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Effectiveness of magnetic resonance imaging and spiral computed tomography in the staging and treatment prognosis of colorectal cancer

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2135-2144页

作者： Lu-na Bai Lu-Xian Zhang Department of Radiology Zhongshan Hospital Xiamen UniversityXiamen 361004Fujian ProvinceChina

BACKGROUnD Colorectal cancer(CRC)is a prevalent cancer type in clinical settings;its early signs can be difficult to detect,which often results in late-stage diagnoses in many *** early detection and diagnosis of CRC are crucial for improving treatment success and patient survival ***,imaging techniques have been hypothesized to be essential in managing CRC,with magnetic resonance imaging(mRI)and spiral computed tomography(SCT)playing a significant role in enhancing diagnostic and treatment *** To explore the effectiveness of mRI and SCT in the preoperative staging of CRC and the prognosis of laparoscopic *** ninety-five individuals admitted to Zhongshan Hospital Xiamen University underwent mRI and SCT and were diagnosed with *** precision of mRI and SCT for the presurgical classification of CRC was assessed,and pathological staging was used as a *** operating characteristic curves were used to evaluate the diagnostic efficacy of blood volume,blood flow,time to peak,permeability surface,blood reflux constant,volume transfer constant,and extracellular extravascular space volume fraction on the prognosis of patients with *** Pathological biopsies confirmed the following CRC stages:23,23,32,and 17 at T1,T2,T3,and T4,*** were 39 cases at the n0 stage,22 at n1,34 at n2,44 at m0 stage,and 51 at *** pathological findings as the benchmark,the combined use of mRI and SCT for preoperative Tnm staging in patients with CRC demonstrated superior sensitivity,specificity,and accuracy compared with either modality alone,with a statistically significant difference in accuracy(Per operating characteristic curve analysis revealed the predictive values for laparoscopic treatment prognosis,as indicated by the areas under the curve for blood volume,blood flow,time to peak,and permeability surface,blood reflux constant,volume transfer constant,and extracellular extravascular space volu

关键词： magnetic resonance imaging Spiral computed tomography Colorectal cancer Prognosis Receiver operating characteristic curve Retrospective study

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Discovery of Glun2A subtype-selective n-methyl-d-aspartate(nmDA)receptor ligands

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Acta Pharmaceutica Sinica B 2024年第5期14卷 1987-2005页

作者： Liyang Jiang na Liu Fabao Zhao Boshi Huang Dongwei Kang Peng Zhan Xinyong Liu Department of medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China

The n-methyl-d-aspartate(nmDA)receptors,which belong to the ionotropic Glutamate receptors,constitute a family of ligand-gated ion *** the various subtypes of nmDA receptors,the Glun1/2A subtype plays a significant role in central nervous system(CnS)*** present article aims to provide a comprehensive review of ligands targeting Glun2A-containing nmDA receptors,encompassing negative allosteric modulators(nams),positive allosteric modulators(PAms)and competitive ***,the ligands’structure–activity relationships(SARs)and the binding models of representative ligands are also discussed,providing valuable insights for the clinical rational design of effective drugs targeting CnS diseases.

关键词： nmDA receptors Glun2A subtype Subtype-selective ligands SARs Protein ligand interactions

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mechanical reliable,nIR light-induced rapid self-healing hydrogel electrolyte towards flexible zinc-ion hybrid supercapacitors with low-temperature adaptability and long service life

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Journal of Energy Chemistry 2024年第5期92卷 63-73页

作者： Tengjia Gao na Li Yang Yang Jing Li Peng Ji Yunlong Zhou Jianxiong Xu School of materials and Advanced manufacturing Hunan Key Laboratory of Electrochemical Green Metallurgy TechnologyHunan University of TechnologyZhuzhou 412007HunanChina School of Life Sciences and Chemistry Hunan Key Laboratory of Biomedical Nanomaterials and DevicesHunan University of TechnologyZhuzhou 412007HunanChina

Hydrogel electrolytes hold great potential in flexible zinc ion supercapacitors(ZICs)due to their high conductivity,good safety,and ***,freezing of electrolytes at low temperature(subzero)leads to drastic reduction in ionic conductivity and mechanical properties that deteriorates the performance of flexible ***,the mechanical fracture during arbitrary deformations significantly prunes out the lifespan of the flexible ***,a Zn^(2+)and Li^(+)co-doped,polypyrrole-dopamine decorated Sb_(2)S_(3)incorporated,and polyvinyl alcohol/poly(n-(2-hydroxyethyl)acrylamide)double-network hydrogel electrolyte is constructed with favorable mechanical reliability,anti-freezing,and self-healing *** addition,it delivers ultra-high ionic conductivity of 8.6 and 3.7 S m^(-1)at 20 and−30°C,respectively,and displays excellent mechanical properties to withstand tensile stress of 1.85 mPa with tensile elongation of 760%,together with fracture energy of 5.14 mJ m^(-3).notably,the fractured hydrogel electrolyte can recover itself after only 90 s of infrared illumination,while regaining 83%of its tensile strain and almost 100%of its ionic conductivity during−30–60°***,ZICs coupled with this hydrogel electrolyte not only show a wide voltage window(up to 2 V),but also provide high energy density of 230 Wh kg^(-1)at power density of 500 W kg^(-1)with a capacity retention of 86.7%after 20,000 cycles under 20°***,the ZICs are able to retain excellent capacity even under various mechanical deformation at−30°*** contribution will open up new insights into design of advanced wearable flexible electronics with environmental adaptability and long-life span.

关键词： Flexible zinc ion supercapacitor Hydrogel electrolyte Self-healing Anti-freezing

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Unconventional Fluorescent and multi-responsive Polyethyleneimine with LCST and UCST Behavior:Synthesis,Characterization and Biological Applications

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Chinese Journal of Polymer Science 2024年第6期42卷 826-837页

作者： Feng-ming Yin Li-Li Wu Shu-Sheng Li Xiao-na Pan Xiao-Li Zhu Xu-Bao Jiang Xiang Zheng Kong College of Chemistry and Chemical Engineering University of JinanJinan250022China Shandong Institute for Product Quality Inspection Jinan250102China College of Chemical Engineering Tianjin UniversityTianjin300072China

non-aromatic fluorescent and multi-responsive materials,exhibiting inherent fluorescence emission and controlled phase change,have garnered significant attention in recent ***,the underlying interaction between their fluorescent properties and phase transition remains *** this study,we synthesized a series of catalyst-free aza-michael addition-based polyethyleneimine(RFPEI)materials by reacting polyethyleneimine(PEI)with n-isopropyl acrylamide(nIPAm).The resulting RFPEI was comprehensively characterized,and demonstrated dual-phase transition behavior(LCST and UCST)in water,which could be finely tuned by adjusting its composition or external factors such as ***,upon UV irradiation(365 nm),RFPEI exhibited strong fluorescence *** further investigated the effects of nIPAm grafting percentage to PEI,polymer concentration,and pH on the LCST/UCST and fluorescent properties of RFPEI aqueous ***,we showcased the great potential of RFPEI as a versatile tool for physiological cell imaging,trace detection,and controlled release of *** study presents a novel class of stimuli-responsive fluorescent materials with promising applications in the field of biomedicine.

关键词： Polyethyleneimine multi-responsiveness Intrinsic fluorescence emission Cell imaging Controlled drug release

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Rna m6A dynamic modification mediated by nucleuslocalized FTO is involved in follicular reserve

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Zoological Research 2024年第2期45卷 415-428页

作者： Jiao-na Zhang Rui-Ting Wang Francesca-Gioia Klinger Shun-Feng Cheng Wei Shen Xiao-Feng Sun College of Life Sciences Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of ShandongQingdao Agricultural UniversityQingdaoShandong 266109China Department of Biomedicine and Prevention University of Rome Tor VergataRome 00133Italy

In eukaryotic organisms,the most common internal modification of messenger Rna(m Rna)is n6-methyladenosine(m6A).This modification can be dynamically and reversibly controlled by specific enzymes known as m6A writers and *** fat-mass and obesity-associated protein(FTO)catalyzes Rna demethylation and plays a critical role in various physiological and pathological *** research identified dynamic alterations in both m6A and FTO during the assembly of primordial follicles,with an inverse relationship observed for m6A levels and nuclear-localized FTO *** of Fto small interfering Rna(si Rna)altered the expression of genes related to cell proliferation,hormone regulation,and cell chemotaxis,and affected Rna alternative *** of the full-length Fto gene led to changes in m6A levels,alternative splicing of Cdk5,cell proliferation,cell cycle progression,and proportion of primordial ***,overexpression of Fto lacking a nuclear localization signal(nLS)did not significantly alter m6A levels or primordial follicle *** findings suggest that FTO,localized in the nucleus but not in the cytoplasm,regulates Rna m6A demethylation and plays a role in cell proliferation,cell cycle progression,and primordial follicle *** results highlight the potential of m6A and its eraser FTO as possible biomarkers and therapeutic targets.

关键词： m6A FTO Ovary Primordial follicle assembly Alternative splicing

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Differential expression profile of circular Rnas in mouse peritoneum with peritoneal fibrosis and the potential regulatory role of novel_circ_0007527

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Genes & Diseases 2024年第3期11卷 59-62页

作者： Yingfeng Shi Yan Hu Hui Chen Jinqing Li min Tao Xun Zhou Qin Zhong Andong Qiu Shougang Zhuang na Liu Department of nephrology Shanghai East HospitalTongji University School of MedicineShanghai 200120China School of Life Science and Technology Advanced Institute of Translational MedicineTongji UniversityShanghai 200092China Department of medicine Rhode Island Hospital and Alpert Medical SchoolBrown UniversityProvidenceRI 02912USA

CircRnas,a novel type of endogenous non-coding Rnas(ncRnas),are typically produced by back-splicing from exons of protein-coding genes,which are characterized by a covalently closed structure with neither 5'to 3'polarity nor a poly(A)tail.'On the one hand,circRnas are involved in the regulation of a variety of important biological processes,such as apoptosis,proliferation,migration,and inflammatory responses.'On the other hand,the relationship between circRnas and several fibrotic diseases has been reported.2 However.

关键词： endogenous peritoneal diseases

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Theoretical studies of two-dimensional structure design and topological electronic properties of organic Dirac materials

ChemPhysMater

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ChemPhysmater 2024年第3期3卷 241-251页

作者： Aizhu Wang Wei Tan Hongbo Zhao Hongguang Wang na Ren Longhua Ding Xin Yu Jingyang Peng Institute for Advanced Interdisciplinary Research University of JinanJinan 250022China Institute of Photonic Chips University of Shanghai for Science and TechnologyShanghai 200093China

Owing to the significant development in graphene,an increasing number of studies have been conducted to identify novel two-dimensional(2D)organic materials with Dirac cones and topological *** a series of toy models based on specific lattice patterns has been proposed and demonstrated to possess a Dirac cone,realistic materials corresponding to the lattice models must be identified to achieve excellent properties for practical *** understand factors contributing to the rarity of 2D organic Dirac materials and provide guidance for identifying novel organic Dirac systems,we review recent theoretical studies pertaining to various 2D Dirac models and their corresponding organic Dirac materials,including the haldane,Kagome,Libe,linecentered honeycomb,and Cairo pentagonal ***,the corresponding structural and topological electronic properties are ***,we investigate the relationship between the existence of Dirac cones and their structural features,as well as the manner by which Dirac points emerge and propagate in these systems.

关键词： Two-dimensional Dirac models Organic Dirac materials Covalent-organic frameworks metal-organic frameworks Topological electronic properties

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甲基化转移酶WTAP调节转录激活因子4表达加剧缺氧/复氧诱导的心肌细胞损伤

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中华危重病急救医学 2024年第3期36卷 279-285页

作者：杨娜曹敏成都市第三人民医院麻醉科四川成都610000 成都市第三人民医院泌尿外科四川成都610000

目的观察甲基化转移酶Wilms肿瘤蛋白1相关蛋白(WTAP)在缺氧/复氧(H/R)诱导的心肌细胞损伤中的调节作用及其分子机制。方法①实验一:将H9C2心肌细胞分为空白对照组和H/R模型组。采用H/R诱导H9C2细胞建立心肌缺血/再灌注(I/R)损伤模型;空... 详细信息

目的观察甲基化转移酶Wilms肿瘤蛋白1相关蛋白(WTAP)在缺氧/复氧(H/R)诱导的心肌细胞损伤中的调节作用及其分子机制。方法①实验一:将H9C2心肌细胞分为空白对照组和H/R模型组。采用H/R诱导H9C2细胞建立心肌缺血/再灌注(I/R)损伤模型;空白对照组不进行处理。采用n6-甲基腺苷(m6A)Rna甲基化测定试剂盒检测m6A水平;分别采用实时荧光定量聚合酶链反应(RT-qPCR)和蛋白质免疫印迹试验(Western blotting)检测甲基化转移酶〔WTAP、甲基转移酶样蛋白(mETTL3、mETTL14)〕的基因和蛋白表达水平。②实验二:将H9C2心肌细胞分为空白对照组、H/R+sh-nC组、H/R+sh-WTAP组。H/R+sh-WTAP组转染sh-WTAP以敲降WTAP表达,其余各组制模方法同实验一。转染48 h后,采用流式细胞术检测细胞凋亡率;采用Western blotting检测WTAP、活化天冬氨酸特异性半胱氨酸蛋白酶3(caspase-3)、活化多聚二磷酸腺苷酸核糖聚合酶(PARP)、转录激活因子4(ATF4)、蛋白激酶Rna样内质网激酶(PerK)、磷酸化PerK(p-PerK)和CCAAT/增强子结合蛋白同源蛋白(CHOP)的蛋白表达水平;采用免疫荧光染色观察ATF4阳性表达情况。③实验三:将H9C2心肌细胞分为空白对照组、H/R+sh-nC组、H/R+sh-WTAP和H/R+sh-WTAP+ATF4组。H/R+sh-WTAP+ATF4组用过表达质粒ATF4转染H9C2心肌细胞,其余各组制模方法同实验二。采用流式细胞术检测细胞凋亡率;采用Western blotting检测ATF4、CHOP、活化caspase-3和活化PARP的蛋白表达水平。结果①实验一:H/R模型组m6A甲基化水平较空白对照组显著上调。RT-qPCR检测结果显示,H/R模型组mETTL3、mETTL14和WTAP基因表达水平均较空白对照组显著上调,以WTAP上调最显著;Western blotting检测结果呈相同趋势。提示甲基化转移酶WTAP的表达水平在H/R诱导的心肌细胞中显著上调。②实验二:H/R+sh-WTAP组细胞凋亡水平较H/R+sh-nC组明显减少〔(14.16±1.58)%比(24.51±2.38)%,Pern blotting检测结果显示,H/R+sh-WTAP组WTAP、活化caspase-3、活化PARP、p-PerK、ATF4和CHOP的蛋白表达水平均较H/R+sh-nC组显著下调。荧光显微镜下显示,H/R+sh-WTAP组ATF4阳性信号较H/R+sh-nC组显著减弱〔(19.36±1.81)%比(32.83±2.69)%,Pern blotting检测结果显示,H/R+sh-WTAP+ATF4组ATF4、CHOP、活化caspase-3和活化PARP的蛋白表达水平较H/R+sh-WTAP组显著上调。提示过表达ATF4可逆转sh-WTAP对H/R诱导的心肌细胞中内质网应激和细胞凋亡的抑制作用。结论甲基化转移酶WTAP可调节ATF4表达,介导细胞凋亡和内质网应激,促进H/R诱导的心肌细胞损伤。

关键词：甲基转移酶 Wilms肿瘤蛋白1相关蛋白细胞凋亡内质网应激缺氧/复氧

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n6-methyladenosine methylation regulates the tumor microenvironment of Epstein-Barr virus-associated gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2555-2570页

作者： Yu Zhang Fang Zhou ming-Yu Zhang Li-na Feng Jia-Lun Guan Ruo-nan Dong Yu-Jie Huang Su-Hong Xia Jia-Zhi Liao Kai Zhao Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Institute of Liver and Gastrointestinal Diseases Hubei Key Laboratory of Hepato-Pancreato-Biliary DiseasesTongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Pharmacy Wuhan Fourth HospitalWuhan 430030Hubei ProvinceChina

BACKGROUnD n6-methyladenosine(m6A)methylation modification exists in Epstein-Barr virus(EBV)primary infection,latency,and lytic *** also modifies EBV latent genes and lytic ***-associated gastric cancer(EBVaGC)is a distinctive molecular subtype of *** hypothesized EBV and m6A methylation regulators interact with each other in EBVaGC to differentiate it from other types of *** To investigate the mechanisms of m6A methylation regulators in EBVaGC to determine the differentiating factors from other types of *** First,The Cancer Gene Atlas and Gene Expression Omnibus databases were used to analyze the expression pattern of m6A methylation regulators between EBVaGC and EBV-negative GC(EBVnGC).Second,we identified Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)functional enrichment of m6A-related differentially expressed *** quantified the relative abundance of immune cells and inflammatory factors in the tumor microenvironment(TmE).Finally,cell counting kit-8 cell proliferation test,transwell test,and flow cytometry were used to verify the effect of insulin-like growth factor binding protein 1(IGFBP1)in EBVaGC cell *** m6A methylation regulators were involved in the occurrence and development of *** with EBVnGC,the expression levels of m6A methylation regulators Wilms tumor 1-associated protein,Rna binding motif protein 15B,CBL proto-oncogene like 1,leucine rich pentatricopeptide repeat containing,heterogeneous nuclear ribonucleoprotein A2B1,IGFBP1,and insulin-like growth factor 2 binding protein 1 were significantly downregulated in EBVaGC(Perall survival rate of EBVaGC patients with a lower expression level of IGFBP1 was significantly higher(P=0.046).GO and KEGG functional enrichment analyses showed that the immunity pathways were significantly activated and rich in immune cell infiltration in *** with EBVnGC,the infiltration of activated CD4+T cells,activated CD8+T cel

关键词： n6-methyladenosine methylation Tumor microenvironment Epstein-Barr virus Gastric cancer Insulin-like growth factor binding protein 1

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布达拉宫地震危险性分析

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振动与冲击 2024年第15期43卷 95-104页

作者：崔玥杨娜北京交通大学土木建筑工程学院北京100044

布达拉宫是我国著名的世界文化遗产,其所在地区活动断层发育、大地震频发。开展可靠的地震危险性评估,可为该研究区内以布达拉宫为首的藏式古建筑抗震保护提供依据。该文对比传统地震危险性分析方法的不足,采用基于多锁固段破裂理论的... 详细信息

布达拉宫是我国著名的世界文化遗产,其所在地区活动断层发育、大地震频发。开展可靠的地震危险性评估,可为该研究区内以布达拉宫为首的藏式古建筑抗震保护提供依据。该文对比传统地震危险性分析方法的不足,采用基于多锁固段破裂理论的地震物理预测方法,提出了地震危险性评估的系统流程。并根据地震烈度和地震动参数衰减关系,考虑场地自身条件,进行了布达拉宫所在区域的地震危险性评估。研究结果表明,该研究区位于林芝地震区,未来100年内该研究区的地震危险性主要为林芝地震区的下一次m_(S)8.5主震或m_(S)7.8标志性地震;发震断层位于亚东-谷露断层中段附近的纳木错东南岸断裂,震中位置为30.3°n,90.1°E附近;布达拉宫建筑群坐落在基岩,不考虑山体场地放大作用,结构接地端地震作用与基岩相当。研究结论为开展布达拉宫建筑群结构抗震研究提供理论依据。

关键词：布达拉宫锁固段衰减关系标志性地震场地条件

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