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Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： Benjamin R.Helmold Angela Ahrens zachary Fitzgerald P.Hande Ozdinler department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and drug discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. Protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SPAST spastin

Xiamen after 20 Years of Ecological Transformation

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China Today 2025年第1期74卷 66-68页

作者： zachary G.LUNdQUIST 不详

The efforts Xiamen has made in ecological protection over the last 20 years have helped it become a beautiful and clean *** years ago,I had the opportunity to travel to the city of Xiamen in southeastern China’s Fujian ***,due to the fact that I was in a rush,I did not have the chance to see the whole *** memory of Xiamen was its pleasant climate and unforgettable beauty-I knew if I ever got the opportunity,I would revisit this *** years went by until I was able to return to this city *** emerging from the airport,I realized that I had grown older,while Xiamen was becoming increasingly youthful and *** exactly had given this city such vitality?

关键词： Ecological Xiamen Transformation

Utilizing multiphoton imaging and integrative clearing to reveal sex differences in neuroimmune interactions after nerve injury

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Neural Regeneration Research 2022年第11期17卷 2429-2430页

作者： zachary W.Castillo Michael d.Burton Neuroimmunology and Behavior Laboratory Department of NeuroscienceSchool of Behavioral and Brain SciencesCenter for Advanced Pain StudiesUniversity of Texas at Dallas

With the constant development of multiphoton microscopy,our ability to observe complex and dynamic biological processes deeper within living tissue,is steadily *** use multiphoton microscopy,because experiments can be conducted with little to no invasiveness or tissue damage over a long period of time with no photodamage(Mancuso et al.,2009).This allows for the introduction of tissue into the context of a three-dimensional 3d environment in which visualization of cellular activation and interaction is *** circumventing a distorted reconstruction with limited z-stacks,multiphoton imaging provides enhanced spatiotemporal resolution.

关键词： resolution. multiphoton distorted

What strategies are implied by STRATEGY?

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Science China(Life Sciences) 2017年第3期60卷 319-320页

作者： zachary Bloomgarden department of Medicine Icahn School of Medicine at Mount SinaiNew York NY 10029USA

Weng and coauthors enrolled 5,535 type 2 diabetic patients in a study of the combined effect of metformin with sitagliptin,nearly half achieving HbAlc〈7.0%,with an average 0.85%fall from a baseline of 8.03%.This supp... 详细信息

关键词：隐含二甲双胍 2型糖尿病联合效应抑制剂

A Multi-Point distance-Bounding Protocol for Securing Automatic dependent Surveillance-Broadcast in Unmanned Aerial Vehicle Applications

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Journal of Computer Science & Technology 2020年第4期35卷 825-842页

作者： zachary P.Languell Qijun Gu department of Computer Science Texas State UniversitySan MarcosTX 78666USA

The Automatic dependent Surveillance-Broadcast(AdS-B)protocol is being adopted for use in unmanned aerial vehicles(UAVs)as the primary source of information for emerging multi-UAV collision avoidance *** lack of security features in AdS-B leaves any processes dependent upon the information vulnerable to a variety of threats from compromised and dishonest *** could result in substantial losses or damage to *** research proposes a new distance-bounding scheme for verifying the distance and flight trajectory in the AdS-B broadcast data from surrounding *** proposed scheme enables UAVs or ground stations to identify fraudulent UAVs and avoid *** scheme was implemented and tested in the ArduPilot SITL(Software In The Loop)simulator to verify its ability to detect fraudulent *** experiments showed that the scheme achieved the desired accuracy in both flight trajectory measurement and attack detection.

关键词： automatic dependent surveillance-broadcast (AdS-B) unmanned aerial vehicle (UAV) distance bounding collision airspace safety

Transcription factors promote neural regeneration after spinal cord injury

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Neural Regeneration Research 2022年第11期17卷 2439-2440页

作者： zachary Finkel Li Cai department of Biomedical Engineering Rutgers University

Human spinal cord injury (SCI) results in locomotor and sensory disabilities,which severely affect the quality of *** restore function after SCI,it is necessary to repair and reconstruct the damaged local *** hurdles in neural regeneration include a limited level of neurogenesis in the adult spinal cord and an inflammatory microenvironment that inhibits neurogenesis and axon regeneration.

关键词： neural injury SCI

First integrals of the axisymmetric shape equation of lipid membranes

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Chinese Physics B 2018年第3期27卷 551-559页

作者： Yi-Heng Zhang zachary Mcdargh Zhan-Chun Tu department of Physics Beijing Normal UniversityBeijing 100875China department of Physics Carnegie Mellon University5000 Forbes AvenuePittsburgh PA 15213USA

The shape equation of lipid membranes is a fourth-order partial differential *** the axisymmetric condi-tion,this equation was transformed into a second-order ordinary differential equation(OdE)by Zheng and Liu(***.E 482856(1993)).Here we try to further reduce this second-order OdE to a first-order ***,we invert the usual process of variational calculus,that is,we construct a Lagrangian for which the OdE is the corresponding Euler-Lagrange ***,we seek symmetries of this Lagrangian according to the Noether *** a certain restriction on Lie groups of the shape equation,we find that the first integral only exists when the shape equation is identical to the Will-more equation,in which case the symmetry leading to the first integral is scale *** also obtain the mechanical interpretation of the first integral by using the membrane stress tensor.

关键词： lipid membrane shape equation first integral Noether theorem

Impact of hydrolysis on surface area and energy storage applications of activated carbons produced from corn fiber and soy hulls

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Carbon Resources Conversion 2020年第1期3卷 19-28页

作者： zachary d.Herde Ruchira dharmasena Gamini Sumanasekera Jaya Shankar Tumuluru Jagannadh Satyavolu Conn Center for Renewable Energy Research University of LouisvilleLouisvilleKYUSA Energy Systems Laboratory Idaho National LaboratoryIdaho FallsIDUSA School of Chemical and Biomolecular Eng Georgia Institute of TechnologyUnited States

Complete utilization of lignocellulosic biomass through the creation of value-added coproducts is one of the key strategies of the Bioenergy Technologies Office(BETO)for the cost-effective production of biofuels and biochemicals.A green approach to producing lightweight and high specific surface area(SSA)activated carbons(ACs)from sustainable biomass sources is of great interest to producers and users of energy devices such as batteries and *** direct conversion from biomass has been studied extensively,AC with relatively high surface areas can be produced more cost-effectively when leveraged as a co-product from a *** this paper,we discuss the production of high specific surface area activated carbons from residual fiber(fiber remaining after extraction of C5-sugars)generated as part of a C5 *** surface,morphological characteristics using SEM and TEM,and energy storage behavior of ACs produced using the C5 extracted residual fiber were evaluated in the present *** ACs produced from the residual fiber delivered an order of magnitude higher surface area than the one directly from corn pericarp fiber and soy *** surface area of the ACs produced from pre-hydrolysis ddG was only 10 m^(2)/g compared to 689 m^(2)/g for soy hulls whereas after hydrolysis these values increased significantly(ddG:1700 m^(2)/g and soy hulls:1300 m^(2)/g).TEM images indicated high exfoliation,explaining the change in surface area *** the same current density(500 mA/g)the cycling performance of the ACs increased as the surface area increased significantly.

关键词： Agricultural residues Hydrolysis Activated carbon Surface area characterization Surface morphology

From landrace to modern hybrid broccoli:the genomic and morphological domestication syndrome within a diverse *** collection

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Horticulture Research 2020年第1期7卷 574-590页

作者： zachary Stansell Thomas Björkman Cornell University School of Integrative Plant ScienceCornell UniversityIthacaNY 14850USA Cornell AgriTech Cornell UniversityGenevaNY 14456USA

Worldwide,broccoli(Brassica oleracea ***)is among the most economically important,nutritionally rich,and widely-grown vegetable *** explore the genomic basis of the dramatic changes in broccoli morphology in the last century,we evaluated 109 broccoli or broccoli/cauliflower intermediates for 24 horticultural ***-bysequencing markers were used to determine four subpopulations within italica:Calabrese broccoli landraces and hybrids,sprouting broccoli,and violet cauliflower,and to evaluate between and within group relatedness and *** overall horticultural quality and harvest index of improved hybrid broccoli germplasm has increased by year of cultivar release,this improvement has been accompanied by a considerable reduction in allelic diversity when compared to the larger pool of *** landraces are the most likely founding source of modern broccoli hybrids,and within these modern hybrids,we identified 13 reduction-in-diversity genomic regions,53 selective sweeps,and 30(>1 Mbp)runs of *** accessions collected in southern Italy contained 4.8-fold greater unique alleles per accessions compared to modern hybrids and provide a valuable resource in subsequent improvement *** work broadens the understanding of broccoli germplasm,informs conservation efforts,and enables breeding for complex quality traits and regionally adapted cultivars.

关键词： cultivar germplasm breeding