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Journal of Cosmetics, Dermatological Sciences and Applications 2015年第4期5卷 262-274页

作者： Gallant Kar Lun Chan zack chun fai wong Kelly Yin Ching Lam Lily Kwan Wai Cheng Laura Minglu Zhang Huangquan Lin Tina Tingxia Dong Karl Wah Keung Tsim Division of Life Science and Center for Chinese Medicine R&D The Hong Kong University of Science and Technology Kowloon Hong Kong China

Edible bird’s nest (EBN;Yan Wo), or cubilose, is originated from the salivary secretion of Aerodramus fuciphagus. In Asia, EBN is famous for its unproven skin lightening function. Here, we aim to reveal the active ingredients of EBN responsible for skin lightening function. Three major fractions were isolated from EBN water extract by chromatography using LC-MS/MS, bioactivities of these isolated fractions were analyzed by assays of tyrosinase, melanocytes and 3D human skin model, from which, N-acetylneuraminic acid (NANA), the second isolated fraction showed an inhibition effect on tyrosinase activity in a dose-dependent manner. The IC50 of tyrosinase originated from mushroom and human was 16.93 mM and 0.10 mM respectively. Furthermore, only EBN with higher content of NANA (e.g. White and Red EBN), but not EBN with less NANA (e.g. Grass EBN), showed promising skin lightening function. This is the first report to reveal NANA being an active ingredient of EBN on skin lightening function.

关键词： Cubilose N-Acetylneuraminic Acid Chemical Analysis Skin Lightening Human Skin Model

Longest survival with primary intracranial malignant melanoma:A case report and literature review

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World Journal of Clinical Cases 2022年第30期10卷 11162-11171页

作者： Tang-fai wong Yin-Sheng Chen Xiang-Heng Zhang Wan-Ming Hu Xiao-Shi Zhang Yan-chun Lv Dong-Cun Huang Mei-Ling Deng Zhong-Ping Chen Department of Neurosurgery Macao Kiang Wu HospitalMacao 999078Sichuan ProvinceChina Department of Neurosurgery/Neuro-Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Pathology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Biotherapy State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Medical Imaging Sun Yat-sen University Cancer CenterCollaborative Innovation Center for Cancer MedicineGuangzhou 510060Guangdong ProvinceChina Department of Radiotherapy State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Primary intracranial malignant melanoma(PIMM)is rare,and its prognosis is very *** is not clear what systematic treatment strategy can achieve long-term *** case study attempted to identify the optimal strategy for long-term survival outcomes by reviewing the PIMM patient with the longest survival following comprehensive treatment and by reviewing the related *** SUMMARY The patient is a 47-year-old Chinese man who suffered from dizziness and gait *** underwent surgery for right cerebellum melanoma and was subsequently diagnosed by pathology in June *** the surgery,the patient received three cycles of chemotherapy but relapsed locally within 4 *** the second surgery for total tumor resection,the patient received an injection of Newcastle disease virus-modified tumor vaccine,interferon,andβ-elemene *** patient was tumor-free with a normal life for 21 years before the onset of the recurrence of melanoma without any symptoms in July 2021.A third gross-total resection with adjuvant radiotherapy and temozolomide therapy was *** magnetic resonance imaging showed no residual tumor or recurrence 3 mo after the 3rd operation,and the patient recovered well without neurological dysfunction until the last follow-up in June 2022,which was 22 years following the initial *** It is important for patients with PIMM to receive comprehensive treatment to enable the application of the most appropriate treatment ***-term survival is not impossible in patients with these malignancies.

关键词： Primary intracranial malignant melanoma Immunotherapy Newcastle disease virus-modified tumor vaccine β-elemene Long-term survival Case report

Early-onset primary torsional dystonia in a 4-generation Chinese family with a mutation in the DYT1 gene

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Chinese Medical Journal 2005年第10期118卷 873-876页

作者： YEUNG Wai Lan LAM Ching Wan CHENG Wai Tsoi SIN Ngai Chuen wong Wing Kin wong chun Nei TSE Ka Ming FOK Tai fai Departments of Paediatrics Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina Chemical Patholog Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina Department of Paediatrics and Adolescent Medicine Queen Mary HospitalUniversity of Hong Kong Nuclear Medicine&PET Division Scanning DepartmentSt.Teresa’s HospitalHong KongChina

Primary torsion dystonia(PTD)is a clinically and genetically heterogeneous movement *** least thirteen different types of dystonia can be distinguished on a genetic basis.~1 The DYT1 gene was first mapped by Ozelius et al in 1989.~2(Kramer et)al^3 linked the same locus to PTD in 12 Ashkenazi Jewish families in *** patients with early-onset generalized PTD were caused by the same three base pair(GAG)deletion in the DYT1 gene on chromosome 9q34.^(1,4,5)The product of the gene is a protein called torsinA.~5(Although the)function of this protein is as yet uncertain,it is widely distributed throughout the brain with high levels in the substantia nigra compacta dopamine neurones.

关键词： DYT1 gene dystonia positron emission tomography

Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver

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Cellular & Molecular Immunology 2022年第7期19卷 834-847页

作者： Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam Howard H.W.Leung Anthony W.H.Chan Ka fai To John wong Paul B.S.Lai Kelvin K.C.Ng Simon K.H.wong Vincent W.S.wong Alice P.S.Kong Joseph J.Y.Sung Alfred S.L.Cheng school of Biomedical Sciences The Chinese University of Hong KongHong Kong SAR 999077China Department of Anatomical and Cellular Pathology The Chinese University of Hong KongHong Kong SAR 999077China Department of Liver Surgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of Surgery The Chinese University of Hong KongHong Kong SAR 999077China Department of Medicine and Therapeutics The Chinese University of Hong Kong.Hong Kong SAR 999077China State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong Kong SAR 999077China Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 639798Singapore Institute of Precision Medicine The First Affliated HospitalSun Yat-sen UniversityGuangzhou 510080China

Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of *** cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains *** high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor *** analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD ***,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC ***,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell ***,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and *** study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic.

关键词： Cancer microenvironment Cancer models Tumour immunology

SHIP:Searching Heuristically over the Internet for the Desired Page

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SHIP:Searching Heuristically over the Internet for the Desir...

Characterization of edible bird’s nest by peptide fingerprinting with principal component analysis

第二十届全国数据库学术会议

作者： Kam-fai wong chun-Hung Cheng Department of Systems Engineering and Engineering Management The Chinese University of Hong Kong

In this paper a novel heuristic-based algorithm,SHIP,for deriving a Web address from a given company name is *** enables a user to locate the desired Web pages *** to classical contentbased algorithms for"company sear... 详细信息

关键词： Web page Searching Heuristically Desired page

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Food Quality and Safety 2017年第1期1卷 83-92页

作者： chun-fai wong Gallant Kar-Lun Chan Ming-Lu Zhang Ping Yao Huang-Quan Lin Tina Ting-Xia Dong Geng Li Xiao-Ping Lai Karl Wah-Keung Tsim Division of Life Science and Center for Chinese Medicine R&D The Hong Kong University of Science and TechnologyClear Water BayKowloon HKUST Shenzhen Research Institute Hi-Tech ParkNanshan School of Chinese Herbal Medicine Guangzhou University of Chinese Medicine Dongguan Mathematical Engineering Academy of Chinese Medicine Guangzhou University of Chinese MedicineChina

OBJECTIVES:Proteins are the major component and play a key role in nutritious and therapeutic functions of edible bird’s nest(EBN);however,limited studies have been conducted on the protein due to difficulties in extraction,isolation as well as *** study aimed to provide comprehensive information for the quality evaluation of EBN peptides,which would be a valuable reference for further study on EBN ***:Here,we developed a quality control method using high performance liquid chromatography(HPLC)peptide fingerprints deriving from EBN being digested with simulated gastric *** characteristic peptide peaks were collected and identified by LC-MS/***:The characteristic peptide peaks,corresponding to the protein fragments of acidic mammalian chitinase-like,lysyl oxidase,and Mucin-5AC-like,were identified and ***,the principal component analysis indicated that the fingerprints were able to discriminate colour of EBN(white/red)and production sites(cave/house)of White EBN on the same weight *** proposed by the model developed in this study,Muc-5AC-like and AMCaselike proteins were the markers with the highest discriminative ***:The overall findings suggest that HPLC peptide fingerprints were able to clearly demonstrate peptide profile differences between genuine and adulterated EBN samples;and classify EBN samples by its color and production *** addition,the protein identification results suggested that Muc-5AC-like protein was the major protein in EBN.

关键词： Edible bird’s nest Peptide fingerprint Mucin-5AC-like Acidic mammalian chitinase-like Principal component analysis

A cross-sectional study on compliance with topical glaucoma medication and its associated socioeconomic burden for a Chinese population

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 293-299页

作者： Man-Hin Lui Jason chun Ho Lam Yi Lee Kwong Tak Siu wong Pak Long Cheung Sherri Shun Yan Lai Pak Lun Yuen Wai Yiu Lam Ho Yan Chan Yiu fai wong Jimmy Shiu Ming Lai Kendrick Co Shih Li Ka Shing Faculty of Medicine the University of Hong KongPokfulamHong KongChina Department of Ophthalmology Li Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHongKongChina Department of Ophthalmology Queen Mary HospitalPokfulamHong KongChina

AIM： To estimate the overall drug compliance for local Chinese glaucoma patients on long-term topical ***： This was a retrospective cross-sectional ***-seven primary glaucoma patients from the subspecialty clinic of a publicly-funded tertiary care hospital in Hong Kong completed a questionnaire on compliance with topical glaucoma medication,attitude towards glaucoma and therapy and vision related quality of *** was defined as reporting missing more than or equal to 10% of the prescribed topical glaucoma medication during the 2wk immediately prior to the *** between noncompliance and demographics,attitude,disease and treatment status was *** was estimated with quality of life and direct medical cost involved with *** logistic regression on noncompliance was performed on selected ***： Compliance was calculated as 75%（95% CI： 64%-87%） among 57 subjects（mean age 69 y,female 51%）.No statistical significant relationship was established between noncompliance and any single factors or ***（P=0.048） and forgetfulness（P=0.064） were found to be marginally significant predictive factors on noncompliance in multivariable logistic *** might be related（P=0.130） to poorer self-rated vision-associated quality of *** societal cost of noncompliance was estimated to be over 2510 life-years and US$ 3.7 million ***： The compliance of Chinese glaucoma patients in Hong Kong is comparable to other parts in the world,and carries detrimental impacts on individual and societal *** and forgetfulness are two possible independent predictors for noncompliance.

关键词： glaucoma eye drop compliance quality of life

Transurethral resection of prostate for acute urinary retention is linked to shorter survival in younger men

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Asian Journal of Andrology 2019年第5期21卷 468-472页

作者： Jeremy Yuen-chun Teoh Chi-Kwok Chan Maggie Haitian Wang Chi-Ho Leung Eddie Shu-Yin Chan Peter Ka-Fung Chiu Chi-Hang Yee Hon-Ming wong Simon See-Ming Hou Chi-fai Ng S.H.Ho Urology Centre Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina Division of Biostatistics JC School of Public Health and Primary CareThe Chinese University of Hong KongHong KongChina Division of Urology Department of SurgeryNorth District HospitalHong KongChina Division of Urology Department of SurgeryAlice Ho Miu Ling Nethersole HospitalHong KongChina

It is largely unknown whether lower urinary tract symptoms(LUTS)or acute retention of urine(AROU)is linked to shorter life expectancy in *** conducted a multicenter,retrospective database analysis of patients undergoing transurethral resection of prostate(TURP)to study their *** Cox regression analysis and Kaplan-Meier analysis with stratification to age and indication of TURP were *** further performed an age-and sex-matched survival analysis with the general population using data from the Census and Statistics Department of the Hong Kong Special Administrative Region(Hong Kong,China).From January 2002 to December 2012,3496 patients undergoing TURP were included in our study,with 1764 patients in the LUTS group and 1732 patients in the AROU *** age,ischemic heart disease,cerebrovascular accident,and AROU were risk factors of *** aged80 *** to the general population,younger patients in the LUTS group appeared to have better survival(80 years,survival was similar with the general population in both the LUTS and AROU *** conclusion,AROU at young age was associated with mortality,while early detection and management of LUTS may improve survival.

关键词： acute retention of urine lower urinary tract symptoms mortality transurethral resection of prostate

Rare case of intussusception in an adult with acute myeloid leukemia

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World Journal of Gastroenterology 2015年第2期21卷 688-693页

作者： Man fai Law Cheuk Kei wong chun Yin Pang Hay Nun Chan Ho Kei Lai chung Yin Ha Celia Ng Yiu Ming Yeung Sze fai Yip Department of Medicine Tuen Mun Hospital Department of Medicine and Therapeutics Prince of Wales Hospital Department of Radiology Kwong Wah Hospital Department of Pathology Tuen Mun Hospital

Intussusception is rarely reported in adult patients with acute leukemia. We report a case of intussusception in a 29-year-old woman with acute myeloid leukemia(AML). She developed right lower quadrant pain, fever, and vomiting on day 16 of induction *** examination showed tenderness and guarding at the right lower quadrant of the abdomen. Abdominal computed tomography(CT) showed distension of the cecum and ascending colon, which were filled with loops of small bowel, and herniation of the ileocecal valve into the cecum. We proceeded to laparotomy and revealed ileocecal intussusception with the ileocecal valve as the leading point. The terminal ileum was thickened and invaginated into the cecum, which showed gangrenous changes. Right hemicolectomy was performed and microscopic examination of the colonic tissue showed infiltration of leukemic cells. The patient recovered after the operation and was subsequently able to continue treatment for AML. This case demonstrates that the diagnosis of intussusception is difficult because the presenting symptoms can be non-specific, but abdominal CT can be informative for preoperative diagnosis. Resection of the involved bowel is recommended when malignancy is suspected or confirmed. Intussusception should be considered in any leukemia patients presenting with acute abdomen. A high index of clinical suspicion is important for early diagnosis.

关键词： Intussusception Acute leukemia Abdominal pain Colo

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Cellular & Molecular Immunology 2021年第4期18卷 1005-1015页

作者： Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip chun Yeung John wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng School of Biomedical Sciences The Chinese University of Hong KongHong Kong SARChina lnstitute of Precision Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Liver Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Pharmacy The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Anatomical and Cellular Pathology The Chinese University of Hong KongHong Kong SARChina Department of Liver Surgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Division of Life Science Hong Kong University of Science and TechnologyHong Kong SARChina Department of Surgery The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Translational Oncology The Chinese University of Hong KongHong Kong SARChina Department of Clinical Oncology The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Oncogenes and Related Genes Stem Cell Research CenterRen Ji HospitalSchool of MedicineShanghai Cancer InstituteShanghai Jiao Tong UniversityShanghaiChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong Kong SARChina Clinical Trial Unit The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Cancer Center The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina

The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer *** a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely ***,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive *** an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)*** of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,***,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic ***,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation *** summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic *** findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention.

关键词： Cell cycle related kinase liver metastasis liver immune microenvironment myeloid-derived suppressor cell natural killer T cell