并认为在国际创业的一些维度上运用本土理论的时机已成熟。

关键词：国际创业微观基础本土理论

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Fungal diversity notes 1611-1716: taxonomic and phylogenetic contributions on fungal genera and species emphasis in south China

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Fungal diversity 2023年第5期122卷 161-403页

作者： Indunil C.Senanayake Walter Rossi Marco Leonardi Alex Weir Mark McHugh Kunhiraman C.Rajeshkumar Rajnish K.Verma Samantha C.Karunarathna Saowaluck Tibpromma Nikhil Ashtekar Sreejith K.Ashtamoorthy Sanjay Raveendran Gurmeet Kour Aishwarya Singh Saúl de la Peña-Lastra Antonio Mateos Miroslav Kolařík Vladimír Antonín HanaŠevčíková Fernando Esteve-Raventós Ellen Larsson Fermín Pancorbo Gabriel Moreno Alberto Altés Yolanda Turégano Tian-Ye du Li Lu Qi-Rui Li Ji-Chuan Kang Sugantha Gunaseelan Kezhocuyi Kezo Malarvizhi Kaliyaperumal Jizhen Fu Milan C.Samarakoon Yusufjon Gafforov Shakhnoza Teshaboeva Pradeep C.Kunjan Arya Chamaparambath Adam Flakus Javier Etayo Pamela Rodriguez-Flakus Mikhail P.Zhurbenko Nimali Ide Silva danushka S.Tennakoon KPdeepna Latha Patinjareveettil Manimohan KNAnil Raj Mark S.Calabon Abdollah Ahmadpour Zeinab Heidarian zahra Alavi Fatemeh Alavi Youbert Ghosta Razmig Azizi Mei Luo Min-Ping Zhao Nuwan d.Kularathnage Li Hua Yun-Hui Yang Chun-Fang Liao Hai-Jun Zhao Anis S.Lestari Subashini C.Jayasiri Feng-Ming Yu Lei Lei Jian-Wei Liu Omid Karimi Song-Ming Tang Ya-Ru Sun Yong Wang Ming Zeng Zin H.Htet Benedetto T.Linaldeddu Artur Alves Alan J.L.Phillips Carlo Bregant Lucio Montecchio Andréde Kesel Vincent P.Hustad Andrew N.Miller Anna G.Fedosova Viktor Kučera Mubashar Raza Muzammil Hussain Yan-Peng Chen Vinodhini Thiyagaraja deecksha Gomdola Achala R.Rathnayaka Asha J.dissanayake Nakarin Suwannarach Sinang Hongsanan Sajeewa S.N.Maharachchikumbura Lakmali S.dissanayake Nalin N.Wijayawardene Rungtiwa Phookamsak Saisamorn Lumyong E.B.Gareth Jones Neelamanie Yapa dhanushka N.Wanasinghe Ning Xie Mingkwan doilom Ishara S.Manawasinghe Jian-Kui(Jack)Liu Qi Zhao Biao Xu Kevin d.Hyde Jiage Song Innovative Institute for Plant Health/Key Laboratory of Green Prevention and Control On Fruits and Vegetables in South China Ministry of Agriculture and Rural AffairsZhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225GuangdongChina Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Guangdong Provincial Key Laboratory for Plant Epigenetics College of Life Science and OceanographyShenzhen University3688Nanhai AvenueNanshanShenzhen 518055GuangdongChina Sect.Environmental Sciences Department MeSVAUniversity of L’AquilaVia Vetoio67100 CoppitoAQItaly department of Environmental Biology SUNY-ESF241 Illick Hall1 Forestry DriveSyracuseNY 13210USA National Fungal Culture Collection of India MACS Agharkar Research InstitutePuneMaharashtra 411004India department of Plant Pathology Punjab Agricultural UniversityLudhianaPunjab 141004India Center for Yunnan Plateau Biological Resources Protection and Utilization College of Biological Resource and Food EngineeringQujing Normal UniversityQujing 655011YunnanChina department of Forest Ecology Kerala Forest Research InstitutePeechiThrissurKerala 680653India department of Botany The American CollegeTallakkulamMaduraiTamil Nadu 625002India department of Zoology Savitribai Phule Pune UniversityGaneshkhind RdGaneshkhindPuneMaharashtra 411007India University of Santiago de Compostela 15782 Santiago de CompostelaSpain Sociedad Micológica Extremeña C/Sagitario 1410001 CáceresSpain Institute of Microbiology of the Czech Academy of Sciences Vídeňská108314220 Prague 4Czech Republic department of Botany Moravian MuseumZelnýtrh 665937 BrnoCzech Republic department of Life Sciences(Botany Unit) University of Alcalá28805 Alcaláde HenaresMadridSpain Biological and Enviromental Sciences University of Gothemburgand Gothemburg Global Biodiversity CentreBox 46140530 GöteborgSweden Madrid Mycological Society Real Jardín BotánicoC/Claudio Moyano 128014 MadridSpain State Ke

This article is the 15th contribution in the Fungal diversity Notes series,wherein 115 taxa from three phyla,nine classes,28 orders,48 families,and 64 genera are *** taxa described and illustrated in the present study include a new family,five new genera,61 new species,five new combinations,one synonym,one new variety and 31 records on new hosts or new geographical *** *** introduced and accommodated in *** new genera introduced in this study are Ageratinicola,Kevinia,Pseudomultiseptospora(Parabambusicolaceae),Marasmiellomycena,and Vizzinia(Porotheleaceae).Newly described species are Abrothallus altoandinus,Ageratinicola kunmingensis,Allocryptovalsa aceris,Allophoma yuccae,Apiospora cannae,***,***,Boeremia wisteriae,Calycina papaeana,Clypeo-coccum lichenostigmoides,Coniochaeta riskali-shoyakubovii,Cryphonectria kunmingensis,diaporthe angustiapiculata,***,***,diatrypella guangdongense,dothiorella franceschinii,Endocalyx phoenicis,Epicoc-cum terminosporum,Fulvifomes karaiensis,***,Ganoderma ghatensis,Hysterobrevium baoshanense,Inocybe avellaneorosea,***,Jahnula oblonga,Kevinia lignicola,Kirschsteiniothelia guangdongensis,Laboulbenia caprina,***,***,***,***,***,***,***,***,Laccaria rubriporus,Lasiodiplodia morindae,Lyophyllum agnijum,Marasmiellomycena pseudoomphaliiformis,Melomastia beihaiensis,Nemania guangdongensis,Nigrograna thailandica,Nigrospora ficuum,Oxydothis chinensis,***,Petriella thailandica,Phaeoacremonium chinensis,Phialocephala chinensis,Phytophthora debattistii,Polyplosphaeria nigrospora,Pronectria loweniae,Seriascoma acutispora,Setoseptoria bambusae,Stictis anomianthi,Tarzetta tibetensis,Tarzetta urceolata,Tetraploa obpyriformis,Trichoglossum beninense,and Tricoderma *** provide an emendation for Urnula ailaoshanensis Agaricus duplocingulatoides *** i

关键词： Agaricomycetes Ascomycota Basidiomycota dothideomycetes Eurotiomycetes Fungal diversity Geoglossomycetes Geographical distribution Host records Incertae sedis Laboulbeniomycetes Lecanoromycetes Leotiomycetes Novel taxa New combination Oomycota Peronosporea Pezizomycetes Phylogeny Sordariomycetes South Chinese fungi Taxonomy

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