检索结果-南通市图书馆

世界核心医学期刊文摘（胃肠病学分册） 2005年第6期1卷 59-60页

作者： Schiefke I. Soeder H. zabel-langhennig a. 王志宇 Dept. of Internal Medicine II University of Leipzig Leipzig Germany

Background: Endoluminal gastroplication (EndoCinch) has emerged as an endoscopic anti-reflux therapy, but predictive factors for symptom relief have not been established. The aim of this study was to evaluate the major determinants to predict outcome in patients treated with EndoCinch. Methods: A total of 53 consecutive patients, treated with EndoCinch at a single center were included in this prospective study. Inclusion criteria were symptoms of chronic heartburn, dependency on proton-pump inhibitors, documented pathological esophageal acid exposure, and a hiatal hernia smaller than 3 cm in length. All patients underwent endoscopy, 24-h pH monitoring, esophageal manometry, barium esophagram, and a detailed questionnaire regarding their symptoms before treatment. Patients were stratified into a responder and a non-responder group using a questionnaire at 3-month follow-up. A multivariate analysis was performed. Results: The success rate was 64%(34/53 patients). Three variables were significantly predictive for successful endoscopic anti-reflux treatment at the multivariate level: presence of typical symptoms (P = 0.01), complete symptom relief with acid suppressive therapy (P = 0.01), and normal lower esophageal sphincter pressure (P = 0.04). Not predictive of outcome were age, body mass index, esophagitis, other manometric findings, hiatal hernia size, or pathological level of pH < 4/24 h. Barium esophagram did not add any additional predictive information. Conclusions: Since no single factor can predict outcome after EndoCinch, a careful patient selection is mandatory to maximize the success rate. The ideal candidate for EndoCinch is a gastroesophageal (GERD) patient with a normal lower esophageal sphincter pressure, whose typical symptoms completely resolved with acid suppressive therapy.

关键词：缝合术预后预测食管钡餐造影抑酸治疗食管测压食管下括约肌裂孔疝胃食管反流预测意义食管炎

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

长期疗效失败的内镜下胃内折叠缝合术

引用

世界核心医学期刊文摘（胃肠病学分册） 2005年第9期1卷 34-35页

作者： Schiefke I. zabel-langhennig a. Neumann S. K. Caca 成虹 Department of Medicine II University of Leipzig Philipp-Rosenthal Str 27 04103 Leipzig Germany Prof.

Introduction: Endoluminal gastroplication (EndoCinch; Bard)has been introduced as an endoscopic treatment option in gastro-oesophageal reflux disease (GORD) patients with promising short term results. However, little is known about the long term efficacy of endoscopic suturing. The aim of this study was to evaluate prospectively the long term outcome after EndoCinch. Patients and methods: A total of 70 patients treated with EndoCinch at a single referral centre were studied prospectively. All patients were interviewed using a standardised questionnaire regarding their symptoms and medication prior to and 18 months after EndoCinch. In addition, follow up included endoscopy, 24 hour pH monitoring, and oesophageal manometry. Results: The procedurewas well tolerated without major short or long term complications. Eighteen months after EndoCinch, 56/70 patients (80%) were considered treatment failures as their heartburn symptoms did not improve or proton pump inhibitor medication exceeded 50%of the initial dose. Endoscopy showed all sutures in situ in 12/70 (17%) patients while no remaining sutures could be detected in 18/70 (26%). In 54 and 50 patients examined, respectively, no significant changes in 24 hour pH monitoring (median pH < 4/24 hours, 9.1%v 8.5%; p = 0.82) or lower oesophageal sphincter (LOS) pressure (7.7 v 10.3 mm Hg; p = 0.051) were observed while median LOS length slightly increased (3.0 to 3.2 cm; p< 0.05). Conclusion: Endoscopic gastroplication (EndoCinch) is a safe and minimally invasive endoscopic treatment for GORD with reasonable short term results. In contrast, long term outcome is disappointing, probably due to suture loss in the majority of patients. Therefore, technical improvements to ensure suture durability are mandatory before endoscopic suturing can evolve as a therapeutic option for GORD treatment.

关键词：缝合术胃食管反流下食管括约肌胃灼热食管测压检查短期疗效胃镜检查问卷调查前有令人

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CD200Rhigghh neutrophils with dysfunctional autophagy establish systemic immunosuppression by increasing regulatory T cells

引用

Cellular & Molecular Immunology 2024年第4期21卷 349-361页

作者： Ye Seon Kim Yu Sun Jeong Geon Ho Bae Ji Hyeon Kang Mingyu Lee Brian A.zabel Yoe-Sik Bae Department of Biological Sciences Sungkyunkwan UniversitySuwon16419Republic of Korea Department of Health Science and Technology SAIHSTSungkyunkwan UniversitySeoul06351Republic of Korea Palo Alto Veterans Institute for Research Veterans Affairs HospitalPalo AltoCA94304USA

Distinct neutrophil populations arise during certain pathological *** generation of dysfunctional neutrophils during sepsis and their contribution to septicemia-related systemic immune suppression remain *** this study,using an experimental sepsis model that features immunosuppression,we identified a novel population of pathogenic CD200R^(high) neutrophils that are generated during the initial stages of sepsis and contribute to systemic immune suppression by enhancing regulatory T(T_(reg))*** to their CD200R^(low)counterparts,sepsis-generated CD200Rhigh neutrophils exhibit impaired autophagy and dysfunction,with reduced chemotactic migration,superoxide anion production,and TNF-α*** soluble CD200 blocks autophagy and neutrophil maturation in the bone marrow during experimental sepsis,and recombinant CD200 treatment in vitro can induce neutrophil dysfunction similar to that observed in CD200R^(high) *** administration of anα-CD200R antibody effectively reversed neutrophil dysfunction by enhancing autophagy and protecting against a secondary infection challenge,leading to increased *** analysis revealed that CD200R^(high) neutrophils expressed high levels of Igf1,which elicits the generation of Treg cells,while the administration of anα-CD200R antibody inhibited Treg cell generation in a secondary infection *** together,our findings revealed a novel CD200R^(high) neutrophil population that mediates the pathogenesis of sepsis-induced systemic immunosuppression by generating Treg cells.

关键词： Sepsis Neutrophils CD200R Autophagy IGF-1 Regulatory T cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

内镜缝合装置在胃食管反流病中的使用:继EndoCinch腔内胃折叠术后又一个失败

引用

世界核心医学期刊文摘（胃肠病学分册） 2005年第11期1卷 23-23页

作者： Schiefke I. Neumann S. zabel-langhennig a. K. Caca 尹勇 Department of Medicine II University of Leipzig Philipp-Rosenthal Str. 27 04103 Leipzig Germany Dr.

Background: Endoluminal gastroplication, using the Endo- Cinch procedure, has emerged as a potential endoscopic antireflux therapy. Although initial results have been promising, the long-term durability of the treatment is uncertain due to suture loss. A new endoscopic suturing device, the “ ESD," has been developed that promises excellent visibility and endoscopic control. at The aim of this study was to evaluate prospectively the feasibility and efficacy of the ESD method after EndoCinch failure. Methods: The study involved 20 patients with gastroesophageal reflux disease (GERD), who had been initially treated with an EndoCinch procedure, but had relapsed after a median of 7.5 months, with lost or dysfunctional sutures and with reflux symptoms that required proton pump inhibitor (PPI) treatment. Using the ESD, at least three plications were created at the gastroesophageal junction. Patients underwent endoscopy, 24-hour pH monitoring and esophageal manometry before treatment and 6 months afterwards. In addition, reflux symptoms as well as quality-of-life scores were assessed (using the SF-6 and GERD-HRQL scales). Results: The ESD procedure (median procedure time 45 min) was performed successfully in all patients without major complications. After 6 months only one patient (5% ) still had all sutures in situ, while no remaining sutures could be detected in 3/20 (15% ). No significant changes in reflux esophagitis; 24-hour pH monitoring results (median pH< 4/24 h 9.9% vs. 12.3% ; P = 0.60);manometry findings (median lower esophageal sphincter pressure 7.2 mm Hg vs. 9.9 mm Hg; P = 0.22); PPI use; or reflux esophagitis could be detected after 6 months. While reflux symptoms improved (heartbu-rn severity score 30 vs. 48, P < 0,05), no changes in quality-of-life scores were detected. Conclusions: Endoluminal gastroplication using the ESD is an easy and safe, but unfortunately ineffective procedure for endoscopic GERD treatment. Endoluminal gastroplication techniques clea

关键词：胃折叠术 EndoCinch 胃食管反流食管测压反流症状食管下括约肌反流性食管炎胃灼热严重度功能不良

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

内镜抗反流治疗比腹腔镜胃底折叠术更合算吗?

引用

世界核心医学期刊文摘（胃肠病学分册） 2005年第8期1卷 16-16页

作者： Schiefke I Rogalski C zabel-langhennig a K.Caca 王志宇 Department of Medicine II University of LeipzigPhilipp-Rosenthal-Strafle 27 04103 Leipzi g Germany.Dr

Background and Study Aims: A number of endoscopic antireflux therapies (EATS) have emerged as potential nonmedical treatment options for patients with gastroe sophageal reflux disease(GERD). Concerns about clinical efficacy and costs have given rise to debate about their role in GERD management. The costs of laparosco pic fundoplication (LF) were compared with the costs of EAT when used in a seque ntial strategy that reserves the option of LF for EAT failure. Methods: A simple mathematical criterion of direct medical costs was applied. Published articles concerning EAT were reviewed to assess its effectiveness,durability and costs, i n order to estimate the parameters of the model. The costs of EAT and LF were ev aluated from the perspective of a German third-party payer. Only direct medical costs were considered. Results: Assuming that EAT has no impact on potential LF later on, the outcome of both strategies (LF, or EAT first with LF in case of f ailure of EAT) is identical and preference is a simple question of costs. The se quential strategy in nonmedical GERD treatment would be preferable if the long- term relief rate with EAT exceeds the ratio of the cost of EAT to the cost of LF . Long-term success rates of EAT do not exceed 0.65. At current prices EAT is c learly not cost-effective in Germany. Conclusion: Our simple criterion indicate s that EAT would only be cost-effective and beneficial in a sequential strategy if the costs of EAT were to be decreased to around 30%of current retail prices . However, long-term studies and randomized controlled trials are necessary to finally determine the role of EAT in GERD treatment, and the preference may chan ge in either direction.

关键词：胃食管反流医疗花费药物治疗方法随机对照试验临床疗效模型参数持久性第三方

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Heavy metals in Changjiang estuarine and offshore sediments:responding to human activities

引用

Acta Oceanologica Sinica 2012年第2期31卷 88-101页

作者： DONG Aiguo ZHAI Shikui Matthias zabel YU Zenghui ZHANG Huaijing LIU Feifei College of Marine Geoscience Ocean University of ChinaQingdao 266100China Key Laboratory of Submarine Geosciences and Prospecting Techniques Ministry of EducationOcean University of ChinaQingdao 266100China Fachbereich Geowissenschaften Universitat BremenPostfach 330440D-28334 BremenGermany

The Changjiang （Yangtze） estuarine and offshore sediments were analyzed for total heavy metals concentrations and chemical fractions. Distributions of heavy metals show typical banded diffusion pattern, with high concentrations near the river mouth and following a decreasing trend in the offshore direction. According to chemical fractions, Fe/Mn oxide fraction is the major non-residual fraction in the Changjiang estuarine and offshore sediments, Higher percentage of non-residual fraction of Pb implies that, the industrial contaminations transported via the atmosphere and river input, may affect the non-residual fraction of heavy metals. Over past fifteen years, the concentration of Pb normalizing to A1 presents significant increasing trend, corresponding to the effect of human activities. By comparison of heavy metals fractions in 2003 to 2006, it has been realized that increasing water and sediment may cause a higher percentage non-residual fraction of Cu in the southern part of offshore muddy sediments.

关键词： sediment heavy metal fraction Changjiang (Yangtze) River

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The fractional coupled KdV equations: Exact solutions and white noise functional approach

引用

Chinese Physics B 2013年第8期22卷 302-308页

作者： Hossam A. Ghany A. S. Okb El Bab A. M. zabel Abd-Allah Hyder Department of Mathematics Faculty of Science Taif UniversityTaif Saudi Arabia Department of Mathematics Faculty of Industrial Education Helwan UniversityCairo Egypt Department of Mathematics Faculty of Science Al-Azhar UniversityCairo Egypt Department of Physics and Mathematics Faculty of Engineering Al-Azhar UniversityCairo Egypt

Variable coefficients and Wick-type stochastic fractional coupled KdV equations are investigated. By using the mod- ified fractional sub-equation method, Hermite transform, and white noise theory the exact travelling wave solutions and white noise functional solutions are obtained, including the generalized exponential, hyperbolic, and trigonometric types.

关键词： coupled KdV equations fractional calculus white noise Hermite transform

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

长江口及邻近海域表层沉积物中重金属元素含量分布及其影响因素

引用

海洋学报 2009年第6期31卷 54-68页

作者：董爱国翟世奎 zabel Matthias 于增慧中国海洋大学海底科学与探测技术教育部重点实验室山东青岛266100 不来梅大学海洋地球科学学院不来梅d28334

根据2003和2006年长江口及邻近海域表层沉积物样品的粒度组成和元素铬、铜、镍、铅、锌、铝、钙和锶的含量,分析了重金属元素含量的分布特征,探讨了含量的变化趋势及其对人类活动的响应。自2003年三峡工程一期蓄水完成到2006年6月,长江... 详细信息

根据2003和2006年长江口及邻近海域表层沉积物样品的粒度组成和元素铬、铜、镍、铅、锌、铝、钙和锶的含量,分析了重金属元素含量的分布特征,探讨了含量的变化趋势及其对人类活动的响应。自2003年三峡工程一期蓄水完成到2006年6月,长江输沙量逐年减少,长江口海域沉积物中黏土的百分含量明显增加,但是沉积物分布的总体格局并没有发生明显的变化。重金属元素大多在泥质区沉积物中富集,高值区沿岸线呈带状分布,在最大浑浊带和口外羽状锋处达到峰值。在长江大量物质输入的背景下,研究区沉积物中重金属元素含量相对其他类似河口较低。河流的陆源颗粒输入、水动力条件、细颗粒物质的吸附以及絮凝作用是控制沉积物中重金属元素含量分布的主要因素,氧化还原条件也对重金属元素含量变化有一定的影响。人类活动(重大工程的建设和人为污染)对长江口外泥质区中重金属元素含量有重要影响,尤其对铅和锌的含量及其分布的影响显著。自2003年三峡工程一期蓄水以来,长江口海域表层沉积物中重金属元素沉积机制未有明显的变化,但是重金属元素含量有逐渐降低的趋势。

关键词：长江口海域表层沉积物重金属元素三峡工程一期蓄水

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Correlation between Thermal Expansion and Magnetic Characteristics of Fe-Ni Alloys in Fe_(1-x)Ni_x/Cu Superlattices

引用

International Journal of Minerals,Metallurgy and Materials 1998年第3期12卷 169-174页

作者： Weizhong Tang H zabel(Matrial Science and Engineering School, University of Science and Technology Beijing, Beijing 100083, China)(Institute of Experimental Physics/Solid State Physics, Ruhr University Bochum, 44780 Bochum, Germany) Material Science and Engineering School University of Science and Technology Beijing Beijing 100083 China Institute of Experimental Physics/Solid State Physics Ruhr University Bochum 44780 Bochum Germany

Thermal expansion behaviors of FeNi alloys were investigated by means of X-ray diffraction technique within a Fe1 -xNix/Cu superiattice structure. It was found that with a Ni concentration of x = 0.35, FeNi alloy layers showed the well-known Invar behavior, but for alloy layers with either lower or higher Ni concentrations, thermal expansion coefficients were larger. Based on results of magnetic measurements it is concluded that FeNi alloy layers with Ni concentrations lower than the Invar composition are in a superparamagnetic state which leads not only to low spontaneous magnetizations but also to large thermal expansions of the alloy layers.

关键词： thermal expansion Invar behavior FeNi alloys superlattice magnetism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

长江口外海域岩心沉积物地球化学特征及其对人类活动的响应

引用

海洋地质与第四纪地质 2009年第4期29卷 107-114页

作者：董爱国翟世奎 zabel Matthias 于增慧褚忠信中国海洋大学海底科学与探测技术教育部重点实验室青岛266100 德国不来梅大学海洋地球科学学院不来梅d28334

对长江口外海域Y16站岩心沉积物中元素含量和粒度组成进行了分析,并通过137Cs测定了年龄。结果表明,该岩心沉积物中元素含量在垂向上的变化与沉积物粒度组成的变化密切相关,根据元素含量的变化特征可将其分为3段:1966年之前、1967—198... 详细信息

对长江口外海域Y16站岩心沉积物中元素含量和粒度组成进行了分析,并通过137Cs测定了年龄。结果表明,该岩心沉积物中元素含量在垂向上的变化与沉积物粒度组成的变化密切相关,根据元素含量的变化特征可将其分为3段:1966年之前、1967—1989年和1990—2006年。R型因子分析表明,影响该岩心沉积物中元素含量变化的主要因素为陆源物质供给。另外,生物沉积作用和人为污染对部分元素含量的变化有一定影响。元素含量的变化特征在前两个阶段主要与流域自然过程相联系,在后一阶段(1990—2006年)人为污染对沉积物中Pb和Zn元素含量的变化有所影响,但这种影响在长江大量输沙的背景下被明显减少。目前,由于长江输沙量的大幅下降(2006年长江输沙量仅为0.85亿t)以及人为污染影响程度的增强(煤、石油燃料消耗的持续增加以及工业的持续发展),未来长江口海域重金属元素的污染情况将面临更大的挑战。

关键词：岩心沉积物重金属地球化学人为污染长江口

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：