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Breaking the Ice

China Today 2022年第2期71卷 62-63页

作者： zachary LUNdQUIST 不详

Learning how to winter swim in Beijing not only helped Fabian Beltran,a native Columbian,enjoy greater health,but also has given him another window to learn about Chinese people.

关键词： winter Ice enjoy

Alteration in immune function in patients with fatty liver disease

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Hepatoma Research 2022年第1期8卷 363-375页

作者： Stephanie N.Gregory Shruthi R.Perati zachary J.Brown department of Surgery Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901USA division of Surgical Oncology Department of SurgeryThe Ohio State University Wexner Medical CenterColumbusOH 43210USA

Nonalcoholic fatty liver disease(NAFLd)is a disease spectrum that spans simple steatosis,fibrosis,and ultimately cirrhosis,and is a leading cause of chronic liver disease *** severe variant of NAFLd,non-alcoholic steatohepatitis(NASH),is characterized by triglyceride accumulation within hepatocytes and the subsequent inflammatory pathway activation,ultimately progressing to cirrhosis in 10%-20%of *** is a known major risk factor for the development of hepatocellular carcinoma(HCC),and there is emerging data demonstrating the impact of NASH on immune subsets and the tumor microenvironment that may influence therapeutic *** review describes the various ways in which the immune system is altered in patients with *** innate immune system in NASH shows alterations in dendritic and Kupffer cells,impaired cytotoxicity of Natural Killer cells,and an accumulation of ***,there is emerging evidence emphasizing the role of the adaptive immune system in the development and progression of NASH,seen in the alteration of B-cells,T-cells,and NKT *** to the complex interplay of the immune system in NAFLd/NASH and its progression to HCC,many current treatments focus on targeting immune cells for HCC ***,immune checkpoint inhibitors such as atezolizumab and bevacizumab have been approved as first-line therapy for unresectable *** an emerging field of research,further studies and clinical trials are needed to understand the complex interface of NASH,HCC and the immune response.

关键词： Non-alcoholic steatohepatitis nonalcoholic fatty liver disease steatohepatitis immunology hepatocellular carcinoma

Scalable and automated CRISPR-based strain engineering using droplet microfluidics

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Microsystems & Nanoengineering 2022年第2期8卷 227-236页

作者： Kosuke Iwai Maren Wehrs Megan Garber Jess Sustarich Lauren Washburn zachary Costello Peter W.Kim david Ando William R.Gaillard Nathan J.Hillson Paul d.Adams Aindrila Mukhopadhyay Hector Garcia Martin Anup K.Singh Technology division DOE Joint BioEnergy InstituteEmeryvilleCA 94608USA Biotechnology and Bioengineering department Sandia National LaboratoriesLivermoreCA 94550USA Biofuels and Bioproducts division DOE Joint BioEnergy InstituteEmeryvilleCA 94608USA Biological Systems and Engineering division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Molecular Biophysics and Integrated Bioimaging division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA department of Bioengineering University of CaliforniaBerkeleyCA 94720USA BCAM Basque Center for Applied MathematicsBilbao 48009Spain

We present a droplet-based microfluidic system that enables CRISPR-based gene editing and high-throughput screening on a *** microfluidic device contains a 10x10 element array,and each element contains sets of electrodes for two electric field-actuated operations:electrowetting for merging droplets to mix reagents and electroporation for *** device can perform up to 100 genetic modification reactions in parallel,providing a scalable platform for generating the large number of engineered strains required for the combinatorial optimization of genetic pathways and predictable *** demonstrate the system's capabilities through the CRISPR-based engineering of two test cases:(1)disruption of the function of the enzyme galactokinase(galK)in£coli and(2)targeted engineering of the glutamine synthetase gene(glnA)and the blue-pigment synthetase gene(bpsA)to improve indigoidine production in£coli.

关键词： operations generating fluid

Impact of Chromium Propionate Supplementation and days of Adaptation on Energy Status in Newly Weaned Steer Calves^*

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Open Journal of Animal Sciences 2023年第4期13卷 409-420页

作者： zachary Kidd Foster Smith department of Animal Science South Dakota State University Brookings USA

The objective of this research was to evaluate the influences that supplemental dietary chromium propionate (CrP;0 or 0.4 mg·kg-1 added to the total diet on a dM basis) has on plasma indicators of energy status in newly weaned steers upon introduction to the feedlot. For this experiment single source, Angus steers (n = 28;BW = 289 ± 12.0 kg) from a ranch in Western South dakota were weaned and immediately shipped 579 km to the Ruminant Nutrition Center (RNC) in Brookings, Sd. Steers were allotted to one of four 7.6 m × 7.6 m pens (2 pens/diet;7 steers/pen) at 4 d post-arrival to the RNC and test diets were initiated. No anabolic implant was used in this study. Subsequent BW measurements were obtained at 1400 h, to accommodate a post-prandial timing for blood sampling. This was 4 h after initial access to feed, and immediately prior to the afternoon feed delivery. Weights and blood sampling occurred on d 5, 12, 19, and 33. Whole blood samples were collected from all steers via jugular venipuncture and separated as plasma. There were no diet x day interactions (P ≥ 0.51) for plasma glucose, insulin, or urea-N. Plasma glucose, insulin, and urea-n levels were similar between diets (P ≥ 0.35). Plasma glucose and urea-n levels were not different across days (P ≥ 0.59). Insulin levels differed as a result of days of adaptation and were greatest (P = 0.01) on d 12 regardless of diet. There tended (P = 0.12) to be a diet x day interaction for NEFA levels. Plasma NEFA levels tended to be lower (P = 0.13) for calves fed CrP on d 5, and were greater (P = 0.09) on d 12 in calves fed CrP. The shift in NEFA on d 12 coincided with the spike in insulin levels. Both events occurred at the time that NEg intake was approaching the acclimated plateau and neither event impacted glucose status. In non-ruminants, elevated insulin concentrations decrease circulating NEFA levels. We detected minimal differences in regard to plasma indicators of lipid metabolism in this

关键词： Beef Steers Chromium Feedlot Adaptation Insulin Newly Weaned

Longitudinal Participatory Surveillance Highlights Association Between Mask-Wearing and Lower COVId-19 Risk-United States,2020

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China CdC weekly 2022年第52期4卷 1169-1175页

作者： Makayla Swaciak zachary Popp Autumn Gertz Kara Sewalk Marinanicole Schultheiss Benjamin Rader John S.Brownstein Computational Epidemiology Lab Boston Children’s HospitalBostonMAUSA Boston University School of Public Health Boston UniversityBostonMAUSA Harvard Medical School Harvard UniversityCambridgeMAUSA.

Summary What is already known about this topic?Numerous ecological and laboratory studies suggest face masks are an effective non-pharmaceutical intervention for reducing the spread of coronavirus disease 2019(COVId-19),but cannot otherwise assess individual-level *** is added by this report?Using a prospective cohort of individuals enrolled in a participatory,syndromic surveillance tool prior to the first case of COVId-19 in the United States,we present a novel longitudinal assessment of the effectiveness of face masks.

关键词： Lower otherwise COV

How Agent Orange impacts prostate cancer risk,pathology,and treatment outcomes

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Current Urology 2024年第2期18卷 79-86页

作者： Awais Paracha Zohair Siddiqui Ali Abid Ekamjit deol Fatima Waheed zachary Hamilton Saint Louis University School of Medicine Saint LouisMOUSA Saint Louis University Saint LouisMOUSA New York Institute of Technology College of Osteopathic Medicine OldWestburyNYUSA department of Surgery Division of UrologySaint Louis University School of MedicineSaint LouisMOUSA

Between 2.6 and 3.8 million veterans served in Vietnam while the US military dispersed Agent Orange(AO),although the exact number of exposed individuals is *** Orange,an herbicide,is a known risk factor for various cancers,including sarcoma and leukemia,but less is known about its link with prostate cancer(PC).Prostate cancer is the most commonly diagnosed malignancy in men and the fifth most common cause of cancer-related death in men *** 2023,approximately 288,300 patients will be given a diagnosis of PC,and an estimated 34,700 fatalities will occur in the United ***,whether the pathologic characteristics of PC among those exposed to AO differ from those in the general population remains *** review synthesizes the literature regarding the impact of AO exposure on PC incidence and disease course.A comprehensive PubMed literature search of articles published beginning in 1950 was performed using the primary search terms“Agent Orange,”“TCdd,”and“tetrachlorodibenzodioxin”and the secondary search terms“prostate cancer”or“prostate neoplasm.”The search was limited to studies that focused on human participants and were published in *** authors thoroughly reviewed the retrieved articles for relevancy to the study aims:discussion of PC diagnosis,prognosis,or management among patients exposed to *** 108 studies identified in our search,13 were included in this systematic *** within studies concerning AO exposure with relation to PC incidence,age at diagnosis or treatment initiation,and PC severity seemed to be mixed and generally ***,the literature seems to indicate that there are no significant differences in survivorship between exposed and unexposed veterans who are given a diagnosis of *** these heterogeneous outcomes,the evidence does not encourage a significantly different approach to the diagnosis and management of PC for veterans exposed to *** shouldmake case-by-case decision

关键词： Agent Orange 2,3,7,8-Tetrachlorodibenzo-p-dioxin Prostate cancer Veterans

THE STATE OF SUSTAINABILITY BEST PRACTICES IN CONSTRUCTION: A BENCHMARK STUdY

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Journal of Green Building 2010年第3期5卷 116-130页

作者： Annie R.Pearce Sushil Shenoy Christine M.Fiori zachary Winters department of Building Construction Virginia TechBlacksburgVA 24061 department of Civil&Environmental Engineering Virginia TechBlacksburgVA 24061 Myers-Lawson School of Construction Virginia TechBlacksburgVA 24061

during the last decade,sustainability-related technologies and practices have become increasingly common among construction companies,both in the home office and on the job *** drivers are fueling this trend,including government policies for sustainability in capital projects and increased recognition of the benefits of sustainable practices in the private ***,the extent to which sustainability-related technologies and practices have been adopted by companies in the field has not been systematically *** study used semi-structured interviews and field observations to document the sustainability-related practices of 28 construction firms in the eastern United *** purpose of the study was to benchmark current industry use of construction sustainability best *** of the study show that most firms have tried sustainability practices in the field on at least some of their projects,sometimes without being aware that those practices were related to *** variation was observed among self-reported trial and adoption rates across the practices in the *** study serves as a first step toward understanding why some sustainability innovations are being embraced more readily than others,and may lead to a better understanding of how to increase adoption of sustainability innovations.

关键词： sustainability construction best practices benchmark

Understanding perceptions of college students on the operation of automated shuttle for persons with disabilities on campus walkways

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Digital Transportation and Safety

digital Transportation and Safety 2024年第2期3卷 36-45页

作者： Sia M.Lyimo Valerian Kwigizile Boniphace Kutela zachary d.Asher Progressive Companies 18114 Mile Rd NEGrand RapidsMI 49525USA Civil and Construction Engineering Western Michigan UniversityKalamazooMI 49008USA Texas A&M Transportation Institute 701 N Post Oak Ln#430HoustonTX 77024USA Mechanical and Aerospace Engineering Western Michigan UniversityKalamazooMI 49008USA

Persons with disabilities have difficulties traveling from one point to the other due to the limited options of travel modes for the first and last *** Michigan University tested using an autonomous shuttle on the main campus's sidewalks for persons with *** study's objectives are to understand the empathy college students without disabilities had on the need for suitable transportation services for students with disabilities and the perceived risks of the services'operation on *** Bayesian ordered logit model and text mining analyzed 396 survey *** Bayesian ordered logistic regression results revealed that age,gender,and ethnicity are important factors that contribute to different opinions concerning perceived risks and sympathy brought by an autonomous shuttle operating on pedestrians'*** text mining results revealed several *** respondents who were against the operation focused on potential safety hazards and the crowdedness of the sidewalks,supporters focused on the expected improved mobility for people with *** findings from this study are expected to assist policymakers and vehicle manufacturers with pedestrian expectations and considerations related to risk and safety when sharing their walkways with the autonomous shuttle.

关键词： Autonomous shuttle University campus disabled students Sidewalk operations

Genotyping-by-sequencing of Brassica oleracea vegetables reveals unique phylogenetic patterns, population structure and domestication footprints

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Horticulture Research 2018年第1期5卷 460-469页

作者： zachary Stansell Katie Hyma Jonathan Fresnedo-Ramírez Qi Sun Sharon Mitchell Thomas Björkman Jian Hua School of Integrative Plant Science Horticulture SectionCornell UniversityGenevaNY14456USA Genomic diversity Facility Institute of BiotechnologyCornell UniversityIthacaNY14853USA Bioinformatics Facility Institute of BiotechnologyCornell UniversityIthacaNY14853USA School of Integrative Plant Science Plant Biology SectionCornell UniversityIthacaNY14853USA Syracuse University SyracuseNYUSA department of Horticulture and Crop Science The Ohio State University/OARDCWoosterOH44691USA

Brassica oleracea forms a diverse and economically significant crop *** efforts are often hindered by limited knowledge of diversity contained within available ***,we employ genotyping-by-sequencing to investigate a diverse panel of 85 landrace and improved *** broccoli,cauliflower,and Chinese kale ***,21,680 high-quality SNPs were used to reveal a complex and admixed population structure and clarify phylogenetic relationships among *** *** broccoli landrace contained,on average,8.4 times as many unique alleles as an improved broccoli and landraces collectively represented 81%of all broccoli-specific *** broccoli hybrids were largely represented by a single subpopulation identified within a complex population *** allelic diversity in landrace broccoli and 96.1%of SNPs differentiating improved cauliflower from landrace cauliflower were common to the larger pool of broccoli germplasm,supporting a parallel or later development of cauliflower due to introgression events from *** kale was readily distinguished by principal coordinate *** was accomplished with and without reliance upon a reference genome producing 141,317 and 20,815 filtered SNPs,respectively,supporting robust SNP discovery methods in neglected or unimproved crop groups that lack a reference *** work clarifies the population structure,phylogeny,and domestication footprints of landrace and improved *** broccoli using many genotyping-by-sequencing ***,a large pool of genetic diversity contained in broccoli landraces is described which may enhance future breeding efforts.

关键词： breeding structure supporting