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piEnPred:a bi-layered discriminative model for enhancers and their subtypes via novel cascade multi-level subset feature selection algorithm

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Frontiers of Computer Science 2021年第6期15卷 175-185页

作者： zaheer ullah khan Dechang PI Shuanglong YAO Asif NAWAZ Farman ALI Shaukat ALI School of Computer Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China School of Computer Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China Department of Computer Science Islamia College University PeshawarPeshawar 25000Pakistan

Enhancers are short DNA cis-elements that can be bound by proteins(activators)to increase the possibility that transcription of a particular gene will *** Enhancers perform a significant role in the formation of proteins and regulating the gene transcription *** diseases such as cancer,inflammatory bowel disease,Parkinson’s,addiction,and schizophrenia are due to genetic variation in *** the current study,we havemade an effort by building,amore robust and novel computational a bi-layered *** representative feature vector was constructed over a linear combination of six *** optimum Hybrid feature vector was obtained via the Novel Cascade Multi-Level Subset Feature selection(CMSFS)*** first layer predicts the enhancer,and the secondary layer carries the prediction of their *** baseline model obtained 87.88%of accuracy,95.29%of sensitivity,80.47%of specificity,0.766 of MCC,and 0.9603 of a roc value on ***,the model obtained 68.24%,65.54%,70.95%,0.3654,and 0.7568 as an Accuracy,sensitivity,specificity,MCC,and ROC values on layer-2 *** an independent dataset on layer-1,the piEnPred secured 80.4%accuracy,82.5%of sensitivity,78.4%of specificity,and 0.6099 as MCC,***,the proposed predictor obtained 72.5%of accuracy,70.0%of sensitivity,75%of specificity,and 0.4506 of MCC on layer-2,*** proposed method remarkably performed in contrast to other state-of-the-art *** the convenience of most experimental scientists,a user-friendly and publicly freely accessible web server@/bienhancer dot pythonanywhere dot com has been developed.

关键词： enhancer enhancer types novel CM-SFS algorithm feature selection SVM

Prevalence of Infectious Complications in Children with Cancer

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Journal of Cancer Therapy 2019年第12期10卷 938-947页

作者： zaheer ullah khan Nagi Amin Gaafar Ahmed Mustafa Mohammad Sanad Tarmoom Mohammad Yousef AlGhar Anwaar Saud Aldahir Dayel AlShahrani Department of Paediatric Haematology and Oncology King Fahad Medical City Riyadh Kingdom of Saudi Arabia Department of Infectious Diseases King Fahad Medical City Riyadh Kingdom of Saudi Arabia Department of General Paediatric King Fahad Medical City Riyadh Kingdom of Saudi Arabia

Background:?Infections are the most common complications during chemotherapy. The trends have been changing over time due to use of multi-agent intensive chemotherapy.?Procedure:?We looked?over?our data to see what complications we get in our patients. The data was collected on patients treated in King Fahad Medical City from July 2009 to Dec 2015.?Results:?We?found that 86 patients had one episode only while 92 had 2 or more episodes reaching up to 11 episodes in 1 patient. We found positive cultures in 17.3% of episodes with staphylococcus as common gram positive and Klebsiella pneumoniae as common gram negative bacteria, respiratory viral infections in 13.8% and GI infections in 9%. We found Candida albicans as the most common fungus while other yeasts followed. Acute lymphoblastic leukaemia was the most common diagnosis. The episodes were associated with neutropenia of 7 days in 1st?episode and 56.8% in cases with repeated episodes. We had 2 deaths one from recurrent infections with CNS (Central Nervous System) damage and one from Pulmonary infections causing pulmonary haemorrhage. We had one with persistent neurological sequele from prolonged fungal infection.?Conclusions:Neutropenia of 7 days came out to be significant risk factors for infection across all diseases. We have an acceptable level of morbidity and mortality due to good supportive services.?We need prospective studies to get an up-to-date picture of our practice.?We need prophylactic antibiotics and antifungals for high-risk patients like AML.

关键词： Infections Cancer Children

Neuroblastoma in Saudi Children: A Single Center Experience (2006-2014)

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Journal of Cancer Therapy 2015年第10期6卷 896-905页

作者： Zaid Al Naqib Atif A. Ahmed Musa Al Harbi Fahad Al Manjomi zaheer ullah khan Awatif Alanazi Othman Mosleh Walid Ballourah Mohammed Rayis Pediatric Hematology/Oncology Division King Fahad Medical City Riyadh Saudi Arabia Department of Pathology and Laboratory Medicine Children’s Mercy Hospital Kansas City USA

Introduction: Neuroblastoma is the most common extracranial solid tumor in childhood and survival rate has improved during the last few decades. Only a few studies, related to Neuroblastoma in Saudi Arabian children, have been performed. We report epidemiologic data and our clinical experience from the department of Pediatric Hematology Oncology (PHO), King Fahad Medical City (KFMC), Riyadh, Saudi Arabia. Method: A retrospective observational study of all patients, with diagnosis of Neuroblastoma, who attended PHO-KFMC from July 2006 to June 2014 was performed. The survival periods (overall survival and disease-free survival) and the final outcomes for patients treated and followed at KFMC were recorded. The survival data were statistically correlated with the clinical, pathological and biological features of patients and tumors and compared to national and international cohorts. Results: Eight-year data were available for the 42 patients of which 22 (52.4%) were male and 20 (47.6%) were females. Age at diagnosis ranged 0 - 91 months with a mean and median of 26.3 and 18.5 months respectively. 16 (38.1%) patients were under one year and 26 (61.9%) above 1 year of age. The event-free survival (EFS) and overall survival (OS) rates were 66.5% and 71.5% respectively. EFS and OS among those who were <1 year age at presentation was 75% and 82%, whereas ≥1 yr age group had 59% and 62% survival rates respectively. Patients with tumors in the adrenal had considerably lower EFS (59%) and OS (63%);in comparison to patients with tumors sites other than the adrenal who had EFS and OS of 85% and 89% respectively. Both EFS and OS survival rates at the end of follow-up interval were 100.0%, in the low and intermediate risk groups. In contrast, patients in the high risk group had EFS and OS rates of 44% and 48% respectively. This difference was statistically significant (p < 0.05). Conclusion: Our results are very encouraging and comparable with known published international cohorts

关键词： Children Neuroblastoma Saudi Arabia Survival

Development and characterization of hot dip aluminide coated stainless steel 316L

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Journal of Central South University 2018年第11期25卷 2578-2588页

作者： Sehrish MUKHTAR Waqas ASGHAR Zubair BUTT zaheer ABBAS Mudaser ullah Rana ATTA-UR-REHMAN College of Engineering and Emerging Technologies University of the PunjabLahorePakistan University of Engineering and Technology Taxila 47050TaxilaPakistan Ningbo Institute of Materials Technology and Engineering(NIMTE) Chinese Academy of Sciences(CAS)Ningbo 315201China Mechatronics Engineering Department University of Engineering and Technology TaxilaChakwal Campus48800ChakwalPakistan MOE Key Lab for Liquid-Solid Structure Evolution and Materials Processing Institute of Materials JoiningShandong UniversityJi’nan 250061China Department of Mechanical Engineering CETUniversity of SargodhaPakistan

Stainless steel(SS)grade 316L is used for orthopedic implants due to its biocompatibility;yet the effort should be done to minimize the carcinogenic and inflammatory effects related to SS 316L *** this research,aluminide coating of Al–Si alloy on SS 316L is characterized by using optical microscopy,energy dispersive spectroscopy(EDS),nano-indentation and corrosion testing *** dip aluminizing process is used to coat the SS 316L specimens at 765°C for 2 min immersion *** of the specimens are also diffusion treated in a Muffle furnace at 550°C for 4 h to produce diffused specimens of SS *** examination shows the formation of flat coating/substrate interface due to Si *** analysis confirms the formation of complex intermetallic at the coating/substrate interface which finally results in increasing the hardness and corrosion resistance properties of coating.

关键词： stainless steel aluminide coating microstructure intermetallics nano-indentation corrosion testing

Retraction note to “Development and characterization of hot dip aluminide coated stainless steel 316L”(J. Cent. South Univ., 10.1007/s11771-018-3937-y)

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Journal of Central South University 2020年第9期27卷 2792-2792页

The Editor-in-Chief has retracted this article [1] because Figures 11 and 12 appear to be identical with Figures 3 and 4respectively from a previously published article [2].Sehrish MUKHTAR,Waqas ASGHAR,Zubair BUTT,Zah... 详细信息

关键词： steel aluminide dip

Pediatric Non-Hodgkin Lymphoma: A Retrospective 7-Year Experience in Children &Adolescents with Non-Hodgkin Lymphoma Treated in King Fahad Medical City (KFMC)

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Journal of Cancer Therapy 2015年第4期6卷 299-314页

作者： Nahla Ali Mobark Suha A. Tashkandi Wafa Al Shakweer Khalid Al Saidi Suha A. Fataftah Mohammed M. Al Nemer Awatif Alanazi Mohammed Rayis Walid Ballourah Othman Mosleh zaheer ullah Fahad El Manjomi Musa Al Harbi Department of Pediatric Hematology and Oncology Comprehensive Cancer Centre KFMC Riyadh Saudi Arabia Department of Cytogenetic and Molecular Cytogenetic Laboratory KFMC Riyadh Saudi Arabia Department of Anatomical Pathology KFMC Riyadh Saudi Arabia

Background: Non-Hodgkin’s lymphoma is an aggressive malignant disease in children and adolescents. Although it is the fourth most common malignancy in Saudi children as reported in Saudi cancer registry, less information is available about pediatric Non-Hodgkin lymphoma and its outcome in Saudi Arabia. Study Objectives: To provide demographic data, disease characteristics, treatment protocol, toxicity and outcome of treatment in children & adolescents with Non-Hodgkin’s lymphoma treated at KFMC. This study will form base line for future studies about pediatric Non-Hodgkin’s lymphoma in KFMC, which may help to improve outcome for children with cancer in Saudi Arabia. Study Patients and Method: We retrospectively analyzed 28 children and adolescents diagnosed to have Non-Hodgkin’s lymphoma at KFMC between December 2006 and December 2013, followed-up through June 2014. Results: Of the 28 patients, 10 (35.7%) girls and 18 (64.3%) boys, the male-to-female ratio was 1.8;1. The median age at time of diagnosis was 6.4 years old (range 2.0 to 13.0 years old). The majority of patients (64.3%) were aged between 5 and 12 years old. Burkitt’s lymphoma BL/BLL was the most common pathological subtype (60.7%), and DLBCL was the second most common subtype (21.4%). Abdominal and Retroperitoneal involvement was the most common primary site (78.6%) including the ileocaecal region. Most of the children presented with advanced Stage III and IV (75%), Cytogenetic study which screens specifically for the t (8;14) (q24;q32) a characteristic genetic feature of Burkitt’s Lymphoma was obtained from 21 patients, variant rearrangement was observed in 3/21 samples and complex chromosomes karyotype in addition to IGH/MYC rearrangement was observed in 2/21 samples. Those patients presented with very aggressive lymphoma and combined BM and CNS involvement. We use the French-American-British Mature B-Cell Lymphoma 96 Protocol (FAB LMB 96) for treatment fornewly diagnosed Mature B-Cell type NHL and hi

关键词： Non-Hodgkin Lymphoma Disease Patients Children and Adolescents