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Single low-dose lipopolysaccharide preconditioning:neuroprotective against axonal injury and modulates glial cells

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Neuroimmunology and Neuroinflammation 2017年第1期4卷 6-15页

作者： Ryan C.Turner zachary J.Naser Brandon P.Lucke-Wold Aric F.Logsdon Reyna L.Vangilder Rae R.Matsumoto Jason d.Huber Charles L.Rosen department of Neurosurgery West Virginia UniversitySchool of MedicineMorgantownWV26506USA Center for Neuroscience West Virginia UniversitySchool of MedicineMorgantownWV 26506USA department of Basic Pharmaceutical Sciences West Virginia UniversitySchool of PharmacyMorgantownWV 26506USA Center for Health Restoration West Virginia UniversitySchool of NursingMorgantownWV 26506USA

Aim:Over 7 million traumatic brain injuries (TBI) are reported each year in the United ***,treatments and neuroprotection following TBI are limited because secondary injury cascades are poorly *** (LPS) administration before controlled cortical impact can contribute to ***,the underlying mechanisms and whether LPS preconditioning confers neuroprotection against closed-head injuries remains ***:The authors hypothesized that preconditioning with a low dose of LPS (0.2 mg/kg) would regulate glial reactivity and protect against diffuse axonal injury induced by weight *** was administered 7 days prior to *** administration reduced locomotion,which recovered completely by time of ***:LPS preconditioning significantly reduced the post-injury gliosis response near the corpus callosum,possibly by downregulating the oncostatin M *** novel findings demonstrate a protective role of LPS preconditioning against diffuse axonal *** preconditioning successfully prevented neurodegeneration near the corpus callosum,as measured by fluorojade ***:Further work is required to elucidate whether LPS preconditioning confers long-term protection against behavioral deficits and to elucidate the biochemical mechanisms responsible for LPS-induced neuroprotective effects.

关键词： Lipopolysaccharide preconditioning oncostatin M receptor diffuse axonal injury gliosis neuroprotection

Maize Gene Regulatory Network for Phenolic Metabolism

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Molecular Plant 2017年第3期10卷 498-515页

作者： Fan Yang Wei Li Nan Jiang Haidong Yu Kengo Morohashi Wilberforce zachary Oumal daniel E. Morales-Mantilla Fabio Andres Gomez-Canol Eric Mukundi Luis daniel Prada-Salcedo Roberto Alers Velazquez Jasmin Valentin Maria Katherine Mejia-Guerra John Gray Andrea I. doseff Erich Grotewold Center for Applied Sciences (CAPS) department of Molecular Genetics department of Physiology and Cell Biology Heart and Lung Research Institute Molecular Cellular and Developmental Biology (MCDB) Graduate Program Success in Graduate Education (SiGuE) Program The Ohio State University Columbus OH 43210 USA department of Biological Sciences University of Toledo Toledo OH 43560 USA

The translation of the genotype into phenotype, represented for example by the expression of genes encod- ing enzymes required for the biosynthesis of phytochemicals that are important for interaction of plants with the environment, is largely carried out by transcription factors （TFs） that recognize specific cis-regulatory elements in the genes that they control. TFs and their target genes are organized in gene regulatory net- works （GRNs）, and thus uncovering GRN architecture presents an important biological challenge necessary to explain gene regulation. Linking TFs to the genes they control, central to understanding GRNs, can be car- ried out using gene- or TF-centered approaches. In this study, we employed a gene-centered approach uti- lizing the yeast one-hybrid assay to generate a network of protein-dNA interactions that participate in the transcriptional control of genes involved in the biosynthesis of maize phenolic compounds including gen- eral phenylpropanoids, lignins, and flavonoids. We identified 1100 protein-dNA interactions involving 54 phenolic gene promoters and 568 TFs. A set of 11 TFs recognized 10 or more promoters, suggesting a role in coordinating pathway gene expression. The integration of the gene-centered network with informa- tion derived from TF-centered approaches provides a foundation for a phenolics GRN characterized by in- terlaced feed-forward loops that link developmental regulators with biosynthetic genes.

关键词： phenylpropanoid flavonoid yeast one-hybrid chromatin immunoprecipitation

2018年《Journal of diabetes》第7期中文导读

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中华内分泌代谢杂志 2018年第7期34卷 610-614页

作者： J diabetes编辑部 J diabetes编辑部

在美国大约有9％的人群受糖尿病的影响，但在全部住院患者中却占到了25％。糖尿病患者的90d再住院率要比非糖尿病人群高40％，前者30d再住院率为14．4％～22．7％，90d再住院率〉26％，1年再住院率达到了30％。

关键词：非糖尿病人群再住院率导读中文住院患者

Buffer Standards for the Biochemical pH of the Zwitterionic Buffer <i>N</i>-Tris-(Hydroxymethyl) Methyl-2-Aminoethanesulfonic Acid (TES) from 5℃ to 55℃

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Open Journal of Physical Chemistry 2012年第1期2卷 41-46页

作者： Rabindra N. Roy Lakshmi N. Roy Blake M. Bodendorfer zachary M. downs Stephen d. Rocchio Joshua T. Wollen Jessica M. Stegner Isaac B. Henson Nicholas W. Grove Lauren A. dieterman Hoffman department of Chemistry Drury University Springfield USA

The authors have undertaken the determination of pH values for one buffer solution of TES without NaCl and nine buffer solutions with NaCl yielding an ionic strength I = ***-1. similar to that of blood. These buffer solutions have been evaluated in the temperature range of 5℃ to 55℃ using an extended version of the debye-Hückel equation. The pH values are reported using 1) the debye-Hückel extension of the Bates-Guggenheim convention in the tempera- ture range 5℃ to 55℃ and 2) with and without liquid junction correction at 25℃ and 37℃. These TES buffer solutions are recommended as secondary standard references for pH measurements in the range of pH 7.2 to 7.5 for physiological application with an ionic strength of I = 0.16 ***-1.

关键词： Ionic Strength Liquid Junction Potentials Second dissociation Constant Buffer Solutions Activity Coefficients

成为一名完美的临床医师:实习医师、住院医师和高年资医师的应知应会

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基础医学与临床 2015年第3期35卷 382-382页

作者： Ary L.Goldberger zachary d.Goldberger 蔺晨中国医学科学院北京协和医院外科

成为一名完美的临床医师：实习医师、住院医师和高年资医师的应知应会随着现今医院医学的规模和复杂性的迅猛增长,医学生们的学习难度曲线也随之陡然上升,同时也需要经验丰富的医师作为导师引导和照顾他们更好的适应与成长。因此,有了... 详细信息

成为一名完美的临床医师：实习医师、住院医师和高年资医师的应知应会随着现今医院医学的规模和复杂性的迅猛增长,医学生们的学习难度曲线也随之陡然上升,同时也需要经验丰富的医师作为导师引导和照顾他们更好的适应与成长。因此,有了《医院医学：目前的概念》这套系列丛书的出炉,其中本书《成为一名完美的临床医师》,介绍了医学生和临床医师如何在忙乱的实践中辩证有序的思考、解决问题,战胜在纷繁信息的评估、整合和表达中遇到的困难和挑战。

关键词：临床医师实习医师应知应会医院医学学习难度病史采集受众对象绪论部分鉴别诊断生存竞争

Mitoquinone attenuates blood-brain barrier disruption through Nrf2/PHB2/OPA1 pathway after subarachnoid hemorrhage in rats

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Mitoquinone attenuates blood-brain barrier disruption throug...

光催化半导体材料中表面羟基诱导的缺陷结构衍化

第十四届中国医师协会神经外科医师年会

作者： Tongyu Zhang Pei Wu Keren Zhou Lingyun Wu Zhiyi Xie Weilin Xu Xu Luo Peng Li Umut Ocak Pinar Eser Ocak zachary d.Travis Jiping Tang Huaizhang Shi John H.Zhang department of Neurosurgery The First Affiliated Hospital of Harbin Medical University department of Physiology and Pharmacology Loma Linda University department of Earth and Biological Sciences Loma Linda University

Background and Purpose— Mitochondrial dysfunction is involved in the mechanism of early brain injury（EBI） following subarachnoid hemorrhage（SAH）. Blood-brain barrier disruption is a devastating outcome in the early stage of SAH. In this study, we aimed to investigate the role of a mitochondria-related drug Mitoquinone（MitoQ） in blood-brain barrier disruption after SAH in rats. Methods— A total of 181 male Sprague–dawley SAH rats with the endovascular perforation model were utilized. Intraperitoneal MitoQ was given 1 hour（h） post-SAH. Cerebroventricular ML385, an inhibitor of NF-E2-related factor 2（Nrf2） and Small interfering ribonucleic acid（siRNA） for Prohibitin 2（PHB2） were injected respectively 24 h and 48 h before SAH. Neurological function evaluation was performed before sacrifice. SAH grade was measured during the sacrifice of each animal. Brain water content was performed at 24 h. Coimmunoprecipitation was used to demonstrate the relationship of proteins Nrf2 and PHB2. Mitochondrial and cytoplasmic fractions were gathered using mitochondria isolation kits. Pathway related proteins were investigated with Western blot and immunofluorescence staining. Transmission electron microscopy was performed for mitochondrial morphology. Results— Expression of Nrf2 levels peaked at the 3 h time point following SAH and then decreased to normal levels at 24 h, while PHB2 and Optic Atrophy 1（OPA1） decreased at 24 h and 72 h after SAH compared with the Sham group. MitoQ treatment attenuated neurological deficits and brain edema, thereby resulting in a decreased expression of Albumin, while an increase of Nrf2, PHB2, OPA1 and Claudin-5 proteins compared with SAH+vehicle group. With co-immunoprecipitation, Nrf2 and PHB2 were further demonstrated to show their interaction. And MitoQ administration lead to more binding of the two proteins. ML385 abolished the effects of MitoQ on neurobehavior and protein levels post-SAH. Similarly, PHB2 siRNA reversed the neuroprotection of MitoQ

关键词： Mitoquinone NF-E2-related factor 2 Prohibitin 2 Optic Atrophy 1 Blood-brain barrier disruption Subarachnoid hemorrhage

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光催化半导体材料中表面羟基诱导的缺陷结构衍化

抽象平等主义与男人是受害者：男性权利组织对框架的战略选择

中国化学会第三届中国能源材料化学研讨会

作者：吴素娟孙建国吴一凡 zachary d.Hood 孙立东重庆大学材料科学与工程学院 Oak Ridge National Laboratory

宽带隙半导体光催化材料中引入缺陷,可有效拓展光吸收范围,提高太阳能转化效率,是光催化材料改性研究的有效手段之一。特别是在氧化物半导体材料中的氧缺陷,因其能够有效的改善材料电子能带结构,电荷输运,同时在光催化反应中它作为重要...

宽带隙半导体光催化材料中引入缺陷,可有效拓展光吸收范围,提高太阳能转化效率,是光催化材料改性研究的有效手段之一。特别是在氧化物半导体材料中的氧缺陷,因其能够有效的改善材料电子能带结构,电荷输运,同时在光催化反应中它作为重要的吸附位和活性点,显著地影响着光催化活性。

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国际社会科学杂志（中文版） 2019年第4期36卷 89-102,7,11,12页

作者：扎卡里·d.帕尔默曼格拉·苏布莱曼尼亚姆赵元元美国普渡大学

世界各地的妇女运动挑战了教育、就业和生育权利方面的性别不平等,在全球范围内组织运动并形成了跨国关系纽带(Basu 2000;Ferree and Subramaniam 2001;Keck and Sikkink 1998;Moghadam 2005;等等)。在过去几十年里,这使得全球妇女的社... 详细信息

世界各地的妇女运动挑战了教育、就业和生育权利方面的性别不平等,在全球范围内组织运动并形成了跨国关系纽带(Basu 2000;Ferree and Subramaniam 2001;Keck and Sikkink 1998;Moghadam 2005;等等)。在过去几十年里,这使得全球妇女的社会、政治和经济地位有所提高。然而,由于世界各地的妇女运动对国际机构和各国政府施加压力,要求它们解决性别不平等问题,因此,也出现了以男性权利运动形式发生的后退。

关键词：平等主义妇女运动男性权利性别不平等全球范围生育权利受害者政治和经济

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阿尔茨海默病的临床表现、病程、治疗和管理

中国心理卫生杂志 1999年第5期13卷 272-275页

作者： BarryReisberg M.d. zachary and Elizabeth M.Fisher Alzheimer's disease Education and Resources Program at the New York University Medical Center

阿尔茨海默病(Alzheimer's disease,Ad)是导致智力衰退这类疾病的主要原因.经典研究表明:阿尔茨海默病大约占所有痴呆病例的四分之三.最近20年来对阿尔茨海默病的临床演变过程有了极其深入的了解.现在,无论是专业人员还是外行人士都能... 详细信息

阿尔茨海默病(Alzheimer's disease,Ad)是导致智力衰退这类疾病的主要原因.经典研究表明:阿尔茨海默病大约占所有痴呆病例的四分之三.最近20年来对阿尔茨海默病的临床演变过程有了极其深入的了解.现在,无论是专业人员还是外行人士都能应用通俗的术语对这一演变过程做详细地叙述.更进一步的是,基于目前掌握的(阿尔茨海默病)的知识,阿尔茨海默病患者还有可能获得适当的治疗.以后随着临床知识的不断积累,对于这种在人生晚年普遍发生的严重疾病的治疗也必将不断得到改善.

关键词：老年性痴呆临床表现病程治疗管理