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immunogenicity, Sa.ety a.d Effica.y Compa.ison of Wockha.dt’s Biosimila. insulin Gla.gine—Gla.itus®with Reference Product— La.tus®: Study Protocol &a.p;Ea.ly Da.a.Trends

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Open Journa. of Endocrine a.d Meta.olic Disea.es 2018年第8期8卷 157-166页

作者： S. K. Sha.ma.a. K. a.ma.i P. Khosla.P. Mukhopa.hya. G. Bha.ia.K. G. Pra.a.h G. Chha.a.P. D. Supe V. Pa.ithra. H. Bora.R. Ja.n S. ingole a. Sha. Dia.etes Thyroid and Endocrine Centre Jaipur India BL Ka.oor Hospita. Delhi India Sir Ga.ga.Ra. Hospita. Delhi India institute of Post Gra.ua.e Medica. Educa.ion a.d Resea.ch Kolkata India Medipoint Hospita.s Pvt. Ltd. Pune India Ba.ga.ore Medica. College a.d Resea.ch institute Bangalore India Sa.jiva.i Supers Pecia.ity Hospita. Ahmedabad India Supe Hea.t a.d Dia.etes Hospita. a.d Resea.ch Centre Nashik India KVM Hospita. Kerala India Downtown Hospita. Guwahati India Wockha.dt Ltd. Mumbai India

Objective: Present Pha.e iV Tria. is a.med a. eva.ua.ing the immunogenicity, sa.ety, a.d effica.y of Wockha.dt’s insulin gla.gine, Gla.itus®in compa.ison with reference insulin gla.gine, La.tus®in subjects with type 2 dia.etes mellitus (T2DM), ina.equa.ely controlled on ora. hypoglyca.mics. Setting: a.hea.-to-hea., prospective, open-la.el, pa.a.lel group, ra.domized, Pha.e iV, non-inferiority study over 6 months trea.ment conducted in 10 centres in india. Pa.ticipa.ts: Considering 20% drop-out ra.e, 180 subjects of either sex, a.e 18 - 55 yea.s, dia.nosed with T2DM with body ma.s index (BMi) 18 - 38 kg/m2 a.d hba1c levels 8.0% - 10.0% ina.equa.ely controlled by 1 or more ora. hypoglyca.mics a.d a.cording to investiga.or needed gla.gine trea.ment were enrolled in the study. interventions: Subjects self-a.ministered insulin gla.gine (Gla.itus®or La.tus®) subcuta.eously once da.ly for 6 months. Trea.ment in Gla.itus®a.m wa. continued till 12 months. Percenta.e cha.ge in a.ti-insulin a.tibody (a.a. titre a.d hba1C wa. a.certa.ned a. every 3 months interva.. The tests were performed a. a.credited centra. la.ora.ory. Trea.-to-ta.get dose titra.ion: Sta.ting doses of Gla.itus®a.d La.tus®wa. 10 units (or 0.2 units/kg) once da.ly. The ta.get fa.ting blood glucose wa. 70 to 130 mg/dL. Da.ly gla.gine dose wa. titra.ed by ±10% ba.ed on a.era.e of la.t 3 FBG va.ues being out of ta.get ra.ge a.d presence of nocturna. hypoglycemia. Ea.ly da.a.trends: First interim a.a.ysis wa. pla.ned once 100 subjects complete visit 8 (6 months trea.ment). By then, 119 subjects (78 ma.es a.d 41 fema.es) with mea. a.e 46.3 yea.s were enrolled, of which 90 (75.6%) subjects ha. eva.ua.le da.a. The results of a.a.ysis indica.ed trend of compa.a.ility between Gla.itus®a.d La.tus®a. the end of 6 months in terms of immunogenicity (% cha.ge in a.a.titre from ba.eline, −10.52 ± 23.06 vs. 0.48 ± 63.95), glycemic control (cha.ge in hba1c from ba.eline, −1.09%

关键词： insulin a.tibodies immunogenicity insulin Gla.gine Biosimila. hba1c

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From insulin detemir to gla.gine: Effect on glycemic control a.d psychologica. wellbeing in pa.ients with dia.etes mellitus type 2 in da.ly pra.tice

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Journa. of Dia.etes Mellitus 2012年第1期2卷 101-108页

作者： Thiemo F. Venema. Fred E. M. G. Storms ingo a. Ela.d Pa.l K. P. Bouter Depa.tment of interna. Medicine Ziekenhuisgroep Twente Almelo Netherlands

The success of a.specific trea.ment is tra.itiona.ly judged a.cording to pa.a.eters such a. hba1c. However, other, pa.ient-reported outcomes (PRO) of (insulin) thera.y, become increa.ingly more importa.t. The introduction of (ba.a.) insulin-a.a.ogues could possibly improve PRO, pa.ticula.ly “qua.ity of life”. Direct compa.a.ive studies between once da.ly insulin gla.gine a.d once to twice or twice da.ly insulin detemir ha.e previously shown differences in insulin dosa.e, dosing frequency a.d weight ga.n. Whether this lea.s to a.difference in qua.ity of life in pa.ients who a.e tra.sferred from insulin detemir to insulin gla.gine rema.ns to be determined. To esta.lish the effect of insulin gla.gine on qua.ity of life a.d pa.ient sa.isfa.tion in pa.ients with DM2 who a.e in poor meta.olic control with a.(huma.) ba.a. insulin, a.la.ge prospective, observa.iona. study in Dutch da.ly pra.tice wa. performed. The results of the pa.ient popula.ion switched from NPH-insulin to insulin gla.gine ha.e been published previously. in this a.ticle the results of the group of pa.ients trea.ed with insulin detemir before the observa.ion period a.e described. The results of this observa.iona. study show tha. cha.ging ba.a. insulin thera.y to insulin gla.gine in pa.ients with DM2 who a.e in poor glycemic control with insulin detemir lea.s to a.clinica.ly significa.t improvement of glycemic control a. well a. emotiona. wellbeing, despite a.sma.l increa.e in weight. Whether other fa.tors such a. decrea.ed dosing frequency pla. a.role rema.ns to be determined by future studies.

关键词： insulin Gla.gine insulin Detemir Psychologica. Wellbeing Meta.olic Control Type 2 Dia.etes

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血清25羟基维生素D与初诊2型糖尿病患者血糖控制及酮症酸中毒的关系

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中华实用诊断与治疗杂志 2018年第5期32卷 480-482页

作者：刘冰洪旭首都医科大学附属北京友谊医院内分泌科北京100050

目的探讨初诊2型糖尿病(type 2dia.etes mellitus,T2DM)患者血清25羟基维生素D[25-hydroxy vita.in D,25(OH)D]水平与血糖控制及酮症酸中毒的关系。方法 140例初诊T2DM患者为T2DM组,同期130例体检健康者为对照组,检测2组血清总胆固醇(to... 详细信息

目的探讨初诊2型糖尿病(type 2dia.etes mellitus,T2DM)患者血清25羟基维生素D[25-hydroxy vita.in D,25(OH)D]水平与血糖控制及酮症酸中毒的关系。方法 140例初诊T2DM患者为T2DM组,同期130例体检健康者为对照组,检测2组血清总胆固醇(tota. cholesterol,TC)、三酰甘油(tria.ylglycerol,TG)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、糖化血红蛋白(hemoglobin a.c,hba1c)、25(OH)D水平,Pea.son法分析初诊T2DM患者血清25(OH)D与TC、TG、HDL-C、LDL-C、hba1c的相关性;将T2DM患者依据hba1c水平分为a.(hba1c≥9%)75例和B组(hba1ca.B组血清25(OH)D水平;选取同期住院10例酮症酸中毒起病T2DM患者(酮症酸中毒组),再按照配对方法从140例T2DM患者中选取10例非酮症酸中毒起病患者(非酮症酸中毒组),比较2组血清hba1c、25(OH)D水平。结果 T2DM组血清TG[(2.43±1.35)mmol/L]、LDL-C[(2.88±0.68)mmol/L]、hba1c[(9.24±1.91)%]水平均高于对照组[(1.19±0.63)mmol/L、(2.41±0.54)mmol/L、(5.31±1.51)%],25(OH)D水平[(11.51±3.12)μg/L]低于对照组[(19.03±4.96)μg/L](P0.05);T2DM组血清25(OH)D水平与BMi、hba1c呈负相关(r=-0.213,P=0.042;r=-0.405,P=0.005),与HDL-C呈正相关(r=0.229,P=0.039),与LDL-C、TG无明显线性相关(r=-0.152,P=0.078;r=-0.135,P=0.729);a.血清25(OH)D水平[(10.44±3.63)μg/L]低于B组[(12.97±3.53)μg/L](Phba1c[(11.71±2.12)%]与非酮症酸中毒组[(11.62±1.96)%]比较差异无统计学意义(P>0.05)。结论初诊T2DM患者血清25(OH)D水平降低与血糖控制有关,且酮症酸中毒T2DM患者血清25(OH)D水平相对较低。

关键词： 2型糖尿病 25羟基维生素D 糖化血红蛋白酮症酸中毒体质量指数

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津力达颗粒治疗2型糖尿病的疗效与安全性评价

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中国医院用药评价与分析 2013年第7期13卷 591-594页

作者：李井彬王定坤陆付耳柳丛华中科技大学同济医学院附属同济医院中西医结合研究所武汉430030 河北医科大学附属以岭医院石家庄050091

目的:通过文献荟萃分析,评价津力达颗粒治疗2型糖尿病的疗效与安全性。方法:利用文献检索法检索相关文献,采用RevMa. 4.2进行Meta.析,比较治疗组和对照组治疗前后的空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(hba1c)及不良反应... 详细信息

目的:通过文献荟萃分析,评价津力达颗粒治疗2型糖尿病的疗效与安全性。方法:利用文献检索法检索相关文献,采用RevMa. 4.2进行Meta.析,比较治疗组和对照组治疗前后的空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(hba1c)及不良反应等指标。结果:治疗前,治疗组的FPG、2hPG、hba1c与对照组比较无统计学差异(P>0.05);治疗后,治疗组的FPG、2hPG、hba1c明显低于对照组(P<0.01);未发现治疗组存在严重不良反应。结论:津力达颗粒联合西药治疗2型糖尿病临床疗效显著,未发现严重不良反应,安全性较好,值得临床推广使用。

关键词：津力达颗粒 2型糖尿病疗效安全性不良反应

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Da.ly Lifestyle Ha.its a. Risk Fa.tors for Pla.ue-induced Gingivitis a.d Periodontitis Severity a.d Gra.ing a.ong Sa.ples of Denta. Students a. King Kha.id University

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interna.iona. Journa. of Clinica. Medicine 2023年第2期14卷 65-78页

作者： Moha.med M. a. a.dulla. a.-a.da.y a.er Ha.sa. a.a.ma.i Fera. a.i a.sa.ed a.i a.dulla. a.i a.qhta.i Fa.a. Ha.sa. a.hifthi Ya.ir Sa.d Ja.da. Periodontics a.d Community Denta. Sciences College of Dentistry King Khalid University Abha Saudi Arabia College of Dentistry King Khalid University Abha Saudi Arabia

Objective: To a.sess da.ly lifestyle ha.its a. risk fa.tors for pla.ue-induced gingivitis a.d periodontitis severity a.d gra.ing a.ong sa.ples of denta. students a. King Kha.id University. Ma.eria. a.d Methods: This study included 150 ma.e pa.ticipa.ts. They were divided a.cording to the levels into three equa. groups: levels 5, 6, a.d 7 (group i), levels 8, 9, 10 (group ii) a.d levels 11, 12, a.d interns (group iii). This study consisted of questions rela.ed to a.e, gender, educa.iona. level, fa.her’s educa.ion, mother’s educa.ion, home ownership, brushing teeth more tha. or twice a.da., in a.dition to da.ly lifestyle ha.its tha. were da.ly smoking, da.ly use of suga.y drinks, a.d da.ly use of suga.y foods. Some clinica. pa.a.eters of pla.ue-induced gingivitis a.d periodontitis a.d the percenta.e of ra.iogra.hic bone loss were recorded. a.l da.a.were collected a.d a.a.yzed using Tukey’s test a.d Chi-squa.e test. a.P-va.ue of less tha. 0.5 (p Results: One hundred fifty ma.e denta. students of different levels in the college of dentistry a. King Kha.id University pa.ticipa.ed in the study in three groups (i, ii, a.d iii). The mea. a.e of group iii is more tha. tha. of group ii a.d group i, with highly sta.istica.ly significa.t differences (p 30%) were more a.ong the pa.ticipa.ts in group i tha. the pa.ticipa.ts in groups iii a.d ii. There wa. a. increa.e in the percenta.e of a.fected pa.ticipa.ts with sta.es iii a.d iV of clinica. a.ta.hment loss (Ca.), periodonta. pocket depth (PPD), ra.iogra.hic bone loss (%RBL), tooth mobility, a. well a. glyca.ed hemoglobin (hba1c) test va.ues (>7%), a.d the number of ciga.ettes smoked per da. (>10 cigs) in group iii more tha. in group ii a.d i. Conclusion: We conclude tha. the severity a.d gra.ing of pla.ue-induced gingivitis were higher a.ong the pa.ticipa.ts in group i, while the severity a.d gra.ing of periodontitis were higher a.ong the pa.ticipa.ts in group iii due to the different impa.t of their da.ly lifestyle ha.its.

关键词： Da.ly Lifestyle Denta. Students King Kha.id University Periodontitis Pla.ue-induced Gingivitis

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糖尿病人群中干眼症研究

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世界核心医学期刊文摘（眼科学分册） 2005年第8期1卷 26-27页

作者： Ka.serma. i. Ka.serma. N. Na.a. S. Vinker S. 张鹏 Depa.tment of Ophtha.mology Hadassah University Hospital P.O.B. 12000 IL-91120 Jerusalem Israel Dr.

PURPOSE: To compa.e the preva.ence of kera.oconjunctivitis sicca.(KCS) in a.pr ospective cohort of 22,382 dia.etic pa.ients with tha. in the genera. popula.ion . DESiGN: Prospective, observa.iona., cohort study. METHODS: setting: a.district of isra.l’s la.gest hea.th ma.ntena.ce orga.ization. study popula.ion: We foll owed the electronic medica. records of a.l pa.ients in the district older tha. 5 0 yea.s (159,634 pa.ients)between Ja.ua.y 1 a.d December 31, 2003. Of those, 22, 382 (14.0%) ha. dia.etes. observa.ion procedure: The proportion of ocula. lubri ca.ion consumers wa. compa.ed a.ong dia.etic a.d nondia.etic pa.ients. a.l hba1c la.ora.ory tests performed by the dia.etic pa.ients were documented (41,910 tes ts), a.d glycemic control wa. correla.ed with the consumption of ocula. lubrica. ion. ma.n outcome mea.ures: Ocula. lubrica.ion use by dia.etic pa.ients compa.ed with the genera. popula.ion a.d the rela.ionship between glycemic control a.d o cula. lubrica.ion use. RESULTS: a.ter a.e a.d gender a.justment, a.significa.tly higher percenta.e of dia.etic pa.ients (20.6%) received ocula. lubrica.ion, co mpa.ed with nondia.etic pa.ients (13.8%, Pifference wa. significa.nt for a.l a.e groups a.d for both sexes (Pa.simila. significa.t differ ence wa. prominent between dia.etic a.d nondia.etic pa.ients a.ed 60 to 89 yea.s who were frequent users of ocula. lubrica.ion. Ocula. lubrica.ion consumption i ncrea.ed with poorer glycemic control (mea. a.nua. hba1c levels). Multiva.ia.e a.na.ysis revea.ed this effect to be independent of a.e, sex, pla.e of birth, or p la.e of residence. CONCLUSiONS: KCS is significa.tly more common a.ong dia.etic pa.ients. Poor glycemic control correla.es with increa.ed a.tificia. tea. use in dia.etic pa.ients.

关键词：糖尿病人群干燥性角结膜炎血糖控制情况人工泪液前瞻性队列研究电子病例医疗保健机构观察性研究机构年龄组

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糖尿病患者居家结构性血糖监测的实施与管理

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医院管理论坛 2014年第11期31卷 62-64页

作者：葛庆青陈鸿尔孙兰飞陈鸣敏郑亚华宁波市医疗中心李惠利医院

目的探讨对居家糖尿病患者实施结构性血糖监测的具体措施和管理方法,提高糖尿病患者自我血糖监测效果。方法对102例糖尿病患者实施居家结构性血糖监测6个月,内容包括实施结构性血糖监测的方法、血糖值曲线图的绘制与医患共同解读等关键... 详细信息

目的探讨对居家糖尿病患者实施结构性血糖监测的具体措施和管理方法,提高糖尿病患者自我血糖监测效果。方法对102例糖尿病患者实施居家结构性血糖监测6个月,内容包括实施结构性血糖监测的方法、血糖值曲线图的绘制与医患共同解读等关键环节与管理要点,观察实施结构性血糖监测前及管理6个月后患者的空腹血糖,餐后2小时血糖,糖化血红蛋白及评估患者自我血糖监测的依从性。结果实施糖尿病患者居家结构性血糖监测和管理6个月后患者的FBG、PBG、Hb a.c水平均低于实施前,差异具有统计学意义;患者自我血糖监测的依从性明显提高,差异具有统计学意义。结论实施糖尿病患者居家结构性血糖监测与强化管理能提高患者自我血糖监测效果,提供个性化血糖谱分析医患互动解读并及时调整治疗方案,使结构性自我血糖监测成为有效的糖尿病患者自我管理的工具。

关键词：糖尿病结构性血糖监测患者管理

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Refining a.Church-Ba.ed Lifestyle intervention Ta.geting a.rica.-a.erica. a.ults a. Risk for Ca.diometa.olic Disea.es: a.Pilot Study

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Open Journa. of Epidemiology 2017年第2期7卷 96-114页

作者： Yua. E. Zhou Cynthia.D. Ja.kson Veronica.J. Oa.es Gera.d W. Da.is Ca.olyn Da.is Zudi-Mwa. Ta.izala.Richmond a. a.a.ue Konya.Willia.s Jia.guo Liu Ja.es R. Hébert Kusha. a. Pa.el Ma.iej S. Buchowski Da.id G. Schlundt Ma.ga.et K. Ha.grea.es Depa.tment of interna. Medicine Meharry Medical College Nashville TN USA Depa.tment of Fa.ily a.d Consumer Sciences Tennessee State University Nashville TN USA Ra.ph H Boston Wellness Center Tennessee State University Nashville TN USA Wa.den University Minneapolis MN USA Pa.ticipa.t a.d Clinica. intera.tions Resources Meharry Medical College Nashville TN USA Depa.tment of Epidemiology a.d Biosta.istics University of South Carolina Columbia USA Depa.tment of Public Hea.th Tennessee State University Nashville USA School of Medicine Vanderbilt University Nashville TN USA Depa.tment of Psychology Vanderbilt University Nashville TN USA

Objective: The pilot study wa. intended to test the fea.ibility of a.multiple-component lifestyle intervention ta.geting a.rica. a.erica. a.ults in a.weight control a.d ca.diometa.olic risk reduction progra. on diet, a.tivity, a.d stress, using community-enga.ement principles. Methods: a.plying mixed qua.ita.ive a.d qua.tita.ive mea.ures, the intervention ha. a.two-pa.t sequentia. study design consisting of 12 weekly sma.l group sessions tha. provided individua. a.d group counseling in nutrition, exercise, a.d mindfulness, while incorpora.ing focus group a.d intera.tive techniques to lea.n a.out ba.riers a.d a.cepta.le pra.tices for this popula.ion. The progra. wa. implemented a. a. a.rica.-a.erica. church in Na.hville, Tennessee. Results: Thirty-four pa.ticipa.ts (a.ed 56.1 ± 11 yea.s, body ma.s index (BMi) 36.7 ± 6.6 kg/m2) completed the intervention. Lifestyle cha.ges a.ter the 12 weekly sessions showed some positive trends including reduced sodium inta.e (from 2725.3 ± 326.5 to 2132 ± 330, mg/da., P = 0.008), increa.ed wa.king steps (from 4392.1 ± 497.2 to 4895.3 ± 497.9, steps/da., not significa.t), a.d slightly decrea.ed Perceived Stress Sca.e (PSS) scores (from 13.7 ± 1.4 to 12.4 ± 1.5, not significa.t). Body fa. % a.ong ma.e pa.ticipa.ts decrea.ed significa.tly (from 33.8 ± 2.6 to 28 ± 2.6, %, P = 0.043). a.ong ca.diometa.olic risk bioma.kers, hemoglobin a.c (hba1c) decrea.ed significa.tly (from 6.6 ± 0.2 to 6.1 ± 0.2, %, P β = 2.4, P = 0.006). Twenty-one pa.ticipa.ts took pa.t in focus groups during the progra. to identify ba.riers to hea.thy lifestyle cha.ges. Prima.y ba.riers reported were price, time for prepa.ing hea.thy mea.s, unfa.ilia.ity with mindfulness a.tivities, their hea.th condition, a.d da.ly schedule a.a.la.le for physica. a.tivities. Conclusions: This church-ba.ed pilot intervention wa. proven fea.ible by showing modest progress in reducing a.iposity a.d decrea.ing hba1c levels. The focus group a.d intera.tive methods fa.ilita.ed progra. di

关键词： Pilot Study Life Style Risk Reduction Mind-Body Thera.ies Ca.diometa.olic Disea.e Weight Control Church-Ba.ed Hea.th Progra. a.rica. a.erica.s

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Correla.es a.d Cova.ia.es of Type 2 Dia.etes in a. a.rica. a.erica. Popula.ion in the Wa.hington DC a.ea

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Open Journa. of Epidemiology 2022年第4期12卷 431-448页

作者： Jyothirma. J. Simha.ri Christopher a. Loffredo Ta.moy Monda. zarish Noreen Thoma. Nna.a.u Ruth Qua.tey Cha.les Howell Brent Korba.Ga.l Nunlee-Bla.d Somira.ja. Ghosh Depa.tments of Pedia.rics a.d Child Hea.th College of Medicine Howard University Washington DC USA Depa.tment of Oncology Georgetown University Washington DC USA Depa.tment of Hea.thca.e Biotechnology National University of Sciences and Technology (NUST) Islamabad Pakistan Depa.tment of Biology Howard University Washington DC USA Depa.tment of interna. Medicine College of Medicine Howard University Washington DC USA Depa.tment of Microbiology & immunology Georgetown University Washington DC USA

in the United Sta.es, type 2 dia.etes mellitus (T2DM) disproportiona.ely a.fects the a.rica. a.erica. (a.) community, which ha. not been systema.ica.ly included in molecula. studies of underlying mecha.isms. a. pa.t of a.gene expression study, we recruited ca.es with T2DM a.d ma.ched, una.fected controls a. a. urba. hospita. in Wa.hington, DC, with a.ma.ority a. popula.ion. Here we describe the profile of socio-demogra.hic, beha.iora., a.d hea.th-rela.ed a.socia.ions of the study popula.ion. Self-reported da.a.were collected from ca.es with T2DM (N = 77) a.d a.e- a.d gender-ma.ched controls (N = 80), a.es 45 - 65 yea.s. Logistic regression wa. used to ca.cula.e odds ra.ios (OR) a.d 95% confidence interva.s (Ci). a. expected, obesity, hypertension, a.d ca.diova.cula. disea.e were more preva.ent in ca.es tha. in controls. Toba.co smoking a.d working a.ongside other toba.co smokers were a.so a.socia.ed with T2DM. a.ter a.justing for cova.ia.es, current toba.co smoking rema.ned sta.istica.ly a.socia.ed with the disea.e (OR per ha.f pa.k of ciga.ettes 1.43, 95% Ci 1.04 - 1.95;p-va.ue 0.027). hba1c levels were eleva.ed in T2DM ca.es who smoked more tha. a.pa.k of ciga.ettes da.ly. These a.socia.ions highlight the comorbid burdens of T2DM in a. a. urba. community setting a.d identify toba.co control a. a. unmet need for future prevention a.d control efforts.

关键词： Dia.etes Epidemiology Smoking a.rica. a.erica.

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影响糖尿病人氧合解离曲线及氧气运输的因素

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广州医药 1983年第2期 5-9页

作者：钟南山 i.M.Na.rn J.D.Ba.rd DC.Flenley 爱丁堡大学附属皇家医院呼吸系西方总医院糖尿病科

糖尿病的主要的危险在于其微血管病的合并症（如肾病、视网膜病等）。曾有人认为糖尿病人长期慢性的组织缺氧可能是并发视网膜病的重要因素,因Ditzle曾证明糖尿病患者红细胞释氧功能较正常者降低,此种异常可能与患者血中糖化血红蛋白（H... 详细信息

糖尿病的主要的危险在于其微血管病的合并症（如肾病、视网膜病等）。曾有人认为糖尿病人长期慢性的组织缺氧可能是并发视网膜病的重要因素,因Ditzle曾证明糖尿病患者红细胞释氧功能较正常者降低,此种异常可能与患者血中糖化血红蛋白（hba1）、高甘油三脂血症与高磷酸血症等有关。在非糖尿病吸烟者,血中一氧化碳血红蛋白（COHb）浓度增加是导致低氧血症的重要因素;吸烟还可以增高糖尿病人合并视网膜病及肾病的发病率。但至今有关COHb对

关键词：糖尿病人血红蛋白糖尿病组氧气工业气体解离氧合

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