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Characterizing the patient experience during neoadjuvant therapy for pancreatic ductal adenocarcinoma:A qualitative study

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World Journal of Gastrointestinal Oncology 2022年第6期14卷 1175-1186页

作者： Lena Stevens zachary J Brown Ryan Zeh Christina monsour Sharla Wells-Di Gregorio Heena Santry Aslam m Ejaz Timothy michael Pawlik Jordan m Cloyd Department of Surgery The Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of General Surgery University of Pittsburgh Medical CenterPittsburghPA 15213United States Department of Psychiatry Center for Palliative CareThe Ohio State University Wexner Medical CenterColumbusOH 43210United States

BACKGROUnD neoadjuvant therapy(nT)has increasingly been utilized for patients with localized pancreatic ductal adenocarcinoma(PDAC).It is the recommended approach for borderline resectable(BR)and locally advanced(LA)cancers and an increasingly utilized option for potentially resectable(PR)*** its increased use,little research has focused on patient-centered metrics among patients undergoing nT,including patient experiences,preferences,and recommendations.A better understanding of all aspects of the patient experience during nT may identify opportunities to design interventions aimed at improving quality of life;it may also facilitate the completion of nT and receipt of surgery,ultimately optimizing long-term *** To understand the experience of patients initiating and receiving nT to identify opportunities to improve neoadjuvant cancer care *** Semi-structured interviews of patients with localized PDAC during nT were conducted to explore their experience initiating and receiving *** took place between August 2020 and October *** to the descriptive nature of the research,questions were open *** were conducted over the phone,audio recorded and then *** interviews were coded by two independent researchers using nVivo 12,iteratively identifying themes until thematic saturation was *** integrative approach to qualitative analysis was used,utilizing both inductive and deductive *** A total of 12 patients with localized PDAC were *** with BR(n=7),PR(n=2),and LA(n=3)cancers participated in the *** patients indicated that choosing nT was the doctor’s recommendation,while most reported not being familiar with the concept of nT(n=11)and that nT was presented as the only option(n=8).Five themes describing the patient experience emerged:physical symptoms,emotional symptoms,coping mechanisms,access to care,and life *** most commonly cited recommendation for

关键词： Pancreatic ductal adenocarcinoma neoadjuvant therapy Patient experience Patient-centered care Quality of life Qualitative research

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Enzymatic Hydrolysis of an Organic Sulfur Compound

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Advances in Enzyme Research 2019年第1期7卷 1-13页

作者： Terrence G. Gardner zachary n. Senwo Department of Crop and Soil Sciences North Carolina State University Raleigh NC USA Department of Biological & Environmental Sciences Alabama A&M University Normal AL USA

Sulfatases which cleave sulfate esters in biological systems are key enzymes that deserve special attention due to their significant roles in organic sulfur (OS) mineralization and inorganic sulfur () release. In this study, in-vitro experiments were conducted to evaluate S bonded substrate hydrolysis by a commercially available arylsulfatase (EC 3.***.6.1) from Aerobacter aerogenes. The enzyme-substrate interactions were assessed to determine: 1) rate of hydrolysis, 2) catalytic efficiency, 3) thermal stability, and 4) optimal pH of this enzyme. Arylsulfatase exhibited substrate hydrolysis with a high affinity for p-nitrophenyl sulfate (potassium 4-nitrophenyl sulfate (pnPS)). The optimum activity for the enzyme was observed to occur at a pH of 7.1. The optimal temperature was 37°C but ranged from 35°C - 45°C. The apparent Km and Kcat of the enzyme for pnPS hydrolysis at the optimal pH, and temperature were determined to be 1.03 mm and 75.73 μm/min, respectively. This work defines the catalytic and kinetic properties of arylsulfatase (EC 3.***.6.1) and confirms the optimal conditions for sulfatase activity testing. The resulting information is useful in elucidating the contributions that individual enzymes have for specific reactions rather than relying on traditional total enzyme activity measurements.

关键词： Enzymes Sulfatases Organic Sulfur mineralization

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The Relativistic Time-Dependent Aharonov-Bohm Effect

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Journal of modern Physics 2014年第16期5卷 1640-1651页

作者： Athanasios n. Petridis zachary Kertzman Khinlay Win Department of Physics and Astronomy Drake University Des Moines USA

The relativistic Aharonov-Bohm (AB) effect is studied using the time-dependent Dirac equation. It is shown that if the initial electron distribution is a pulse it is possible to define time-dependent signals that dist... 详细信息

关键词： Aharonov-Bohm Effect Dirac Equation Time-Dependent Quantum mechanics

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Silica-coating-assisted nitridation of TiO_(2) nanoparticles and their photothermal property

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nano Research 2021年第9期14卷 3228-3233页

作者： Qilin Wei Danielle L.Kuhn zachary Zander Brendan G.DeLacy Hai-Lung Dai Yugang Sun Department of Chemistry Temple University1901 North 13th StreetPhiladelphiaPennsylvania 19122USA U.S.Army Edgewood Chemical Biological Center Research&Technology DirectorateAberdeen Proving GroundMaryland 21010USA

nanoparticles of refractory compounds represent a class of stable materials showing a great promise to support localized surface plasmon resonances(LSPRs)in both visible and near infrared(nIR)spectral *** is still challenging to rationally tune the LSPR band because of the difficulty to control the density of charge carriers in individual refractory nanoparticles and maintain the dispersity of nanoparticles in the processes of synthesis and *** this work,controlled chemical transformation of titanium dioxide(TiO_(2))nanoparticles encapsulated with mesoporous silica(SiO_(2))shells to titanium nitride(Tin)via nitridation reaction at elevated temperatures is developed to tune the density of free electrons in the resulting titanium-oxide-nitride(TiO_(x)n_(y))*** tunability enables a flexibility to support LSPR-based optical absorption in the synthesized TiO_(x)n_(y)@SiO_(2) core-shell nanoparticles across both the visible and nIR *** silica shells play a crucial role in preventing the sintering of TiO_(x)n_(y) nanoparticles in the nitridation reaction and maintaining the stability of TiOxny nanoparticles in *** LSPR-based broadband absorption of light in the TiO_(x)n_(y)@SiO_(2) nanoparticles exhibits strong photothermal effect with photo-to-thermal conversion efficiency as high as〜76%.

关键词： titanium-oxide-nitride nanoparticles mesoporous silica coating nitridation reaction structural transformation plasmonic absorption photothermal effect

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A gap-free genome assembly of Chlamydomonas reinhardtii anddetection of translocations induced by CRISPR-mediated mutagenesis

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Plant Communications 2023年第2期4卷 249-271页

作者： zachary L.Payne Gervette m.Penny Tychele n.Turner Susan K.Dutcher Department of Genetics Washington University School of MedicineSaint LouisMO 63110USA

Genomic assemblies of the unicellular green alga Chlamydomonas reinhardtii have provided important resources for ***,assembly errors,large gaps,and unplaced scaffolds as well as strain-specific variants currently impede many types of *** combining PacBio HiFi and Oxford nanopore long-read technologies,we generated a de novo genome assembly for strain CC-5816,derived from crosses of strains CC-125 and *** methods of evaluating genome completeness and base-pair error rate suggest that the final telomere-to-telomere assembly is highly *** CC-5816 assembly enabled previously difficult analyses that include characterization of the 17 centromeres,rDnA arrays on three chromosomes,and 56 insertions of organellar DnA into the nuclear *** nanopore sequencing,we identified sites of cytosine(CpG)methylation,which are enriched at *** analyzed CRISPR-Cas9 insertional mutants in the PF23 *** of the three alleles produced progeny that displayed patterns of meiotic inviability that suggested the presence of a chromosomal *** nanopore reads from pf23-2 and pf23-3 onto the CC-5816 genome showed that these two strains each carry a translocation that was initiated at the PF23 gene locus on chromosome 11 and joined with chromosomes 5 or 3,*** translocations were verified by demonstrating linkage between loci on the two translocated chromosomes in meiotic *** three pf23 alleles display the expected short-cilia phenotype,and immunoblotting showed that pf23-2 lacks the PF23 *** CC-5816 genome assembly will undoubtedly provide an important tool for the Chlamydomonas research community.

关键词： alga reference genome de novo PacBio nanopore structural variation

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Factors and expectations influencing concussion disclosure within nCAA DivisionⅠathletes:A mixed methodological approach

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Journal of Sport and Health Science 2023年第3期12卷 388-397页

作者： melissa C.Kay Heidi Hennink-Kaminski zachary Y.Kerr Paula Gildner Brittany m.Ingram Kenneth L.Cameron megan n.Houston Laura A.Linnan Stephen W.marshall Karen Y.Peck Johna K.Register-mihalik School of Health Professions College of Nursing and Health ProfessionsUniversity of Southern MississippiHattiesburgMS 39406USA School of media and Journalism University of North Carolina at Chapel HillChapel HillNC 27599USA Injury Prevention Research Center University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Exercise and Sport Science College of Arts and SciencesUniversity of North Carolina at Chapel HillChapel HillNC 27599USA matthew Gfeller Sport-Related Traumatic Brain Injury Research Center University of North Carolina at Chapel HillChapel HillNC 27599USA Center for the Study of Retired Athletes University of North Carolina at Chapel HillChapel HillNC 27599USA Keller Army Hospital United States Military AcademyWest PointNY 10996USA Departments of Physical medicine and Rehabilitation and Surgery Uniformed Services University of the Health SciencesBethesdaMD 20814USA Department of Health Behavior School of Public HealthUniversity of North Carolina at Chapel HillChapel HillNC 27599USA Department of Epidemiology School of Public HealthUniversity of North Carolina at Chapel HillChapel HillNC 27599USA

Background:Participation in sports is associated with many benefits to all aspects of health;however,it also comes with the risk of injury,particularly ***-disclosure and care seeking following a concussion are especially important because of the lack of outwardly visible signs and/or *** recent research has explored factors affecting concussion disclosure,use of isolated methodologies limits the ability to contextualize how disclosure or nondisclosure ***,the purpose of this study was to describe the factors and expectations of national Collegiate Athletic Association(nCAA)athletes that may influence concussion ***:This mixed-methods convergent parallel research study included 25 nCAA Division I athletes representing 13 sports,all of whom completed a concussion-education session with pre-/post-test surveys and a semistructured *** athletes were at least 18 years old and on an nCAA *** surveys focused on previous concussion-related disclosure behaviors,knowledge,attitudes,beliefs,norms,and intentions about disclosing *** focused on the athletes’experiences related to concussion *** data were analyzed using descriptive statistics and mann-Whitney U *** were analyzed using a Consensual Qualitative Research ***:Participants had good concussion knowledge(median=46.0),positive attitudes(median=38.0),strong beliefs(median=13.0),and strong intentions to disclose concussion symptoms(median=7.0).none of the constructs differed by participants’*** quantitative findings were mostly positive,interview data highlighted factors that may explain why some participants are successful in disclosing concussions and why others may find disclosure *** efforts,sport culture,and medical professional presence were the primary facilitators discussed by ***,pressure,and a lack of team support were perceived as di

关键词： Education medical professional presence mixed methodological research Reporting Sport culture

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Phosphatase Hydrolysis of Organic Phosphorus Compounds

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Advances in Enzyme Research 2015年第2期3卷 39-51页

作者： Irenus A. Tazisong zachary n. Senwo Zhongqi He Department of Biological & Environmental Sciences Alabama A&M University Normal AL USA USDA-ARS Southern Regional Research Center New Orleans LA USA

Phosphatases are diverse groups of enzymes that deserve special attention because of their significant roles in organic phosphorus (OP) mineralization to inorganic available forms (Pi). This work 1) compared the catalytic potentials of commercially acid phosphatase from wheat germ, sweet potato, and potato, and alkaline phosphatase from E. coli;2) demonstrated that the rate of hydrolysis, catalytic efficiency, thermal stability, and optimal pH of these enzymes depended on enzyme sources and the stereochemical or stereoisomeric structures of the substrates;3) revealed that both acid and alkaline phosphatases exhibited broad range of substrate hydrolysis with high affinity for p-nitrophenyl phosphate bis (cyclohexylammonium) than the widely used p-nitrophenyl phosphate disodium hexahydrate for phosphatase assay. Sweet potato had relatively higher reaction kinetics (Vmax, Km, Kcat, Kcat/Km) values with most substrates tested. The order of catalytic activity was in the order: sweet potato > wheat germ > potato, while the order of substrate hydrolyzed was: PnPBC > PnP > PnP2A2E > DG6P2na > DG6Pna > Bis-PnP > phytate. The optimum pH for the acid phosphatase was observed to be 5.0. Generally, the activity of alkaline phosphatase was similar to that of acid phosphatase with optimal pH between 10 and 13, depending on the substrates. Knowledge derived from this work would be helpful in enzyme catalysis in soils and water environments.

关键词： Enzymes Phosphatases Organic Phosphorus mineralization Wheat Germ Sweet Potato E. coli

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A GPU-Accelerated mixed-Precision WEnO method for Extremal Black Hole and Gravitational Wave Physics Computations

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Communications on Applied mathematics and Computation 2023年第1期5卷 97-115页

作者： Scott E.Field Sigal Gottlieb zachary J.Grant Leah F.Isherwood Gaurav Khanna University of massachusetts Dartmouth North DartmouthMA 02747USA Department of Computational and Applied mathematics Oak Ridge National LaboratoryOak RidgeTN 37830USA University of Rhode Island KingstonRI 02881USA

We develop and use a novel mixed-precision weighted essentially non-oscillatory(WEnO)method for solving the Teukolsky equation,which arises when modeling perturbations of Kerr black *** show that WEnO methods outperform higher-order finite-difference methods,standard in the discretization of the Teukolsky equation,due to the need to add dissipation for stability purposes in the *** particular,as the WEnO scheme uses no additional dissipation,it is well suited for scenarios requiring long-time evolution such as the study of price tails and gravitational wave emission from extreme mass ratio *** the mixed-precision approach,the expensive computation of the WEnO weights is performed in reduced floating-point precision that results in a significant speedup factor of≈*** addition,we use state-of-the-art nvidia general-purpose graphics processing units and cluster parallelism to further accelerate the WEnO *** optimized WEnO solver can be used to quickly generate accurate results of significance in the field of black hole and gravitational wave *** apply our solver to study the behavior of the Aretakis charge—a conserved quantity,that if detected by a gravitational wave observatory like LIGO/Virgo would prove the existence of extremal black holes.

关键词： numerical methods-Finite differencing Hyperbolic Partial differential equations Black holesblack holes WEnO

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Buffer standards for the physiological pH of the zwitterionic buffer 3-[<i>n</i>-tris(hydroxymethyl)methylamino]-2-hydroxypropanesulfonic Acid (TAPSO) From (278.15 to 328.15) K

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Journal of Biophysical Chemistry 2011年第4期2卷 414-421页

作者： Lakshmi n. Roy Rabindra n. Roy Blake m. Bodendorfer zachary m. Downs Stephen D. Rocchio Jessica m. Stegner Isaac B. Henson 不详

The second dissociation constant, pK2, and related thermodynamic quantities for TAPSO have been previously determined and reported from the temperatures (278.15 to 328.15) K. In the current study there are five buffer solutions without naCl and five buffer solutions with naCl present which yield an ionic strength (I = 0.16 mol·kg-1) similar to that of blood plasma. These buffer solutions have been evaluated in the temperature range of (278.15 to 328.15) K using the extended Debye-Hückel equation, due to the limitations of the Bates-Guggenheim convention such that it is only valid when I -1. The liquid junction potential (Ej) values between the TAPSO solution and the saturated KCl calomel electrode solution have been estimated at (298.15 and 310.15) K using a flowing junction cell measurement. The previously mentioned Ej values have been used in determining the operational pH values at (298.15 and 310.15) K. These TAPSO buffer solutions are recommended as reference solutions for pH measurements in saline media with an ionic strength of I = 0.16 mol·kg-1.

关键词： Zwitterionic Buffer pH Liquid Junction Physiological

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Impact of Chromium Propionate Supplementation and Days of Adaptation on Energy Status in newly Weaned Steer Calves^*

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Open Journal of Animal Sciences 2023年第4期13卷 409-420页

作者： zachary Kidd Foster Smith Department of Animal Science South Dakota State University Brookings USA

The objective of this research was to evaluate the influences that supplemental dietary chromium propionate (CrP;0 or 0.4 mg·kg-1 added to the total diet on a Dm basis) has on plasma indicators of energy status in newly weaned steers upon introduction to the feedlot. For this experiment single source, Angus steers (n = 28;BW = 289 ± 12.0 kg) from a ranch in Western South Dakota were weaned and immediately shipped 579 km to the Ruminant nutrition Center (RnC) in Brookings, SD. Steers were allotted to one of four 7.6 m × 7.6 m pens (2 pens/diet;7 steers/pen) at 4 d post-arrival to the RnC and test diets were initiated. no anabolic implant was used in this study. Subsequent BW measurements were obtained at 1400 h, to accommodate a post-prandial timing for blood sampling. This was 4 h after initial access to feed, and immediately prior to the afternoon feed delivery. Weights and blood sampling occurred on d 5, 12, 19, and 33. Whole blood samples were collected from all steers via jugular venipuncture and separated as plasma. There were no diet x day interactions (P ≥ 0.51) for plasma glucose, insulin, or urea-n. Plasma glucose, insulin, and urea-n levels were similar between diets (P ≥ 0.35). Plasma glucose and urea-n levels were not different across days (P ≥ 0.59). Insulin levels differed as a result of days of adaptation and were greatest (P = 0.01) on d 12 regardless of diet. There tended (P = 0.12) to be a diet x day interaction for nEFA levels. Plasma nEFA levels tended to be lower (P = 0.13) for calves fed CrP on d 5, and were greater (P = 0.09) on d 12 in calves fed CrP. The shift in nEFA on d 12 coincided with the spike in insulin levels. Both events occurred at the time that nEg intake was approaching the acclimated plateau and neither event impacted glucose status. In non-ruminants, elevated insulin concentrations decrease circulating nEFA levels. We detected minimal differences in regard to plasma indicators of lipid metabolism in this

关键词： Beef Steers Chromium Feedlot Adaptation Insulin newly Weaned

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