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Conservative management of spinal pathology with autologous conditioned serum: A systematic review of the literature

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World Journal of Orthopedics 2024年第9期15卷 870-881页

作者： Christian J Rajkovic Matthew L Merckling Alyssa W Lee Galadu Subah Aryan Malhotra zachary d Thomas Sabrina L Zeller John V Wainwright Merritt d Kinon department of Neurosurgery Westchester Medical CenterValhallaNY 10595United States

BACKGROUNd Chronic inflammatory pain is associated with increased expression of interleukin(IL)-1,an inflammatory cytokine,and activity on its receptor(IL-1R).In response,the body produces IL-1R antagonist(IL-1Ra)to reduce this *** conditioned serum(ACS)is the only biologic therapy for spinal pathologies that enhances the action of endogenous IL-1Ra reserves to improve *** systematic review investigates the effectiveness of ACS in treating pain and dis-ability caused by spinal *** To evaluate the use of ACS as a conservative management option for spinal *** A systematic review of PubMed/Medline was performed to identify studies inve-stigating administration of ACS for treatment of any spinal *** Six articles were included,comprising 684 patients treated with epidural(n=133)or transforaminal(n=551)ACS *** had an average age of 54.0 years with slight female predominance(53.2%).The lumbar spine was most com-monly treated,with 567 patients(82.9%)receiving injections for lumbar radicu-lopathy(n=67),degenerative disc disease(ddd)(n=372),or spinal stenosis(n=128);cervical injections were performed in 109 patients(15.9%).Mean(Sd)follow-up was 21.7(4.8)weeks from first ACS *** studies investigating mecha-nical lumbar and lumbar or cervical radicular pain reported significant pain re-duction at final follow-up compared to *** achieved comparable or su-perior results to lumbar epidural steroid *** events were reported in 21 patients(3.1%),with no serious adverse *** ACS injection is a safe and effective intervention for pain reduction in many spinal pathologies,including cervical and lumbar radiculopathies.

关键词： Spine Autologous conditioned serum Orthokine Regenokine Epidural steroid injection Interleukin-1 Inter-leukin-1 receptor antagonist

A gap-free genome assembly of Chlamydomonas reinhardtii anddetection of translocations induced by CRISPR-mediated mutagenesis

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Plant Communications 2023年第2期4卷 249-271页

作者： zachary L.Payne Gervette M.Penny Tychele N.Turner Susan K.dutcher department of Genetics Washington University School of MedicineSaint LouisMO 63110USA

Genomic assemblies of the unicellular green alga Chlamydomonas reinhardtii have provided important resources for ***,assembly errors,large gaps,and unplaced scaffolds as well as strain-specific variants currently impede many types of *** combining PacBio HiFi and Oxford Nanopore long-read technologies,we generated a de novo genome assembly for strain CC-5816,derived from crosses of strains CC-125 and *** methods of evaluating genome completeness and base-pair error rate suggest that the final telomere-to-telomere assembly is highly *** CC-5816 assembly enabled previously difficult analyses that include characterization of the 17 centromeres,rdNA arrays on three chromosomes,and 56 insertions of organellar dNA into the nuclear *** Nanopore sequencing,we identified sites of cytosine(CpG)methylation,which are enriched at *** analyzed CRISPR-Cas9 insertional mutants in the PF23 *** of the three alleles produced progeny that displayed patterns of meiotic inviability that suggested the presence of a chromosomal *** Nanopore reads from pf23-2 and pf23-3 onto the CC-5816 genome showed that these two strains each carry a translocation that was initiated at the PF23 gene locus on chromosome 11 and joined with chromosomes 5 or 3,*** translocations were verified by demonstrating linkage between loci on the two translocated chromosomes in meiotic *** three pf23 alleles display the expected short-cilia phenotype,and immunoblotting showed that pf23-2 lacks the PF23 *** CC-5816 genome assembly will undoubtedly provide an important tool for the Chlamydomonas research community.

关键词： alga reference genome de novo PacBio Nanopore structural variation

Regional and National Trends of Adult Living donor Liver Transplantation in the United States Over the Last Two decades

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Journal of Clinical and Translational Hepatology 2022年第5期10卷 814-824页

作者： Saleh A.Alqahtani Ahmet Gurakar Hani Tamim Thomas d.Schiano Alan Bonder zachary Fricker Marwan Kazimi devin E.Eckhoff Michael P.Curry Behnam Saberi Johns Hopkins University Division of Gastroenterology and HepatologyBaltimoreMDUSA American University of Beirut Department of Internal MedicineBeirutLebanon Icahn School of Medicine at Mount Sinai Division of Liver DiseasesNew YorkNYUSA Beth Israel deaconess Medical Center Harvard Medical SchoolBostonMAUSA

Background and Aims:Liver organ shortage remains a major health burden in the US,with more patients being waitlisted than the number of liver transplants(LTs)*** study investigated US national and regional trends in living donor LT(LdLT)and identified factors associated with recipient ***:We retrospectively analyzed LdLT recipients and donors from the United Network Organ Sharing/Organ Procurement Transplant Network database from 1998 until 2019 for clinical characteristics,demographic differences,and survival *** and regional trends in LdLT,recipient outcomes,and predictors of survival were ***:Of the 223,571 candidates listed for an LT,57.5%received an organ,of which only 4.2%were *** adult LdLTs first peaked at 412 in 2001 but experienced a significant decline to 168 by *** then gradually increased to 445 in *** 2 had the highest LdLT numbers(n=919),while region 1 had the highest proportion(11.1%).Overall,post-LT mortality was 21.4%among LdLT ***-LdLT survival rates after 1-,5-,and 10-years were 92%,87%,and 70%,*** analysis(2004–2019)showed that patients undergoing LdLT in recent years had lower mortality than in earlier years(hazard ratio=0.81,95%confidence interval=0.75–0.88).Conclusions:Following a substantial decline after a peak in 2001,the number of adult LdLTs steadily increased from 2011 to ***,LdLTs still constitute the minority of the transplant pool in the *** policies to increase the use of LdLTs,particularly in regions of high organ demand,should be implemented.

关键词： Living donor Liver transplantation Survival UNOS Organ demand

Utility of d-dimer in total joint arthroplasty

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World Journal of Orthopedics 2023年第3期14卷 90-102页

作者： Brenden Cutter zachary C Lum Mauro Giordani John P Meehan department of Orthopedic Surgery Valley Orthopedic Surgery Residency/Valley Consortium for Medical EducationModestoCA 95351United States department of Orthopaedics Adult Reconstruction DivisionUniversity of CaliforniaDavis Medical CenterSacramentoCA 95817United States

As the number of patients receiving total joint replacements continues to rise,considerable attention has been directed towards the early detection and prevention of postoperative *** d-dimer has long been studied as a diagnostic tool in venous thromboembolism(VTE),this assay has recently received considerable attention in the diagnosis of periprosthetic joint infection(PJI).d-dimer values are substantially elevated in the acute postoperative period after total joint arthroplasty,with levels often exceeding the standard institutional cutoff for VTE(500µg/L).The utility of d-dimer in detecting VTE after total joint replacement is currently limited,and more research to assess its value in the setting of contemporary prophylaxis protocols is *** literature supports d-dimer as a good to excellent biomarker for the diagnosis of chronic PJI,especially when using serum sample *** should exercise caution when interpreting d-dimer levels in patients with inflammatory and hypercoagulability disorders,as the diagnostic value is *** updated 2018 Musculoskeletal Infection Society criteria,which includes d-dimer levels>860µg/L as a minor criterion,may be the most accurate for diagnosing chronic PJI to *** prospective trials with transparent lab testing protocols are needed to establish best assay practices and optimal cutoff values for d-dimer in the diagnosis of *** review summarizes the most current literature on the value of d-dimer in total joint arthroplasty and elucidates areas for future progress.

关键词： d-dimer diagnosis Periprosthetic joint infection Venous thromboembolism deep vein thrombosis Arthroplasty

Why total knees fail-A modern perspective review

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World Journal of Orthopedics 2018年第4期9卷 60-64页

作者： zachary C Lum Alvin K Shieh Lawrence d dorr department of Orthopaedic Surgery Davis Medical Center University of California department of Orthopaedic Surgery Keck Medical Center of University of Southern California

Historically, the most common mechanism of total kneearthroplasty(TKA) failures included aseptic loosening, instability and malalignment. As polyethylene production improved, modes of failure from polyethylene wear and subsequent osteolysis became less prevalent. Newer longitudinal studies report that infection has become the primary acute cause of failure with loosening and instability remaining as the overall greatest reasons for revision. Clinical database and worldwide national registries confirm these reports. With an increasing amount of TKA operations performed in the United States, and with focus on value-based healthcare, it is imperative to understand why total knees fail.

关键词： Total knee arthroplasty failure mechanism Total knee arthroplasty failure mode Revision total knee arthroplasty Periprosthetic joint infection Aseptic loosening total knee Total knee arthroplasty instability

Leg Extension Strength, Explosive Strength, Muscle Activation, and Growth as Predictors of Vertical Jump Performance in Youth Athletes

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Journal of Science in Sport and Exercise 2020年第4期2卷 336-348页

作者： zachary M.Gillen Marni E.Shoemaker Brianna d.McKay Nicholas A.Bohannon Sydney M.Gibson Joel T.Cramer department of Nutrition and Health Sciences University of Nebraska-Lincoln211 Ruth Leverton HallLincolnNE 68583USA

Purpose The purpose of this study was to examine the relationships among leg extension strength,explosive strength,muscle activation,and measurements of growth to predictions of vertical jump performance in youth *** Height,body mass,skinfolds,and quadriceps femoris muscle cross-sectional area were measured in 39 sports active children(20 females,19 males,age=12.52±0.62 years old).Peak torque(PT),rate of torque development(RTd),rate of velocity development(RVd),and rate of electromyographic amplitude rise(RER)were measured during isometric and isokinetic leg ***,RTd,and RVd were expressed in absolute terms and normalized to body *** jump height(JH)and peak power(PP)were assessed during static(SJ),counter-movement(CMJ),and drop(dJ)*** JH exhibited greater correlations with PT normalized to body mass(r=0.387-0.758)than absolute PT(r=0.338-0.417),whereas PP exhibited greater correlations with absolute PT(r=0.368-0.837).Only negligible to moderate relation-ships existed between JH and PP across all jumps(r=0.053-0.605).Over 50%of the variability in PP was predicted in 24 of 30 regression models with absolute muscle strength,muscle activation,and measurements of growth,while only 6 of 30 models predicted more than 50%of the variability in *** Overall,absolute static and dynamic muscle strength,muscle activation,and growth better explained PP meas-ured during vertical jumps than estimated JH.

关键词： Children Adolescent Torque Jump height Power

Scavenger Receptor Class B type 1(SR-B1)and the modifiable risk factors of stroke

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Chinese Neurosurgical Journal 2020年第1期6卷 35-44页

作者： Lenahan Cameron Huang Lei Travis zachary d. Zhang John H. Burrell College of Osteopathic Medicine Las CrucesNM 88003USA Center for Neuroscience Research School of MedicineLoma Linda UniversityLoma LindaCA 92324USA department of Neurosurgery School of MedicineLoma Linda UniversityLoma LindaCA 92350USA department of Physiology&Pharmacology School of MedicineLoma Linda UniversityLoma LindaCA 92350USA department of Earth and Biological Sciences School of MedicineLoma Linda UniversityLoma LindaCA 92350USA department of Anesthesiology School of MedicineLoma Linda UniversityLoma LindaCA 92324USA

Stroke is a devastating disease that occurs when a blood vessel in the brain is either blocked or ruptured,consequently leading to deficits in neurological *** consistently ranked as one of the top causes of mortality,and with the mean age of incidence decreasing,there is renewed interest to seek novel therapeutic *** Scavenger Receptor Class B type 1(SR-B1)is a multifunctional protein found on the surface of a variety of *** has found that that SR-B1 primarily functions in an anti-inflammatory and antiatherosclerotic *** this review,we discuss the characteristics of SR-B1 and focus on its potential correlation with the modifiable risk factors of ***-B1 likely has an impact on stroke through its interaction with smoking,diabetes mellitus,diet,physical inactivity,obesity,hypercholesterolemia,atherosclerosis,coronary heart disease,hypertension,and sickle cell disease,all of which are critical risk factors in the pathogenesis of stroke.

关键词： Scavenger Receptor Class B type 1 SR-B1 Atherosclerosis Coronary heart disease diabetes mellitus Sickle cell Obesity Physical inactivity Hypercholesterolemia Hypertension

Anneal-free ultra-low loss silicon nitride integrated photonics

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Light(Science & Applications) 2024年第8期13卷 1565-1577页

作者： debapam Bose Mark W.Harrington Andrei Isichenko Kaikai Liu Jiawei Wang Nitesh Chauhan zachary L.Newman daniel J.Blumenthal department of Electrical and Computer Engineering University of California Santa BarbaraSanta BarbaraCA 93106USA Octave Photonics LouisvilleCO 80027USA

Heterogeneous and monolithic integration of the versatile low-loss silicon nitride platform with low-temperature materials such as silicon electronics and photonics,III–V compound semiconductors,lithium niobate,organics,and glasses has been inhibited by the need for high-temperature annealing as well as the need for different process flows for thin and thick *** techniques are needed to maintain the state-of-the-art losses,nonlinear properties,and CMOS-compatible processes while enabling this next generation of 3d silicon nitride *** report a significant advance in silicon nitride integrated photonics,demonstrating the lowest losses to date for an anneal-free process at a maximum temperature 250℃,with the same deuterated silane based fabrication flow,for nitride and oxide,for an order of magnitude range in nitride thickness without requiring stress mitigation or *** report record low anneal-free losses for both nitride core and oxide cladding,enabling 1.77 dBm^(-1) loss and 14.9 million Q for 80 nm nitride core waveguides,more than half an order magnitude lower loss than previously reported sub 300℃ *** 800 nm-thick nitride,we achieve as good as 8.66 dBm^(-1) loss and 4.03 million Q,the highest reported Q for a low temperature processed resonator with equivalent device area,with a median of loss and Q of 13.9 dBm^(-1) and 2.59 million each *** demonstrate laser stabilization with over 4 orders of magnitude frequency noise reduction using a thin nitride reference cavity,and using a thick nitride micro-resonator we demonstrate OPO,over two octave supercontinuum generation,and four-wave mixing and parametric gain with the lowest reported optical parametric oscillation threshold per unit resonator *** results represent a significant step towards a uniform ultra-low loss silicon nitride homogeneous and heterogeneous platform for both thin and thick waveguides capable of linear and nonlinear photonic circuits and

关键词： resonator thick free

Scalable and automated CRISPR-based strain engineering using droplet microfluidics

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Microsystems & Nanoengineering 2022年第2期8卷 227-236页

作者： Kosuke Iwai Maren Wehrs Megan Garber Jess Sustarich Lauren Washburn zachary Costello Peter W.Kim david Ando William R.Gaillard Nathan J.Hillson Paul d.Adams Aindrila Mukhopadhyay Hector Garcia Martin Anup K.Singh Technology division DOE Joint BioEnergy InstituteEmeryvilleCA 94608USA Biotechnology and Bioengineering department Sandia National LaboratoriesLivermoreCA 94550USA Biofuels and Bioproducts division DOE Joint BioEnergy InstituteEmeryvilleCA 94608USA Biological Systems and Engineering division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Molecular Biophysics and Integrated Bioimaging division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA department of Bioengineering University of CaliforniaBerkeleyCA 94720USA BCAM Basque Center for Applied MathematicsBilbao 48009Spain

We present a droplet-based microfluidic system that enables CRISPR-based gene editing and high-throughput screening on a *** microfluidic device contains a 10x10 element array,and each element contains sets of electrodes for two electric field-actuated operations:electrowetting for merging droplets to mix reagents and electroporation for *** device can perform up to 100 genetic modification reactions in parallel,providing a scalable platform for generating the large number of engineered strains required for the combinatorial optimization of genetic pathways and predictable *** demonstrate the system's capabilities through the CRISPR-based engineering of two test cases:(1)disruption of the function of the enzyme galactokinase(galK)in£coli and(2)targeted engineering of the glutamine synthetase gene(glnA)and the blue-pigment synthetase gene(bpsA)to improve indigoidine production in£coli.

关键词： operations generating fluid