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Continuous release of interleukin 12 from microencapsulated engineered cells for colon cancer therapy

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World Journal of Gastroenterology 2003年第5期9卷 951-955页

作者： Shu Zheng zuo-Xiang xiao Yue-long Pan Ming-Yong Han Qi Dong Cancer Institute,Zhejiang University,Hangzhou 310009,Zhejiang Province,China Cancer Institute Zhejiang University Hangzhou 310009 Zhejiang Province China. zhengshu@***

AIM: To explore the anti-tumor immunity against CT26 colon tumor of the microencapsulated cells modified with murine interleukine-12 (mIL-12) ***: Mouse fibroblasts (NIH3T3) were stably transfected to express mIL-12 using expression plasmids carrying mIL-12 gene (p35 and p40), and NIH3T3-mIL-12cells were encapsulated in alginate microcapsules for longterm delivery of mIL-12. mIL-12 released from the microencapsulated NIH3T3-mIL-12 cells was confirmed using ELISA assay. Transplantation of the microencapsulated NIH3T3-mIL-12 cells was performed in the tumor-bearing mice with CT26 cells. The anti-tumor responses and the anti-tumor activities of the microencapsulated NIH3T3-mIL12 cells were ***: Microencapsulated NIH3T3-mIL-12 cells could release mIL-12 continuously and stably for a long time. After the microencapsulated NIH3T3-mIL-12 cells were transplanted subcutaneously into the tumor-bearing mice for 21 d, the serum concentrations of mIL-12, mIL-2 and mIFN-γ the cytotoxicity of the CTL from the splenocytes and the NK activity in the treatment group were significantly higher than those in the controls. Moreover, mIL-12 released from the microencapsulated NIH3T3-mIL-12 cells resulted in a significant inhibition of tumor proliferation and a prolonged survival of tumor-bearing ***: The microencapsulated NIH3T3-mIL-12cells have a significant therapeutic effect on the experimental colon tumor by activating anti-tumor immune responses in vivo. Microencapsulated and genetically engineered cells may be an extremely versatile tool for tumor gene therapy.

关键词：微胶囊化工程细胞白细胞介素-12 结肠癌肿瘤治疗学肿瘤抑制细胞因子

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流动性过剩与我国货币政策效果的原因分析

河北大学学报（哲学社会科学版） 2008年第1期33卷 26-29页

作者：左晓龙顾瑶叶军利河北大学经济学院河北保定071002 河北工程大学经济管理学院河北邯郸056038 邯郸县农村信用联社河北邯郸056000

近两年来,我国银行的流动性过剩问题日益凸显,并极大地影响了中央银行货币政策的有效性。本文首先描述了我国流动性问题的现状,并分析了中央银行针对流动性过剩采取的各种调控政策及其实施的效果。然后分析了央行货币政策无效的原因,即... 详细信息

近两年来,我国银行的流动性过剩问题日益凸显,并极大地影响了中央银行货币政策的有效性。本文首先描述了我国流动性问题的现状,并分析了中央银行针对流动性过剩采取的各种调控政策及其实施的效果。然后分析了央行货币政策无效的原因,即三元悖论。最后根据三元悖论的原理提出缓解流动性过剩,提高货币政策有效性的建议。

关键词：流动性过剩货币政策三元悖论

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杂交玉米皖试3号高产栽培技术研究

玉米科学 2007年第B09期15卷 119-122页

作者：童有才张会南左晓龙安徽省农业科学院作物研究所合肥230031

采用四因素五水平二次回归正交旋转组合设计,建立了皖试3号产量(Y)与密度(X1)、施氮量(X2)、复合肥量(X3)和施钾量(X4)的数学模型。对回归方程进行了统计选优和降维分析。结果表明,各因素的重要性依次为密度、施氮量、施复合肥量、施钾... 详细信息

采用四因素五水平二次回归正交旋转组合设计,建立了皖试3号产量(Y)与密度(X1)、施氮量(X2)、复合肥量(X3)和施钾量(X4)的数学模型。对回归方程进行了统计选优和降维分析。结果表明,各因素的重要性依次为密度、施氮量、施复合肥量、施钾量;产量在9 000 kg/hm2以上的栽培模式为密度78 845～80 892株/hm2,氮肥用量为尿素380～423 kg/hm2,复合肥用量为597～700 kg/hm2,氯化钾178～218 kg/hm2。

关键词：杂交玉米皖试3号高产栽培技术

An Unprecedented Efficiency with Approaching 21%Enabled by Additive‑Assisted Layer‑by‑Layer Processing in Organic Solar Cells

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Nano-Micro Letters 2025年第2期17卷 372-375页

作者： Shuai Xu Youdi Zhang Yanna Sun Pei Cheng Zhaoyang Yao Ning Li long Ye Lijian zuo Ke Gao Key Laboratory of Advanced Green Functional Materials College of ChemistryChangchun Normal UniversityChangchun 130032People’s Republic of China Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237People’s Republic of China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China State Key Laboratory and Institute of Elemento‑Organic Chemistry Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsRenewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071People’s Republic of China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Tianjin Key Laboratory of Molecular Optoelectronic Sciences School of Materials Science and EngineeringTianjin UniversityTianjin 300350People’s Republic of China State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Recently published in Joule,Feng Liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8%power conversion efficiency in organic solar cells(OSCs)with an interpenetrating fibril network active layer morphology,featuring a bulk p-in structure and proper vertical segregation achieved through additive-assisted layer-by-layer *** optimized hierarchical gradient fibrillar morphology and optical management synergistically facilitates exciton diffusion,reduces recombination losses,and enhances light capture *** approach not only offers a solution to achieving high-efficiency devices but also demonstrates the potential for commercial applications of OSCs.

关键词： Organic solar cells Additive-assisted layer-by-layer processing Three-dimensional fibril morphology Bulk p-i-n structure Optical management

玉米种子萌发响应淹水胁迫的定量蛋白质组学研究

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安徽农业科学 2017年第9期45卷 134-136,166页

作者：张玮阮龙张欣左晓龙安徽省农业科学院烟草研究所安徽合肥230031 安徽农业大学生命科学学院安徽合肥230036

[目的]从蛋白质组水平上研究淹水胁迫对玉米种子萌发的影响,筛选重要蛋白质,阐明相关的代谢通路,为深入研究植物种子萌发过程中的耐淹机制提供新的思路。[方法]以玉米自交系196为试验材料,对种子萌发进行淹水胁迫72 h处理,利用TMT标记结... 详细信息

[目的]从蛋白质组水平上研究淹水胁迫对玉米种子萌发的影响,筛选重要蛋白质,阐明相关的代谢通路,为深入研究植物种子萌发过程中的耐淹机制提供新的思路。[方法]以玉米自交系196为试验材料,对种子萌发进行淹水胁迫72 h处理,利用TMT标记结合LC-MS/MS的定量蛋白质组学技术对蛋白质组成进行分析,对差异表达的蛋白质进行鉴定及功能分析。[结果]此次试验总共鉴定到1 456个蛋白,通过比较、筛选,鉴定到281个差异蛋白,其中244个上调蛋白,37个下调蛋白。通过对差异表达的蛋白质进行了GO功能富集分析和KEGG通路富集分析,发现这些差异蛋白大多参与了碳代谢、糖酵解过程、氨基酸代谢、抗逆与胁迫等过程。[结论]试验表明淹水胁迫抑制了玉米种子的萌发,通过不同代谢类型的动态变化和不同的信号转导来提高种子耐受性。

关键词：玉米定量蛋白质组学淹水胁迫

Construction and Application of a High-throughput Method for Identifying Maize Resistance to Aspergillus flavus in the Field

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Agricultural Science & Technology 2018年第5期19卷 43-49页

作者： QI Yao-cheng DING Jian-zhou zuo xiao-long ZHANG Wei QIAN Yi-liang REN Si-hai WANG Jun GUO Jin RUAN long Tobacco Research Institute Anhui Academy of Agricultural SciencesHefei 230031PRC

In order to establish a fast and effective high-throughput method for identifying maize resistance to Aspergillus flavus infection in the field,5 conidial concentrations and 3 inoculation methods were compared and optimized. A correlation model between disease levels and aflatoxin B1 accumulation was established. The results showed that inoculating maize inbred lines with the optimal conidial concentration of 1.0×10^6 c/mL could accurately show the different resistance levels of maize to *** infection,and the spiral quantitative inoculation technique could effectively avoid the defect of calculation error caused by commonly used methods. The positive correlation model of resistance level and aflatoxin B1 accumulation could effectively predict the capability of maize being resistant to ***. 8 resistant and 9 medium resistant maize inbred lines of the RIL population were *** spiral quantitative identification method realized the high-throughput identification of maize inbred lines resistant to *** infection in the field,and the results have shown high accuracy,stability and repeatability.

关键词： Maize Aspergillus flavus Inoculation method Disease level Resistance evaluation

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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栽培密度对黑糯玉米秋季性状指标的影响

安徽农业科学 2019年第1期47卷 24-25,44页

作者：任四海阮龙左晓龙齐耀程钱益亮王俊张玮郭进安徽省农业科学院烟草研究所安徽合肥230031

研究了在江淮地区,栽培密度对黑糯玉米秋季田间性状、产量及品质指标的影响。结果表明,栽培密度由45 000株/hm^2提高到75 000株/hm^2,果穗籽粒颜色由白色转为黑色的速率变慢,籽粒完全转为黑色所需时间约相差2 d;株高、穗位表现为先逐步... 详细信息

研究了在江淮地区,栽培密度对黑糯玉米秋季田间性状、产量及品质指标的影响。结果表明,栽培密度由45 000株/hm^2提高到75 000株/hm^2,果穗籽粒颜色由白色转为黑色的速率变慢,籽粒完全转为黑色所需时间约相差2 d;株高、穗位表现为先逐步提高后趋于稳定;单果穗的重量在授粉后18～30 d内先快速增加后缓慢降低,单果穗重量的峰值随栽培密度的增加在时间上向后推移;鲜果穗产量随栽培密度的提高先增加后降低,以60 000株/hm^2的栽培密度产量最高;鲜果穗的感官品质在栽培密度达到67 500株/hm^2后,品质变差,综合品尝总分随栽培密度的提高先略有提高,后明显降低。

关键词：黑糯玉米栽培密度籽粒颜色田间性状品尝指标

Vector meson's spin alignments in high energy reactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 5-20页

作者： Jin-Hui Chen zuo-Tang Liang Yu-Gang Ma Xin-Li Sheng Qun Wang Key Laboratory of Nuclear Physics and Ion-beam Application (MoE) Institute of Modern PhysicsFudan University Institute of Frontier and Interdisciplinary Science Key Laboratory of Particle Physics and Particle Irradiation (MOE)Shandong University INFN-Firenze Department of Modern Physics University of Science and Technology of China School of Mechanics and Physics Anhui University of Science and Technology

The global spin alignment of vector mesons has been observed by the STAR collaboration at the Relativistic Heavy Ion Collider （RHIC） at Brookhaven National Laboratory （BNL）.It provides a unique opportunity to probe the correlation between the polarized quark and antiquark in the strongly coupled quark-gluon plasma （sQGP） produced in relativistic heavy ion collisions,opening a new window to explore the properties of s *** addition,spin alignments of vector mesons have also been observed in other high-energy particle collisions such as e+e-annihilations at high energies where hadron production is dominated by quark fragmentation *** results obtained are quite different from those obtained in heavy ion collisions where quark coalescence/combination mechanism dominates suggesting strong dependence on hadronization *** comprehensive studies in different hadronization processes are *** this article,we present a brief review of theoretical and experimental advances in the study of vector meson’s spin alignments in a variety of high-energy particle collisions,with emphasis on hadronization mechanisms.

关键词： vector meson spin alignment global polarization relativistic heavy ion collisions fragmentation