检索结果-南通市图书馆

Altered serotonin metabolism in Takeda G protein-coupled receptor 5 knockout mice protects against diet-induced hepatic fibrosis

在线全文

学校读者我要写书评

暂无评论

Liver Research 2022年第4期6卷 214-226页

作者： jessica M.Ferrell Matthew Dilts zachary Stahl Shannon Boehme Sabita Pokhrel Xinwen Wang john Y.L.Chiang Department of Integrative Medical Sciences Northeast Ohio Medical UniversityRootstownOHUSA Department of Pharmaceutical Sciences Northeast Ohio Medical UniversityRootstownOHUSA

Background and aims:Diet-induced obesity and metabolic syndrome can trigger the progression of fatty liver disease to non-alcoholic steatohepatitis and fibrosis,which is a major public health *** acids regulate metabolic homeostasis and inflammation in the liver and gut via the activation of nuclear farnesoid X receptor(Fxr)and the membrane receptor Takeda G protein-coupled receptor 5(Tgr5).Tgr5 is highly expressed in the gut and skeletal muscle,and in cholangiocytes and Kupffer cells of the ***5 is implicated in the mediation of liver and gut inflammation,as well as the maintenance of energy ***,we used a high fat,high fructose,and high sucrose(HFS)diet to determine how bile acid signaling through Tgr5 may regulate metabolism during the progression from fatty liver to non-alcoholic steatohepatitis and *** and methods:Female C57BL/6j control wild type(WT)and Tgr5 knockout(Tgr5^(-/-))mice were fed HFS(high fat(40%kcal),high fructose,and 20%sucrose water)diet for 20 *** phe-notypes were characterized through examination of bile acid synthesis pathways,lipid and cholesterol metabolism pathways,and fibrosis and inflammation ***:Tgr5^(-/-)mice were more glucose intolerant when fed HFS diet,despite gaining the same amount of weight as WT ***5^(-/-)mice accumulated significantly more hepatic cholesterol and triglycerides on HFS diet compared to WT mice,and gene expression of lipogenic genes was significantly *** cholesterol 7alpha-hydroxylase(Cyp7a1)gene expression was consistently elevated in Tgr5^(-/-)mice,while oxysterol 7alpha-hydroxylase(Cyp7b1),sterol 27-hydroxylase(Cyp27a1),Fxr,and small heterodimer partner(Shp)were downregulated by HFS ***,hepatic inflammation and fibrosis were also significantly reduced in Tgr5^(-/-)mice fed HFS diet,which may be due to altered se-rotonin signaling in the ***:Tgr5^(-/-)mice may be protected from high fat,high sugar-

关键词： Non-alcoholic fatty liver disease(NAFLD) Liver fibrosis Takeda G protein-coupled receptor 5(TGR5) Serotonin(5-HT) High fat,high fructose,and high sucrose (HFS)

Neoadjuvant therapy for pancreatic ductal adenocarcinoma:Opportunities for personalized cancer care

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2021年第27期27卷 4383-4394页

作者： Ahmad Hamad zachary j Brown Aslam M Ejaz Mary Dillhoff jordan M Cloyd Department of Surgery The Ohio State University Wexner Medical CenterColumbusOH 43215United States

Pancreatic ductal adenocarcinoma(PDAC)is an aggressive malignancy that is best treated in a multidisciplinary fashion using surgery,chemotherapy,and *** chemotherapy has shown to have a significant survival benefit in patients with resected ***,up to 50%of patients fail to receive adjuvant chemotherapy due to postoperative complications,poor patient performance status or early disease *** order to ensure the delivery of chemotherapy,an alternative strategy is to administer systemic treatment prior to *** oncology refers to the application of diverse strategies to target therapies specific to characteristics of a patient’s *** traditionally emphasized in selecting targeted therapies based on molecular,genetic,and radiographic biomarkers for patients with metastatic disease,the neoadjuvant setting is a prime opportunity to utilize personalized *** this article,we describe the current evidence for the use of neoadjuvant therapy(NT)and highlight unique opportunities for personalized care in patients with PDAC undergoing NT.

关键词： Pancreatic cancer Preoperative therapy FOLFIRINOX Precision oncology Patient-reported outcomes Personalized medicine Targeted therapy Whipple Pancreatectomy

iStent inject trabecular microbypass stent implantation with cataract extraction in open-angle glaucoma:early clinical experience

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Eye and Vision 2020年第3期7卷 266-274页

作者： Tanner j.Ferguson zachary Dockter Adam Bleeker Kayla L.Karpuk justin Schweitzer Mitch j.Ibach john P.Berdahl Cole Eye Institute Cleveland ClinicClevelandOHUSA University of South Dakota Sanford School of Medicine Sioux FallsSDUSA Cleveland Eye Clinic ClevelandOHUSA Vance Thompson Vision Sioux FallsSDUSA

Background:Retrospective,consecutive case series to evaluate the implantation of two second-generation trabecular microbypass stents in combination with cataract surgery in a real-world,clinical ***:The series included 56 eyes implanted with the iStent inject device with *** series consisted of eyes with primary open-angle glaucoma(n=52)and pseudoexfoliative glaucoma(n=4).Primary outcome measures included intraocular pressure(IOP)and number of glaucoma *** outcomes included the need for secondary surgical intervention and the incidence of IOP spikes≥10 mmHg and≥15 ***:IOP was reduced by 21%to 14.7±2.9 mmHg(pject device with concomitant cataract surgery effectively provides a sustained reduction in IOP with a markedly improved medication burden out to 6 months *** safety profile is excellent.

关键词： Micro-invasive glaucoma surgery Minimally invasive glaucoma surgery MIGS Trabecular microbypass stent Open-angle glaucoma

Objective screening for olfactory and gustatory dysfunction during the COVID-19 pandemic: A prospective study in healthcare workers using self-administered testing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Otorhinolaryngology-Head and Neck Surgery 2022年第3期8卷 249-256页

作者： Austin C.Cao zachary M.Nimmo Natasha Mirza Noam A.Cohen Robert M.Brody Richard L.Doty Perelman School of Medicine University of PennsylvaniaPhiladelphiaPAUSA Department of Otorhinolaryngology-Head and Neck Surgery University of PennsylvaniaPhiladelphiaPAUSA Corporal Michael j.Crescenz Veterans Administration Medical Center PhiladelphiaPAUSA Monell Chemical Senses Center PhiladelphiaPAUSA

Background: Smell and taste loss are highly prevalent symptoms in coronavirus disease 2019 (COVID-19), although few studies have employed objective measures to quantify these symptoms, especially dysgeusia. Reports of unrecognized anosmia in COVID-19 patients suggests that self-reported measures are insufficient for capturing patients with chemosensory ***: The purpose of this study was to quantify the impact of recent COVID-19 infection on chemosensory function and demonstrate the use of at-home objective smell and taste testing in an at-risk population of healthcare ***: Two hundred and fifty healthcare workers were screened for possible loss of smell and taste using online surveys. Self-administered smell and taste tests were mailed to respondents meeting criteria for elevated risk of infection, and one-month follow-up surveys were ***: Among subjects with prior SARS-CoV-2 infection, 73% reported symptoms of olfactory and/or gustatory dysfunction. Self-reported smell and taste loss were both strong predictors of COVID-19 positivity. Subjects with evidence of recent SARS-CoV-2 infection (jects. There was a time-dependent increase in smell scores but not in taste scores among subjects with prior infection and chemosensory symptoms. The overall infection rate was 4.4%, with 2.5% reported by PCR ***: Healthcare workers with recent SARS-CoV-2 infection had reduced olfaction and normal gustation on self-administered objective testing compared to those without infection. Rates of infection and chemosensory symptoms in our cohort of healthcare workers reflect those of the general public.

关键词： Anosmia Brief Smell Identification Test Chemosensory dysfunction COVID-19 Dysgeusia Gustation Healthcare workers Objective testing Olfaction Screening University of Pennsylvania Smell Identification Test

Effect of heat treatment conditions on the passivation behavior of WE43CMg-Y-Nd alloy in chloride containing alkaline environments

在线全文

学校读者我要写书评

暂无评论

journal of Magnesium and Alloys 2017年第2期5卷 147-165页

作者： jakraphan Ninlachart zachary Karmiol Dev Chidambaram Krishnan SRaja Chemical and Materials Engineering University of IdahoMoscowID 83844-1021USA Chemical and Materials Engineering University of NevadaRenoNV 89557-0388USA

Mg–Y–Nd alloy(WE43C or Elektron 43)is a heat treatable magnesium wrought alloy that can be used up to 250 ℃ for aerospace *** alloy has excellent mechanical properties(UTS:up to 345 MPa at room temperature)and improved corrosion *** passivation studies were conducted on this alloy under different heat treatment conditions in 0.1 M NaOH solution with the addition of chloride from 0 to 1000 *** passive potential range typically extended to more than 1.5 VAg/*** transpassive potential was not dependent on the heat treatment condition of the alloy when the chloride concentration increased up to 500 ***,pitting protection potential varied with the heat treatment condition when the chloride addition was 500 ppm or *** specimen surface was analyzed using scanning electron microscopy(SEM),X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),and Raman spectroscopy to understand the passivation behavior of this *** passivated surface of the WE43C specimens indicated that the surface layer consisted of MgO,Mg(OH)_(2),and rare earth oxide phases,and the heat treatment conditions did not significantly affect the composition of the surface film.

关键词： Elektron 43 Magnesium alloy Corrosion Passivation Chloride

Alteration in immune function in patients with fatty liver disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatoma Research 2022年第1期8卷 363-375页

作者： Stephanie N.Gregory Shruthi R.Perati zachary j.Brown Department of Surgery Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901USA Division of Surgical Oncology Department of SurgeryThe Ohio State University Wexner Medical CenterColumbusOH 43210USA

Nonalcoholic fatty liver disease(NAFLD)is a disease spectrum that spans simple steatosis,fibrosis,and ultimately cirrhosis,and is a leading cause of chronic liver disease *** severe variant of NAFLD,non-alcoholic steatohepatitis(NASH),is characterized by triglyceride accumulation within hepatocytes and the subsequent inflammatory pathway activation,ultimately progressing to cirrhosis in 10%-20%of *** is a known major risk factor for the development of hepatocellular carcinoma(HCC),and there is emerging data demonstrating the impact of NASH on immune subsets and the tumor microenvironment that may influence therapeutic *** review describes the various ways in which the immune system is altered in patients with *** innate immune system in NASH shows alterations in dendritic and Kupffer cells,impaired cytotoxicity of Natural Killer cells,and an accumulation of ***,there is emerging evidence emphasizing the role of the adaptive immune system in the development and progression of NASH,seen in the alteration of B-cells,T-cells,and NKT *** to the complex interplay of the immune system in NAFLD/NASH and its progression to HCC,many current treatments focus on targeting immune cells for HCC ***,immune checkpoint inhibitors such as atezolizumab and bevacizumab have been approved as first-line therapy for unresectable *** an emerging field of research,further studies and clinical trials are needed to understand the complex interface of NASH,HCC and the immune response.

关键词： Non-alcoholic steatohepatitis nonalcoholic fatty liver disease steatohepatitis immunology hepatocellular carcinoma

Exertional heat illness risk factors and physiological responses of youth football players

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Sport and Health Science 2021年第1期10卷 91-98页

作者： Susan W.Yeargin john j.Dickinson Dawn M.Emerson jessica Koller Toni M.Torres-McGehee zachary Y.Kerr Department of Exercise Science University of South CarolinaColumbiaSC 29208USA Palmetto Health/USC Orthopedic Center Keenan High SchoolColumbiaSC 29203USA Department of Health Sportand Exercise SciencesUniversity of KansasLawrenceKS 66045USA Surgi-Care Inc. BostonMA 02115USA Department of Exercise and Sport Science University of North CarolinaChapel HillNC 27599-8700USA

Objective:To determine which intrinsic and extrinsic exertional heat illness(EHI)risk factors exist in youth American football players and observe perceptual and physiological responses of players during events(games and practices).Methods:Cross-sectional cohort study observing 63 youth football players,varying in *** variables were league(weightrestricted(WR,n=27)and age-restricted(AR,n=36))and event *** variables were anthropometrics,work-to-rest ratio,and wet bulb globe *** variables included preparticipation examination and uniform configuration.A subset of 16 players participated in physiological variables(heart rate and gastrointestinal temperature).Data collection occurred on 7 AR and 8 WR nonconsecutive practices and the first 3 games of the ***:Mean values for anthropometric variables were higher(pjority of events(77%)observed were in black and red flag wet bulb globe temperature risk categories.A total of 57%of the players had a preparticipation examination,and up to 82%of events observed were in full *** gastrointestinal temperature and heart rate responses ranged widely and no players reached critical ***:Extrinsic(disproportionate work ratios,environmental conditions)and intrinsic(higher body mass index)EHI risk factors exist in youth *** risk factors may be influenced by event and league *** youth football organizations need to create thorough guidelines that address EHI risk factors for local leagues to adopt.

关键词： Adolescents Anthropometrics Core temperature Heat exchange Pediatric Wet bulb globe temperature

Selective serotonin re-uptake inhibitor sertraline inhibits bone healing in a calvarial defect model

在线全文

学校读者我要写书评

暂无评论

International journal of Oral Science 2018年第4期10卷 212-222页

作者： R.Nicole Howie Samuel Herberg Emily Durham zachary Grey Grace Bennfors Mohammed Elsalanty Amanda C.LaRue William D.Hill james j.Cray Oral Health Sciences Medical University of South CarolinaCharlestonSCUSA Biomedical Engineering Case Western Reserve UniversityClevelandOHUSA Cellular Biology and Anatomy Augusta UniversityAugustaGAUSA Oral Biology Augusta UniversityAugustaGAUSA Orthopaedic Surgery Augusta UniversityAugustaGAUSA Pathology and Laboratory Medicine Medical University of South CarolinaCharlestonSCUSA Institute for Regenerative and Reparative Medicine Augusta UniversityAugustaGAUSA Research Service of the Ralph H johnson VA Medical Center CharlestonSCUSA Charlie Norwood VA Medical Center AugustaGAUSA Department of Regenerative Medicine and Cellular Biology CharlestonSCUSA Wake Forest Institute for Regenerative Medicine Wake Forest School of MedicineWinston-SalemNCUSA Division of Anatomy College of MedicineOhio State UniversityColumbusOHUSA

Bone wound healing is a highly dynamic and precisely controlled process through which damaged bone undergoes repair and complete regeneration. External factors can alter this process, leading to delayed or failed bone wound healing. The findings of recent studies suggest that the use of selective serotonin reuptake inhibitors(SSRIs) can reduce bone mass, precipitate osteoporotic fractures and increase the rate of dental implant failure. With 10% of Americans prescribed antidepressants, the potential of SSRIs to impair bone healing may adversely affect millions of patients’ ability to heal after sustaining trauma. Here, we investigate the effect of the SSRI sertraline on bone healing through pre-treatment with(10 mg·kg-1sertraline in drinking water, n = 26) or without(control, n = 30) SSRI followed by the creation of a 5-mm calvarial defect. Animals were randomized into three surgical groups:(a) empty/sham,(b) implanted with a DermaMatrix scaffold soak-loaded with sterile PBS or(c) DermaMatrix soak-loaded with542.5 ng BMP2. SSRI exposure continued until sacrifice in the exposed groups at 4 weeks after surgery. Sertraline exposure resulted in decreased bone healing with significant decreases in trabecular thickness, trabecular number and osteoclast dysfunction while significantly increasing mature collagen fiber formation. These findings indicate that sertraline exposure can impair bone wound healing through disruption of bone repair and regeneration while promoting or defaulting to scar formation within the defect site.

关键词： Selective serotonin re-uptake inhibitor sertraline inhibits bone healing in a calvarial defect model

Enforced Freedom: Electric-Field-Induced Declustering of Ionic-Liquid Ions in the Electrical Double Layer

在线全文

学校读者我要写书评

暂无评论

Energy & Environmental Materials 2020年第3期3卷 414-420页

作者： Yufan Zhang Ting Ye Ming Chen zachary A.H.Goodwin Guang Feng jun Huang Alexei A.Kornyshev IEK-13 Institute of Energy and Climate ResearchForschungszentrum Jülich GmbHJülich 52425Germany State Key Laboratory of Coal Combustion School of Energy and Power EngineeringHuazhong University of Science and Technology(HUST)Wuhan 430074China Department of Chemistry Imperial College LondonMolecular Sciences Research HubWhite City CampusLondon W120BZUK Department of Physics Imperial College LondonSouth Kensington CampusLondon SW72AZUK Thomas Young Centre for Theory and Simulation of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK Hunan Provincial Key Laboratory of Chemical Power Sources College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China

Ions in the bulk of solvent-free ionic liquids bind into ion pairs and *** competition between the propensity of ions to stay in a bound state,and the reduction of the energy when unbinding in electric field,determines the portion of free ions in the electrical double *** present the simplest possible mean-field theory to study this effect."Cracking"of ion pairs into free ions in electric field is accompanied by the change of the dielectric response of the ionic *** predictions from the theory are verified and further explored by molecular dynamics simulations.A particular finding of the theory is that the differential capacitance vs potential curve displays a bell shape,despite the low concentration of free charge carriers,because the dielectric response reduces the threshold concentration for the bell-to camelshape *** presented theory does not take into account overscreening and oscillating charge distributions in the electrical double *** in spite of the simplicity of the model,its findings demonstrate a clear physical effect:a preference to be a charged monopole rather than a dipole(or higher order multipole)in strong electric field.

关键词： differential capacitance ion pairs ionic liquids unbinding