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Photonics Research 2021年第3期9卷 416-423页

作者： zachary N.coker Xiao-Xuan Liang Allen S.Kiester Gary D.Noojin Joel N.Bixler Bennett L.Ibey Alfred Vogel Vladislav V.Yakovlev Department of Physics and Astronomy Texas A&M UniversityCollege StationTexas 77843USA SAIc Ft Sam HoustonTexas 78234USA Institut fur Biomedizinische Optik Universitat zu Lubeck23562 LubeckGermany Air Force Research Laboratory JBSA Fort Sam HoustonTexas 78234USA Department of Biomedical Engineering Texas A&M UniversityCollege StationTexas 77843USA

The combined effect of short(picosecond) optical and(nanosecond) electrical pulses on dielectric breakdown is investigated both theoretically and experimentally. It was demonstrated that nanosecond electrical pulses(nsEPs),being applied simultaneously with picosecond optical pulses, reduce the threshold for optical *** results are discussed with respect to an extended model for opto-electrical-induced *** newly unveiled effect is expected to play a significant role in spatially confined electroporation and further advances in laser-ablation-based processes while also allowing for measurements of ambipolar diffusion constants.

关键词： breakdown optical picosecond

The joint automated repository for various integrated simulations (JARVIS) for data-driven materials design

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npj computational Materials 2020年第1期6卷 234-246页

作者： Kamal choudhary Kevin F.Garrity Andrew c.E.Reid Brian Decost Adam J.Biacchi Angela R.Hight Walker zachary Trautt Jason Hattrick-Simpers A.Gilad Kusne Andrea centrone Albert Davydov Jie Jiang Ruth Pachter Gowoon cheon Evan Reed Ankit Agrawal Xiaofeng Qian Vinit Sharma Houlong Zhuang Sergei V.Kalinin Bobby G.Sumpter Ghanshyam Pilania Pinar Acar Subhasish Mandal Kristjan Haule David Vanderbilt Karin Rabe Francesca Tavazza Materials Measurement Laboratory National Institute of Standards and TechnologyGaithersburgMD 20899USA Theiss Research La JollaCA 92037USA Department of chemistry and Biochemistry University of MarylandCollege ParkMD 20742USA Physical Measurement Laboratory National Institute of Standards and TechnologyGaithersburgMD 20899USA Materials and Manufacturing Directorate Air Force Research LaboratoryWright–Patterson Air Force BaseDaytonOH 45433USA Department of Materials Science and Engineering Stanford UniversityStanfordCA 94305USA Department of Electrical and computer Engineering Northwestern UniversityEvanstonIL 60208USA Department of Materials Science and Engineering Texas A&M UniversityTexasTX 77843USA Joint Institute for computational Sciences University of TennesseeKnoxvilleTN 37996USA National Institute for computational Sciences Oak Ridge National LaboratoryOak RidgeTN 37831USA School for Engineering of Matter Transport and Energy Arizona State UniversityTempeAZ 85287USA center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTN 37831USA Materials Science and Technology Division Los Alamos National LabLos AlamosNM 87545USA Department of Mechanical Engineering Virginia TechBlacksburgVA 24061USA Department of Physics and Astronomy Rutgers UniversityPiscatawayNJ 08901USA

The Joint Automated Repository for Various Integrated Simulations(JARVIS)is an integrated infrastructure to accelerate materials discovery and design using density functional theory(DFT),classical force-fields(FF),and machine learning(ML)*** is motivated by the Materials Genome Initiative(MGI)principles of developing open-access databases and tools to reduce the cost and development time of materials discovery,optimization,and deployment.

关键词： automated JAR databases

PathoDNA, an Advanced Diagnostic for Lyme Disease &co-Infections Utilizing Next Generation DNA Sequencing with Greater Sensitivity and Selectivity than ELISA/Western Blot

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Advances in Infectious Diseases 2021年第4期11卷 405-429页

作者： Robert Schettig Ruth Tan-Lim Daniel Warren zachary Poteet Rory Sears Michael Hummel connor coffin Kendra Quart christopher Aussems Ronald Matthias Jr. David Medina Matthew Klein Gayle Roberts John c. Oertle III Dino Prato Envita Scottsdale USA

The controversial subject of chronic Lyme disease has occupied medical discourse for years while contributing to unprecedented patient suffering in the United States and abroad. A general misunderstanding of Lyme disease and overconfidence in the center for Disease control’s (cDc) recommended two-step test for Lyme disease has led to misdiagnosis and incorrect treatment over the years. This leads to increasing medical expenses and worse outcomes for patients. The two-step test, an ELISA immunoblot followed by a confirmatory Western blot, yields accuracy rates as low as 29% for acute Lyme disease and 75% for chronic Lyme disease. While these practices have been a staple of microbiology for decades, these accuracy rates are unacceptable for diagnostic tests when better technology is available. PathoDNA, a Next-Generation DNA sequencing test for Lyme disease and other tick-borne pathogens, achieves accuracy rates of 98% for B. burgdorferi and 95% or greater for other common tick-borne pathogens with superior sensitivity and selectivity. PathoDNA is a clinical Laboratory Improvement and Amendments (cLIA)-validated laboratory test that achieves these results utilizing Next Generational DNA Sequencing and a proprietary bioinformatics database. Thus, it allows for rapid results and specific identification of tick-borne illnesses. In this article, we will compare this promising technology against the existing standards for diagnosing and testing Lyme disease. We believe that PathoDNA can set a new standard for identifying Borrelia and diagnosing Lyme disease along with other tick-borne infections.

关键词： Lyme Disease Ticks Tick-Borne Borrelia Sequencing Diagnosis

Decoupling the Electrical and Entropic contributions to Energy Transfer from Infrared Radiation to a Power Generator

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World Journal of condensed Matter Physics 2015年第4期5卷 301-318页

作者： Aidan L. Gordon Yosyp Schwab Brian N. Lang Graham P. Gearhart Tara R. Jobin Justin M. Kaczmar zachary J. Marinelli Harkirat S. Mann Brian c. Utter Giovanna Scarel Department of Physics and Astronomy James Madison University Harrisonburg USA

The interaction between infrared radiation and a power generator device in time is studied as a route to harvest infrared, and possibly other electromagnetic radiations. Broadening the spectrum of the usable electromagnetic spectrum would greatly contribute to the renewable and sustainable energy sources available to humankind. In particular, low frequency and low power radiation is important for applications on ships, satellites, cars, personal backpacks, and, more generally, where non-dangerous energy is needed at all hours of the day, independent of weather conditions. In this work, we identify an electric and an entropic contribution to the energy transfer from low power infrared radiation to the power generator device, representing electrical and thermal contributions to the power generation. The electric contribution prevails, and is important because it offers multiple ways to increase the voltage produced. For example, placing black-colored gaffer tape on the illuminated face doubles the voltage produced, while the temperature difference, thus the entropic contribution, is not sensitive to the presence of the tape. We recognize the electric contribution through the fast changes it imparts to the voltage output of the power generator device, which mirror the instabilities in time of the infrared radiation. The device thus acts as sensor of the infrared radiation’s behavior in time. On the other hand, we distinguish the entropic contribution through the slow changes it causes to the voltage output of the power generator device, which reflect the relative delay with which the two faces of the device respond to thermal perturbations.

关键词： Infrared Power Generators Energy Harvesting Electric contribution

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达沃斯认知偏差评定量表的信效度检验

中华精神科杂志 2014年第4期47卷 232-236页

作者：杨金玉祝一虹王奕權陈致宇刘微波田琪林明霞 zachary cohen Yulia Landa 浙江大学医学部公共卫生学院杭州310058 浙江大学医学部心理健康教育与咨询中心杭州310058 杭州市第七人民医院精神科浙江大学附属第二医院精神科 Warren Alpert Medical School of Brown University Department of Psychiatry Weill Medical College of Cornell University

目的规范化引进达沃斯认知偏差评定量表（Davos Assessment of cognitive Biases Scale,DAcOBS）并检验其信度和效度.方法经原作者授权,将英文版DAcOBS经过翻译和回译后确定中文版（DAcOBS-c）.采用方便抽样方法,选取符合DSM-Ⅳ精神... 详细信息

目的规范化引进达沃斯认知偏差评定量表（Davos Assessment of cognitive Biases Scale,DAcOBS）并检验其信度和效度.方法经原作者授权,将英文版DAcOBS经过翻译和回译后确定中文版（DAcOBS-c）.采用方便抽样方法,选取符合DSM-Ⅳ精神分裂症诊断标准的患者102例（病例组）及某社区居民和在校大学生120名（对照组）完成DAcOBS-c,进行项目分析、探索性因素分析和内部一致性检验.同时抽取部分患者完成认知偏差问卷（cognitive Bias Questionnaire,cBQ）、贝克抑郁量表（Beck Depression Inventory,BDI）、Peter等的妄想问卷（Peters et *** Inventory,PDI）和精神症状评定量表（Psychotic Symptoms Rating Scale,PSYRATS）以检验效标效度.对病例组和对照组DAcOBS-c总分进行独立样本t检验,以检验区分效度.结果（1）根据项目分析的结果,删除条目l、3、12;探索性因素分析中提取出7个因子,共解释方差54.04％,各条目的因子载荷均在0.42 ～***-c总分与cBQ抑郁-歪曲分量表评分呈正相关（r=0.55,P＜0.01）;与BDI总分呈正相关（r =0.61,P＜0.01）;与PDI各分量表评分均呈正相关（r=0.60、0.63、0.56、0.57,均P＜0.01）;与PSYRATS总分呈正相关（r=0.57,P＜0.01）.病例组DAcOBS-c总分高于对照组[（139.23 ±33.33）分比（128.05 ±26.50）分,P＜0.05].（2）DAcOBS-c的克朗巴赫α系数为0.92（P＜0.01）,7个因子的各个内部一致性克朗巴赫α系数为0.66 ～0.81,量表各因子与总分的相关系数为0.53 ～0.68,各因子间的相关系数为0.30 ～0.63.结论 DAcOBS-c的信度、区分效度、结构效度均符合心理测量学要求,可以用于国内精神分裂症认知偏差的研究.

关键词：精神分裂症可重复性,结果达沃斯认知偏差评定量表

Impact of tertiary Gleason pattern 5 on prostate cancer aggressiveness:Lessons from a contemporary single institution radical prostatectomy series

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Asian Journal of Urology 2015年第1期2卷 53-58页

作者： zachary B.Koloff Daniel A.Hamstra John T.Wei Jeffrey S.Montgomery Scott A.Tomlins Angela J.Wu Todd M.Morgan Javed Siddiqui Kellie Paich Arul M.chinnaiyan Felix Y.Feng Alon Z.Weizer Lakshmi P.Kunju Brent K.Hollenbeck David c.Miller Ganesh S.Palapattu Rohit Mehra Department of Urology University of Michigan Medical SchoolAnn ArborMIUSA Department of Radiation Oncology University of Michigan Medical SchoolAnn ArborMIUSA Department of Pathology University of Michigan Medical SchoolAnn ArborMIUSA

Objective:To better evaluate tertiary Gleason pattern reporting and to evaluate the impact of tertiary Gleason pattern 5(TP5)on prostate cancer pathological features and biochemical recurrence at our large single ***:We retrospectively reviewed 1962 patients who underwent radical prostatectomy(RP)for prostate cancer;TP5 was reported in 159 cases(8.1%).Men with Gleason score(GS)7 and GS 8 disease were divided into subgroups with and without TP5,and histopathological features were *** analyses were conducted to assess the impact on TP5 on biochemical-free survival(BFS).Results:Tumors possessing GS 3+4 with TP5 were more likely to exhibit extraprostatic extension(EPE)and had a larger tumor diameter(TD)than GS 3+4 *** 3+4 with TP5 was also associated with positive surgical margins(SM),seminal vesicle involvement(SVI),and higher pre-operative prostate-specific antigen(PSA)values,but without statistical *** 4+3 with TP5 more commonly presented with EPE,positive SM,SVI,and greater TD and pre-operative PSA level than GS 4+3 *** multivariate analysis,Gleason score,EPE,and TP5 were overall independent risk factors for PSA recurrence in this ***,GS 4+3 with TP5 was associated with shorter time to recurrence versus GS 4+3 ***:Our results emphasize the importance of TP5 and suggest that criteria for tertiary pattern reporting in prostate cancer should be *** studies are needed to evaluate the role of tertiary patterns in prognostic models.

关键词： Tertiary Gleason pattern Prostate cancer Prostatic neoplasm Gleason score Radical prostatectomy Disease-free survival

Discovery of Key Molecular Pathways of c1 Metabolism and Formaldehyde Detoxification in Maize through a Systematic Bioinformatics Literature Review

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Agricultural Sciences 2015年第5期6卷 571-585页

作者： P. Deonikar S. Kothandaram M. Mohan cori Kollin Phoebe Konecky Rachael Olovyanniko zachary Zamore Brian carey V. A. S. Ayyadurai International center for Integrative Systems Cambridge MA USA Livingston High School Livingston NJ USA

computational systems biology approaches provide insights to understand complex molecular phenomena in living systems. Such understanding demands the need to systematically interrogate and review existing literature to refine and distil key molecular pathways. This paper explores a methodological process to identify key molecular pathways from systematic bioinformatics literature review. This process is used to identify molecular pathways for a ubiquitous molecular process in all plant biological systems: c1 metabolism and formaldehyde detoxification, specific to maize. The c1 metabolism is essential for all organisms to provide one-carbon units for methylation and other types of modifications, as well as for nucleic acid, amino acid, and other biomolecule syntheses. Formaldehyde is a toxic one-carbon molecule which is produced endogenously and found in the environment, and whose detoxification is an important part of c1 metabolism. This systematic review involves a five-part process: 1) framing of the research question;2) literature collection based on a parallel search strategy;3) relevant study selection based on search refinement;4) molecular pathway identification;and 5) integration of key molecular pathway mechanisms to yield a well-defined set molecular systems associated with a particular biochemical function. Findings from this systematic review produced three main molecular systems: a) methionine biosynthesis;b) the methylation cycle;and c) formaldehyde detoxification. Specific insights from the resulting molecular pathways indicate that normal c1 metabolism involves the transfer of a carbon group from serine through a folate-mediated pathway to methionine, and eventually the methylation of a biomolecule. In photosynthetic tissues, c1 metabolism often proceeds in reverse towards serine biosynthesis and formate oxidation. c1 metabolism, in maize, appears to be present in the developing embryo and endosperm indicating that these cells are vulnerable to pertu

关键词： Systematic Review Bioinformatics Molecular Pathway c1 Metabolism Formaldehyde Detoxification Maize Methionine Biosynthesis Methylation cycle Folate-Mediated Pathways

Vulnerability of Kenya’s Water Towers to Future climate change: An Assessment to Inform Decision Making in Watershed Management

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American Journal of climate change 2020年第3期9卷 317-353页

作者： Kenneth Kemucie Mwangi Anthony M. Musili Viola A. Otieno Hussen S. Endris Geoffrey Sabiiti Mohammed A. Hassan Abebe Tadege Tsehayu Artan Guleid zachary Atheru Alphonce c. Guzha Thomas De Meo Nikola Smith Dickson Lubanga Makanji John Kerkering Brehan Doud Enock Kanyanya IGAD climate Prediction and Applications centre Nairobi Kenya USDA Forest Service International Programs c/o African Wildlife Foundation (AWF) Karen Kenya USDA Forest Service Pacific Northwest Region Portland OR USA Egerton University Njoro Kenya USDA Forest Service International Programs Washington DC USA USDA Forest Service International Programs Seattle USA USAID Kenya and East Africa Nairobi Kenya

Recent trends show that in the coming decades, Kenya’s natural resources will continue to face significant pressure due to both anthropogenic and natural stressors, and this will have greater negative impacts on socio-economic development including food security and livelihoods. Understanding the impacts of these stressors is an important step to developing coping and adaptation strategies at every level. The Water Towers of Kenya play a critical role in supplying ecosystems services such as water supply, timber and non-timber forest products and regulating services such as climate and water quantity and quality. To assess the vulnerability of the Water Towers to climate change, the study adopted the IPcc AR4 framework that defines vulnerability as a function of exposure, sensitivity, and adaptive capacity. The historical trends in rainfall indicate that the three Water Towers show a declining rainfall trend during the March-April-May (MAM) main rainy season, while the October-November-December (OND) short rainy season shows an increase. The temperature patterns are consistent with the domain having a common rising trend with a rate in the range of 0.3°c to 0.5°c per decade. Projection analysis considered three emissions scenarios: low-emission (mitigation) scenario (RcP2.6), a medium-level emission scenario (RcP4.5), and a high-emission (business as usual) scenario (RcP8.5). The results of the high-emission scenario show that the annual temperature over the Water Towers could rise by 3.0°c to 3.5color

关键词： Kenya Water Towers climate change Vulnerability Exposure Sensitivity Adaptive capacity

Buffer Standards for Physiological pH of the Buffer N-(2-Acetamido)-2-aminoethanesulfonic Acid from 5°c to 55°c

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Open Journal of Physical chemistry 2011年第3期1卷 118-123页

作者： Blake M. Bodendorfer zachary M. Downs Isaac B. Henson Lakshmi N. Roy Rabindra N. Roy Jessica M. Stegner Jaime A. Veliz Joshua T. Wollen 不详

Electromotive force (emf) measurements of the cell Pt(s), H2(g)|AcES(m1) + NaAcES(m2) + Nacl (m3)| Agcl, Ag(s) have been carried out from 5°c to 55°c . The agreement of pH values between two calculated (extended Debye-Hückel and liquid junction correction) is very good. Two buffer solutions without the chloride ion and seven buffer solutions with Nacl, at an ionic strength (I = 0.16 ***-1) similar to that of physiological fluids, have been studied. The pH values for these buffer solutions have been evaluated in the temperature range of 5°c to 55°c using the extended Debye-Hückel equation of the Bates-Guggenheim convention. Values of the residual liquid junction potential (δEj) between the AcES solutions and the saturated Kcl calomel electrode solution have been estimated at 25°c and 37°c from the previously determined Ej values using the flowing junction cell to determine the operational pH values at 25°c and 37°c. These AcES buffer solutions are recommended as secondary standard reference solutions for pH measurements in the range of physiological applicati on at I = 0.16 ***-1.

关键词： Buffer Emf pH Zwitterionic

Air quality monitoring using mobile microscopy and machine learning

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Light(Science & Applications) 2017年第1期6卷 555-566页

作者： Yi-chen Wu Ashutosh Shiledar Yi-cheng Li Jeffrey Wong Steve Feng Xuan chen christine chen Kevin Jin Saba Janamian Zhe Yang zachary Scott Ballard Zoltán Göröcs Alborz Feizi Aydogan Ozcan Electrical Engineering Department University of CaliforniaLos AngelesCA 90095USA Bioengineering Department University of CaliforniaLos AngelesCA 90095USA california NanoSystems Institute(cNSI) University of CaliforniaLos AngelesCA 90095USA computer Science Department University of CaliforniaLos AngelesCA 90095USA David Geffen School of Medicine University of CaliforniaLos AngelesCA 90095USA

Rapid,accurate and high-throughput sizing and quantification of particulate matter(PM)in air is crucial for monitoring and improving air *** fact,particles in air with a diameter of≤2.5μm have been classified as carcinogenic by the World Health *** we present a field-portable cost-effective platform for high-throughput quantification of particulate matter using computational lens-free microscopy and *** platform,termed c-Air,is also integrated with a smartphone application for device control and display of *** mobile device rapidly screens 6.5 L of air in 30 s and generates microscopic images of the aerosols in *** provides statistics of the particle size and density distribution with a sizing accuracy of~93%.We tested this mobile platform by measuring the air quality at different indoor and outdoor environments and measurement times,and compared our results to those of an Environmental Protection Agency–approved device based on beta-attenuation monitoring,which showed strong correlation to c-Air ***,we used c-Air to map the air quality around Los Angeles International Airport(LAX)over 24 h to confirm that the impact of LAX on increased PM concentration was present even at 47 km away from the airport,especially along the direction of landing *** its machinelearning-based computational microscopy interface,c-Air can be adaptively tailored to detect specific particles in air,for example,various types of pollen and mold and provide a cost-effective mobile solution for highly accurate and distributed sensing of air quality.

关键词： air-quality monitoring holography machine learning particulate matter