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Utilization of RNA sequencing to investigate olfactory dysfunction in chronic rhinosinusitis without nasal polyps:A pilot study

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 29-36页

作者： Jorge A.Gutierrez III Jeremy L.Barth Rodney J.Schlosser Thomas S.Edwards Timothy L.Smith zac.a.y m.soler Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Regenerative medicine&Cell Biology Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Otolaryngology-Head and Neck Surgery Oregon Health&Science UniversityPortlandOregonUSA

Objectives:Prior research on olfactory dysfunction in chronic rhinosinusitis(CRS)has focused on patients with polyps and suggests that direct inflammation of the olfactory cleft mucosa plays a contributory *** purpose of this study was to evaluate gene expression in superior turbinate mucosal specimens,comparing normosmic and dysosmic CRS patients without polyps(CRSsNP).methods:Tissue samples were obtained from the superior turbinates of patients with CRSsNP at the time of endoscopic sinus *** subsequently underwent RNA sequencing and functional analysis to investigate biological pathways associated with differentially expressed genes between dysosmic(n=7)and normosmic(n=4)***:Differential gene expression analysis comparing dysosmic and normosmic CRSsNP patients showed upregulation of 563 genes and downregulation of 327 *** stringent criteria for multiple comparisons,one upregulated gene(Immediate Early Response 3[IER3])had an false discovery rate(FDR)correction adjustedP value considered statistically significant(Pme functional analysis revealed eight biological pathways significantly different between dysosmic and normosmic patients(Pmation regarding biological pathways and genes involved in olfactory *** study supports literature suggesting that Type 2 inflammation may play a role in olfactory dysfunction in at least some patients with *** study also prompts questions regarding the role of IL-10,rhodopsin-like receptors,andIER3 in the pathogenesis of olfactory dysfunction.

关键词： chronic rhinosinusitis without nasal polyps olfactory dysfunction RNA sequencing

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Comparison of trigeminal lateralization with differing stimulants

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 66-69页

作者： Tiffany Chen Nicolas S.Poupore michael C.Shih Thomas S.Edwards Shaun A.Nguyen zac.a.y m.soler Rodney J.Schlosser Department of Otolaryngology‐Head and Neck Surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA

Trigeminal-specific stimulants have been shown to activate different receptors preferentially and this likely accounts for variation in sensory *** is unclear whether trigeminal sensitivity is similar across different transient receptor potential(TRP)receptors or if dysfunction of different receptors results in differing patient ***,a prospective cohort study was conducted,consisting of trigeminal lateralization testing with three different stimulants(eucalyptol,isothiocyanate,acetic acid),olfaction testing with Sniffin'Sticks,and measurement of various patient‐reported outcome measures(PROms).A total of 50 participants were enrolled across the olfactory *** TDI score was 27.1±8.3(range 7.0–39.5)with 38%normosmic and 62%*** trigeminal lateralization scores out of 20 in the overall cohort were 16.18(2.78)for eucalyptol,14.94(3.49)for mustard oil,and 15.28(3.68)for *** showed a significant correlation with threshold scores of Sniffin'Sticks.A significant correlation was found between acetic acid and various *** of the lateralization scores of the trigeminal stimulants correlated to each other significantly and there was no correlation to *** lack of correlation suggests that the measured sensitivity of one type of TRP receptor may not translate to similar sensitivity of the other *** investigations with TRPV1 and TRPA1 agonists are needed to corroborate our findings.

关键词： chemosensory olfaction trigeminal TRP receptor

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On Certain Distributive Lattices of Subgroups of Finite Soluble Groups

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Acta mathematica Sinica,English Series 2007年第11期23卷 2069-2078页

作者： L.m.EZQUERRO X.soler-ESCRIV InformáticaUniversidad Pública de Navarra Campus de Arrosadía.31006 PamplonaSpain Departamentde matemàtica Aplicada Universitat d'AlacantCampus de Sant Vicent.Ap.Correus 99-03080 AlacantSpain

In this paper, we prove the following result. Let ξ be a saturated formation and ∑ a Hall system of a soluble group G. Let X be a w-solid set of maximal subgroups of G such that ∑ reduces into each element of X. Consider in G the following three subgroups： the ξ-normalizer D of G associated with ∑; the X-prefrattini subgroup W = W（G, X） of G; and a hypercentrally embedded subgroup T of G. Then the lattice ζ（T, W, D） generated by T, D and W is a distributive lattice of pairwise permutable subgroups of G with the cover and avoidance property. This result remains true for the lattice ,ζ（V, W, D）, where V is a subgroup of G whose Sylow subgroups are also Sylow subgroups of hypercentrally embedded subgroups of G such that ∑ reduces into V.

关键词： lattice properties permutability factorizations cover and avoidance properties

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Extra-pair paternity and antiparasitic defence

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Avian Research 2020年第4期11卷 391-397页

作者： Anders Pape møller Jørgen Skavdal Søraker Juan Josésoler ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering College of Life SciencesBeijing Normal UniversityBeijing 100875China Ecologie Systématique et Evolution UniversitéParis-SaclayCNRSAgroParisTech91405 OrsayFrance Centre for Biodiversity Dynamics Department of BiologyNorwegian University of Science and TechnologyHøgskoleringen 5No-7491TrondheimNorway Depto.Ecología Funcional y Evolutiva Estación Experimental de ZonasÁridasCtra.Sacramento S/NLa Cañada de San Urbano04120 AlmeríaSpain

Background:Extra-pair paternity(EPP)in birds provides benefits in terms of more offspring,and characteristics for maintenance of this behaviour have been the subject of *** are known to be transmitted during mating,especially when mating with multiple partners,and factors reducing this cost of multiple mating are ***,plumage brightness and colour intensity have been shown to be important traits to benefits from multiple mating as predicted by sexual *** aim of this study was to investigate the relationship between the rate of extra-pair paternity and the relative size of the uropygial gland at the interspecific level,as the uropygial gland is an exocrine gland hypothesized to produce antiparasitic substances and further identified to affect plumage *** of the expected benefits of large uropygial gland in scenarios of sexual selection,we predicted a positive correlation with ***:We collected information from the literature of uropygial gland size and frequency of extra-pair paternity of 60 avian species of different families and explored the predicted positive correlation between *** did so with means of comparative analyses that considered phylogenetic relationship as random factor and included body mass as *** used markov chain monte Carlo generalized linear mixed models that were weighted by number of nests used to estimate extra-pair ***:We detected a positive relationship between level of extra-pair paternity and uropygial gland size at an interspecific *** finding is consistent with the ***:We discuss the importance of this result in scenarios of sexual selection and argue that the detected relationship may have arisen by utilizing antiparasitic secretions through secondary sexual characters indicating parasite resistance.

关键词： Antiparasitic defence Costs of extra-pair paternity microorganisms Uropygial gland Uropygial secretions

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Jumberca IFPL-R型机—关于毛圈织物质量的一种新概念

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国外纺织技术 1980年第15期 7-8+6页

作者： m.soler Serra 瞿履修

为了使毛圈的长度和形状完整均匀,Jumberca IFPL—R型机使先前形成的横列线圈停放在沉降片的片鼻上。由于这种技术保证了毛圈长度整齐一致,因此织物非常均匀,易于割绒。纱线通过特殊的导纱器垫到针上,这是为了获得与毛圈相反的一面织物... 详细信息

为了使毛圈的长度和形状完整均匀,Jumberca IFPL—R型机使先前形成的横列线圈停放在沉降片的片鼻上。由于这种技术保证了毛圈长度整齐一致,因此织物非常均匀,易于割绒。纱线通过特殊的导纱器垫到针上,这是为了获得与毛圈相反的一面织物完全均匀,并且地纱只显露在这一面上。这种导纱器

关键词：沉降片纱线针舌长度导纱器生克片纺织机械零部件毛圈组织 Jumberca IFPL-R

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Progress of clinical therapies for dry age-related macular degeneration

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International Journal of Ophthalmology(English edition) 2022年第1期15卷 157-166页

作者： Rhianna Rubner Kang V.Li m.Valeria Canto-soler CellSight Ocular Stem Cell and Regeneration Research Program Department of OphthalmologySue Anschutz-Rodgers Eye CenterUniversity of Colorado School of MedicineAuroraCO 80045USA

Dry age-related macular degeneration(AmD)is a progressive blinding disease that currently affects millions of people worldwide with no successful treatment *** research efforts are currently underway to develop therapies aimed at slowing the progression of this disease or,more notably,reversing *** the therapies which have reached clinical trial for treatment of dry AmD were reviewed.A thorough search of Pub med,Embase,and *** has led to a comprehensive collection of the most recent strategies being *** review also endeavors to assess the status and future directions of therapeutics for this debilitating condition.

关键词： dry age-related macular degeneration age-related macular degeneration drug therapy

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morphometric and kinematic sperm subpopulations in split ejaculates of normozoospermic men

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Asian Journal of Andrology 2016年第6期18卷 831-834页

作者： Pilar Santolaria Caries soler Pilar Recreo Teresa Carretero Araceli Bono Jose m Berne Jesus L yaniz TECNOGAm research group Environmental Sciences Institute (IUCA) Department of Animal Production and Food Sciences University of Zaragoza Huesca Spain Department of Functionat 8iotogy and Physical Anthropology University of Valencia 46100 Burjassot Valencia Spain R+D Department Proiser R+D Scientific Park University of Valencia 46980 Paterna Valencia Spain TECNOGAm research group Environmental Sciences Institute (IUCA) Departament of Human Anatomy and Histolosy Faculty of Health and Sport Sciences of Huesca PLaza Universidad 3 22002 Huesca Spain TECNOGAm research group Environmental Sciences Institute (IUCA) Hospital General San Jorge de Huesca Area de Urologia Av. Martinez de Velasco 36 22004 Huesca Spain

This study was designed to analyze the sperm kinematic and morphometric subpopulations in the different fractions of the ejaculate in normozoospermic men. Ejaculates from eight normozoospermic men were collected by masturbation in three fractions after 3-5 days of sexual abstinence. Analyses of sperm motility by computer-assisted sperm analysis （CASA-mot）, and of sperm morphometry by computer-assisted sperm morphometry analysis （CASA-morph） using fluorescence were performed. Clustering and discriminant procedures were performed to identify sperm subpopulations in the kinematic and morphometric data obtained. Clustering procedures resulted in the classification of spermatozoa into three kinematic subpopulations （slow with low ALH [35.6% of all motile spermatozoa], with circular trajectories [32.0%], and rapid with high ALH [32.4%]）, and three morphometric subpopulations （large-round [33.9% of all spermatozoa], elongated [32.0%], and small [34.10%]）. The distribution of kinematic sperm subpopulations was different among ejaculate fractions （P 〈 0.001）, with higher percentages of spermatozoa exhibiting slow movements with low ALH in the second and third portions, and with a more homogeneous distribution of kinematic sperm subpopulations in the first portion. The distribution of morphometric sperm subpopulations was also different among ejaculate fractions （P〈 0.001）, with more elongated spermatozoa in the first, and of small spermatozoa in the third, portion. It is concluded that important variations in the distribution of kinematic and morphometric sperm subpopulations exist between ejaculate fractions, with possible functional implications.

关键词： man sperm morphometry by computer-assisted sperm morphometry analysis sperm motility by computer-assisted spermanalysis sperm subpopulations split ejaculate

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Functional explanation of extreme hatching asynchrony: male manipulation Hypothesis

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Zoological Research 2022年第5期43卷 843-850页

作者： manuel soler Francisco Ruiz-Raya Lucia Sanchez-Perez Juan Diego Ibanez-Álamo Juan Josesoler Departamento de Zoologia Facultad de CienciasUniversidad de GranadaGranada E-18071Spain Unidad Asociada Coevolucion:Cucos Hospedadores y Bacterias SimbiontesUniversidad de GranadaGranada E-18071Spain Centro de Investigacion mariña Universidade de VigoGrupo de Ecoloxia AnimalVigo 36310Spain Departamento de Ecologia Funcional y Evolutiva Estacion Experimental de ZonasÁridas(CSIC)Almeria E-4120Spain

Hatching asynchrony in birds is considered an adaptation to facilitate brood reduction because under conditions of food scarcity, the smallest nestling usually dies soon after hatching, thereby minimizing parental effort. However, in species with extreme hatching asynchrony, the last hatchlings paradoxically experience a very low probability of survival and death can take so long that it can hardly be considered an adaptation. Here, we propose and experimentally tested a new adaptive hypothesis explaining the brood reduction paradox, namely the“male manipulation Hypothesis”. Our hypothesis suggests that by inducing asynchronous hatching,females increase the feeding requirements of the brood, which will induce males to increase provisioning effort. In addition, females may extend the period of male manipulation by feeding the smallest nestling just enough to sustain life. Our study showed that male common blackbirds(Turdus merula) increased their effort(i.e., number of food items per hour) in experimental asynchronous broods compared to synchronous broods, while females reduced their contribution, as predicted by the hypothesis.

关键词： Brood reduction Food allocation Hatchingasynchrony malemanipulation hypothesis Sexual differences in food allocation Turdus merula

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Current status and potential of morphometric sperm analysis

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Asian Journal of Andrology 2016年第6期18卷 863-870页

作者： Alejandro maroto-morales Olga Garcia-Alvarez manuel Ramon Felipe martinez-Pastor m Rocio Fernandez-Santos A Josefa soler Jose Julian Garde SaBio IREC (CSIC - UCLm -JCCm) Albacete Spain Biomedical Center Medical Faculty in Pilsen Charles University in Prague Pilsen Czech Republic Regional Center of Animal Selection and Reproduction (CERSyRA) JCCm Valdepenas Spain 4Institute for Animal Health and Cattle Development University of Leon LeOn Spain Department of molecular Biology University of Leon Leon Spain Faculty of Pharmacy (UCLm) Albacete Spain

The spermatozoon is the most diverse cell type known and this diversity is considered to reflect differences in sperm function. How the diversity in sperm morphology arose during speciation and what role the different specializations play in sperm function, however, remain incompletely characterized. This work reviews the hypotheses proposed to explain sperm morphological evolution, with a focus on some aspects of sperm morphometric evaluation; the ability of morphometrics to predict sperm cryoresistance and male fertility is also discussed. For this, the evaluation of patterns of change of sperm head morphometry throughout a process, instead of the study of the morphometric characteristics of the sperm head at different stages, allows a better identification of the males with different sperm cryoconservation ability. These new approaches, together with more studies employing a greater number of individuals, are needed to obtain novel results concerning the role of sperm morphometry on sperm function. Future studies should aim at understanding the causes of sperm design diversity and the mechanisms that generate them, giving increased attention to other sperm structures besides the sperm head. The implementation of scientific and technological advances could benefit the simultaneous examination of sperm phenotype and sperm function, demonstrating that sperm morphometry could be a useful tool for sperm assessment.

关键词： computer-assisted sperm morphometric analysis mammals sperm function sperm morphometry

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Application of None Cement Aluminamagnesia Gunning mix with Special High Reactive Alumina in Steel Ladles

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China's Refractories 2020年第1期29卷 20-26页

作者： Jérome KIENNEmANN Paul soler Johnson LEE Alteo Gardanne 20062France

During calcining the aluminum hydroxide according to the Bayer process in a rotary kiln,the process of incomplete conversion to alpha alumina by soft calcination leads to a special intermediate alumina product containing microcrystalline of primary crystal alpha alumina particles less than 0.4μm,and other alumina phases with finer microcrystalline of less than 0.2μm *** special alumina powder has similar properties to silica fume or clay,such as high surface area and reactivity,fast wetting,low water demand and high *** can partially or completely replace silica fume and clay in dry gunning *** works towards improving the high temperature resistance of the gunning material matrix as well as the corrosion resistance and service life of the gunning *** application results show that:the ladle cementfree alumina-magnesia dry gunning mix with this special alumina sub-micro powder,compared with traditional dry gunning materials,has lower rebound loss(milar performance.A further improvement goal is to replace the initial casting linings,thus this concept will give a new revolution to the monolithic steel ladles.

关键词： none cement gunning mix special reactive alumina monolithic steel ladles

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