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Washed microbiota transplantation for Crohn’s disease:A metagenomic,metatranscriptomic,and metabolomic-based study

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World Journal of Gastroenterology 2024年第11期30卷 1572-1587页

作者： Shi-Ju Chen Da-Ya Zhang Xia Wu Fa-Ming Zhang Bo-ta Cui Yi-Hao Huang Zu-Lun Zhang Rui Wang Fei-Hu Bai Graduate School Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Department of Microbiota Medicine&Medical Center for Digestive Diseases The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Hainan Medical UniversityHaikou 570216Hainan ProvinceChina

BACKGROUND Fecal microbiota transplantation(FMT)is a promising therapeutic approach for treating Crohn’s disease(CD).The new method of FMT,based on the automatic washing process,was named as washed microbiota transplantation(WMT).Most existing studies have focused on observing the clinical ***,the mechanism of action of FMT for the effective management of CD-particularly in-depth multi-omics analysis involving the metagenome,metatranscriptome,and metabolome-has not yet been *** To assess the efficacy of WMT for CD and explore alterations in the microbiome and metabolome in response to *** We conducted a prospective,open-label,single-center clinical *** CD patients underwent *** clinical responses(defined as a decrease in their CD Activity Index score of>100 points)and their microbiome(metagenome,metatranscriptome)and metabolome profiles were evaluated three months after the *** Seven of the 11 patients(63.6%)showed an optimal clinical response three months *** microbiome diversity significantly increased after WMT,consistent with improved clinical *** of the metagenome and metatranscriptome analyses revealed consistent alterations in certain strains,such as Faecalibac-terium prausnitzii,Roseburia intestinalis,and Escherichia *** addition,metabolomics analyses demonstrated that CD patients had elevated levels of various amino acids before treatment compared to the ***,levels of vital amino acids that may be associated with disease progression(e.g.,L-glutamic acid,gamma-glutamyl-leucine,and prolyl-glutamine)were reduced after *** WMT demonstrated therapeutic efficacy in CD treatment,likely due to the effective reconstruction of the patient’s ***-omics techniques can effectively help decipher the potential mechanisms of WMT in treating CD.

关键词： Crohn’s disease Clinical trials Fecal microbiota transplant Metagenome Metatranscriptome Metabolome

Impacts of brood parasitism by shiny cowbird Molothrus bonariensis on the breeding success of a small host, the black-backed water tyrant Fluvicola albiventer

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Current Zoology 2024年第4期70卷 539-547页

作者： Lorena Vanesa Sovrano Evelina Jesica Leon Rodrigo Ezequiel Lorenzón Pamela Fernanda Olguin Adolfo Héctor Beltzer Alejandro raúl Giraudo Laboratorio de Biodiversidad y Conservacion de Tetrapodos Instituto Nacional de Limnologia(INALICONICET-UNL)Paraje El Pozo s/nSanta Fe(3000)Argentina Departamento de Biologia Universidad Autonoma de Entre RiosKm 10.5 RP 11Oro Verde(3100)Entre RiosArgentina Departamento de Biologia Universidad Nacional del LitoralFacultad de Humanidades y CienciasParaje Ei Pozo s/nSanta Fe(3000)Argentina

The shiny cowbird Molothrus bonariensis parasitizes many species with different life-history traits and has a detrimental effect on the survival of the progeny of the *** response,hosts have developed numerous antiparasitic ***,we examined the effects of brood parasitism by shiny cowbird on the clutch and brood sizes(83 nests)in a small host,the black-backed water tyrant Fluvicola *** also studied whether the death of parasite nestlings was related to the care of the foster parents and whether the host had any antiparasitic defense against the shiny *** results indicate that brood parasitism significantly decreased the host hatching and fledging *** majority of nest failures(57%)were caused by brood *** cowbird parasitism occurred in 52%of nests and the intensity of parasitism was 1.23±0.53 eggs per parasitized *** the total host eggs,54%were *** the incubation stage,20 nests(47%)were abandoned because of egg punctures by shiny cowbirds *** two parasitic fledglings were recorded,while the remaining nestlings either died from starvation(n=12)or predation(n=3).Foster parents abandoned parasitic nestlings between 5 and 10 days *** findings demonstrate that the shiny cowbird has very low rates of fledging success when parasitizing black-backed water ***,parasitism had a high reproductive cost in the black-backed water tyrant because a very low proportion(7%)of the parasitized nests(n=43)were successful.

关键词： brood parasitism host defenses nest desertion shiny cowbird small host.

Behavior of transporting pipeline sections without and with hydrogen exposure based on full-scale tests

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China Welding 2024年第3期33卷 14-24页

作者： Nóra Nagy János Lukács Institute of Materials Science and Technology Faculty of Mechanical Engineering and InformaticsUniversity of MiskolcMiskolc 3515Hungary

Pipeline transport of hydrogen is one of today’s economic and environmental *** order to find safe and reliable applic-ation of both existing gas and build new pipelines,it is essential to carry out tests on full-scale pipeline section,including the potentially more dangerous places than the main pipe,the girth *** the investigations,pipeline sections of P355NH steel with girth welds were prepared and exposed to pure hydrogen at twice the maximum allowable operating pressure for 41 ***,full-scale burst tests were carried out and specimens were cut and prepared from the typical locations of the failed pipeline sections for mechanical,and macro-and microstructural *** results obtained were evaluated and compared with data from previous full-scale tests on pipeline sections without hydrogen *** results showed differences in the behavior of pipeline sections loaded in different ways,with differ-ent characteristics of the materials and the welded joints,both in the cases without hydrogen exposure and in the cases exposed to hydrogen.

关键词： gas transporting pipeline full-scale pipeline test complex loading condition hydrogen exposure safety factor

Long-term outcomes of very low birth weight infants with intraventricular hemorrhage:a nationwide population study from 2011 to 2019

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World Journal of Pediatrics 2024年第7期20卷 692-700页

作者： Joonsik Park Sook-Hyun Park Yu-ra Kwon So Jin Yoon Joo Hee Lim Jung Ho Han Jeong Eun Shin Ho Seon Eun Min Soo Park Soon Min Lee Department of Pediatrics Yonsei University College of Medicine211 Eonjuro GangnamguSeoul 06273Republic of Korea

Background Advancements in neonatal care have increased preterm infant survival but paradoxically raised intraventricular hemorrhage(IVH)*** study explores IVH prevalence and long-term outcomes of very low birth weight(VLBW)infants in Korea over a *** Using Korean National Health Insurance data(NHIS,2010-2019),we identified 3372 VLBW infants with IVH among 4,129,808 live ***-related claims data,encompassing diagnostic codes,diagnostic test costs,and administered procedures were sourced from the NHIS *** results of the developmental assessments are categorized into four groups based on standard deviation(SD)*** characteristics and complications were compared among the *** regression models were employed to identify significant changes in the incidence of complications and to calculate odds ratios with corresponding 95%confidence intervals for each risk factor associated with mortality and morbidity in ***-term growth and development were compared between the two groups(years 2010-2013 and 2014-2017).Results IVH prevalence was 12%in VLBW and 16%in extremely low birth weight(ELBW)*** the past decade,IVH rates increased significantly in ELBW infants(P=0.0113),while mortality decreased(P=0.0225).Major improvements in certain neurodevelopmental outcomes and reductions in early morbidities have been observed among VLBW infants with *** percent of the population received surgical treatments such as external ventricular drainage(EVD)or a ventriculoperitoneal(VP)shunt,with the choice of treatment methods remaining consistent over *** IVH with surgical intervention group exhibited higher incidences of delayed development,cerebral palsy,seizure disorder,and growth failure(height,weight,and head circumference)up to 72 months of age(Ptal screening test *** The neurodevelopmental outcomes of infa

关键词： Cerebral intraventricular hemorrhage Developmental Hydrocephalus Mortality Posthemorrhagic ventricular dilatation Surgery

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社区环境与活动空间共享对社区归属感的影响

地理研究 2024年第9期43卷 2343-2353页

作者：塔娜孙翊豪华东师范大学地理科学学院上海200241 华东师范大学地理信息科学教育部重点实验室上海200241 自然资源部超大城市自然资源时空大数据分析应用重点实验室上海200241

社会转型与移动性背景下,个体与社区环境的互动方式不断重构,社区归属感的形成路径更加复杂。基于此,本文利用上海市居民活动与出行调查数据,建立公共接触潜力的广度、强度和跨群体接触指数测度居民的社区活动空间共享特征,运用有序logi... 详细信息

社会转型与移动性背景下,个体与社区环境的互动方式不断重构,社区归属感的形成路径更加复杂。基于此,本文利用上海市居民活动与出行调查数据,建立公共接触潜力的广度、强度和跨群体接触指数测度居民的社区活动空间共享特征,运用有序logit模型探究社区环境、活动空间共享对居民社区归属感的影响。研究发现:①公共接触潜力广度和跨收入群体公共接触潜力对社区归属感具有负向影响,跨户口群体公共接触潜力具有正向影响,公共接触潜力强度影响不显著。②社区外来人口比例较高有利于提升社区归属感,说明社区社会组成多样有利于提升对社区的情感依赖。③社区环境感知对社区归属感具有正向影响,商品房居民比其他社区居民更有可能表现出高社区归属感。④本地、中收入、已婚和拥有住房产权的居民更有可能对社区产生情感依赖,但日常活动远离社区的人更难建立起对社区的情感。本文提出通过活动空间共享深化移动性背景下社区促进社会融合的机制研究,丰富社区社会融合理论,为构建包容性城市和促进高质量发展提供参考。

关键词：行为地理学户口社会融合社区活动空间

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地铁可达性对生活满意度的影响研究进展

科技导报 2024年第3期42卷 44-52页

作者：塔娜王琦华东师范大学地理信息科学教育部重点实验室上海200241 华东师范大学地理科学学院上海200241 自然资源部超大城市自然资源时空大数据分析应用重点实验室上海200241

总结了地铁可达性的测度方法,梳理了地铁可达性对生活满意度影响的直接与间接效应,构建了地铁可达性对生活满意度影响的行为框架,以行为地理学与城市规划的相关理论为基础,从微观个体的视角出发,探讨地铁可达性、个体时空间行为、生活... 详细信息

总结了地铁可达性的测度方法,梳理了地铁可达性对生活满意度影响的直接与间接效应,构建了地铁可达性对生活满意度影响的行为框架,以行为地理学与城市规划的相关理论为基础,从微观个体的视角出发,探讨地铁可达性、个体时空间行为、生活满意度三者之间的关系。

关键词：地铁可达性时空间行为生活满意度行为地理学

环境何以媒介化?——基于阿拉善左旗荒漠化治理运动的田野考察

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新闻大学 2024年第4期 45-56,118页

作者：阿希塔复旦大学新闻学院上海200433

在深度媒介化社会场景下,环境在生态文明与国际气候双重议题加持下愈发媒介化。本研究以阿拉善左旗荒漠化治理运动为研究对象,探讨了中介过程对环境运动的影响。研究发现,以符号互动为表征的环境运动已经形成了众多深度媒介化情境与社... 详细信息

在深度媒介化社会场景下,环境在生态文明与国际气候双重议题加持下愈发媒介化。本研究以阿拉善左旗荒漠化治理运动为研究对象,探讨了中介过程对环境运动的影响。研究发现,以符号互动为表征的环境运动已经形成了众多深度媒介化情境与社会意义,在这些情境中,不同行动者组群、相关性框架与交往实践的组合所建构的传播互型形成了广泛的社会影响,不仅塑造了具有中心指向性的实践秩序,也创造了众多具有归属感的媒介化集体。

关键词：媒介化社会建构环境传播荒漠化治理

Determinants of Satisfaction at Work and Its Reflections on Performance

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Chinese Business Review 2024年第1期23卷 24-36页

作者： Giovani Luiz Garcia Costantini Everton Anger Cavalheiro Larissa Medianeira Bolzan Alejandro Martins Rodrigues Luíza Roloff Falck Federal University of Pelotas PelotasBrazil

This study examines the relationship between job satisfaction and performance,investigating personality traits and satisfaction aspects among employees of a Federal Higher Education Institution.A questionnaire was administered to 658 participants,using structural equation modeling for *** highlighted that challenging work,neuroticism,and self-esteem significantly influenced overall workplace satisfaction,while general satisfaction,self-efficacy,and lack of attention were key determinants of work *** emphasizes the importance for managers to prioritize factors enhancing employee satisfaction,as it positively correlates with job performance.

关键词： satisfaction at work work performance personality traits facets of job satisfaction Federal Higher Education Institution

Improving the radiological diagnosis of hepatic artery thrombosis after liver transplantation: Current approaches and future challenges

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World Journal of Transplantation 2024年第1期14卷 1-8页

作者： Cristian Lindner raúl Riquelme Rodrigo San Martín Frank Quezada Jorge Valenzuela Juan P Maureira Martín Einersen Department of radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile Department of radiology Hospital Clínico Regional Guillermo Grant BenaventeConcepción 4030000Chile Department of Statistics Catholic University of MauleTalca 3460000Chile Neurovascular Unit Department of RadiologyHospital Clínico Regional Guillermo Grant BenaventeConcepción 4030000Chile

Hepatic artery thrombosis(HAT)is a devastating vascular complication following liver transplantation,requiring prompt diagnosis and rapid revascularization treatment to prevent graft *** present,imaging modalities such as ultrasound,computed tomography,and magnetic resonance play crucial roles in diagnosing *** imaging techniques have improved sensitivity and specificity for HAT diagnosis,they have limitations that hinder the timely diagnosis of this *** this sense,the emergence of artificial intelligence(AI)presents a transformative opportunity to address these diagnostic *** development of machine learning algorithms and deep neural networks has demonstrated the potential to enhance the precision diagnosis of liver transplant complications,enabling quicker and more accurate detection of *** article examines the current landscape of imaging diagnostic techniques for HAT and explores the emerging role of AI in addressing future challenges in the diagnosis of HAT after liver transplant.

关键词： Liver transplantation Postoperative complications Hepatic artery Thrombosis radiology Artificial intelligence