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家鸭资源利用及优良品种培育

厦门大学学报（自然科学版） 2001年第2期40卷 642-646页

作者：陈奕欣陈小麟吕良炬赵扬左正宏赖垣忠厦门大学生命科学学院福建厦门361005 湖南省岳阳卫生学校湖南岳阳414000

家鸭生物学研究为家鸭起源进化及资源利用提供了理论依据 ,指导家鸭生产与育种 .血清前白蛋白、mt DNA限制性内切酶谱和 RAPD证据表明 ,野鸭绿头鸭和斑嘴鸭在我国家鸭品种形成中均有贡献 .生化遗传学作为常规育种辅助手段 ,可用于早期... 详细信息

家鸭生物学研究为家鸭起源进化及资源利用提供了理论依据 ,指导家鸭生产与育种 .血清前白蛋白、mt DNA限制性内切酶谱和 RAPD证据表明 ,野鸭绿头鸭和斑嘴鸭在我国家鸭品种形成中均有贡献 .生化遗传学作为常规育种辅助手段 ,可用于早期选留种禽 .杂种优势利用仍然是提高生产性能的有效手段 .分子生物学与数量遗传学的相互交叉与渗透丰富了遗传育种理论 ,与生产性状相关的多基因性状的遗传规律和分子基础是当前研究的前沿和热点 .常规育种技术与现代生物学技术相结合 ,福建地方良种金定鸭群体平均年产蛋量从 2 12枚提高到 2 6 0枚以上 ;专门化品系最佳配套组合的产蛋量 30 0枚 ,总蛋量 2 2 kg.生产性能居国际先进水平 .金定鸭、北京鸭和番鸭三元杂交的后代 ,获得亲代的高产。

关键词：家鸭遗传育种资源利用遗传多样性养禽业种质资源良种培育

三丁基锡对文蛤鳃酸性磷酸酶、碱性磷酸酶和Na^+,K^+-ATP酶活性的影响

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海洋环境科学 2005年第3期24卷 56-59页

作者：黄周英陈奕欣赵扬左正宏陈美王重刚厦门大学细胞生物学与肿瘤细胞工程教育部重点实验室

在实验生态条件下,观察浓度分别为0.1、1.0和10ng/L的三丁基锡(TBT)暴露2、8、20d以及恢复7d和20d后对文蛤鳃酸性磷酸酶(aaciphosphatase,ACP)、碱性磷酸酶(alkalinephosphatase,AKP)以及Na+,K+-ATPase活性的影响。结果显示在暴露早期TBT不影响ACP、AKP活性,暴露时间延长则主要表现出诱导作用。TBT具有抑制Na+、K+-ATPase活性作用,可观察效应浓度为0.1ng/L。Na+、K+-ATPase可作为一种潜在的有机锡污染监测的生物标志物。

关键词：三丁基锡文蛤酸性磷酸酶碱性磷酸酶 Na^+,K^+-ATPase

AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

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Neural Regeneration Research 2025年第1期20卷 253-264页

作者： zhengwei Hu Jing Yang Shuo Zhang Mengjie Li Chunyan zuo Chengyuan Mao Zhongxian Zhang Mibo Tang Changhe Shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of zhengzhou University ZhengzhouHenan ProvinceChina NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan Key Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao Mei Tian Jian Wang Fengtao Liu Chuantao zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

我国部分家鸭和野鸭遗传多样性及亲缘关系的AFLP分析

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厦门大学学报（自然科学版） 2005年第5期44卷 729-733页

作者：鄢绯寰左正宏陈美宋岳强吕良炬陈奕欣厦门大学生命科学学院福建厦门361005

利用AFLP技术分析我国8种常见家鸭和2种野鸭基因组DNA的多态性,在选取的17对引物中,有9对能得到重复性好的多态性扩增条带.每对引物扩增带数在44～83之间.共得到513个标记位点,其中498个为多态位点,多态位点比率达97.1%;根据AFLP图谱计... 详细信息

利用AFLP技术分析我国8种常见家鸭和2种野鸭基因组DNA的多态性,在选取的17对引物中,有9对能得到重复性好的多态性扩增条带.每对引物扩增带数在44～83之间.共得到513个标记位点,其中498个为多态位点,多态位点比率达97.1%;根据AFLP图谱计算了不同样品间的遗传距离(D)和相似性系数(GS).家鸭品种间的遗传距离在 0.331～0.589范围内,绿头鸭、斑嘴鸭与家鸭品种(系)间的遗传距离分别在0.298～0.520和0.316～0.522之间.方差分析表明两组数据不存在显著差异(p＞0.05),由此得知绿头鸭和斑嘴鸭在家鸭品种的形成过程中都作出了贡献.并根据D值绘制了它们的聚类图谱.

关键词： AFLP 家鸭野鸭遗传多样性

An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro Letters 2025年第1期17卷 548-558页

作者： Ying Wang Kai Zhang Liping Ding Liyun Wu Songfeng E Qian He Nanyang Wang Hui zuo zhengyang Zhou Feng Ding Yue Hu Jin Zhang Yagang Yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

野生及家养动物寄生阔盘属吸虫系统发生关系初步研究

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寄生虫与医学昆虫学报 2005年第2期12卷 71-76页

作者：叶向群左正宏彭文峰李康生汕头大学医学院微生物与免疫学教研室汕头515031 厦门大学生命科学学院厦门361005

本文对普遍寄生于家畜及野生动物胰脏并引起胰吸虫病的几种阔盘属(Eurytrema)吸虫:腔阔盘吸虫(Eurytremacoelomaticum)、胰阔盘吸虫(Eurytremapancreaticun)、枝睾阔盘吸虫(Eurytremacladorchis)及福建阔盘吸虫(Eurytremafukienensis)的系统发生关系进行比较研究。分别提取寄生于不同种类宿主的这4种胰吸虫的基因组DNA ,利用随机引物进行PCR扩增,从80个随机引物中筛选出重复性好、谱带清晰并呈多态性的引物31个,共扩增出30 3条DNA带。根据重复性好、谱带清晰并呈多态性的引物扩增的结果计算遗传距离,根据遗传距离利用UPGMA方法进行聚类分析,构建出阔盘属几种吸虫的系统发生树,分子系统发生与形态学分类一致。

关键词：野生动物家养动物阔盘属吸虫系统发育寄生虫

Low Cycle Fatigue and Strengthening Mechanism of Cold Extruded Large Diameter Internal Thread of Q460 Steel

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Chinese Journal of Mechanical Engineering 2016年第3期29卷 556-563页

作者： MIAO hong MEI Qing YUAN Jingyun zheng Zaixiang JIN Yifu zuo Dunwen College of Mechanical Engineering Yangzhou University College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics

large diameter internal thread of high-strength steel（LDITHSS） manufactured by traditional methods always has the problems of low accuracy and short life. Compared with traditional methods, the cold extrusion process is an effective means to realize higher accuracy and longer life. The low-cycle fatigue properties of LDITHSS are obtained by experiments, and the initiation and propagation of fatigue cracks are observed by scanning electron microscope（SEM）. Based on the mechanical properties, surface microstructure and residual stress, the strengthening mechanism of cold extruded large diameter internal thread（LDIT） is discussed. The results show that new grains or sub-grains can be formed on the surface of LDIT due to grain segmentation and grain refinement during cold extrusion. The fibrous structures appear as elongated and streamlined along the normal direction of the tooth surface which leads to residual compressive stress on the extruded surface. The maximum tension stress of LDIT after cold extrusion is found to be 192.55 k N. Under low stress cycling, the yield stress on thread increases, the propagation rate of crack reduces, the fatigue life is thus improved significantly with decreasing surface grain diameter and the average fatigue life increases to 45.539×10~3 cycle when the maximum applied load decreases to 120 k N. The low cycle fatigue and strengthening mechanism of cold extruded LDIT revealed by this research has significant importance to promote application of internal thread by cold extrusion processing.

关键词： large diameter internal thread cold extrusion low cycle fatigue strengthening fatigue resistance

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坛紫菜叶状体体细胞对抗生素敏感性的研究

台湾海峡 2004年第4期23卷 496-499页

作者：赵扬李秀左正宏王诚王重刚陈奕欣厦门大学生命科学学院细胞生物学与肿瘤细胞工程教育部重点实验室福建厦门361005

坛紫菜(Porphyrahaitanensis)叶状体体细胞对氨苄青霉素有很强的耐受性,但氨苄青霉素对体细胞分裂、分化具有明显的抑制作用,导致更多的体细胞分化形成细胞团,并能抑制叶状体假根的形成.坛紫菜叶状体体细胞对氯霉素敏感,100μg/cm3和800... 详细信息

坛紫菜(Porphyrahaitanensis)叶状体体细胞对氨苄青霉素有很强的耐受性,但氨苄青霉素对体细胞分裂、分化具有明显的抑制作用,导致更多的体细胞分化形成细胞团,并能抑制叶状体假根的形成.坛紫菜叶状体体细胞对氯霉素敏感,100μg/cm3和800μg/cm3组的体细胞分别于培养的12、10d全部死亡.本试验结果初步表明,氯霉素可作为坛紫菜基因工程的有效选择压力.

关键词：坛紫菜体细胞菜叶叶状体抗生素敏感性氯霉素分化氨苄青霉素耐受性细胞团