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Mitoquinone attenuates blood-brain barrier disruption through Nrf2/PHB2/OPA1 pathway after subarachnoid hemorrhage in rats

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Mitoquinone attenuates blood-brain barrier disruption throug...

第十四届中国医师协会神经外科医师年会

作者： Tongyu Zhang Pei Wu Keren Zhou Lingyun Wu Zhiyi Xie Weilin Xu Xu Luo Peng Li Umut Ocak Pinar Eser Ocak zachary d.Travis Jiping Tang Huaizhang Shi John H.Zhang department of Neurosurgery The First Affiliated Hospital of Harbin Medical University department of Physiology and Pharmacology Loma Linda University department of Earth and Biological Sciences Loma Linda University

Background and Purpose— Mitochondrial dysfunction is involved in the mechanism of early brain injury（EBI） following subarachnoid hemorrhage（SAH）. Blood-brain barrier disruption is a devastating outcome in the early stage of SAH. In this study, we aimed to investigate the role of a mitochondria-related drug Mitoquinone（MitoQ） in blood-brain barrier disruption after SAH in rats. Methods— A total of 181 male Sprague–dawley SAH rats with the endovascular perforation model were utilized. Intraperitoneal MitoQ was given 1 hour（h） post-SAH. Cerebroventricular ML385, an inhibitor of NF-E2-related factor 2（Nrf2） and Small interfering ribonucleic acid（siRNA） for Prohibitin 2（PHB2） were injected respectively 24 h and 48 h before SAH. Neurological function evaluation was performed before sacrifice. SAH grade was measured during the sacrifice of each animal. Brain water content was performed at 24 h. Coimmunoprecipitation was used to demonstrate the relationship of proteins Nrf2 and PHB2. Mitochondrial and cytoplasmic fractions were gathered using mitochondria isolation kits. Pathway related proteins were investigated with Western blot and immunofluorescence staining. Transmission electron microscopy was performed for mitochondrial morphology. Results— Expression of Nrf2 levels peaked at the 3 h time point following SAH and then decreased to normal levels at 24 h, while PHB2 and Optic Atrophy 1（OPA1） decreased at 24 h and 72 h after SAH compared with the Sham group. MitoQ treatment attenuated neurological deficits and brain edema, thereby resulting in a decreased expression of Albumin, while an increase of Nrf2, PHB2, OPA1 and Claudin-5 proteins compared with SAH+vehicle group. With co-immunoprecipitation, Nrf2 and PHB2 were further demonstrated to show their interaction. And MitoQ administration lead to more binding of the two proteins. ML385 abolished the effects of MitoQ on neurobehavior and protein levels post-SAH. Similarly, PHB2 siRNA reversed the neuroprotection of MitoQ

关键词： Mitoquinone NF-E2-related factor 2 Prohibitin 2 Optic Atrophy 1 Blood-brain barrier disruption Subarachnoid hemorrhage

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抽象平等主义与男人是受害者：男性权利组织对框架的战略选择

作者： (英)克里斯托弗·胡德(Christopher hood)[等]

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国际社会科学杂志（中文版） 2019年第4期36卷 89-102,7,11,12页

作者：扎卡里·d.帕尔默曼格拉·苏布莱曼尼亚姆赵元元美国普渡大学

世界各地的妇女运动挑战了教育、就业和生育权利方面的性别不平等,在全球范围内组织运动并形成了跨国关系纽带(Basu 2000;Ferree and Subramaniam 2001;Keck and Sikkink 1998;Moghadam 2005;等等)。在过去几十年里,这使得全球妇女的社... 详细信息

世界各地的妇女运动挑战了教育、就业和生育权利方面的性别不平等,在全球范围内组织运动并形成了跨国关系纽带(Basu 2000;Ferree and Subramaniam 2001;Keck and Sikkink 1998;Moghadam 2005;等等)。在过去几十年里,这使得全球妇女的社会、政治和经济地位有所提高。然而,由于世界各地的妇女运动对国际机构和各国政府施加压力,要求它们解决性别不平等问题,因此,也出现了以男性权利运动形式发生的后退。

关键词：平等主义妇女运动男性权利性别不平等全球范围生育权利受害者政治和经济

Comparison of Phosphorus Sorption by Light-Weight Aggregates Produced in the United States

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Pedosphere 2014年第6期24卷 808-816页

作者： M.d.BAKER S.SIMKINS L.A.SPOKAS P.L.M.VENEMAN B.S.XING Stockbridge School of Agriculture University of MassachusettsAmherstMA 01003 (USA) U.S.Army Fort HoodTX 76544 (USA)

In this study, phosphorus(P) sorption of thirteen light-weight aggregates(LWAs) from USA was compared during batch equilibrium experiments in order to identify those materials which had the highest P sorption capacity for further study. Seven different levels of sorption activity were observed, which were broadly grouped into three categories—high performing, middle performing, and low performing aggregates. Chemical analysis of Ca, Al, Fe, and Mg was used to describe the differences between LWAs. There was a significant correlation between cation(especially Al, Ca, Fe, and Mg) content and P sorbed. Langmuir isotherms were used to describe P sorption maximum and binding affinity for four of the top five performing LWAs, Universal, Stalite "d", Stalite "Mix", and *** fifth aggregate, Lehigh, exhibited more complex sorption, and was better described by the Freundlich isotherm. Universal had a mean P sorption at the highest concentration of 824 mg kg-1, well above its calculated sorption maximum(702 mg kg-1), and also had the highest binding affinity(1.1 L mg-1). This experiment suggests that the top performing LWA(Universal) may perform poorly in column and field studies due to observed precipitates, which could degrade constructed wetland performance. Other LWAs may exhibit superior field performance due to their high calculated sorption maxima. In general, these results highlight the importance of batch experiments as a first step in identifying materials suitable for column and field experiments.

关键词： binding affinity constructed wetlands equilibrium P concentration media P sorption capacity

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阿尔茨海默病的临床表现、病程、治疗和管理

中国心理卫生杂志 1999年第5期13卷 272-275页

作者： BarryReisberg M.d. zachary and Elizabeth M.Fisher Alzheimer's disease Education and Resources Program at the New York University Medical Center

阿尔茨海默病(Alzheimer's disease,Ad)是导致智力衰退这类疾病的主要原因.经典研究表明:阿尔茨海默病大约占所有痴呆病例的四分之三.最近20年来对阿尔茨海默病的临床演变过程有了极其深入的了解.现在,无论是专业人员还是外行人士都能... 详细信息

阿尔茨海默病(Alzheimer's disease,Ad)是导致智力衰退这类疾病的主要原因.经典研究表明:阿尔茨海默病大约占所有痴呆病例的四分之三.最近20年来对阿尔茨海默病的临床演变过程有了极其深入的了解.现在,无论是专业人员还是外行人士都能应用通俗的术语对这一演变过程做详细地叙述.更进一步的是,基于目前掌握的(阿尔茨海默病)的知识,阿尔茨海默病患者还有可能获得适当的治疗.以后随着临床知识的不断积累,对于这种在人生晚年普遍发生的严重疾病的治疗也必将不断得到改善.

关键词：老年性痴呆临床表现病程治疗管理

The joint automated repository for various integrated simulations (JARVIS) for data-driven materials design

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npj Computational Materials 2020年第1期6卷 234-246页

作者： Kamal Choudhary Kevin F.Garrity Andrew C.E.Reid Brian deCost Adam J.Biacchi Angela R.Hight Walker zachary Trautt Jason Hattrick-Simpers A.Gilad Kusne Andrea Centrone Albert davydov Jie Jiang Ruth Pachter Gowoon Cheon Evan Reed Ankit Agrawal Xiaofeng Qian Vinit Sharma Houlong Zhuang Sergei V.Kalinin Bobby G.Sumpter Ghanshyam Pilania Pinar Acar Subhasish Mandal Kristjan Haule david Vanderbilt Karin Rabe Francesca Tavazza Materials Measurement Laboratory National Institute of Standards and TechnologyGaithersburgMD 20899USA Theiss Research La JollaCA 92037USA department of Chemistry and Biochemistry University of MarylandCollege ParkMD 20742USA Physical Measurement Laboratory National Institute of Standards and TechnologyGaithersburgMD 20899USA Materials and Manufacturing directorate Air Force Research LaboratoryWright–Patterson Air Force BaseDaytonOH 45433USA department of Materials Science and Engineering Stanford UniversityStanfordCA 94305USA department of Electrical and Computer Engineering Northwestern UniversityEvanstonIL 60208USA department of Materials Science and Engineering Texas A&M UniversityTexasTX 77843USA Joint Institute for Computational Sciences University of TennesseeKnoxvilleTN 37996USA National Institute for Computational Sciences Oak Ridge National LaboratoryOak RidgeTN 37831USA School for Engineering of Matter Transport and Energy Arizona State UniversityTempeAZ 85287USA Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTN 37831USA Materials Science and Technology division Los Alamos National LabLos AlamosNM 87545USA department of Mechanical Engineering Virginia TechBlacksburgVA 24061USA department of Physics and Astronomy Rutgers UniversityPiscatawayNJ 08901USA

The Joint Automated Repository for Various Integrated Simulations(JARVIS)is an integrated infrastructure to accelerate materials discovery and design using density functional theory(dFT),classical force-fields(FF),and machine learning(ML)*** is motivated by the Materials Genome Initiative(MGI)principles of developing open-access databases and tools to reduce the cost and development time of materials discovery,optimization,and deployment.

关键词： automated JAR databases

维普期刊数据库评论

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戛纳评审看移动创新技术应用

成功营销 2015年第9期 65-65页

作者： Andy hood AKQA

重要的不是技术,而是技术的应用如何超出想象、带来哪些实际的意义。Google Cardboard是谷歌推出的一款3d眼镜,它包括了纸板、双凸透镜、磁石、魔力贴、橡皮筋和NFC贴等部件,把这些部件组装在一起,就能变成一部3d眼镜,用户在智能手机上... 详细信息

重要的不是技术,而是技术的应用如何超出想象、带来哪些实际的意义。Google Cardboard是谷歌推出的一款3d眼镜,它包括了纸板、双凸透镜、磁石、魔力贴、橡皮筋和NFC贴等部件,把这些部件组装在一起,就能变成一部3d眼镜,用户在智能手机上下载一个Cardboard应用,然后把手机放到盒子里,就能组成一个简易的虚拟现实设备。

关键词：部件组装双凸透镜虚拟现实谷歌戛纳 Backup 伊利诺伊州潜在需求分享机制替代方案

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公平司法系统需要开放数据访问

数据分析与知识发现 2020年第7期4卷 117-117页

作者：本刊讯 Adam R.Pah david L.Schwartz SarathSanga zachary d.Clopton Peter dicola Rachel davis Mersey Charlotte S.Alexander Kristian J.Hammond Luís A.NunesAmara 不详

尽管美国法院文件可在网上公开获得,但它们位于难以导航的数据库中,且需要支付昂贵的费用。美国西北大学的研究团队认为,这些障碍对建立公正和平等的司法系统所需的透明度造成了阻碍。如果能够公开并提供所有法院记录,那研究人员便能够... 详细信息

尽管美国法院文件可在网上公开获得,但它们位于难以导航的数据库中,且需要支付昂贵的费用。美国西北大学的研究团队认为,这些障碍对建立公正和平等的司法系统所需的透明度造成了阻碍。如果能够公开并提供所有法院记录,那研究人员便能够系统地研究和评估美国司法系统,为相关政策的制定提供有价值的信息。研究人员正在开发一个由人工智能驱动的名为SCALES-OKN(诉讼事件的系统内容分析开放知识网络)的平台,无论用户的数据和分析技能如何,都可以为用户提供隐藏在联邦法院记录中的信息和见解。

关键词：司法系统联邦法院美国法院网上公开人工智能分析技能美国西北大学研究团队

Genomic and transcriptomic analysis unveils population evolution and development of pesticide resistance in fall armyworm Spodoptera frugiperda

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Protein & Cell 2022年第7期13卷 513-531页

作者： Furong Gui Tianming Lan Yue Zhao Wei Guo Yang dong dongming Fang Huan Liu Haimeng Li Hongli Wang Ruoshi Hao Xiaofang Cheng Yahong Li Pengcheng Yang Sunil Kumar Sahu Yaping Chen Le Cheng Shuqi He Ping Liu Guangyi Fan Haorong Lu Guohai Hu Wei dong Bin Chen Yuan Jiang Yongwei Zhang Hanhong Xu Fei Lin Bernard Slippers Alisa Postma Matthew Jackson Birhan Addisie Abate Kassahun Tesfaye Aschalew Lemma demie Meseret destaw Bayeleygne dawit Tesfaye degefu Feng Chen Paul K.Kuria zachary M.Kinyua Tong-Xian Liu Huanming Yang Fangneng Huang Xin Liu Jun Sheng Le Kang State Key Laboratory for Conservation and Utilization of Bioresources in Yunnan Yunnan Agricultural UniversityKunming 650201China State Key Laboratory of Agricultural Genomics BGI-ShenzhenShenzhen 518083China State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institutes of Life Science Chinese Academy of SciencesBeijing 100101China MGI BGI-ShenzhenShenzhen 518083China BGI-Qingdao BGI-ShenzhenQingdao 266555China BGI-Yunnan No.389 Haiyuan RoadHigh-tech Development ZoneKunming 650106China China National GeneBank Jinsha RoadDapeng New DistrictShenzhen 518120China department of Biology University of Copenhagen2100 CopenhagenDenmark Guangdong Provincial Key Laboratory of Genome Read and Write BGI-ShenzhenShenzhen 518120China Guangdong Provincial Academician Workstation of BGI Synthetic Genomics BGI-ShenzhenShenzhen 518120China Yunnan Plateau Characteristic Agriculture Industry Research Institute Kunming 650201China College of Plant Health and Medicine Qingdao Agricultural UniversityQingdao 266109China department of Entomology Louisiana State University Agricultural CenterBaton RougeLA 70803USA CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100101China Yunnan Plant Protection and Quarantine Station Kunming 650034China State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources South China Agricultural UniversityGuangzhou 510642China BGI-Americas One Broadway14th FloorCambridgeMA 02142USA departme nt of Biochemistry Gen etics and MicrobiologyForestry and Agricultural Biotech no logy InstituteUn iversity of PretoriaPretoriaSouth Africa Ethiopian Biotechnology Institute Addis AbabaEthiopia College of Natural Science Addis Ababa UniversityAddis AbabaEthiopia Melkassa Agricultural Research Center Ethiopian Institute of Agricultural ResearchMelkassaAddis AbabaEthiopia Kenya Agricultural and Livestock Res

The fall armyworm(FAW),Spodoptera frugiperda,is a destructive pest native to America and has recently become an invasive insect pest in *** of its rapid spread and great risks in China,understanding of FAW genetic background and pesticide resistance is urgent and essential to develop effective management ***,we assembled a chromosome-level genome of a male FAW(SFynMstLFR)and compared re-sequencing results of the populations from America,Africa,and *** identification of 163 individuals collected from America,Africa and China showed that both C and R strains were found in the American pop-ulations,while only C strain was found in the Chinese and African ***,population geno-mics analysis showed that populations from Africa and China have close relationship with significantly genetic differentiation from American *** toge-ther,FAWs invaded into China were most likely origi-nated from *** genomics analysis displayed that the cytochrome p450 gene family is extremely expanded to 425 members in FAW,of which 283 genes are specific to *** of Chinese populations with twenty-three pesticides showed the variant patterns of transcriptome profiles,and several detoxification genes such as AOX,UGT and GST spe-cially responded to the *** findings will be useful in developing effective strategies for manage-ment of FAW in China and other invaded areas.

关键词： Spodoptera frugiperda chromosome-level genome population differentiation cytochrome p450 pesticides